472 research outputs found
Smart Cities: Towards a New Citizenship Regime? A Discourse Analysis of the British Smart City Standard
Growing practice interest in smart cities has led to calls for a less technology-oriented and more citizen-centric approach. In response, this articles investigates the citizenship mode promulgated by the smart city standard of the British Standards Institution. The analysis uses the concept of citizenship regime and a mixture of quantitative and qualitative methods to discern key discursive frames defining the smart city and the particular citizenship dimensions brought into play. The results confirm an explicit citizenship rationale guiding the smart city (standard), although this displays some substantive shortcomings and contradictions. The article concludes with recommendations for both further theory and practice development
Stochastic Gravity: A Primer with Applications
Stochastic semiclassical gravity of the 90's is a theory naturally evolved
from semiclassical gravity of the 70's and 80's. It improves on the
semiclassical Einstein equation with source given by the expectation value of
the stress-energy tensor of quantum matter fields in curved spacetimes by
incorporating an additional source due to their fluctuations. In stochastic
semiclassical gravity the main object of interest is the noise kernel, the
vacuum expectation value of the (operator-valued) stress-energy bi-tensor, and
the centerpiece is the (stochastic) Einstein-Langevin equation. We describe
this new theory via two approaches: the axiomatic and the functional. The
axiomatic approach is useful to see the structure of the theory from the
framework of semiclassical gravity. The functional approach uses the
Feynman-Vernon influence functional and the Schwinger-Keldysh close-time-path
effective action methods which are convenient for computations. It also brings
out the open systems concepts and the statistical and stochastic contents of
the theory such as dissipation, fluctuations, noise and decoherence. We then
describe the application of stochastic gravity to the backreaction problems in
cosmology and black hole physics. Intended as a first introduction to this
subject, this article places more emphasis on pedagogy than completeness.Comment: 46 pages Latex. Intended as a review in {\it Classical and Quantum
Gravity
B806: Performance Evaluations of Potato Clones and Varieties in the Northeastern States 1984
Cooperative potato clone and variety trials were conducted at 32 locations to determine field performance of selected clones and varieties grown under soil, climatic, and cultural management common to the potato growing areas of 12 cooperating states and the Province of New Brunswick, Canada. A few locations also evaluated storage and processing behavior of selected clones and varieties. These tests are contributions to Regional Project NE107 entitled, Breeding and Evaluation of New Potato Clones for the Northeast. The primary objective of this project is to determine clone performance and stability over a wide range of soil, climate, and cultural conditions.https://digitalcommons.library.umaine.edu/aes_bulletin/1117/thumbnail.jp
Association of high risk human papillomavirus and breast cancer : a UK based study
Infection by human papillomaviruses (HPVs) has been implicated in the aetiology of a variety of cancers. Studies evaluating the presence of HPVs in breast cancer (BC) have generated considerable controversy. To date, most studies have focused on the presence of viral DNA in BC; however there are important gaps in evidencing the role of HPV persistence in the invasiveness of BC. While these studies have been conducted in several countries, none, on the presence and biological activity of high risk (HR) HPV in BC has been done in the UK. Hence, we aimed to investigate these gaps by screening a total of 110 fresh breast tissue specimens from UK patients for the presence of twelve HR-HPV types DNA using PCR and Sanger sequencing. Samples positive for HPV-DNA were screened for viral oncoprotein expression using western blot and dot blot. Data obtained showed the presence of HR-HPVs in 42% of breast tissues of which the viral activity was only confirmed in a number of invasive carcinomas (5/26). This finding, the first to report in the UK, suggests that the selective expression of viral oncoprotein in invasive cases may propose a role for HR-HPVs in the development of some types of BC
Applying the multi-threat framework of stereotype threat in the context of digital gaming.
