The Expression and Roles of Nde1 and Ndel1 in the Adult Mammalian Central Nervous System

Open Access funded by Wellcome Trust Under a Creative Commons license Acknowledgments We thank Prof Angelo Sementilli, Department of Pathology, Universidade Metropolitana de Santos, SP, Brazil, for the human sample collection. This study is funded by Scottish Universities Life Sciences Alliance (HR07019 to S. Shen and C.D. McCaig), Medical Research Scotland (384 FRG to B. Lang, United Kingdom), Tenovus Scotland (G12/25 to B. Lang), Sino-UK Higher Education Research Partnership for PhD Studies (C.D. McCaig and Y.Q. Ding) and Wellcome Trust (WT081633MA-NCE to P.J.A. McCaffery, United Kingdom).Peer reviewedPublisher PD

The impact of financial restatements on financial markets: A systematic review of the literature

Purpose: The purpose of this paper is to discuss the most relevant issues related to the impact of financial restatements in the dynamics of financial markets and identify several research gaps to be investigated in future research. Design/methodology/approach: The methodology is based on a systematic review of the literature described by Tranfield et al. (2003). The final sample includes 47 academic papers published from 1996 to 2019. Findings: Papers in this domain discuss three main topics: how the market prices the announcement of a financial restatement; how financial restatements affect the announcing firm’s cost of capital and how financial restatements affect firms’ reputation. There are several issues to explore in future research, including whether financial restatements affect the dynamics of financial markets in Europe, whether the market fully and promptly assimilates the information content of a restatement, the role of financial analysts’ information disclosures in this process or how regulators may improve the way they provide investors with timely information about firms’ restating problems. Research limitations/implications: There is always some degree of subjectivity in the definition of the keywords, search strings and selection criteria in a systematic review. These are all important aspects, as they delimitate the scope of the study and define the sample of papers to be reviewed. Practical implications: The answers to the research questions identified in this paper may provide regulators with information to improve financial accounting and reporting standards and strengthen investors’ confidence in accounting information and the dynamics of financial markets. Originality/value: This paper systematically reviews the relevant literature exploring the connection between financial restatements and the dynamics of financial markets. It contributes to the academic community by identifying several research questions that may impact the theory and practice related to accounting quality and capital markets.info:eu-repo/semantics/acceptedVersio

Brazil certificate - rice export value added.

The rice produced in Rio Grande do Sul (RS) has quantity (productivity + technologie) that contributes to food security, quality (organoleptide + food safety + varietal identification) that contributes to value addition and positive image and meets safety, requirements environmental (environmental licensing + rural land register) that contribute to the preservation of the Pampa Biome. All these positive aspects are the basis for an official certification of the Brazilian government whose identification label is Brazil Certificate: Quality Agriculture. The rice industry in RS also has technology to focus the concept of quality with consumers and associate positive image, enabling innovation for a market that requires traceability and certification. The challenges faced by Brazilian rice exporters include overcoming phytosanitary and environmental barriers, consolidating sales to newly conquered markets and ensuring customer loyalty. In this context, an internationally recognized certification, such as the Brazil Certified: Quality Agriculture, which has National Institute of Metrology, Quality and Technology as the certifying agency provides confidence to the markets and, consequently, transparency for consumers

Rainfall-triggered landslides in the Lisbon region over 2006 and relationships with the North Atlantic Oscillation

International audienceLandslides occurred in the Lisbon area during the last 50 years were almost always induced by rainfall and have been used to establish rainfall thresholds for regional landslide activity. In 2006, three new rainfall-triggered landslide events occurred in the study area, namely on the 20 March, the 25?27 October, and the 28 November. Landslide events occurred in March and October 2006 include shallow translational slides and few debris flows, and the corresponding absolute antecedent rainfall was found to be above the threshold for durations ranging from 4 to 10 days. These events also fit the combined threshold of daily precipitation and 5 days calibrated antecedent rainfall values. Likewise the landslide event that took place in late November 2006 includes some slope movements with deeper slip surfaces, when compared with landslides dating from March and October. Moreover, the corresponding absolute antecedent rainfall was also found to be above the 40-day period rainfall threshold. Here we characterize in detail the short and long-term atmospheric circulation conditions that were responsible for the intense rainfall episodes that have triggered the corresponding landslide events. It is shown that the three rainfall episodes correspond to considerably different synoptic atmospheric patterns, with the March episode being associated to an intense cut-off low system while the October and November episodes appear to be related to more typical Atlantic low pressure systems (and associated fronts) travelling eastwards. Finally, we analyse the role played by the North Atlantic Oscillation (NAO) during those months marked by landslide activity. It is shown that the NAO index was consistently negative (usually associated with above average precipitation) for the months prior to the landslide events, i.e. between October 2005 and March 2006, and again between August and October 2006

Educational software tool for decoupling control in wind turbines applied to a lab‐scale system

