854 research outputs found
A probable giant planet imaged in the Beta Pictoris disk
Since the discovery of its dusty disk in 1984, Beta Pictoris has become the
prototype of young early-type planetary systems, and there are now various
indications that a massive Jovian planet is orbiting the star at ~ 10 AU.
However, no planets have been detected around this star so far. Our goal was to
investigate the close environment of Beta Pic, searching for planetary
companion(s). Deep adaptive-optics L'-band images of Beta Pic were recorded
using the NaCo instrument at the Very Large Telescope. A faint point-like
signal is detected at a projected distance of ~ 8 AU from the star, within the
North-East side of the dust disk. Various tests were made to rule out with a
good confidence level possible instrumental or atmospheric artifacts. The
probability of a foreground or background contaminant is extremely low, based
in addition on the analysis of previous deep Hubble Space Telescope images. The
object L'=11.2 apparent magnitude would indicate a typical temperature of ~1500
K and a mass of ~ 8 Jovian masses. If confirmed, it could explain the main
morphological and dynamical peculiarities of the Beta Pic system. The present
detection is unique among A-stars by the proximity of the resolved planet to
its parent star. Its closeness and location inside the Beta Pic disk suggest a
formation process by core accretion or disk instabilities rather than a
binary-like formation process.Comment: 5 pages, 3 figures, 1 table. A&A Letters, in pres
EAGLE multi-object AO concept study for the E-ELT
EAGLE is the multi-object, spatially-resolved, near-IR spectrograph
instrument concept for the E-ELT, relying on a distributed Adaptive Optics,
so-called Multi Object Adaptive Optics. This paper presents the results of a
phase A study. Using 84x84 actuator deformable mirrors, the performed analysis
demonstrates that 6 laser guide stars and up to 5 natural guide stars of
magnitude R<17, picked-up in a 7.3' diameter patrol field of view, allow us to
obtain an overall performance in terms of Ensquared Energy of 35% in a 75x75
mas^2 spaxel at H band, whatever the target direction in the centred 5' science
field for median seeing conditions. The computed sky coverage at galactic
latitudes |b|~60 is close to 90%.Comment: 6 pages, to appear in the proceedings of the AO4ELT conference, held
in Paris, 22-26 June 200
A fast ILP-based Heuristic for the robust design of Body Wireless Sensor Networks
We consider the problem of optimally designing a body wireless sensor
network, while taking into account the uncertainty of data generation of
biosensors. Since the related min-max robustness Integer Linear Programming
(ILP) problem can be difficult to solve even for state-of-the-art commercial
optimization solvers, we propose an original heuristic for its solution. The
heuristic combines deterministic and probabilistic variable fixing strategies,
guided by the information coming from strengthened linear relaxations of the
ILP robust model, and includes a very large neighborhood search for reparation
and improvement of generated solutions, formulated as an ILP problem solved
exactly. Computational tests on realistic instances show that our heuristic
finds solutions of much higher quality than a state-of-the-art solver and than
an effective benchmark heuristic.Comment: This is the authors' final version of the paper published in G.
Squillero and K. Sim (Eds.): EvoApplications 2017, Part I, LNCS 10199, pp.
1-17, 2017. DOI: 10.1007/978-3-319-55849-3\_16. The final publication is
available at Springer via http://dx.doi.org/10.1007/978-3-319-55849-3_1
Adaptive Optics for Astronomy
Adaptive Optics is a prime example of how progress in observational astronomy
can be driven by technological developments. At many observatories it is now
considered to be part of a standard instrumentation suite, enabling
ground-based telescopes to reach the diffraction limit and thus providing
spatial resolution superior to that achievable from space with current or
planned satellites. In this review we consider adaptive optics from the
astrophysical perspective. We show that adaptive optics has led to important
advances in our understanding of a multitude of astrophysical processes, and
describe how the requirements from science applications are now driving the
development of the next generation of novel adaptive optics techniques.Comment: to appear in ARA&A vol 50, 201
Correcting pervasive errors in RNA crystallography through enumerative structure prediction
Three-dimensional RNA models fitted into crystallographic density maps
exhibit pervasive conformational ambiguities, geometric errors and steric
clashes. To address these problems, we present enumerative real-space
refinement assisted by electron density under Rosetta (ERRASER), coupled to
Python-based hierarchical environment for integrated 'xtallography' (PHENIX)
diffraction-based refinement. On 24 data sets, ERRASER automatically corrects
the majority of MolProbity-assessed errors, improves the average Rfree factor,
resolves functionally important discrepancies in noncanonical structure and
refines low-resolution models to better match higher-resolution models
Detection of the Sgr A* activity at 3.8 and 4.8 microns with NACO
L'-band (lambda=3.8 microns) and M'-band (lambda=4.8 microns) observations of
the Galactic Center region, performed in 2003 at VLT (ESO) with the adaptive
optics imager NACO, have lead to the detection of an infrared counterpart of
the radio source Sgr A* at both wavelengths. The measured fluxes confirm that
the Sgr A* infrared spectrum is dominated by the synchrotron emission of
nonthermal electrons. The infrared counterpart exhibits no significant short
term variability but demonstrates flux variations on daily and yearly scales.
