Vortices and monopole distributions in Z(2)×SO(3)Z(2) \times SO(3) lattice gauge theory

We examine the occurance of Z(2) and SO(3) vorticies and monopole distributions in the neighborhood of Wilson loops. We use the Tomboulis formulation, equivalent to the Wilson action, in which the links are invariant under Z(2) transformations and new plaquette variables carry the Z(2) degrees of freedom. This gives new gauge invariant observables to help gain insight into the area law and structure of the flux tube.Comment: LaTe

A Generic Framework for Hidden Markov Models on Biomedical Data

Background: Biomedical data are usually collections of longitudinal data assessed at certain points in time. Clinical observations assess the presences and severity of symptoms, which are the basis for description and modeling of disease progression. Deciphering potential underlying unknowns solely from the distinct observation would substantially improve the understanding of pathological cascades. Hidden Markov Models (HMMs) have been successfully applied to the processing of possibly noisy continuous signals. The aim was to improve the application HMMs to multivariate time-series of categorically distributed data. Here, we used HHMs to study prediction of the loss of free walking ability as one major clinical deterioration in the most common autosomal dominantly inherited ataxia disorder worldwide. We used HHMs to investigate the prediction of loss of the ability to walk freely, representing a major clinical deterioration in the most common autosomal-dominant inherited ataxia disorder worldwide. Results: We present a prediction pipeline which processes data paired with a configuration file, enabling to construct, validate and query a fully parameterized HMM-based model. In particular, we provide a theoretical and practical framework for multivariate time-series inference based on HMMs that includes constructing multiple HMMs, each to predict a particular observable variable. Our analysis is done on random data, but also on biomedical data based on Spinocerebellar ataxia type 3 disease. Conclusions: HHMs are a promising approach to study biomedical data that naturally are represented as multivariate time-series. Our implementation of a HHMs framework is publicly available and can easily be adapted for further applications

Disaster Resilience Education and Research Roadmap for Europe 2030 : ANDROID Report

A disaster resilience education and research roadmap for Europe 2030 has been launched. This roadmap represents an important output of the ANDROID disaster resilience network, bringing together existing literature in the field, as well as the results of various analysis and study projects undertaken by project partners.The roadmap sets out five key challenges and opportunities in moving from 2015 to 2030 and aimed at addressing the challenges of the recently announced Sendai Framework for Disaster Risk Reduction 2015-2030. This roadmap was developed as part of the ANDROID Disaster Resilience Network, led by Professor Richard Haigh of the Global Disaster Resilience Centre (www.hud.ac.uk/gdrc ) at the School of Art, Design and Architecture at the University of Huddersfield, UK. The ANDROID consortium of applied, human, social and natural scientists, supported by international organisations and a stakeholder board, worked together to map the field in disaster resilience education, pool their results and findings, develop interdisciplinary explanations, develop capacity, move forward innovative education agendas, discuss methods, and inform policy development. Further information on ANDROID Disaster Resilience network is available at: http://www.disaster-resilience.netAn ANDROID Disaster Resilience Network ReportANDROI

The Black Hole Mass and Extreme Orbital Structure in NGC1399

The largest galaxies, and in particular central galaxies in clusters, offer unique insight into understanding the mechanism for the growth of nuclear black holes. We present Hubble Space Telescope kinematics for NGC1399, the central galaxy in Fornax. We find the best-fit model contains a black hole of 5.1 +-0.7 x 10^8 Msun (at a distance of 21.1 Mpc), a factor of over 2 below the correlation of black hole mass and velocity dispersion. We also find a dramatic signature for central tangential anisotropy. The velocity profiles on adjacent sides 0.5" away from the nucleus show strong bimodality, and the central spectrum shows a large drop in the dispersion. Both of these observations point to an orbital distribution that is tangentially biased. The best-fit orbital model suggests a ratio of the tangential to radial internal velocity dispersions of three. This ratio is the largest seen in any galaxy to date and will provide an important measure for the mode by which the central black hole has grown.Comment: 9 pages, accepted for publication in the Astrophysical Journa

The Bullet cluster at its best: weighing stars, gas and dark matter

We present a new strong lensing mass reconstruction of the Bullet cluster (1E 0657-56) at z=0.296, based on WFC3 and ACS HST imaging and VLT/FORS2 spectroscopy. The strong lensing constraints underwent substantial revision compared to previously published analysis, there are now 14 (six new and eight previously known) multiply-imaged systems, of which three have spectroscopically confirmed redshifts (including one newly measured from this work). The reconstructed mass distribution explicitly included the combination of three mass components: i) the intra-cluster gas mass derived from X-ray observation, ii) the cluster galaxies modeled by their fundamental plane scaling relations and iii) dark matter. The model that includes the intra-cluster gas is the one with the best Bayesian evidence. This model has a total RMS value of 0.158" between the predicted and measured image positions for the 14 multiple images considered. The proximity of the total RMS to resolution of HST/WFC3 and ACS (0.07-0.15" FWHM) demonstrates the excellent precision of our mass model. The derived mass model confirms the spatial offset between the X-ray gas and dark matter peaks. The fraction of the galaxy halos mass to total mass is found to be f_s=11+/-5% for a total mass of 2.5+/-0.1 x 10^14 solar mass within a 250 kpc radial aperture.Comment: Accepted by A&A 15 pages, 12 figure

