Evaluation of radiative transfer schemes for mesoscale model data assimilation: a case study

The assimilation of Special Sensor Microwave Imager (SSM/I) data into the Mesoscale Model 5 (MM5) allows for improving the weather forecast. However the results suggested an update the Radiative Transfer Equation (RTE) within the three-dimensional variational (3DVAR) algorithm which is tailored for non rainy conditions only. To this purpose, a new RTE algorithm is tested, in order to account for radiometric response in rainy regions. The new brightness temperatures (<i>T_B</i>) are estimated by using hydrometeor profiles from the MM5 mesoscale model, running with two different microphysical parameterizations. The goodness of the results is assessed by comparing the new <i>T_B</i> with those of the original RTE algorithm in the 3DVAR code and the SSM/I observed data. The results confirm a better reliability of the new RTE compared to the old one

Long-Run Macroeconomic Determinants of Cancer Incidence

yesAbstract: Background: Understanding how cancer incidence evolves during economic growth is useful for forecasting the economic impact of cancerous diseases, and for governing the process of resources allocation in planning health services. We analyse the relationship between economic growth and cancer incidence in order to describe and measure the influence of an increasing real per capita income on the overall rate of cancer incidence. Method:We test the relationship between real per capita income and the overall rate of cancer incidence with a cross-sectional analysis, using data from the World Bank and the World Health Organization databases, for 165 countries in 2008. We measure the elasticity of cancer incidence with respect to per capita income, and we decompose the elasticities coefficients into two components: age-effect and lifestyle-effect. Results: An Engel’s model, in a double-log quadratic specification, explains about half of the variations in the age-standardised rates and nearly two thirds of the variations in the incidence crude rates. All the elasticities of the crude rates are positive, but less than one. The income elasticity of the age-standardised rates are negative in lower income countries, and positive (around 0.25 and 0.32) in upper middle and high income countries, respectively. Conclusions:These results are used to develop a basic framework in order to explain how demand-side economic structural changes may affect the long run evolution of cancer incidence. At theoretical level, a J-Curve is a possible general model to represents, other things being equal, how economic growth influence cancer incidence

A discrete-cracking numerical model for the in-plane behavior of FRCM strengthened masonry panels

In this paper, the structural behavior of masonry panels strengthened with a system made up of composite fiber grids embedded in a cementitious matrix (FRCM) is presented. The non-linear behavior of the unreinforced and reinforced panels is numerically simulated by means of a simplified micro-modelling approach. This approach concentrates all the non-linearities and failures in the joints and in potential crack surfaces within the bricks, placed vertically in the middle of each brick. The FRCM strengthening system is discretized by a continuous bi-directional fiber grid constituted by trusses embedded into a cementitious matrix. A calibrated bond-slip relationship is applied between the fibers and the mortar matrix assuming an idealized bilinear law. The typical experimental load–displacement curve for a FRCM strengthened panel shows three principal phases that correspond to different failure mechanisms: masonry cracking, mortar matrix cracking and ultimate failure of the panel. The non-linear numerical analyses show a good agreement with experimental results and the modeling approach is found to be adequate to reproduce the described experimental behavior. The results of a parametric study on both the material and the geometrical properties of the FRCM system are also presented

Impressive long-term response with pertuzumab and trastuzumab in HER2-positive breast cancer with brain metastasis

This is a case report of a 40-year-old woman who, after conservative breast cancer treatment, developed a HER2 positive solitary brain metastasis in the left temporal lobe, without extracranial disease. She underwent surgery resection followed by stereotactic radiotherapy and, because of early brain progression, she was submitted to the first line therapy with pertuzumab, trastuzumab and weekly paclitaxel. After six months of treatment, a brain magnetic resonance imaging revealed a complete disappearance of brain recurrence, which persisted for more than 24 months

Evaluation of radiative transfer schemes for mesoscale model data assimilation: a case study

International audienceThe assimilation of Special Sensor Microwave Imager (SSM/I) data into the Mesoscale Model 5 (MM5) allows for improving the weather forecast. However the results suggested an update the Radiative Transfer Equation (RTE) within the three-dimensional variational (3DVAR) algorithm which is tailored for non rainy conditions only. To this purpose, a new RTE algorithm is tested, in order to account for radiometric response in rainy regions. The new brightness temperatures (TB) are estimated by using hydrometeor profiles from the MM5 mesoscale model, running with two different microphysical parameterizations. The goodness of the results is assessed by comparing the new TB with those of the original RTE algorithm in the 3DVAR code and the SSM/I observed data. The results confirm a better reliability of the new RTE compared to the old one

The Sentinel-1 mission for the improvement of the scientific understanding and the operational monitoring of the seismic cycle

