Stress transmission in wet granular materials

We analyze stress transmission in wet granular media in the pendular state by means of three-dimensional molecular dynamics simulations. We show that the tensile action of capillary bonds induces a self-stressed particle network organized in two percolating "phases" of positive and negative particle pressures. Various statistical descriptors of the microstructure and bond force network are used to characterize this partition. Two basic properties emerge: 1) The highest particle pressure is located in the bulk of each phase; 2) The lowest pressure level occurs at the interface between the two phases, involving also the largest connectivity of the particles via tensile and compressive bonds. When a confining pressure is applied, the number of tensile bonds falls off and the negative phase breaks into aggregates and isolated sites

FAKTOR YANG BERHUBUNGAN DENGAN PERILAKU MEROKOK PADA SISWA SMA DI KECAMATAN PAHUNGA LODU SUMBA TIMUR TAHUN 2022

Merokok merupakan masalah yang belum bisa terselesaikan hingga saat ini. Perilaku merokok dapat disebabkan oleh beberapa faktor, yakni pengetahuan, sikap, orang tua, teman sebaya, iklan rokok dan uang saku. Penelitian ini bertujuan untuk mengetahui faktor yang berhubungan dengan perilaku merokok pada siswa SMA di Kecamatan Pahunga Lodu Sumba Timur Tahun 2022. Jenis penelitian ini adalah penelitian survey analitik dengan desain case-control. Penelitian ini dilakukan di SMA Negeri 1 Pahunga Lodu. Penelitian dilakukan pada bulan oktober sampai dengan bulan november tahun 2022. Populasi dalam penelitian ini berjumlah 156 orang. Sampel dalam penelitian ini sebesar 50 kasus dan 50 kontrol. Teknik pengambilan sampel dalan penelitian ini yaitu Simple Random Sampling. Analisis data yang digunakan adalah analisis univariat dan bivariat. Data dianalisis dengan menggunakan uji chi square dengan tingkat kemaknaan ?=0,05. Berdasarkan hasil penelitian menunjukkan bahwa ada hubungan yang signifikan antara pengetahuan (p=0,002 dan PR=2,020), sikap (p=0,001 dan PR=0,511), teman sebaya (p=0,001 dan PR=2,329) dan uang saku (p=0,001 dan PR=3,435) dengan perilaku merokok pada siswa SMA di kecamatan Pahunga Lodu. Berdasarkan hasil penelitian juga menunjukan faktor yang tidak memiliki hubungan dengan perilaku merokok adalah faktor orang tua (p=0,537 dan 95% CI=0,316-1,601) dan iklan rokok (p=0,685 dan 95% CI=0,577-2,849). Diharapkan kepada siswa untuk melakukan perilaku hidup bersih dan sehat sebagai upaya untuk berhenti merokok dan menghindari rokok

Failure in porous granular aggregates

We use a 3D Lattice Element Method, based on the discretization of the particles and binding matrix on a regular lattice, to investigate the particle-scale origins of the strength and failure of porous granular aggregates under tensile loading. Damage growth is analyzed by considering the evolution of stress probability density and the number of broken bonds in the particle phase. We show that the stress probability density functions are increasingly broader for a decreasing matrix volume fraction, the stresses being more and more concentrated in the interparticle contact zones with an exponential distribution as in cohesionless granular media [4]. We carried out a detailed parametric study in order to evaluate the combined influence of the matrix volume fraction and particlematrix adherence. Our findings are in agreement with 2D results previously reported in the literature [6]. Three regimes of crack propagation are evidenced, corresponding to no particle damage, particle abrasion and particle fragmentation, respectively. The crack morphology (tortuosity...) is another important feature that we investigate for different distributions of the particles and pores within porous granular aggregates

Adolescent Sexual Behavior in Cartintes Atambua Health Vocational School Belu District

Adolescent reproductive health can have a good impact and prevent the occurrence of deviations in sexual behavior among adolescents. Report from the Integrated Service Center for the Empowerment of Women and Children (P2TP2A) in Belu Regency in 2019, there were 102 cases of unwanted pregnancy and more cases of unwanted pregnancy occurred in young girls aged 15-19 years.(P2TP2A, 2019). The purpose of this study was to describe the factors that influence the sexual behavior of adolescents in the Cartintes Atambua Health Vocational School. This type of research is descriptive quantitative. The population in this study were 115 students of class XI and XII at SMK Kesehatan Cartintes Atambua and the sampling technique used was total sampling with a total of 115 people. The results of the analysis showed that there were 79 people (68.7%) who had good knowledge about reproductive health and 36 people (31.3%) had less knowledge. Permissive attitude towards sexual behavior as much78 people (67.8%) and non-permissive attitudes as many as 37 people (32.2%). The role of good peers as many as 100 people (87.0%) and the role of bad peers as much 15people (13.0%). There were 70 people (60.9%) who were not exposed to pornography media and 45 people (39.1%) were exposed to pornographic media. Adolescent sexual behavior among students of the Atambua Cartintes Health Vocational School as many as 113 people (98.3%) had done it and 2 people (1.7%) had never done sexual behavior. Suggestions for schools can provide materials related to Adolescent Reproductive Health (KRR), hold a Youth Information and Counseling Center (PIK-R) program in schools, and participate in supporting government programs related to adolescent problem

Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function

The present studies examined the role of norepinephrine (NE) system in mediating the enhancement of 5-HT function produced by neurokinin (NK)1 receptor antagonism. Dorsal raphe 5-HT and locus coeruleus NE neurons were recorded in vivo in mice lacking NK1 receptors in wildtype mice pretreated with the NK1 antagonist RP67580 and its inactive enantiomer RP 68651. RP67580 and RP68651 were also tested on 5-HT neurons of mice lacking the 5-HT(1A) receptor. RP67580 increased the firing rate of 5-HT neurons in wildtype mice and in 5-HT(1A) null mutant mice to the same degree, thus indicating that the mechanism by which NK1 antagonists enhances 5-HT firing is independent of 5-HT(1A) receptors. NE neuronal burst activity was increased in NK1 null mutant and wildtype mice given RP67580, but not with RP68651. After NE depletion, RP67580 was ineffective in increasing 5-HT neuronal firing activity in NK1 wildtype mice, and the enhancement of 5-HT neuronal firing observed in NK1 null mutant mice was abolished. In conclusion, NE neurons are essential for the action of NK1 antagonists on 5-HT neurons. In addition, the desensitization of 5-HT(1A) autoreceptors produced by NK1 receptor antagonism is not critical for enhancing 5-HT neuronal firing

Antalogi puisi: karya anak-anak bangsa dari Papua

Antalogi puisi karya anak-anak bangsa dari Papua merupakan salah satu bentuk apresiasi Balai Bahasa Papua, Badan Pengembangan dan Pembinaan Bahasa, Kementerian Pendidikan dan Kebudayaan terhadap anak-anak bangsa yang memiliki keterampilan menulis sastra, terutama puisi. Hal ini dilakukan mengingat pemahaman masyarakat terhadap konsep estetika masih kurang. Puisi dalam buku ini merupakan hasil karya sastra siswa-siswi sekolah dasar dan sekolah menengah pertama yang mengikuti sayembara penulisan puisi bagi siwa SD dan SMP se-Papua dan Papua Barat

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies