Longitudinal evaluation of hepatic osteodystrophy in children and adolescents with chronic cholestatic liver disease

Bone mass loss is a major complication of chronic cholestatic liver disease (CCD). However, the long-term impact of CCD on bone mass acquisition is unknown. We longitudinally assessed bone mineral density (BMD) and factors involved in bone remodeling in 9 children and adolescents with CCD Child-Pugh A (5 boys/4 girls) and in 13 controls (6 boys/7 girls). The groups were evaluated twice, at baseline (T0) and after 3 years (T1), when osteocalcin, deoxypyridinoline, 25-hydroxyvitamin-D, parathyroid hormone, insulin-like growth factor-I (IGF-I), and BMD (L1-L4, proximal femur and total body) were determined. Serum levels of receptor activator for nuclear factor kB ligand (RANKL) and osteoprotegerin were measured only at T1. Lumbar spine BMD was reanalyzed twice: after adjustment for bone age and to compensate for the height factor. Volumetric density was also estimated mathematically in L2-L4. The BMD of L1-L4 was lower in the CCD group (Z-score at T0: control = -1.2 ± 0.8 vs CCD = -2.2 ± 1.4, P < 0.05; T1: control = -0.7 ± 0.8 vs CCD = -2.1 ± 1.1, P < 0.05). Osteocalcin and deoxypyridinoline were similar for the two groups. The CCD group presented lower IGF-I (Z-score at T1: control = 1.4 ± 2.8 vs CCD = -1.5 ± 1.0, P < 0.05) and RANKL (control = 0.465 ± 0.275 vs CCD = 0.195 ± 0.250 pM, P < 0.05) than control. Children with compensated CCD Child-Pugh A showed early impairment of bone acquisition, with the impact being more severe in an initial phase and then tapering in a slowly progressive way. Reduction in endocrine IGF-I has a crucial role in this process

Spatial and temporal concentration of tourism demand in northern Portugal: regional policy recommendations to promote tourism competition and portofolio diversity

The northern region of Portugal, in the last years, has experienced a growing number of visitors from different countries, which may indicate the emergence of an overtourism phenomenon in some particular municipalities or specific spaces. This phenomenon may cause significant destruction of the living conditions of residents, landscapes, seascapes, air and water quality, causing economic inequalities and social exclusion. The concentration of tourism activity in different municipality regions can be measured with a well know concentration measured, the Herfindahl-Hirschman Index. Using as variables the number and nationality of visitors and their expenditures it is possible to follow the concentration of tourism visitors and expenditure, all over the 8 NUTIII regions located in the Northen of Portugal, and describe the routes of distribution of the tourism indicators from urban to rural areas following a more nature-oriented tourism. The results serve as a dipping compass for more oriented and well-targeted tourism policies.info:eu-repo/semantics/publishedVersio

Enhanced solar driven photocatalytic removal of antibiotics from aquaculture effluents by TiO2/carbon quantum dot composites

Aquaculture exploitation is associated with the consumption of antibiotics, such as sulfadiazine (SDZ), sulfamethoxazole (SMX) and trimethoprim (TMP), the latter two being also vastly used to treat bacterial infections in humans. Consequently, and given that aquaculture wastewater treatments are not actually designed for the removal of antibiotics, they are ubiquitous in aquaculture effluents, which sets the risk of bacterial resistance. To face the need for an efficient and sustainable treatment to remove these antibiotics from the referred effluents, carbon quantum dots (CQDs) were produced, incorporated into titanium dioxide (TiO2), and evaluated for solar driven photodegradation of SDZ, SMX and TMP. Eleven different materials were synthesized and tested for their photocatalytic activity in phosphate buffer solution (PBS) and synthetic sea salts (SSS), used as synthetic matrices to simulate fresh and brackish water, respectively. Upon selection of the most efficient photocatalyst for each antibiotic and matrix, kinetic results demonstrated that its use allowed for remarkable reductions of SDZ, SMX and TMP half-life times (t1/2) in both matrices (between 19 and 68 times). Therefore, the application of the here synthesized photocatalysts for the advanced treatment of aquaculture effluents is promising, allowing for a green solar driven removal of antibiotics.publishe

Demand and supply of outdoor tourism activities in Northern Portugal: a survey-based approach

