Inclusion of new 5-fluorouracil amphiphilic derivatives in liposome formulation for cancer treatment

Correction for 'Inclusion of new 5-fluorouracil amphiphilic derivatives in liposome formulation for cancer treatment' by M. Petaccia et al., Med. Chem. Commun., 2015, 6, 1639–1642

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at lysine 18 is a surprisingly abundant modification in the small intestine crypt and colon, and is linked to gene regulation. We show that this modification is highly dynamic and regulated during the cell cycle. We identify class I histone deacetylases, HDAC1, HDAC2, and HDAC3, as major executors of histone decrotonylation. We show that known HDAC inhibitors, including the gut microbiota-derived butyrate, affect histone decrotonylation. Consistent with this, we find that depletion of the gut microbiota leads to a global change in histone crotonylation in the colon. Our results suggest that histone crotonylation connects chromatin to the gut microbiota, at least in part, via short-chain fatty acids and HDACs

Pilot study of the multicentre DISCHARGE trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography (vol 30, pg 1997, 2020)

The original version of this article, published on 16 December 2019, unfortunately contained two mistakes.Cardiovascular Aspects of Radiolog

Nuovi dati sull'origine di Sena Gallica

Il contributo rende noti i risultati dei nuovi scavi effettuati a Senigallia (via Cavallotti). Si tratta della scoperta dell'esistenza di una fase preromana, databile tra V e IV sec. a.C., mai intravista prima al di sotto dell'area urbana occupata dalla colonia romana di III sec. a.C

Nuovi dati sull'origine di Sena Gallica

Il contributo rende noti i risultati dei nuovi scavi effettuati a Senigallia (via Cavallotti). Si tratta della scoperta dell'esistenza di una fase preromana, databile tra V e IV sec. a.C., mai intravista prima al di sotto dell'area urbana occupata dalla colonia romana di III sec. a.C