Soil-vegetation relationships and community structure in a "terra-firme"-white-sand vegetation gradient in Viruá National Park, northern Amazon, Brazil

Viruá National Park encompasses a vast and complex system of hydromorphic sandy soils covered largely by the white sand vegetation ("Campinarana") ecosystem. The purpose of this study was to investigate a vegetation gradient of "terra-firme"-white sand vegetation at the Viruá National Park. Nine plots representing three physiognomic units were installed for floristic and phytosociological surveys as well as to collect composite soil samples. The data were subjected to assessments of floristic diversity and similarity, phytosociological parameters and to statistical analyses, focused on principal components (PC) and canonical correspondence analysis (CCA). The vegetation of the Campinaranas types and Forest differed in biomass and species density. Ten species, endemic to Brazil, were particularly well-represented. PC and CCA indicated a clear distinction between the studied plots, based on measured soil variables, especially base sum and clay, which were the most differentiating properties between Campinarana and Forest; For the separation of the Campinarana types, the main distinguishing variable was organic matter content and cation exchange capacity. Higher similarity of Campinaranas was associated to a monodominant species and the lower similarity of Forest was related to the high occurrence of locally rare species

New cathepsin V inhibitor from stems of Bowdichia virgilioides

Bioassay-guided fractionation of Bowdichia virgilioides Kunth, Fabaceae, extracts has led to the isolation of cathepsin V inhibitors. The investigation of the hexane and ethyl acetate extracts allowed the characterization of eleven compounds: lupeol, lupenone, β-sitosterol and stigmasterol in mixture, trans p-coumaric acid ester derivative, syringaresinol, bowdenol, 8-methoxycoumestrol, 3,4-hydroxy-7-methoxyisoflavone, 7,3′-dihydroxy-4′-methoxyisoflavone, and 5,4′-dihydroxy-7′-methoxyisoflavone. Structures of compounds were stablished by 1D and 2D NMR, and MS experiments. Among the isolated compounds, trans p-coumaric acid ester derivative and 8-methoxycoumestrol showed significant inhibition on cathepsin V, which is up to now unexplored. Keywords: Cathepsin, Cysteine peptidases, Inhibitors, Cerrado biom

Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine

Funding Information: This research was supported by Fundação para a Ciência e Tecnologia (PTDC/MED-TOX/30418/2017) and iNOVA4Health (UID/Multi/04462/2013). M.J.C., D.G.F.F. and J.M. were supported by FCT (PhD grant SFRH/BD/131331/2017, PhD grant PD/BD/135484/2018 and postdoctoral contract PTDC/MED-TOX/30418/2017, respectively).In this review encouraged by original data, we first provided in vivo evidence that the kidney, comparative to the liver or brain, is an organ particularly rich in cysteine. In the kidney, the total availability of cysteine was higher in cortex tissue than in the medulla and distributed in free reduced, free oxidized and protein-bound fractions (in descending order). Next, we provided a comprehensive integrated review on the evidence that supports the reliance on cysteine of the kidney beyond cysteine antioxidant properties, highlighting the relevance of cysteine and its renal metabolism in the control of cysteine excess in the body as a pivotal source of metabolites to kidney biomass and bioenergetics and a promoter of adaptive responses to stressors. This view might translate into novel perspectives on the mechanisms of kidney function and blood pressure regulation and on clinical implications of the cysteine-related thiolome as a tool in precision medicine.publishersversionpublishe

The Fueling and Evolution of AGN: Internal and External Triggers

In this chapter, I review the fueling and evolution of active galactic nuclei (AGN) under the influence of internal and external triggers, namely intrinsic properties of host galaxies (morphological or Hubble type, color, presence of bars and other non-axisymmetric features, etc) and external factors such as environment and interactions. The most daunting challenge in fueling AGN is arguably the angular momentum problem as even matter located at a radius of a few hundred pc must lose more than 99.99 % of its specific angular momentum before it is fit for consumption by a BH. I review mass accretion rates, angular momentum requirements, the effectiveness of different fueling mechanisms, and the growth and mass density of black BHs at different epochs. I discuss connections between the nuclear and larger-scale properties of AGN, both locally and at intermediate redshifts, outlining some recent results from the GEMS and GOODS HST surveys.Comment: Invited Review Chapter to appear in LNP Volume on "AGN Physics on All Scales", Chapter 6, in press. 40 pages, 12 figures. Typo in Eq 5 correcte

