Physiological ecology of the ciliated protozoon Loxodes

Loxodes faces special problems in living close to the oxic-anoxic boundary. In tightly-stratified ponds like Priest Pot its optimum environment may be quite narrow and it can be displaced by the slightest turbulence. Loxodes cannot sense an O sub(2) gradient directly but its ability to perceive gravity allows it to make relatively long vertical migrations. It is also sensitive to light and oxygen and it uses these environmental cues to modulate the parameters of its random motility: in the dark, it aggregates at a low O sub(2) tension and in bright light it aggregates in anoxic water. The oxic-anoxic boundary is also a zone where O sub(2) may be a scarce and transient resource, but Loxodes) can switch to nitrate respiration and exploit the pool of nitrate that often exists close to the base of the oxycline

A unified flow approach to smooth, even LpL_p-Minkowski problems

We study long-time existence and asymptotic behaviour for a class of anisotropic, expanding curvature flows. For this we adapt new curvature estimates, which were developed by Guan, Ren and Wang to treat some stationary prescribed curvature problems. As an application we give a unified flow approach to the existence of smooth, even $L_p$-Minkowski problems in $\mathbb{R}^{n+1}$ for $p>-n-1.$Comment: 21 pages. Comments are welcom

A new invariant on hyperbolic Dehn surgery space

In this paper we define a new invariant of the incomplete hyperbolic structures on a 1-cusped finite volume hyperbolic 3-manifold M, called the ortholength invariant. We show that away from a (possibly empty) subvariety of excluded values this invariant both locally parameterises equivalence classes of hyperbolic structures and is a complete invariant of the Dehn fillings of M which admit a hyperbolic structure. We also give an explicit formula for the ortholength invariant in terms of the traces of the holonomies of certain loops in M. Conjecturally this new invariant is intimately related to the boundary of the hyperbolic Dehn surgery space of M.Comment: Published by Algebraic and Geometric Topology at http://www.maths.warwick.ac.uk/agt/AGTVol2/agt-2-23.abs.htm

From Cosmos to Intelligent Life: The Four Ages of Astrobiology

The history of life on Earth and in other potential life-bearing planetary platforms is deeply linked to the history of the universe. Since life as we know it relies on chemical elements forged in dying heavy stars, the universe needs to be old enough for stars to form and evolve. Current cosmological theory indicates that the universe is 13.7$\pm 0.13$ billion years old and that the first stars formed hundreds of millions of years after the big bang. At least some stars formed with stable planetary systems wherein a set of biochemical reactions leading to life could have taken place. In this lecture, I argue that we can divide cosmological history into four ages, from the big bang to intelligent life. The Physical Age describes the origin of the universe, of matter, of cosmic nucleosynthesis, as well as the formation of the first stars and galaxies. The Chemical Age begun when heavy stars provided the raw ingredients for life through stellar nucleosynthesis and describes how heavier chemical elements collected in nascent planets and moons to give rise to prebiotic biomolecules. The Biological Age describes the origin of early life, its evolution through Darwinian natural selection, and the emergence of complex multicellular life forms. Finally, the Cognitive Age describes how complex life evolved into intelligent life capable of self-awareness and of developing technology through the directed manipulation of energy and materials. We conclude discussing whether we are the rule or the exception.Comment: 7 pages, Opening plenary talk delivered at the S\~ao Paulo Advanced School of Astrobiology, S\~ao Paulo, December 2011. In press, Int. J. Astrobio. Reference update

Cosmopolitan metapopulations?

A “metapopulation” is a group of populations of the same species separated by space but linked by dispersal and migration. Metapopulations of macroscopic organisms tend to have geographically-restricted distributions, but this does not seem to be the case in microbial eukaryotes due to their astronomical abundance. The term “metapopulation” was first applied to protists’ biogeography in the article Finlay and Fenchel (2004), published in PROTIST, which contributed to the popularity of the paper. The article considered protist species as consisting of a single, cosmopolitan population. Here, we recall this paper, and assess developments during the last 15 years with respect to the question of protist species distribution on the surface of the earth

Targeting SHP-1,2 and SHIP pathways – a novel strategy for cancer treatment?

