Processos condicionantes de alterações em variáveis limnológicas: uma abordagem estatística na Represa de São Pedro, Juiz de Fora (MG)

RESUMO Os mananciais de abastecimento de água são ativos ambientais que precisam da atenção de toda a sociedade. O monitoramento de variáveis limnológicas possibilita inferir sobre as condições do recurso hídrico, além de oferecer indicativos de toda a dinâmica natural ou antrópica compreendida na bacia hidrográfica. A precipitação é um dos principais mecanismos atuantes nos parâmetros de qualidade de água, o que justifica sua relevância nesse tipo de análise. O teste t de Student e a análise fatorial/análise de componentes principais constituíram importantes ferramentas na interpretação dos dados limnológicos da captação da Represa de São Pedro, Juiz de Fora, Minas Gerais. O teste t de Student possibilitou verificar quais parâmetros apresentaram variação sazonal estatisticamente significativa. Já os resultados da análise fatorial/análise de componentes principais apontaram as variáveis mais relevantes na qualidade da água do manancial. A análise conjunta dos resultados estatísticos definiu os processos condicionantes das alterações nas variáveis estudadas, indicando o escoamento superficial como principal determinante das variáveis que compõem as componentes após rotação da matriz de componentes principais, Fator Varimax FV1 e FV4, e a contribuição orgânica, não associada à precipitação, como reflexo das variáveis da FV2 e FV3

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362