Computer-generated preliminary design of room and corridor arrangements under geometric constraints.

Massachusetts Institute of Technology. Dept. of Architecture. Thesis. 1972. M.Arch.Bibliography: leaf 64.M.Arch

Wissen und Streiten in der Aufklärungsepoche: Ein neues Akademieprojekt in Leipzig

Seit 2011 widmet sich eine Arbeitsstelle der Akademie der Wissenschaften zu Göttingen an der Universitätsbibliothek Leipzig der Erschließung der breiten Tradition gelehrter Zeitschriften des 18. Jahrhunderts. Das bis 2025 laufende Langfristprojekt (eine andere Arbeitsstelle befindet sich an der Bayerischen Staatsbibliothek München) will die Beiträge erfassen und zugleich die konkreten Effekte der publizistisch-öffentlichen Diskussion herausstellen. Ein Datenbankportal wird Artikel, Rezensionen und gelehrte Nachrichten aus rund 128 Zeitschriften des 18. Jahrhunderts detailliert recherchierbar machen. Für Fragen einer allgemeinen Wissenstopographie und Wissensvernetzung des 18. Jahrhunderts ist das Projekt ebenso bedeutend wie für die Rezeptionsgeschichte einzelner Werke sowie für die Entwicklung gesellschaftlicher Debatten

Trace gas/aerosol boundary concentrations and their impacts on continental-scale AQMEII modeling domains

Copyright 2011 Elsevier B.V., All rights reserved.Over twenty modeling groups are participating in the Air Quality Model Evaluation International Initiative (AQMEII) in which a variety of mesoscale photochemical and aerosol air quality modeling systems are being applied to continental-scale domains in North America and Europe for 2006 full-year simulations for model inter-comparisons and evaluations. To better understand the reasons for differences in model results among these participating groups, each group was asked to use the same source of emissions and boundary concentration data for their simulations. This paper describes the development and application of the boundary concentration data for this AQMEII modeling exercise. The European project known as GEMS (Global and regional Earth-system Monitoring using Satellite and in-situ data) has produced global-scale re-analyses of air quality for several years, including 2006 (http://gems.ecmwf.int). The GEMS trace gas and aerosol data were made available at 3-hourly intervals on a regular latitude/longitude grid of approximately 1.9° resolution within 2 "cut-outs" from the global model domain. One cut-out was centered over North America and the other over Europe, covering sufficient spatial domain for each modeling group to extract the necessary time- and space-varying (horizontal and vertical) concentrations for their mesoscale model boundaries. Examples of the impact of these boundary concentrations on the AQMEII continental simulations are presented to quantify the sensitivity of the simulations to boundary concentrations. In addition, some participating groups were not able to use the GEMS data and instead relied upon other sources for their boundary concentration specifications. These are noted, and the contrasting impacts of other data sources for boundary data are presented. How one specifies four-dimensional boundary concentrations for mesoscale air quality simulations can have a profound impact on the model results, and hence, this aspect of data preparation must be performed with considerable care.Peer reviewedFinal Accepted Versio

Methodology to predict stiffness knock-down in laminates for wind turbine blades with artificial wrinkles

This work presents a methodology to evaluate the effect of wrinkle defects in the stiffness response of laminate characteristic of wind turbine blades. The assessment is carried out through numerical models and experimental tests with coupon specimens embedded with artificial wrinkles. Specimens are manufactured with two types of defects, prone to arising along the manufacturing process of wind turbine blades. Image-based numerical models were built to enclose the actual features of the cross-sectional wrinkling of each defect type. Experimental quasi-static tension and compression tests were performed, where extensometers collect the strain distribution about the wrinkle section as around the flat section of the test specimens. Two-dimensional finite element simulations carried out in Abaqus/Standard captured the stiffness behaviour of the two types of wrinkles. The numerical approach is validated against the quasi-static tests retrieving a fair agreement with experimental data. A significant knock-down in the stiffness response was found due to the wrinkle with larger aspect ratio of amplitude / half-wavelength.</p

Deciphering the Transcriptomic Heterogeneity of Duodenal Coeliac Disease Biopsies

Coeliac disease (CD) is a clinically heterogeneous autoimmune disease with variable presentation and progression triggered by gluten intake. Molecular or genetic factors contribute to disease heterogeneity, but the reasons for different outcomes are poorly understood. Transcriptome studies of tissue biopsies from CD patients are scarce. Here, we present a high-resolution analysis of the transcriptomes extracted from duodenal biopsies of 24 children and adolescents with active CD and 21 individuals without CD but with intestinal afflictions as controls. The transcriptomes of CD patients divide into three groups—a mixed group presenting the control cases, and CD-low and CD-high groups referring to lower and higher levels of CD severity. Persistence of symptoms was weakly associated with subgroup, but the highest marsh stages were present in subgroup CD-high, together with the highest cell cycle rates as an indicator of virtually complete villous atrophy. Considerable variation in inflammation-level between subgroups was further deciphered into immune cell types using cell type de-convolution. Self-organizing maps portrayal was applied to provide high-resolution landscapes of the CD-transcriptome. We find asymmetric patterns of miRNA and long non-coding RNA and discuss the effect of epigenetic regulation. Expression of genes involved in interferon gamma signaling represent suitable markers to distinguish CD from non-CD cases. Multiple pathways overlay in CD biopsies in different ways, giving rise to heterogeneous transcriptional patterns, which potentially provide information about etiology and the course of the disease

Artificial intelligence-based measurements of PET/CT imaging biomarkers are associated with disease-specific survival of high-risk prostate cancer patients

