Experimental investigation of fuel-cooled combustor: Cooling efficiency and coke formation

Scramjet is an air-breathing engine designed to propel advanced aircrafts in the atmosphere, suitable, according to various studies, to thrust high-speed hypersonic flights (over Mach 5). The thermal protection of vehicles flying at hypersonic velocities is a critical problem; as at supersonic speeds the incoming air is at too high temperature to be used as a coolant, the fuel becomes the only adequate source of cooling for the vehicle. Regenerative cooling is a well-known cooling technique using the fuel as coolant. As the development of regeneratively cooled engines faces many difficulties, an empirical study of this cooling technology and of its complex dynamics is of high interest. In this context, a remotely controlled fuel-cooled combustor, suitable for the experimental analysis of the pyrolysis-combustion coupling characterizing a fuel-cooled combustion chamber when a hydrocarbon propellant is used, has been designed. Tests are realized under both stationary and transient conditions using ethylene as fuel and air as oxidizer. Two operating parameters, i.e. fuel mass flow rate (between 0.010 and 0.040 g.s-1) and equivalence ratio (between 1.0 and 1.5), have been investigated. It has been observed that fuel mass flow rate increases always result in the raise of the heat flux density passing from the combustion gases to the combustor walls. It has been seen that mass flow rate raises between 16 and 20 % lead to increases in the thermal energy evacuated by the fuel-coolant in the range from 30.4 to 48.5 %, depending on equivalence ratio and pressure. The dependence of the cooling system heat exchange efficiency on the two operating parameters has been demonstrated. The consequences of the coking activity of the fuel have also been investigated. For applied interest, a monitoring method for carbon deposits formation has been developed and validated

Experimental investigation on the concentration and voltage effects on the characteristics of deposited magnesium–lanthanum powder

International audiencePhone: +33 248 484 065 Highlights x We synthetize Mg-La powders by means of an electrodeposition process. x We characterize Mg-La powders using EDS, SEM, XRD and FTIR techniques

High-Temperature Transport Properties of Yb4−xSmxSb3

Polycrystalline L4Sb3 (L = La, Ce, Sm, and Yb) and Yb4−x Sm x Sb3, which crystallizes in the anti-Th3P4 structure type (I-43d no. 220), were synthesized via high-temperature reaction. Structural and chemical characterization were performed by x-ray diffraction and electronic microscopy with energy-dispersive x-ray analysis. Pucks were densified by spark plasma sintering. Transport property measurements showed that these compounds are n-type with low Seebeck coefficients, except for Yb4Sb3, which shows semimetallic behavior with hole conduction above 523 K. By partially substituting Yb by a trivalent rare earth we successfully improved the thermoelectric figure of merit of Yb4Sb3 up to 0.7 at 1273 K

Severe bronchiolitis in infants born very preterm and neurodevelopmental outcome at 2 years

Preterm infants are at greater risk of bronchopulmonary dysplasia, which is associated with neurodevelopmental impairment. These infants are also more likely to develop severe bronchiolitis, which can contribute to neurodevelopmental impairment. The aim of this study was to determine whether severe bronchiolitis in very preterm infants (born before 33 weeks of gestation) was associated with an increased risk of neurodevelopmental impairment at 2 years of age. We analyzed a population-based cohort of infants (the Loire Infant Follow-up Team cohort) born between 1 January 2003 and 31 December 2009. Severe bronchiolitis was defined as hospitalization due to bronchiolitis during the first year of life. Neurodevelopmental outcome was assessed at 2 years of corrected age. A total of 2,405 infants were included in this analysis and categorized based on neonatal respiratory status: 1,308 (54.4 %) received no respiratory assistance, 864(35.9 %) received oxygen for <28 days, and 167 (6.9 %) had mild and 66 (2.7) moderate or severe bronchopulmonary dysplasia. At 2 years, 502 children displayed non-optimal neurodevelopmental outcome (20.9 %). Moderate or severe bronchopulmonary dysplasia was significantly associated with non-optimal neurodevelopmental outcome at 2 years (adjusted odds ratios (OR) = 2.3 [95 % confidence interval (CI): 1.3–3.9], p = 0.003). In the first year, 318 infants acquired severe bronchiolitis (13.2 %), which was not associated with non-optimal neurodevelopmental outcome (adjusted OR = 1.0 [95 % CI: 0.8–1.4]; p = 0.88). In conclusion, respiratory status in the neonatal period was significantly associated with non-optimal neurodevelopmental outcome at 2 years, while severe bronchiolitis was not

Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas.

In this study, we attempted to find genetic variants affecting gene expression (eQTL = expression Quantitative Trait Loci) in the human placenta in normal and pathological situations. The analysis of gene expression in placental diseases (Pre-eclampsia and Intra-Uterine Growth Restriction) is hindered by the fact that diseased placental tissue samples are generally taken at earlier gestations compared to control samples. The difference in gestational age is considered a major confounding factor in the transcriptome regulation of the placenta. To alleviate this significant problem, we propose here a novel approach to pinpoint disease-specific cis-eQTLs. By statistical correction for gestational age at sampling as well as other confounding/surrogate variables systematically searched and identified, we found 43 e-genes for which proximal SNPs influence expression level. Then, we performed the analysis again, removing the disease status from the covariates, and we identified 54 e-genes, 16 of which are identified de novo and, thus, possibly related to placental disease. We found a highly significant overlap with previous studies for the list of 43 e-genes, validating our methodology and findings. Among the 16 disease-specific e-genes, several are intrinsic to trophoblast biology and, therefore, constitute novel targets of interest to better characterize placental pathology and its varied clinical consequences. The approach that we used may also be applied to the study of other human diseases where confounding factors have hampered a better understanding of the pathology

