Transmission properties of a single metallic slit: From the subwavelength regime to the geometrical-optics limit

In this work we explore the transmission properties of a single slit in a metallic screen. We analyze the dependence of these properties on both slit width and angle of incident radiation. We study in detail the crossover between the subwavelength regime and the geometrical-optics limit. In the subwavelength regime, resonant transmission linked to the excitation of waveguide resonances is analyzed. Linewidth of these resonances and their associated electric field intensities are controlled by just the width of the slit. More complex transmission spectra appear when the wavelength of light is comparable to the slit width. Rapid oscillations associated to the emergence of different propagating modes inside the slit are the main features appearing in this regime.Comment: Accepted for publication in Phys. Rev.

Validation of a CFD model by using 3D sonic anemometers to analyse the air velocity generated by an air-assisted sprayer equipped with two axial fans

A computational fluid dynamics (CFD) model of the air flow generated by an air-assisted sprayer equipped with two axial fans was developed and validated by practical experiments in the laboratory. The CFD model was developed by considering the total air flow supplied by the sprayer fan to be the main parameter, rather than the outlet air velocity. The model was developed for three air flows corresponding to three fan blade settings and assuming that the sprayer is stationary. Actual measurements of the air velocity near the sprayer were taken using 3D sonic anemometers. The workspace sprayer was divided into three sections, and the air velocity was measured in each section on both sides of the machine at a horizontal distance of 1.5, 2.5, and 3.5 m from the machine, and at heights of 1, 2, 3, and 4 m above the ground The coefficient of determination (R2) between the simulated and measured values was 0.859, which demonstrates a good correlation between the simulated and measured data. Considering the overall data, the air velocity values produced by the CFD model were not significantly different from the measured values

Effect of an educational intervention in primary care physicians on the compliance of indicators of good clinical practice in the treatment of type 2 diabetes mellitus [OBTEDIGA project]

[Abstract] Aim. To evaluate the effect of an educational intervention among primary care physicians on several indicators of good clinical practice in diabetes care. Methods. Two groups of physicians were randomly assigned to the intervention or control group (IG and CG). Every physician randomly selected two samples of patients from all type 2 diabetic patients aged 40 years and above and diagnosed more than a year ago. Baseline and final information were collected cross-sectionally 12 months apart, in two independent samples of 30 patients per physician. The educational intervention comprised: distribution of educational materials and physicians' specific bench-marking information, an on-line course and three on-site educational workshops on diabetes. External observers collected information directly from the physicians and from the medical records of the patients on personal and family history of disease and on the evolution and treatment of their disease. Baseline information was collected retrospectively in the control group. Results. Intervention group comprised 53 physicians who included a total of 3018 patients in the baseline and final evaluations. CG comprised 50 physicians who included 2868 patients in the same evaluations. Measurement of micro-albuminuria in the last 12 months (OR = 1.6, 95% CI: 1.1–2.4) and foot examination in the last year (OR = 2.0, 95% CI: 1.1–3.6) were the indicators for which greater improvement was found in the IG. No other indicator considered showed statistically significant improvement between groups. Conclusions. The identification of indicators with very low level of compliance and the implementation of a simple intervention in physicians to correct them is effective in improving the quality of care of diabetic patients

Tracing the retina to analyze the integrity and phagocytic capacity of the retinal pigment epithelium

We have developed a new technique to study the integrity, morphology and functionality of the retinal neurons and the retinal pigment epithelium (RPE). Young and old control albino (Sprague-Dawley) and pigmented (Piebald Virol Glaxo) rats, and dystrophic albino (P23H-1) and pigmented (Royal College of Surgeons) rats received a single intravitreal injection of 3% Fluorogold (FG) and their retinas were analyzed from 5 minutes to 30 days later. Retinas were imaged in vivo with SD-OCT and ex vivo in flat-mounts and in cross-sections. Fifteen minutes and 24 hours after intravitreal administration of FG retinal neurons and the RPE, but no glial cells, were labeled with FG-filled vesicles. The tracer reached the RPE 15 minutes after FG administration, and this labeling remained up to 30 days. Tracing for 15 minutes or 24 hours did not cause oxidative stress. Intraretinal tracing delineated the pathological retinal remodelling occurring in the dystrophic strains. The RPE of the P23H-1 strain was highly altered in aged animals, while the RPE of the RCS strain, which is unable to phagocytose, did not accumulate the tracer even at young ages when the retinal neural circuit is still preserved. In both dystrophic strains, the RPE cells were pleomorphic and polymegathic

Correction to: A Phase II Study Evaluating Combined Neoadjuvant Cetuximab and Chemotherapy Followed by Chemoradiotherapy and Concomitant Cetuximab in Locoregional Oesophageal Cancer Patients

Errors were subsequently identified in the article and the following corrections should be note

Efficacy and safety of preoperative preparation with Lugol''s iodine solution in euthyroid patients with Graves’ disease (LIGRADIS Trial): Study protocol for a multicenter randomized trial

