Reconstructing the Engram: Simultaneous, Multisite, Many Single Neuron Recordings

AbstractLittle is known about the physiological principles that govern large-scale neuronal interactions in the mammalian brain. Here, we describe an electrophysiological paradigm capable of simultaneously recording the extracellular activity of large populations of single neurons, distributed across multiple cortical and subcortical structures in behaving and anesthetized animals. Up to 100 neurons were simultaneously recorded after 48 microwires were implanted in the brain stem, thalamus, and somatosensory cortex of rats. Overall, 86% of the implanted microwires yielded single neurons, and an average of 2.3 neurons were discriminated per microwire. Our population recordings remained stable for weeks, demonstrating that this method can be employed to investigate the dynamic and distributed neuronal ensemble interactions that underlie processes such as sensory perception, motor control, and sensorimotor learning in freely behaving animals

Prevalence of fetal-type smooth muscle cells in the media of microvessels from hypertensive patients

IF 5,6

Measurements of heavy-flavour correlations and jets with ALICE at the LHC

In this work, the latest heavy-flavour correlation and jet measurements at mid-rapidity with the ALICE detector in pp, p-Pb and Pb-Pb collisions from the LHC Run 2 are reported. In particular, the results of azimuthal correlation measurements of D mesons with charged particles in pp collisions at root s = 13 TeV and in p-Pb collisions at root S-NN = 5.02 TeV are presented. Studies on the centrality-dependent azimuthal correlations of heavy-flavour hadron decay electrons with charged particles in Pb Pb collisions at root S-NN = 5.02 TeV are shown. In addition, measurements of D-meson tagged jet production in pp collisions at root s = 7 TeV and in p Pb collisions at root S-NN = 5.02 TeV are presented, including studies in pp collisions of the jet momentum fraction carried by the D meson. A first result on the D-meson tagged jet nuclear modification factor in central Pb Pb collisions at root S-NN = 5.02 TeV is also reported

Measurements of heavy-flavour correlations and jets with ALICE at the LHC

In this work, the latest heavy-flavour correlation and jet measurements at mid-rapidity with the ALICE detector in pp, p-Pb and Pb-Pb collisions from the LHC Run 2 are reported. In particular, the results of azimuthal correlation measurements of D mesons with charged particles in pp collisions at root s = 13 TeV and in p-Pb collisions at root S-NN = 5.02 TeV are presented. Studies on the centrality-dependent azimuthal correlations of heavy-flavour hadron decay electrons with charged particles in Pb Pb collisions at root S-NN = 5.02 TeV are shown. In addition, measurements of D-meson tagged jet production in pp collisions at root s = 7 TeV and in p Pb collisions at root S-NN = 5.02 TeV are presented, including studies in pp collisions of the jet momentum fraction carried by the D meson. A first result on the D-meson tagged jet nuclear modification factor in central Pb Pb collisions at root S-NN = 5.02 TeV is also reported

Direct observation of the dead-cone effect in quantum chromodynamics

The direct measurement of the QCD dead cone in charm quark fragmentation is reported, using iterative declustering of jets tagged with a fully reconstructed charmed hadron

Λ c+ production in Pb–Pb collisions at s NN =5.02 TeV

AA measurement of the production of prompt Λ c + baryons in Pb–Pb collisions at s NN =5.02 TeV with the ALICE detector at the LHC is reported. The Λ c + and Λ‾ c − were reconstructed at midrapidity (|y|<0.5) via the hadronic decay channel Λ c + →pK S 0 (and charge conjugate) in the transverse momentum and centrality intervals