Well balanced levels of tyrosine phosphorylation, maintained by the reversible and coordinated actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), are critical for a wide range of cellular processes including growth, differentiation, metabolism, migration, and survival. Aberrant tyrosine phosphorylation, as a result of a perturbed balance between the activities of PTKs and PTPs, however, is linked to the pathogenesis of numerous human diseases, including cancer, suggesting that PTPs may be innovative molecular targets for cancer treatment. Two PTPs that have an important inhibitory role in lymphocytes and other haematopoietic cells are SHP-1 and SHP-2 (SH2 domain-containing phosphatases 1 and 2), SHP-1,2 have been shown to promote cell growth and act by both upregulating positive signaling pathways and by downregulating negative signaling pathways. SHIP (SH2 domain-containing inositol phosphatase) is another inhibitory phosphatase that is rather specific for the inositol phospholipid phosphatidylinositol-3,4,5-trisphosphate (PIP3). SHIP acts as a negative regulator of immune response by hydrolysing PIP3, and, as a result, a SHIP defiency results in myeloproliferation and B cell lymphoma in mice. This strong validation of SHP-1,2 and SHIP as oncology targets has generated considerable interest in the development of small molecule inhibitors as potential therapeutic agents for haematologic malignancies and solid tumours, however, SHP-1,2 and SHIP have proven to be an extremely difficult target for drug discovery, due primarily to the highly conserved and positively charged nature of its PTP active site. The majority of reported PTP inhibitors lack either appropriate selectivity or membrane permeability, limiting their utility in modulating the activity of the intracellular PTPs. In order to overcome these caveats novel techniques have been employed to synthesise new inhibitors that specifically attentuate the PTP-dependent signaling inside the cell and amongst them some are already in clinical development (e.g., SHP-1 inhibitor sodium stibogluconate; SHP-2 inhibitor TNO155; SHIP-1 activator AQX-1125). In this review the mechanisms of action and the clinical development of newly available SHP-1,2 and SHIP inhibitors and activators are decribed and the major issues facing this rapidly evolving field are discussed

The ecology of marine microbenthos. 1. The quantitative importance of ciliates as cornpared with Metazoans in various types of sediments

ABSTRACT An investigation of the quantitative importance of protozoans -especially ciliates -has been undertaken in Scandinavian waters. Ciliates were found in numbers from 10 6 to 4 X 10 7 individuals per m' representing 0.03-2.3 grammes wet weight per m'. Highest numbers were found in fine sand and in localities with a rich growth of sulphur-bacteria. In these sediments ciliates are 10 to 100 times more numerous than the total number of metazoans, and their biomass is of the same order or sometimes larger than the biomass of the micro-metazoans (nematodes, turbellarians, gastrotrichs etc.). In coarser sand ciliates are fewer, and micro-metazoans play a larger quantitative role. This distribution is explained by the small size and other morphological adaptations making ciliates able to inhabit the small interstitia of fine sand, and also their ability to endure reducing and anaerobic conditions. In the detritus layers which cover clayey and muddy sediments ciliates are few in number and play a small role compared with metazoan groups, such as nematodes, which may sometimes be as numerous as ciliates. A comparison with the enumeration of the benthic metazoans in Niva Bay carried out by Muus (J 967) shows that 93 % of all animals in the bay are ciliates which, however, only comprise 0.4 % of the total animal biomass. Large dinofiagellates were found in numbers of 10 5 to 1.5 X 10 7 per m'. Euglenoids are less numerous, normally fewer than 5 X 10 5 per m'. Naked amoebae seem also to play a small quantitative role; more than 10 5 per m' were rarely found. Ciliates show a maximum population size in summer, but this maximum may be obscured by other factors in more exposed localities. Large populations of active animals are found throughout the year. The importance of ciliates in community respiration is discussed. It is concluded that in localities with fine sand and in sulphureta the ciliates account for a larger part than the rnicro-rnetazoa, and that the ciliates contribute significantly to the energetics of these communities

Entre petite criminalité et grande misère : la prison des hommes à Montréal et sa population (1836-1912)

Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal

Controls on development and diversity of Early Archean stromatolites

The ≈3,450-million-year-old Strelley Pool Formation in Western Australia contains a reef-like assembly of laminated sedimentary accretion structures (stromatolites) that have macroscale characteristics suggestive of biological influence. However, direct microscale evidence of biology—namely, organic microbial remains or biosedimentary fabrics—has to date eluded discovery in the extensively-recrystallized rocks. Recently-identified outcrops with relatively good textural preservation record microscale evidence of primary sedimentary processes, including some that indicate probable microbial mat formation. Furthermore, we find relict fabrics and organic layers that covary with stromatolite morphology, linking morphologic diversity to changes in sedimentation, seafloor mineral precipitation, and inferred microbial mat development. Thus, the most direct and compelling signatures of life in the Strelley Pool Formation are those observed at the microscopic scale. By examining spatiotemporal changes in microscale characteristics it is possible not only to recognize the presence of probable microbial mats during stromatolite development, but also to infer aspects of the biological inputs to stromatolite morphogenesis. The persistence of an inferred biological signal through changing environmental circumstances and stromatolite types indicates that benthic microbial populations adapted to shifting environmental conditions in early oceans