Females often report experiencing stigmatisation pertaining to their competency in digital gaming communities. Employing the principles of the multi-Threat framework of stereotype threat, the current research examined the impact of gender-related stereotypes on females' gaming performance and related self-perceptions. In Experiment 1, 90 females were assigned to one of three conditions in which they were primed that their performance would be either diagnostic of their personal (self-As-Target) or gender group's ability (group-As-Target) or would be non-diagnostic of gaming ability (control). In Experiment 2, 90 females were primed that their performance would be judged by a group of other females (in-group source) or males (out-group source), or would be non-diagnostic of ability (control). Participants then completed a casual gaming task, as well as measures of competence beliefs, self-efficacy and self-esteem. Findings from Experiment 1 indicate that neither a self-As-Target nor a group-As-Target stereotype affected significantly gaming performance, or gamerelated self-efficacy, self-esteem and competency beliefs. Findings from Experiment 2 reveal further that females' gaming performance and associated self-perceptions were not impacted significantly by an in-group or out-group source of stereotype threat. The discussion turns to potential explanations for these findings, proposing that females may not perceive negative gender-gaming stereotypes to be an accurate representation of their personal or social group's gaming ability. We also discuss the implications of the experimental design and difficulty, as well as the potential for domain identification to moderate performance outcomes under stereotype threat
The violence of narrative: embodying responsibility for poverty-related distress
This is the final version. Available on open access from Wiley via the DOI in this record.Narratives of self-responsibility are pervasive in neo-liberally oriented contexts, and
have been found to engender feelings of shame and failure amongst those affected by
poverty. Here we use findings from research in two low-income communities in
south-west England to examine how these narratives become embodied within
people’s daily lives when they intersect with systems of welfare support and the
current political drive to upscale treatment for common mental health conditions.
Drawing on Bourdieu’s notion of symbolic violence, we examine how narratives of
self-responsibility and associated welfare reform strategies impact on the mental
health of people living in economic hardship. The data show how such narratives
inflict, sustain and exacerbate mental distress and suffering, and how they become
naturalised and normalised by individuals themselves. We demonstrate how this
situation pushes people to seek support from General Practitioners, and how clinical
interactions can normalise, and in turn, medicalise, poverty-related distress. Whilst
some people actively resist dominant narratives around self-responsibility, we argue
that this is insufficient under broader socio- cultural and political circumstances, to
free themselves from the harms perpetuated by symbolic violence.Economic and Social Research Council (ESRC
Altered T Cell Memory and Effector Cell Development in Chronic Lymphatic Filarial Infection That Is Independent of Persistent Parasite Antigen
Chronic lymphatic filarial (LF) infection is associated with suppression of parasite-specific T cell responses that persist even following elimination of infection. While several mechanisms have been implicated in mediating this T cell specific downregulation, a role for alterations in the homeostasis of T effector and memory cell populations has not been explored. Using multiparameter flow cytometry, we investigated the role of persistent filarial infection on the maintenance of T cell memory in patients from the filarial-endemic Cook Islands. Compared to filarial-uninfected endemic normals (EN), microfilaria (mf) positive infected patients (Inf) had a reduced CD4 central memory (TCM) compartment. In addition, Inf patients tended to have more effector memory cells (TEM) and fewer effector cells (TEFF) than did ENs giving significantly smaller TEFF ∶ TEM ratios. These contracted TCM and TEFF populations were still evident in patients previously mf+ who had cleared their infection (CLInf). Moreover, the density of IL-7Rα, necessary for T memory cell maintenance (but decreased in T effector cells), was significantly higher on memory cells of Inf and CLInf patients, although there was no evidence for decreased IL-7 or increased soluble IL7-Rα, both possible mechanisms for signaling defects in memory cells. However, effector cells that were present in Inf and CLInf patients had lower percentages of HLA-DR suggesting impaired function. These changes in T cell populations appear to reflect chronicity of infection, as filarial-infected children, despite the presence of active infection, did not show alterations in the frequencies of these T cell phenotypes. These data indicate that filarial-infected patients have contracted TCM compartments and a defect in effector cell development, defects that persist even following clearance of infection. The fact that these global changes in memory and effector cell compartments do not yet occur in infected children makes early treatment of LF even more crucial
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