Quem somos nós? Ou perfis da comunidade profissional arqueológica no Brasil: primeiras aproximações

WHO ARE WE? OR A PROFILE OF THE ARCHAEOLOGICAL PROFESSIONAL COMMUNITY IN BRAZIL: FIRST APPROACHESIn the last twenty years, archeological academic-scientific training has grown exponen-tially in Brazil, culminating in the recognition of the profession in 2018. However, little is known about the demographic profiles of people working in the area, as well as of students in the process of training, in undergraduate and graduate levels. By updating some data from previous studies, in this manuscript we present the results of an initial survey on the professional profile in Brazilian archeology, which includes information on the trajectory of education, gender, nationality and re-search themes. This initiative allows us to outline the challenges of inclusion and representativeness in the exercise of the profession, whose reflections will assist us in the conceiving of practical measures for a change in this situation in the future.Archaeology of the AmericasArchaeological Heritage Managemen

Characterization of large area avalanche photodiodes in X-ray and VUV-light detection

The present manuscript summarizes novel studies on the application of large area avalanche photodiodes (LAAPDs) to the detection of X-rays and vacuum ultraviolet (VUV) light. The operational characteristics of four different LAAPDs manufactured by Advanced Photonix Inc., with active areas of 80 and 200 mm^2 were investigated for X-ray detection at room temperature. The best energy resolution was found to be in the 10-18% range for 5.9 keV X-rays. The LAAPD, being compact, simple to operate and with high counting rate capability (up to about 10^5/s), proved to be useful in several applications, such as low-energy X-ray detection, where they can reach better performance than proportional counters. Since X-rays are used as reference in light measurements, the gain non-linearity between 5.9 keV X-rays and light pulses was investigated. The gain ratio between X-rays and VUV light decreases with gain, reaching 10 and 6% variations for VUV light produced in argon (~128 nm) and xenon (~172 nm), respectively, for a gain 200, while for visible light (~635 nm) the variation is lower than 1%. The effect of temperature on the LAAPD performance was investigated. Relative gain variations of about -5% per Celsius degree were observed for the highest gains. The excess noise factor was found to be independent on temperature, being between 1.8 and 2.3 for gains from 50 to 300. The energy resolution is better for decreasing temperatures due mainly to the dark current. LAAPDs were tested under intense magnetic fields up to 5 T, being insensitive when used in X-ray and visible-light detection, while for VUV light a significant amplitude reduction was observed at 5 T.Comment: 25 pages, 40 figures, submitted to JINS

Characterization of large area avalanche photodiodes in X-ray and VUV-light detection

The present manuscript summarizes novel studies on the application of large area avalanche photodiodes (LAAPDs) to the detection of X-rays and vacuum ultraviolet (VUV) light. The operational characteristics of four different LAAPDs manufactured by Advanced Photonix Inc., with active areas of 80 and 200 mm^2 were investigated for X-ray detection at room temperature. The best energy resolution was found to be in the 10-18% range for 5.9 keV X-rays. The LAAPD, being compact, simple to operate and with high counting rate capability (up to about 10^5/s), proved to be useful in several applications, such as low-energy X-ray detection, where they can reach better performance than proportional counters. Since X-rays are used as reference in light measurements, the gain non-linearity between 5.9 keV X-rays and light pulses was investigated. The gain ratio between X-rays and VUV light decreases with gain, reaching 10 and 6% variations for VUV light produced in argon (~128 nm) and xenon (~172 nm), respectively, for a gain 200, while for visible light (~635 nm) the variation is lower than 1%. The effect of temperature on the LAAPD performance was investigated. Relative gain variations of about -5% per Celsius degree were observed for the highest gains. The excess noise factor was found to be independent on temperature, being between 1.8 and 2.3 for gains from 50 to 300. The energy resolution is better for decreasing temperatures due mainly to the dark current. LAAPDs were tested under intense magnetic fields up to 5 T, being insensitive when used in X-ray and visible-light detection, while for VUV light a significant amplitude reduction was observed at 5 T.Comment: 25 pages, 40 figures, submitted to JINS