Estudio de calidad de vida de pacientes con coxartrosis

La artroplastia de cadera secundaria a artrosis es una de las intervenciones más frecuentes dentro de la cirugía ortopédica. La coxartrosis produce una limitación funcional severa, que invalida a los pacientes y los hace dependientes para sus actividades cotidianas. Se calcula la calidad de vida aportada en las intervenciones de reemplazo articular de cadera de 85 pacientes con coxartrosis utilizando el “EQ-5D”. La puntuación media preoperatoria fue 0,222 ± 0,320 y la postoperatoria 0,794 ± 0,251. El incremento de calidad de vida en función de la edad de los pacientes siguió una tendencia descendente (β= −0,010), sin diferencias significativas (p=0,214). El incremento de calidad de vida no se vió condicionado por la presencia de infección (p>0,5), duración de la intervención (p>0,5) ni tiempo de estancia hospitalaria (p>0,5). La sustitución de esta articulación ha transformado la vida de muchos de los pacientes incrementando su calidad de vida, principalmente en pacientes que ingresan por coxartrosis en comparación con otros diagnósticos.Hip replacement secondary to osteoarthritis is one of the most performed surgeries in orthopaedic surgery. Osteoarthritis produces a severe functional limitation that invalidates patients and makes them dependent for their daily activities. It is calculated the quality of life provided by hip replacement procedure in 85 osteoarthritis patients using the “EQ-5D”. The mean preoperative score was 0.222 ± 0.320 and the postoperative score 0.794 ± 0.251. The increase in quality of life according to patients age followed a descendent tendency (β= −0.010), without a statitically relationship (p=0.214). The increase in quality of life was not conditioned by infection (p>0.5), length of stay (p>0.5) or length of the procedure (p>0.5). Joint replacement has changed the lives of many patients, increasing their quality of life, mainly in osteoarthritis patients compared to patients with other diagnosis

Phoretic Motion of Spheroidal Particles Due To Self-Generated Solute Gradients

We study theoretically the phoretic motion of a spheroidal particle, which generates solute gradients in the surrounding unbounded solvent via chemical reactions active on its surface in a cap-like region centered at one of the poles of the particle. We derive, within the constraints of the mapping to classical diffusio-phoresis, an analytical expression for the phoretic velocity of such an object. This allows us to analyze in detail the dependence of the velocity on the aspect ratio of the polar and the equatorial diameters of the particle and on the fraction of the particle surface contributing to the chemical reaction. The particular cases of a sphere and of an approximation for a needle-like particle, which are the most common shapes employed in experimental realizations of such self-propelled objects, are obtained from the general solution in the limits that the aspect ratio approaches one or becomes very large, respectively.Comment: 18 pages, 5 figures, to appear in European Physical Journal

Tratamiento de oligometástasis mediante cirugía oncológica con intención curativa

Oligometastasis is a clinical condition characterized by the presence of one to five metastases in a controlled or potentially controllable neoplasm, which can be treated at a local level through ablative therapy. Material and methods. We report the case of a 49 years old male who is diagnosed of a renal cell carcinoma, and presents metastases in the left humerus and the right radius. Two-stage surgery is carried out with the placement of tumor prosthesis in the humerus and reconstruction by using the fibula and osteosynthesis with a plate in the radius. Results. In the course of two years of monitoring, the patient is now disease free at both a local and systemic levels with a good clinical, functional and radiological condition. Conclusions. The management of patients with metastatic cancer has changed. Patients affected by oligometastasis can be treated with oncology surgery with a curative intention, increasing the chances of survival and even achieving the recovery of the patient

The Gypsy Database (GyDB) of mobile genetic elements: release 2.0

This article introduces the second release of the Gypsy Database of Mobile Genetic Elements (GyDB 2.0): a research project devoted to the evolutionary dynamics of viruses and transposable elements based on their phylogenetic classification (per lineage and protein domain). The Gypsy Database (GyDB) is a long-term project that is continuously progressing, and that owing to the high molecular diversity of mobile elements requires to be completed in several stages. GyDB 2.0 has been powered with a wiki to allow other researchers participate in the project. The current database stage and scope are long terminal repeats (LTR) retroelements and relatives. GyDB 2.0 is an update based on the analysis of Ty3/Gypsy, Retroviridae, Ty1/Copia and Bel/Pao LTR retroelements and the Caulimoviridae pararetroviruses of plants. Among other features, in terms of the aforementioned topics, this update adds: (i) a variety of descriptions and reviews distributed in multiple web pages; (ii) protein-based phylogenies, where phylogenetic levels are assigned to distinct classified elements; (iii) a collection of multiple alignments, lineage-specific hidden Markov models and consensus sequences, called GyDB collection; (iv) updated RefSeq databases and BLAST and HMM servers to facilitate sequence characterization of new LTR retroelement and caulimovirus queries; and (v) a bibliographic server. GyDB 2.0 is available at http://gydb.org

Plant Reactome: a knowledgebase and resource for comparative pathway analysis

Plant Reactome (https://plantreactome.gramene.org) is an open-source, comparative plant pathway knowledgebase of the Gramene project. It uses Oryza sativa (rice) as a reference species for manual curation of pathways and extends pathway knowledge to another 82 plant species via gene-orthology projection using the Reactome data model and framework. It currently hosts 298 reference pathways, including metabolic and transport pathways, transcriptional networks, hormone signaling pathways, and plant developmental processes. In addition to browsing plant pathways, users can upload and analyze their omics data, such as the gene-expression data, and overlay curated or experimental gene-gene interaction data to extend pathway knowledge. The curation team actively engages researchers and students on gene and pathway curation by offering workshops and online tutorials. The Plant Reactome supports, implements and collaborates with the wider community to make data and tools related to genes, genomes, and pathways Findable, Accessible, Interoperable and Re-usable (FAIR)

Partitioning the variation among spatial, temporal and environmental components in a multivariate data set

Abstract We propose a method of partitioning the variation in a multivariate set of data according to (i) environmental variables, (ii) variables describing the spatial structure in the data and (iii) temporal variables. This method is an extension of an existing method for partialling out the spatial component of environmental variation, using canonical analysis. Our proposed method extends this approach by including temporal variables in the analysis. Thus, the partitioning of variation for a data matrix of species’abundances or biomass can include, by our methodology, the following components: (1) pure environmental, (2) pure spatial, (3) pure temporal, (4) pure spatial component of environmental, (5) pure temporal component of environmental, (6) pure combined spatial/temporal component, (7) combined spatial/temporal component of environmental and (8) unexplained. In addition, permutation testing accompanying the analyses allows tests of significance for the relationship between the different components and the species data. We illustrate the method with a set of survey data of penaeid species (prawns) obtained on the far northern Great Barrier Reef, Australia. This extension is a useful tool for multivariate analysis of ecological data from surveys, where space, time and environment commonly overlap and are important influences on observed variation