Por Martin Sanchez de Peña y Franca Garzez de Ortiz con Doña Rafaela de Ayerbe ...

Texto a dos col.Copia digital : Diputación Provincial de Zaragoza. Servicio de Archivos y Bibliotecas, 2010Sign.: A\p4\

Cancer mortality in the Republic of San Marino

Artículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 1986The Republic of San Marino (RSM) is a small independent nation on the Italian peninsula located within the Emilia-Romagna region near the Adriatic sea. The population in 1980 was 21500. Until 1950 the economy was essentially based on agriculture, but since 1950 there has been a noticeable development of tourism. Traditions and ancient laws have increased the isolation of people living in the RSM and the population still shows characteristics of 'genetic segregation'. In 1949 Suzzi-Valli noted the possible relationship between this phenomenon and mortality rates for neoplasms.' Well-organized health services and the small population made possible a careful statistical recording of causes of death in the RSM since the beginning of the century. Suzzi-Valli,' Bisbini et al,' studying cancer mortality in the RSM during the periods 1908 to 1947 and 1948 to 1965 respectively, found high crude mortality rates for all neoplasms and stomach cancer as the leading cause of death. This paper reports on the cancer mortality data of the RSM for the years 1966 to 1980.Universidad de Costa RicaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA

Traqueostomia para retirada de corpo estranho em vias aéreas / Tracheostomy for removal of foreign body in airway

Analisar riscos, benefícios e indicações de retirada de corpo estranho por meio de traqueostomia

Euro Surveill

In September 2023, a severe outbreak of type B botulism with fifteen cases was linked to consumption of canned sardines at a restaurant in Bordeaux, France, during the Rugby World Cup. The cases were from seven countries. One death was recorded. Outbreak investigation using credit card data, rapid communication between health authorities of the affected countries and broad media communication allowed identification of cases and exposed persons and prevented further severe outcomes

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

A new side-neck turtle (Pelomedusoides: Bothremydidae) from the Early Paleocene (Danian) Maria Farinha Formation, Paraíba Basin, Brazil

Carvalho, Anny Rafaela De Araújo, Ghilardi, Aline Marcele, Barreto, Alcina Magnólia Franca (2016): A new side-neck turtle (Pelomedusoides: Bothremydidae) from the Early Paleocene (Danian) Maria Farinha Formation, Paraíba Basin, Brazil. Zootaxa 4126 (4): 491-513, DOI: http://doi.org/10.11646/zootaxa.4126.4.

Electroanalytical determination of carbendazim and fenamiphos in natural waters using a diamond electrode

In this study, a method for electroanalytical determination of carbendazim (CBZ) and fenamiphos (FNP) in natural and spiked water was developed using square wave voltammetly in Na2HPO4 0.1 mol L-1 as supporting electrolyte. the calibration curve for carbendazim detection presented good linearity in the concentration range of 0.50 to 15.0 mu M, with a sensitivity of 0.080 A/mol L-1 and a linearity of 0.998. the oxidation of fenamiphos on BDD electrode shows a dynamic range of concentration of 0.5 to 25.0 mu M and sensibility of 0.14 A/mol L-1. the recovery experiments showed values between 70 and 100% for spiked samples thus indicating the feasibility of the electroanalytical methodology to quantify CBZ and FNP in pure or natural waters. (C) 2012 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação para o Desenvolvimento da UNESP (FUNDUNESP)Universidade Federal de São Paulo, Dept Ciencias Exatas & Terra, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, BrazilUniv Camilo Castelo Branco, Sao Jose Dos Campos, SP, BrazilUniv Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Pelotas, RS, BrazilUNESP, Dept Chem & Biochem, Inst Biosci, Botucatu, SP, BrazilUniversidade Federal de São Paulo, Dept Ciencias Exatas & Terra, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, BrazilFAPESP: 2008/50588-6FUNDUNESP: 0049/11-DFPWeb of Scienc

Human Neuronal Cell Lines as An In Vitro Toxicological Tool for the Evaluation of Novel Psychoactive Substances

Novel psychoactive substances (NPS) are synthetic substances belonging to diverse groups, designed to mimic the effects of scheduled drugs, resulting in altered toxicity and potency. Up to now, information available on the pharmacology and toxicology of these new substances is very limited, posing a considerable challenge for prevention and treatment. The present in vitro study investigated the possible mechanisms of toxicity of two emerging NPS (i) 4′-methyl-alpha-pyrrolidinoexanophenone (3,4-MDPHP), a synthetic cathinone, and (ii) 2-chloro-4,5-methylenedioxymethamphetamine (2-Cl-4,5-MDMA), a phenethylamine. In addition, to apply our model to the class of synthetic opioids, we evaluated the toxicity of fentanyl, as a reference compound for this group of frequently abused substances. To this aim, the in vitro toxic effects of these three compounds were evaluated in dopaminergic-differentiated SH-SY5Y cells. Following 24 h of exposure, all compounds induced a loss of viability, and oxidative stress in a concentration-dependent manner. 2-Cl-4,5-MDMA activates apoptotic processes, while 3,4-MDPHP elicits cell death by necrosis. Fentanyl triggers cell death through both mechanisms. Increased expression levels of pro-apoptotic Bax and caspase 3 activity were observed following 2-Cl-4,5-MDMA and fentanyl, but not 3,4-MDPHP exposure, confirming the different modes of cell death