We describe the state of the art of scientific research on the earthquake cycle based on the analysis of Synthetic Aperture Radar (SAR) data acquired from satellite platforms. We examine the achievements and the main limitations of present SAR systems for the measurement and analysis of crustal deformation, and envision the foreseeable advances that the Sentinel-1 data will generate in the fields of geophysics and tectonics. We also review the technological and scientific issues which have limited so far the operational use of satellite data in seismic hazard assessment and crisis management, and show the improvements expected from Sentinel-1 dat

Critical analysis on the use of the shove test for investigating the shear-sliding behavior of brick masonry

The shove test (ASTM Standard C1531) is an experimental technique aimed at studying the shear-sliding behavior of brick masonry. It can be executed according to various testing methods that differ in the way the vertical compression load is applied and in the way bricks and/or joints are locally removed for inserting jacks. One of the most critical aspects is the correct evaluation of the compressive stress state on the sliding brick. The objective of the present paper is to investigate the capability of the shove test in determining the shear strength parameters of brick masonries and to highlight the main advantages and disadvantages of the various testing methods. To this aim, nonlinear numerical simulations of the shove test were performed by adopting a brick-to-brick modeling strategy. The 2D numerical model was calibrated and validated through comparisons with experimental results of triplet tests and shove tests. The numerical analyses allowed to understand the influence the different testing methods and the masonry mechanical properties, such as dilatancy, may have on the test results. Based on the numerical outcomes, correction factors were calibrated for the proper evaluation of the compressive stress state on the sliding brick. Improvements with regards to the experimental procedures, i.e. additional test phases and measurements, were also proposed to enhance the results interpretation

3DVAR assimilation of SSM/I data over the sea for the IOP2b MAP case

International audienceData assimilation by 3DVAR of data from the Special Sensor Microwave/Imager (SSM/I) has been performed to study the IOP2b case (19-21 September 1999) of the Mesoscale Alpine Programme (MAP). Only data over the sea surface are used to avoid the contamination of the surface emissivity. Moreover, the rainy data are filtered out because the assimilation algorithm of 3DVAR does not take into account the scattering processes. SSM/I data are assimilated in two different ways: as Brightness Temperature directly, or as Precipitable Water and surface wind speed retrieved from the Brightness Temperature. The effect of the thinning of the observations has been studied and a set of sensitivity test cases has been carried out; the one by one removal of the SSM/I frequencies from the initial dataset allows to evaluate their impact on the Initial Conditions. A few experiments are performed using these new Initial Conditions to initialize the MM5 (PSU/NCAR) model. The results show that the assimilation of the retrieved quantities, i.e. Precipitable Water and surface wind speed, does not produces large improvement in the Initial Conditions. Vice versa, the assimilation of the Brightness temperatures produces a large variability of the Initial Conditions. The forecast experiments show that the model is very sensitive to the 22GHz and 37GHz frequencies

Prospective study on nanoparticle albumin-bound paclitaxel in advanced breast cancer. Clinical results and biological observations in taxane-pretreated patients

Background: There is a deep need to improve the care of metastatic breast cancer (MBC) patients, since even today it remains an incurable disease. Taxanes are considered the most effective cytotoxic drugs for the treatment of MBC, both in monotherapy and in combined schedules, but the need for synthetic solvents contributes to the severe toxicities and may have a negative impact on the efficacy. Nanoparticle albumin-bound paclitaxel (Nab-paclitaxel) is a colloidal suspension of paclitaxel and human serum albumin initially developed to avoid the toxicities associated with conventional taxanes. Patients and methods: The aim of this prospective, single-center open-label, noncomparative study was to evaluate the efficacy and safety of nab-paclitaxel in MBC patients pretreated with taxanes. The patients were treated with nab-paclitaxel as a single agent, 260 mg/m2 on day 1 of each 3-week cycle or 125 mg/m2 weekly. The primary endpoint was the overall response rate (ORR). Secondary objectives were duration of response, clinical benefit rate, progression-free survival (PFS), overall survival, and safety. Results: A total of 42 patients (median age 48 years, median Eastern Cooperative Oncology Group performance status 0, triple-negative MBC 19%, all pretreated with a taxane-based therapy, mainly in advanced disease) were enrolled in the study. The ORR was 23.8%, including one complete response (2.4%) and nine partial responses (21.4%); the disease control rate was 50%. The median duration of response was 7.2 months. After a median follow-up of 9 months, the median PFS was 4.6 months. ORR and PFS were similar irrespective of the previous chemotherapy lines, metastatic sites, and biomolecular expression. Nab-paclitaxel was well tolerated, and the most frequent treatment-related toxicities were mild to moderate (grades 1–2). Conclusion: This real-life study shows that nab-paclitaxel has a significant antitumor activity and a manageable safety profile in patients pretreated with taxanes and experiencing a treatment failure after at least one line of chemotherapy