A Quintet Of Black Hole Mass Determinations

We report five new measurements of central black hole masses based on Space Telescope Imaging Spectrograph and Wide Field Planetary Camera 2 observations with the Hubble Space Telescope (HST) and on axisymmetric, three-integral, Schwarzschild orbit-library kinematic models. We selected a sample of galaxies within a narrow range in velocity dispersion that cover a range of galaxy parameters (including Hubble type and core/power-law surface density profile) where we expected to be able to resolve the galaxy's sphere of influence based on the predicted value of the black hole mass from the M-sigma relation. We find masses for the following galaxies: NGC3585, M(BH) = 3.4(-0.6)(+1.5) x 10(8) M(circle dot;) NGC 3607, M(BH) = 1.2(-0.4)(+0.4) x 10(8) M(circle dot); NGC 4026, M(BH) = 2.1(-0.4)(+0.7) x 10(8) M(circle dot); and NGC 5576, M(BH) = 1.8(-0.4)(+0.3) x 10(8) M(circle dot), all significantly excluding M(BH) = 0. For NGC 3945, M(BH) = 9(-21)(+17) x 10(6) M(circle dot), which is significantly below predictions from M-sigma and M-L relations and consistent with MBH = 0, though the presence of a double bar in this galaxy may present problems for our axisymmetric code.NASA/HST GO-5999, GO-6587, GO-6633, GO-7468, GO-9107NASA NAS 5-26555Astronom

Differential diagnostic challenge of chronic neutrophilic leukemia in a patient with prolonged leukocytosis

Our interesting case deals with the clinical and morphological aspects of a chronic neutrophilic leukemia and the critical evaluation of differential diagnosis of leukemoid reaction in bone marrow biopsies

The M-sigma and M-L Relations in Galactic Bulges and Determinations of their Intrinsic Scatter

We derive improved versions of the relations between supermassive black hole mass (M_BH) and host-galaxy bulge velocity dispersion (sigma) and luminosity (L) (the M-sigma and M-L relations), based on 49 M_BH measurements and 19 upper limits. Particular attention is paid to recovery of the intrinsic scatter (epsilon_0) in both relations. We find log(M_BH / M_sun) = alpha + beta * log(sigma / 200 km/s) with (alpha, beta, epsilon_0) = (8.12 +/- 0.08, 4.24 +/- 0.41, 0.44 +/- 0.06) for all galaxies and (alpha, beta, epsilon_0) = (8.23 +/- 0.08, 3.96 +/- 0.42, 0.31 +/- 0.06) for ellipticals. The results for ellipticals are consistent with previous studies, but the intrinsic scatter recovered for spirals is significantly larger. The scatter inferred reinforces the need for its consideration when calculating local black hole mass function based on the M-sigma relation, and further implies that there may be substantial selection bias in studies of the evolution of the M-sigma relation. We estimate the M-L relationship as log(M_BH / M_sun) = alpha + beta * log(L_V / 10^11 L_sun,V) of (alpha, beta, epsilon_0) = (8.95 +/- 0.11, 1.11 +/- 0.18, 0.38 +/- 0.09); using only early-type galaxies. These results appear to be insensitive to a wide range of assumptions about the measurement errors and the distribution of intrinsic scatter. We show that culling the sample according to the resolution of the black hole's sphere of influence biases the relations to larger mean masses, larger slopes, and incorrect intrinsic residuals.Comment: 27 pages, 18 figures, 7 tables, ApJ accepte

The Importance of <em>Sceletium tortuosum</em> (L.) N.E. Brown and Its Viability as a Traditional African Medicinal Plant

Sceletium tortuosum is a succulent plant that belongs to the family Mesembryanthemaceae (Aizoaceae). It is indigenous to South Africa, where it is well known by the indigenous people, especially in Namaqualand where the plant is utilized regularly for its medicinal and psycho-active properties. The main alkaloids responsible for these properties are mesembrine, mesembrenine (mesembrenone), and mesembrenol. The potential of the plant to be an alternative supplement in the promotion of health and treating a variety of psychological and psychiatric disorders such as depression and anxiety has stimulated interest in its pharmacological property and possibility of its commercialization. The economic value of indigenous medicinal plants in South Africa is approximately US$60 000 000 or R4 000 000 000 annually. Thus, interest in the knowledge and use of Traditional African Medicinal Plants (TAMP) as well as meeting pharmacological and economic needs of ever-increasing human population has led to the commercialization of traditional African medicines at a fast rate. It was found that S. tortuosum has clear pharmaceutical and economical importance and is one of the only known plants to contain the alkaloids mesembrenone and mesembrine which can be utilized for the promotion of health and/or treating a variety of psychological disorders such as anxiety and depression