A genome-wide approach reveals novel imprinted genes expressed in the human placenta

Genomic imprinting characterizes genes with a monoallelic expression, which is dependent on the parental origin of each allele. Approximately 150 imprinted genes are known to date, in humans and mice but, though computational searches have tried to extract intrinsic characteristics of these genes to identify new ones, the existing list is probably far from being comprehensive. We used a high-throughput strategy by diverting the classical use of genotyping microarrays to compare the genotypes of mRNA/cDNA vs. genomic DNA to identify new genes presenting monoallelic expression, starting from human placental material. After filtering of data, we obtained a list of 1,082 putative candidate monoallelic SNPs located in more than one hundred candidate genes. Among these, we found known imprinted genes, such as IPW, GRB10, INPP5F and ZNF597, which contribute to validate the approach. We also explored some likely candidates of our list and identified seven new imprinted genes, including ZFAT, ZFAT-AS1, GLIS3, NTM, MAGI2, ZC3H12Cand LIN28B, four of which encode zinc finger transcription factors. They are, however, not imprinted in the mouse placenta, except for Magi2. We analyzed in more details the ZFAT gene, which is paternally expressed in the placenta (as ZFAT-AS1, a non-coding antisense RNA) but biallelic in other tissues. The ZFAT protein is expressed in endothelial cells, as well as in syncytiotrophoblasts. The expression of this gene is, moreover, downregulated in placentas from complicated pregnancies. With this work we increase by about 10% the number of known imprinted genes in humans

Resonant bonding, multiband thermoelectric transport and native defects in n-type BaBiTe_(3-x)Se_x (x = 0, 0.05 and 0.1)

The unique crystal structure of BaBiTe_3 containing Te···Te resonant bonds and its narrow band gap motivated the systematic study of the thermoelectric transport properties of BaBiTe_(3–x)Se_x (x = 0, 0.05, and 0.1) presented here. This study gives insight in the chemical bonding and thermoelectric transport properties of BaBiTe_3. The study shows that the presence of Te···Te resonant bonds in BaBiTe_3 is best described as a linear combination of interdigitating (Te^(1–))_2 side groups and infinite Te_n chains. Rietveld X-ray structure refinements and extrinsic defect calculations reveal that the substitution of Te by Se occurs preferentially on the Te4 and Te5 sites, which are not involved in Te···Te bonding. This work strongly suggests that both multiband effects and native defects play an important role in the transport properties of BaBiTe_(3–x)Se_x (x = 0, 0.05, and 0.1). The carrier concentration of BaBiTe_3 can be tuned via Se substitution (BaBiTe_(3–x)Se_x with x = 0, 0.05, and 0.1) to values near those needed to optimize the thermoelectric performance. The thermal conductivity of BaBiTe_(3–x)Se_x (x = 0, 0.05, and 0.1) is found to be remarkably low (ca. 0.4 Wm^(–1)K^(–1) at 600 K), reaching values close to the glass limit of BaBiSe_3 (0.34 W m^(–1) K^(–1)) and BaBiTe_3 (0.28 W m^(–1) K^(–1)). Calculations of the defect formation energies in BaBiTe_3 suggest the presence of native Bi_(Ba)^(+1) and Te_(Bi)^(+1) antisite defects, which are low in energy and likely responsible for the native n-type conduction and the high carrier concentration (ca. 10^(20) cm^(–3)) found for all samples. The analyses of the electronic structure of BaBiTe_3 and of the optical absorption spectra of BaBiTe_(3–x)Se_x (x = 0, 0.05, 0.1, and 3) strongly suggest the presence of multiple electron pockets in the conduction band (CB) in all samples. These analyses also provide a possible explanation for the two optical transitions observed for BaBiTe_3. High-temperature optical absorption measurements and thermoelectric transport analyses indicate that bands higher in the conduction band converge with the conduction band minimum (CBM) with increasing temperature and contribute to the thermoelectric transport properties of BaBiTe_3 and BaBiTe_(2.95)Se_(0.05). This multiband contribution can account for the ∼50% higher zT_(max) of BaBiTe_3 and BaBiTe_(2.95)Se_(0.05) (∼0.4 at 617 K) compared to BaBiTe_(2.9)Se_(0.1) (∼0.2 at 617 K), for which no such contribution was found. The increase in the band offset between the CBM and bands higher in the conduction band with respect to the selenium content is one possible explanation for the absence of multiband effects in the thermoelectric transport properties of BaBiTe_(2.9)Se_(0.1)

A massive rock and ice avalanche caused the 2021 disaster at Chamoli, Indian Himalaya

On 7 Feb 2021, a catastrophic mass flow descended the Ronti Gad, Rishiganga, and Dhauliganga valleys in Chamoli, Uttarakhand, India, causing widespread devastation and severely damaging two hydropower projects. Over 200 people were killed or are missing. Our analysis of satellite imagery, seismic records, numerical model results, and eyewitness videos reveals that ~27x106 m3 of rock and glacier ice collapsed from the steep north face of Ronti Peak. The rock and ice avalanche rapidly transformed into an extraordinarily large and mobile debris flow that transported boulders >20 m in diameter, and scoured the valley walls up to 220 m above the valley floor. The intersection of the hazard cascade with downvalley infrastructure resulted in a disaster, which highlights key questions about adequate monitoring and sustainable development in the Himalaya as well as other remote, high-mountain environments