The observed emission arises away from the position of the dynamical center of
the S2 orbit and would then not originate from the closest regions of the black
hole.Comment: 5 pages, 3 figures, accepted in Astronomy & Astrophysic
Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation
BACKGROUND: The relationship between lung and joint inflammation in rheumatoid arthritis is poorly understood. Lung inflammation with resultant protein citrullination may trigger anti-citrullinated protein antibodies, inflammation, and arthritis. Alternatively, lung and joint inflammation may be two manifestations of a single underlying pathology. The lung has increased citrullination and TNF-alpha levels are high in rheumatoid arthritis; however, it is unknown if TNF-alpha can induce lung protein citrullination. The citrullinating enzyme peptidylarginine deiminase 4 (PAD4) exacerbates TNF-alpha-induced arthritis, but a role for PAD4 in lung citrullination and TNF-alpha-induced lung inflammation has not been explored. Our aim was to use TNF-alpha-overexpressing mice to clarify the intersection of TNF-alpha, citrullination, PAD4, arthritis, and lung inflammation.
METHODS: Lung protein citrullination in wild-type mice, mice that overexpress TNF-alpha systemically (TNF(+)), TNF(+)PAD4(+/+), and TNF(+)PAD4(-/-) mice was quantified by both gel electrophoresis using a citrulline probe and western blot. Hematoxylin and eosin (HandE)-stained lung sections from TNF(+)PAD4(+/+) and TNF(+)PAD4(-/-) mice were scored for lung inflammation. HandE-stained ankle joint sections from mice that overexpress TNF-alpha only in the lungs were assessed for arthritis.
RESULTS: TNF(+) mice have increased lung protein citrullination. TNF(+)PAD4(-/-) mice do not have significantly reduced lung protein citrullination, but do have decreased lung inflammation compared to TNF(+)PAD4(+/+) mice. Mice that overexpress TNF-alpha only in the lungs do not develop arthritis.
CONCLUSIONS: PAD4 exacerbates lung inflammation downstream of TNF-alpha without having a major role in generalized protein citrullination in inflamed lungs. Also, TNF-alpha-induced lung inflammation is not sufficient to drive murine arthritis
GRAVITY: getting to the event horizon of Sgr A*
We present the second-generation VLTI instrument GRAVITY, which currently is
in the preliminary design phase. GRAVITY is specifically designed to observe
highly relativistic motions of matter close to the event horizon of Sgr A*, the
massive black hole at center of the Milky Way. We have identified the key
design features needed to achieve this goal and present the resulting
instrument concept. It includes an integrated optics, 4-telescope, dual feed
beam combiner operated in a cryogenic vessel; near infrared wavefront sensing
adaptive optics; fringe tracking on secondary sources within the field of view
of the VLTI and a novel metrology concept. Simulations show that the planned
design matches the scientific needs; in particular that 10 microarcsecond
astrometry is feasible for a source with a magnitude of K=15 like Sgr A*, given
the availability of suitable phase reference sources.Comment: 13 pages, 11 figures, to appear in the conference proceedings of SPIE
Astronomical Instrumentation, 23-28 June 2008, Marseille, Franc
Meta-analyses of whale-watching impact studies : Comparisons of cetacean responses to disturbance
Acknowledgements. The International Whaling Commission funded this study through a grant assigned to D.L. D.L. was also funded by the Scottish Funding Council for funding through grant HR09011 to the Marine Alliance for Science and Technology for Scotland. While writing the manuscript, V.S. was sponsored by a Fulbright scholarship. We thank the many people that replied to the 2 MAR - MAM calls and Dr. Stankowich for his previous comments on the manuscript.Peer reviewedPublisher PD
First direct detection of an exoplanet by optical interferometry; Astrometry and K-band spectroscopy of HR8799 e
To date, infrared interferometry at best achieved contrast ratios of a few
times on bright targets. GRAVITY, with its dual-field mode, is now
capable of high contrast observations, enabling the direct observation of
exoplanets. We demonstrate the technique on HR8799, a young planetary system
composed of four known giant exoplanets. We used the GRAVITY fringe tracker to
lock the fringes on the central star, and integrated off-axis on the HR8799e
planet situated at 390 mas from the star. Data reduction included
post-processing to remove the flux leaking from the central star and to extract
the coherent flux of the planet. The inferred K band spectrum of the planet has
a spectral resolution of 500. We also derive the astrometric position of the
planet relative to the star with a precision on the order of 100as. The
GRAVITY astrometric measurement disfavors perfectly coplanar stable orbital
solutions. A small adjustment of a few degrees to the orbital inclination of HR
8799 e can resolve the tension, implying that the orbits are close to, but not
strictly coplanar. The spectrum, with a signal-to-noise ratio of
per spectral channel, is compatible with a late-type L brown dwarf. Using
Exo-REM synthetic spectra, we derive a temperature of \,K and a
surface gravity of cm/s. This corresponds to a radius
of and a mass of , which is an independent confirmation of mass estimates from evolutionary
models. Our results demonstrate the power of interferometry for the direct
detection and spectroscopic study of exoplanets at close angular separations
from their stars.Comment: published in A&
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