Background: Currently, both the American Thyroid Association and the European Thyroid Association recommend preoperative preparation with Lugol''s Solution (LS) for patients undergoing thyroidectomy for Graves’ Disease (GD), but their recommendations are based on low-quality evidence. The LIGRADIS trial aims to provide evidence either to support or refute the systematic use of LS in euthyroid patients undergoing thyroidectomy for GD. Methods: A multicenter randomized controlled trial will be performed. Patients =18 years of age, diagnosed with GD, treated with antithyroid drugs, euthyroid and proposed for total thyroidectomy will be eligible for inclusion. Exclusion criteria will be prior thyroid or parathyroid surgery, hyperparathyroidism that requires associated parathyroidectomy, thyroid cancer that requires adding a lymph node dissection, iodine allergy, consumption of lithium or amiodarone, medically unfit patients (ASA-IV), breastfeeding women, preoperative vocal cord palsy and planned endoscopic, video-assisted or remote access surgery. Between January 2020 and January 2022, 270 patients will be randomized for either receiving or not preoperative preparation with LS. Researchers will be blinded to treatment assignment. The primary outcome will be the rate of postoperative complications: hypoparathyroidism, recurrent laryngeal nerve injury, hematoma, surgical site infection or death. Secondary outcomes will be intraoperative events (Thyroidectomy Difficulty Scale score, blood loss, recurrent laryngeal nerve neuromonitoring signal loss), operative time, postoperative length of stay, hospital readmissions, permanent complications and adverse events associated to LS. Conclusions: There is no conclusive evidence supporting the benefits of preoperative treatment with LS in this setting. This trial aims to provide new insights into future Clinical Practice Guidelines recommendations. Trial registration: ClinicalTrials.gov identifier: NCT03980132. © 202

Demonstration of the event identification capabilities of the NEXT-White detector