Objective: Artificial intelligence (AI) offers new opportunities for objective quantitative measurements of imaging biomarkers from positron-emission tomography/computed tomography (PET/CT). Clinical image reporting relies predominantly on observer-dependent visual assessment and easily accessible measures like SUVmax, representing lesion uptake in a relatively small amount of tissue. Our hypothesis is that measurements of total volume and lesion uptake of the entire tumour would better reflect the disease`s activity with prognostic significance, compared with conventional measurements. Methods: An AI-based algorithm was trained to automatically measure the prostate and its tumour content in PET/CT of 145 patients. The algorithm was then tested retrospectively on 285 high-risk patients, who were examined using 18F-choline PET/CT for primary staging between April 2008 and July 2015. Prostate tumour volume, tumour fraction of the prostate gland, lesion uptake of the entire tumour, and SUVmax were obtained automatically. Associations between these measurements, age, PSA, Gleason score and prostate cancer-specific survival were studied, using a Cox proportional-hazards regression model. Results: Twenty-three patients died of prostate cancer during follow-up (median survival 3.8 years). Total tumour volume of the prostate (p = 0.008), tumour fraction of the gland (p = 0.005), total lesion uptake of the prostate (p = 0.02), and age (p = 0.01) were significantly associated with disease-specific survival, whereas SUVmax (p = 0.2), PSA (p = 0.2), and Gleason score (p = 0.8) were not. Conclusion: AI-based assessments of total tumour volume and lesion uptake were significantly associated with disease-specific survival in this patient cohort, whereas SUVmax and Gleason scores were not. The AI-based approach appears well-suited for clinically relevant patient stratification and monitoring of individual therapy

Deep learning-based quantification of PET/CT prostate gland uptake: association with overall survival

Aim: To validate a deep-learning (DL) algorithm for automated quantification of prostate cancer on positron emission tomography/computed tomography (PET/CT) and explore the potential of PET/CT measurements as prognostic biomarkers. Material and methods: Training of the DL-algorithm regarding prostate volume was performed on manually segmented CT images in 100 patients. Validation of the DL-algorithm was carried out in 45 patients with biopsy-proven hormone-na\uefve prostate cancer. The automated measurements of prostate volume were compared with manual measurements made independently by two observers. PET/CT measurements of tumour burden based on volume and SUV of abnormal voxels were calculated automatically. Voxels in the co-registered 18F-choline PET images above a standardized uptake value (SUV) of 2\ub765, and corresponding to the prostate as defined by the automated segmentation in the CT images, were defined as abnormal. Validation of abnormal voxels was performed by manual segmentation of radiotracer uptake. Agreement between algorithm and observers regarding prostate volume was analysed by S\uf8rensen-Dice index (SDI). Associations between automatically based PET/CT biomarkers and age, prostate-specific antigen (PSA), Gleason score as well as overall survival were evaluated by a univariate Cox regression model. Results: The SDI between the automated and the manual volume segmentations was 0\ub778 and 0\ub779, respectively. Automated PET/CT measures reflecting total lesion uptake and the relation between volume of abnormal voxels and total prostate volume were significantly associated with overall survival (P\ua0=\ua00\ub702), whereas age, PSA, and Gleason score were not. Conclusion: Automated PET/CT biomarkers showed good agreement to manual measurements and were significantly associated with overall survival

Evaluating the assimilation of S5P/TROPOMI near real-time SO2 columns and layer height data into the CAMS integrated forecasting system (CY47R1), based on a case study of the 2019 Raikoke eruption

The Copernicus Atmosphere Monitoring Service(CAMS), operated by the European Centre for Medium-Range Weather Forecasts on behalf of the European Com-mission, provides daily analyses and 5 d forecasts of atmospheric composition, including forecasts of volcanic sulfur dioxide (SO2) in near real time. CAMS currently assimilates total column SO2products from the GOME-2 instruments on MetOp-B and MetOp-C and the TROPOMI instrument on Sentinel-5P, which give information about the location and strength of volcanic plumes. However, the operational TROPOMI and GOME-2 data do not provide any information about the height of the volcanic plumes, and therefore some prior assumptions need to be made in the CAMS data assimilation system about where to place the resulting SO2increments in the vertical. In the current operational CAMS configuration, the SO2increments are placed in the mid-troposphere, around 550 hPa or 5 km. While this gives good results for the majority of volcanic emissions, it will clearly be wrong for eruptions that inject SO2at very different altitudes, in particular exceptional events where part of the SO2plume reaches the stratosphere.A new algorithm, developed by the German Aerospace Centre (DLR) for GOME-2 and TROPOMI, optimized in the frame of the ESA-funded Sentinel-5P Innovation–SO2Layer Height Project, and known as the Full-Physics Inverse Learning Machine (FP_ILM) algorithm, retrieves SO2 layer height from TROPOMI in near real time (NRT) in addition to the SO2column. CAMS is testing the assimilation of these products, making use of the NRT layer height information to place the SO2increments at a retrieved altitude. Assimilation tests with the TROPOMI SO2layer height data for the Raikoke eruption in June 2019 show that the resulting CAMSSO2plume heights agree better with IASI plume height data than operational CAMS runs without the TROPOMI SO2layer height information and show that making use of the additional layer height information leads to improved SO2 forecasts. Including the layer height information leads to higher modelled total column SO2values in better agreement with the satellite observations. However, the plume area and SO2burden are generally also overestimated in the CAMS analysis when layer height data are used. The main reason for this overestimation is the coarse horizontal resolution used in the minimizations. By assimilating the SO2layer height data, the CAMS system can predict the overall location of the Raikoke SO2plume up to 5 d in advance for about 20 dafter the initial eruption, which is better than with the operational CAMS configuration (without prior knowledge of the plume height) where the forecast skill is much more reduced for longer forecast lead times