This paper focuses on the North of Portugal, as a diversified region with unique natural resources, to create information regarding both resources and equipment and business dynamics; the evolution of tourism supply and demand.This research is a part of a project title “TURNOUT: Desenvolvimento do Turismo Outdoor da Região Norte de Portugal”, with the reference POCI-01-0145-FEDER-032289; funded by the European Regional Development Fund (FEDER) (through the Operational Programme ‘Innovation and competitiveness’) and by the Portuguese Foundation for the Development of Science and Technology (FCT), of the Ministry of Science, Technology and Higher Education. This work is, also, funded by National Funds through the Foundation for Science and Technology under the project UIDB/04752/2020. The SABI database was made available by the Applied Management Research Unit (UNIAG), according to the protocol between UNIAG and COFACE.info:eu-repo/semantics/publishedVersio

The paleoenvironmental and thermal histories of the Permian Irati formation shale in the paraná basin, Brazil: An integrated approach based on mineralogical and organic imprints

ABSTRACT: Mineralogical assemblages and organofacies are important sources of information to recover the paleoenvironmental and thermal histories of shale deposits. In this study, a detailed qualitative and quantitative characterization of the Permian Irati Formation (Assistência Member) shale is based on mineralogical (XRD and SEM-EDS) and organic components (TOC, Rock-Eval pyrolysis, organofacies, TAI, fluorescence and vitrinite reflectance measurements) and provides integrated data about sediment provenance, depositional environment, diagenesis, and thermal history, while supporting interpretations on the Paraná Basin (PB), Brazil, paleogeography and its correlation to the southwest Gondwana. The results revealed a prevailing type I/II kerogen, with type III kerogen being also present but mainly confined along the paleoshoreline of the PB. The dominance of fluorescent amorphous organic matter (AOM) combined with framboidal pyrite suggests microbial activity in an anoxic-dysoxic neritic-marine paleoenvironment. Additionally, common to abundant well-preserved phytoclasts, as well as the occurrence of Botryococcus braunii, indicates freshwater influx in a brackish marine depositional setting. Immature to early-oil window thermal maturities prevail across the PB, according to the organic maturation indicators. The combined analysis between the organic matter evolution with clay mineralogy, such as the occurrence of interstratified clays (e.g., I/S) and its positive correlation with depth suggest that burial diagenesis reached the transition to early catagenesis on the north, southeast, and south of the basin, attributing a shale oil potential for the Irati Formation on a regional scale. Local scale imprints of the Early Cretaceous Paraná-Etendeka Large Igneous Province (LIP), and its thermal effect in the Irati Formation shale components, are recorded as clay authigenesis (e.g., smectite webby texture and clay coating development), crystallization of minerals by low to high-grade of thermal alteration (e.g., corrensite, talc, lizardite and diopside), and by local scale gas-window maturities. Such thermal alteration, identified in the proximity to intruded sills and dykes, led to a heterogeneous organic maturation pattern with implications on shale gas and shale oil potential of the Irati Formation shale, demonstrating that these subjects in the Paraná Basin should be assessed locally.info:eu-repo/semantics/publishedVersio

Suppression of airway inflammation by Illicium verum and trans-anethole

_Background_ SH2 domain containing inositol-5-phosphatase (SHIP1) is an important modulator of innate and adaptive immunity. In mice, loss of SHIP1 provokes severe ileitis resembling Crohn's disease (CD), as a result of deregulated immune responses, altered cytokine production and intestinal fibrosis. Recently, SHIP1 activity was shown to be correlated to the presence of a CD-associated single nucleotide polymorphism in ATG16L1. Here, we studied SHIP1 activity and expression in an adult cohort of CD patients. _Methods_ SHIP1 activity, protein and mRNA expression in peripheral blood mononuclear cells from CD patients in clinical remission were determined by Malachite green assay, Western blotting an

Integration of magnetoresistive biochips on a CMOS circuit

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Benefícios Da Adequação Postural Em Cadeira De Rodas E Fatores Que Interferem Em Sua Utilização: Uma Revisão Sistemática

Seating and positioning are an assistive technology resource that aims to improve functional performance in the wheelchair. The aim of this paper was to find in the literature studies that addressed the benefits of seating and positioning in a wheelchair and factors that interfere with the prescription and use of this technology. Articles found that discuss the benefits addressed: the functionality and respiratory function; the pressure ulcer prevention; and user satisfaction and the family with assistive technology. Articles discussing the factors linked to prescription and use of adapting wheelchairs are those that address the environmental factors, components and wheelchair accessories. There are factors involved in the prescription process to achieve its benefits through its use, the prescribed process must have an interdisciplinary and biopsychosocial approach applied individually to each patient.5218119