[EN] In experiments searching for neutrinoless double-beta decay, the possibility of identifying the two emitted electrons is a powerful tool in rejecting background events and therefore improving the overall sensitivity of the experiment. In this paper we present the first measurement of the efficiency of a cut based on the different event signatures of double and single electron tracks, using the data of the NEXT-White detector, the first detector of the NEXT experiment operating underground. Using a 228Th calibration source to produce signal-like and background-like events with energies near 1.6 MeV, a signal efficiency of 71.6 ± 1.5 stat ± 0.3 sys% for a background acceptance of 20.6 ± 0.4 stat ± 0.3 sys% is found, in good agreement with Monte Carlo simulations. An extrapolation to the energy region of the neutrinoless double beta decay by means of Monte Carlo simulations is also carried out, and the results obtained show an improvement in background rejection over those obtained at lower energies.The NEXT Collaboration acknowledges support from the following agencies and institutions: the European Research Council (ERC) under the Advanced Grant 339787NEXT; the European Union's Framework Programme for Research and Innovation Horizon 2020 (2014-2020) under the Marie Sklodowska-Curie Grant Agreements No. 674896, 690575 and 740055; the Ministerio de Economia y Competitividad and the Ministerio de Ciencia, Innovacion y Universidades of Spain under grants FIS2014-53371-C04, RTI2018-095979, the Severo Ochoa Program SEV-2014-0398 and the Maria de Maetzu Program MDM-2016-0692; the GVA of Spain under grants PROMETEO/2016/120 and SEJI/2017/011; the Portuguese FCT under project PTDC/FIS-NUC/2525/2014, under project UID/FIS/04559/2013 to fund the activities of LIBPhys, and under grants PD/BD/FBD/105921/2014, SFRH/BPD/109180/2015 and SFRH/BPD/76842/2011; the U.S. Department of Energy under contracts number DE-AC02-06CH11357 (Argonne National Laboratory), DE-AC02-07CH11359 (Fermi National Accelerator Laboratory), DE-FG02-13ER42020 (Texas A&M) and DE-SC0019223/DE-SC0019054 (University of Texas at Arlington); and the University of Texas at Arlington. DGD acknowledges Ramon y Cajal program (Spain) under contract number RYC-2015-18820. We also warmly acknowledge the Laboratori Nazionali del Gran Sasso (LNGS) and the Dark Side collaboration for their help with TPB coating of various parts of the NEXT-White TPC. Finally, we are grateful to the Laboratorio Subterraneo de Canfranc for hosting and supporting the NEXT experiment.Ferrario, P.; Benlloch-Rodríguez, J.; Díaz López, G.; Hernando Morata, J.; Kekic, M.; Renner, J.; Usón, A.... (2019). Demonstration of the event identification capabilities of the NEXT-White detector. Journal of High Energy Physics (Online). (10):1-17. https://doi.org/10.1007/JHEP10(2019)052S11710M. Fukugita and T. Yanagida, Baryogenesis without grand unification, Phys. Lett.B 174 (1986) 45 [ INSPIRE ].EXO-200 collaboration, Improved measurement of the 2νββ half-life of136Xe with the EXO-200 detector, Phys. Rev.C 89 (2014) 015502 [ arXiv:1306.6106 ] [ INSPIRE ].XENON collaboration, Dark matter search results from a one ton-year exposure of XENON1T, Phys. Rev. Lett.121 (2018) 111302 [ arXiv:1805.12562 ] [ INSPIRE ].Caltech-Neuchâtel-PSI collaboration, Search for ββ decay in136Xe: new results from the Gotthard experiment, Phys. Lett.B 434 (1998) 407 [ INSPIRE ].NEXT collaboration, First proof of topological signature in the high pressure xenon gas TPC with electroluminescence amplification for the NEXT experiment, JHEP01 (2016) 104 [ arXiv:1507.05902 ] [ INSPIRE ].NEXT collaboration, The Next White (NEW) detector, 2018 JINST13 P12010 [ arXiv:1804.02409 ] [ INSPIRE ].M. Redshaw, E. Wingfield, J. McDaniel and E.G. Myers, Mass and double-beta-decay Q value of136Xe, Phys. Rev. Lett.98 (2007) 053003 [ INSPIRE ].NEXT collaboration, Initial results on energy resolution of the NEXT-White detector, 2018 JINST13 P10020 [ arXiv:1808.01804 ] [ INSPIRE ].NEXT collaboration, Energy calibration of the NEXT-White detector with 1% resolution near Qββ of136Xe, arXiv:1905.13110 [ INSPIRE ].NEXT collaboration, Electron drift properties in high pressure gaseous xenon, 2018 JINST13 P07013 [ arXiv:1804.01680 ] [ INSPIRE ].T.H. Cormen, C. Stein, R.L. Rivest and C.E. Leiserson, Introduction to algorithms, 2nd ed., McGraw-Hill Higher Education, U.S.A. (2001).NEXT collaboration, Calibration of the NEXT-White detector using83mKr decays, 2018 JINST13 P10014 [ arXiv:1804.01780 ] [ INSPIRE ].J. Martín-Albo, The NEXT experiment for neutrinoless double beta decay searches, Ph.D. thesis, Valencia U., IFIC, Valencia, Spain (2015).GEANT4 collaboration, GEANT4: a simulation toolkit, Nucl. Instrum. Meth.A 506 (2003) 250 [ INSPIRE ].J.J. Gomez-Cadenas et al., Sense and sensitivity of double beta decay experiments, JCAP06 (2011) 007 [ arXiv:1010.5112 ] [ INSPIRE ].NEXT collaboration, Radiogenic backgrounds in the NEXT double beta decay experiment, arXiv:1905.13625 [ INSPIRE ].NEXT collaboration, Background rejection in NEXT using deep neural networks, 2017 JINST12 T01004 [ arXiv:1609.06202 ] [ INSPIRE ].NEXT collaboration, Application and performance of an ML-EM algorithm in NEXT, 2017 JINST12 P08009 [ arXiv:1705.10270 ] [ INSPIRE ].NEXT collaboration, Secondary scintillation yield of xenon with sub-percent levels of CO2 additive for rare-event detection, Phys. Lett.B 773 (2017) 663 [ arXiv:1704.01623 ] [ INSPIRE ].NEXT collaboration, Electroluminescence TPCs at the thermal diffusion limit, JHEP01 (2019) 027 [ arXiv:1806.05891 ] [ INSPIRE ].R. Felkai et al., Helium-xenon mixtures to improve the topological signature in high pressure gas xenon TPCs, Nucl. Instrum. Meth.A 905 (2018) 82 [ arXiv:1710.05600 ] [ INSPIRE ].NEXT collaboration, Electron drift and longitudinal diffusion in high pressure xenon-helium gas mixtures, 2019 JINST14 P08009 [ arXiv:1902.05544 ] [ INSPIRE ].NEXT collaboration, Sensitivity of NEXT-100 to neutrinoless double beta decay, JHEP05 (2016) 159 [ arXiv:1511.09246 ] [ INSPIRE ].J. Muñoz Vidal, The NEXT path to neutrino inverse hierarchy, Ph.D. thesis, Valencia U., IFIC, Valencia, Spain (2018)

Long daytime napping is associated with increased adiposity and type 2 diabetes in an elderly population with metabolic syndrome

Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly participants with overweight/obesity and metabolic syndrome, in the PREDIMED-Plus trial, was carried out. Accelerometer-derived napping was measured. Prevalence ratios (PR) and 95% confidence intervals (CI) for T2D were obtained using multivariable-adjusted Cox regression with constant time. Linear regression models were fitted to examine associations of napping with body mass index (BMI) and waist circumference (WC). Participants napping ≥90 min had a higher prevalence of T2D (PR 1.37 (1.06, 1.78)) compared with those napping 5 to <30 min per day. Significant positive associations with BMI and WC were found in those participants napping ≥30 min as compared to those napping 5 to <30 min per day. The findings of this study suggest that longer daytime napping is associated with higher T2D prevalence and greater adiposity measures in an elderly Spanish population at high cardiovascular risk