This paper presents an educational software tool, called wtControlGUI, whose main purpose is to show the applicability and performance of different decoupling control strategies in wind turbines. Nowadays wind turbines are a very important field in control engineering. Therefore, from an educational point of view, the tool also aims to improve the learning of multivariable control concepts applied on this control field. In addition, wtControlGUI allows for testing and control of a lab-scale system which emulates the dynamic response of a largescale wind turbine. The designed graphical user interface essentially allows simulation and experimental testing of decoupling networks and other multivariable methodologies, such as robust and decentralized control strategies. The tool is available for master degree students in control engineering. A survey was performed to evaluate the effectiveness of the proposed tool when used in educational related tasks

EGS4 and MCNP4b MC Simulation of a Siemens KD2 Accelerator in 6 MV Photon Mode

The geometry of a Siemens Mevatron KD2 linear accelerator in 6 MV photon mode was modeled with EGS4 and MCNP4b. Energy spectra and other phase space distributions have been extensively compared in different plans along the beam line. The differences found have been evaluated both qualitative and quantitatively. The final aim was that both codes, running in different operating systems and with a common set of simulation conditions, met the requirement of fitting the experimental depth dose curves and dose profiles, measured in water for different field sizes. Whereas depth dose calculations are in a certain extent insensible to some simulation parameters like electron nominal energy, dose profiles have revealed to be a much better indicator to appreciate that feature. Fine energy tuning has been tried and the best fit was obtained for a nominal electron energy of 6.15 MeV

Recognition of prior learning at the centre of a national strategy: tensions between professional gains and personal development

This paper focuses on recognition of prior learning as part of a national policy based on European Union guidelines for lifelong learning, and it explains how recognition of prior learning has been perceived since it was implemented in Portugal in 2000. Data discussed are the result of a mixed method research project that surveyed adult learners, some of whom were interviewed, who successfully completed the recognition of prior learning process from 2007 to 2011 in a new opportunities centre. Adult educators, and workplace representatives from the companies in which these adults in the recognition of prior learning process were working, were also part of the survey. A theme-based content analysis was done on the resulting data. Findings revealed tension between the goals of economic and human resource management and the change experienced by these adult learners in their professional status. Based on these results, the closing remarks to this article highlight the tensions caused by the failure of the goals of the policy to which recognition of prior learning was central, and the personal and social changes referred to by learners. Important educational changes were achieved although they were undermined by the adult education policy and European Union guidelines.The writing of this article was funded by Cied – Institute of Education, University of Minho and the Unidade de Investigação e Desenvolvimento em Educação e Formação, Instituto de Educação, Universidade de Lisboa

Effects of low-intensity electrical stimulation and adipose derived stem cells transplantation on the time-domain analysis-based electromyographic signals in dogs with SCI

The application of low-intensity electrical stimulation (LIES) to neural tissue increases neurochemical factors responsible for regeneration as nerve growth factor. Stem cell (SC) therapy for patients with Spinal cord injury (SCI) promote some increase functional improvement.ObjectiveInvestigate the electromyographic response in paraplegic dogs undergoing LIES and SC transplantation.Methods27 dogs paraplegics with SCI were divided into three groups with different types of therapy. GADSC: two SC transplants (n = 9); GLIES: LIES (n = 8); GCOMB: two SC transplants and LIES (n = 10). Adipose derived mesenchymal stem cells (ADSCs) were transplanted by lumbar puncture in the amount of 1.2 × 106 cells/50 μL. Acupuncture needles positioned in the interspinous space were used for stimulation. The electrical stimulation was applied with a mean voltage ∼30 mV and four consecutive modulated frequencies (5 Hz, 10 Hz, 15 Hz and 20 Hz) within 5 min each. The patients motor performance was evaluated before (Pre) the procedure and after 30 (Post30) and 60 (Post60) days, from electromyography root mean square (EMGRMS) registered with subcutaneous electrodes in the vastus lateralis muscle, while the animals were in quadrupedal position.ResultsAll three groups showed a significant intra-group increase of EMGRMS (Pre vs. Post30 or Pre vs. Post60). However, there were no statistically significant differences between Post30 and Post60. The inter-group test (GADSC X GLIES X GCOMB) did not present significance when compared the instants Pre (p = 0.34), Post30 (p = 0.78) and Post60 (p = 0.64).ConclusionSome dogs recovered motor activity, expressed by the EMGRMS, in all groups, in pre vs. post (30 or 60 days) comparisons.This is the peer-reviewed version of the article: Krueger, E., Magri, L.M.S., Botelho, A.S., Bach, F.S., Rebellato, C.L.K., Fracaro, L., Fragoso, F.Y.I., Villanova, J.A., Brofman, P.R.S., Popović-Maneski, L., 2019. Effects of low-intensity electrical stimulation and adipose derived stem cells transplantation on the time-domain analysis-based electromyographic signals in dogs with SCI. Neuroscience Letters 696, 38–45. [https://doi.org/10.1016/j.neulet.2018.12.004]Published version: [https://hdl.handle.net/21.15107/rcub_dais_4595