309 research outputs found
Weak Poisson structures on infinite dimensional manifolds and hamiltonian actions
We introduce a notion of a weak Poisson structure on a manifold modeled
on a locally convex space. This is done by specifying a Poisson bracket on a
subalgebra \cA \subeq C^\infty(M) which has to satisfy a non-degeneracy
condition (the differentials of elements of \cA separate tangent vectors) and
we postulate the existence of smooth Hamiltonian vector fields. Motivated by
applications to Hamiltonian actions, we focus on affine Poisson spaces which
include in particular the linear and affine Poisson structures on duals of
locally convex Lie algebras. As an interesting byproduct of our approach, we
can associate to an invariant symmetric bilinear form on a Lie algebra
\g and a -skew-symmetric derivation a weak affine Poisson
structure on \g itself. This leads naturally to a concept of a Hamiltonian
-action on a weak Poisson manifold with a \g-valued momentum map and hence
to a generalization of quasi-hamiltonian group actions
Closed forms and multi-moment maps
We extend the notion of multi-moment map to geometries defined by closed
forms of arbitrary degree. We give fundamental existence and uniqueness results
and discuss a number of essential examples, including geometries related to
special holonomy. For forms of degree four, multi-moment maps are guaranteed to
exist and are unique when the symmetry group is (3,4)-trivial, meaning that the
group is connected and the third and fourth Lie algebra Betti numbers vanish.
We give a structural description of some classes of (3,4)-trivial algebras and
provide a number of examples.Comment: 36 page
Invariants of Lie algebras extended over commutative algebras without unit
We establish results about the second cohomology with coefficients in the
trivial module, symmetric invariant bilinear forms and derivations of a Lie
algebra extended over a commutative associative algebra without unit. These
results provide a simple unified approach to a number of questions treated
earlier in completely separated ways: periodization of semisimple Lie algebras
(Anna Larsson), derivation algebras, with prescribed semisimple part, of
nilpotent Lie algebras (Benoist), and presentations of affine Kac-Moody
algebras.Comment: v3: added a footnote on p.10 about a wrong derivation of the correct
statemen
Search for the exotic Resonance in 340GeV/c -Nucleus Interactions
We report on a high statistics search for the resonance in
-nucleus collisions at 340GeV/c. No evidence for this resonance is
found in our data sample which contains 676000 candidates above
background. For the decay channel and the
kinematic range 0.150.9 we find a 3 upper limit for the
production cross section of 3.1 and 3.5 b per nucleon for reactions with
carbon and copper, respectively.Comment: 5 pages, 4 figures, modification of ref. 43 and 4
A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer
Background: miR‑346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)‑linked transcripts in prostate cancer (PC). We sought to delineate the impact of miR‑346 on DNA damage, and its potential as a therapeutic agent. Methods: RNA‑IP, RNA‑seq, RNA‑ISH, DNA fibre assays, in vivo xenograft studies and bioinformatics approaches were used alongside a novel method for amplification‑free, single nucleotide‑resolution genome‑wide mapping of DNA breaks (INDUCE‑seq). Results: miR‑346 induces rapid and extensive DNA damage in PC cells ‑ the first report of microRNA‑induced DNA damage. Mechanistically, this is achieved through transcriptional hyperactivation, R‑loop formation and replication stress, leading to checkpoint activation and cell cycle arrest. miR‑346 also interacts with genome‑protective lncRNA NORAD to disrupt its interaction with PUM2, leading to PUM2 stabilisation and its increased turnover of DNA damage response (DDR) transcripts. Confirming clinical relevance, NORAD expression and activity strongly correlate with poor PC clinical outcomes and increased DDR in biopsy RNA‑seq studies. In contrast, miR‑346 is associated with improved PC survival. INDUCE‑seq reveals that miR‑346‑induced DSBs occur preferentially at binding sites of the most highly‑transcriptionally active transcription factors in PC cells, including c‑Myc, FOXA1, HOXB13, NKX3.1, and importantly, AR, resulting in target transcript downregulation. Further, RNA‑seq reveals widespread miR‑346 and shNORAD dysregulation of DNA damage, replication and cell cycle processes. NORAD drives target‑directed miR decay (TDMD) of miR‑346 as a novel genome protection mechanism: NORAD silencing increases mature miR‑346 levels by several thousand‑fold, and WT but not TDMD‑mutant NORAD rescues miR‑346‑induced DNA damage. Importantly, miR‑346 sensitises PC cells to DNA‑damaging drugs including PARP inhibitor and chemotherapy, and induces tumour regression as a monotherapy in vivo, indicating that targeting miR‑346:NORAD balance is a valid therapeutic strategy
Estimating the apparent transverse relaxation time (R2*) from images with different contrasts (ESTATICS) reduces motion artifacts
Relaxation rates provide important information about tissue microstructure. Multi-parameter mapping (MPM) estimates multiple relaxation parameters from multi-echo FLASH acquisitions with different basic contrasts, i.e., proton density (PD), T1 or magnetization transfer (MT) weighting. Motion can particularly affect maps of the apparent transverse relaxation rate R2*, which are derived from the signal of PD-weighted images acquired at different echo times. To address the motion artifacts, we introduce ESTATICS, which robustly estimates R2* from images even when acquired with different basic contrasts. ESTATICS extends the fitted signal model to account for inherent contrast differences in the PDw, T1w and MTw images. The fit was implemented as a conventional ordinary least squares optimization and as a robust fit with a small or large confidence interval. These three different implementations of ESTATICS were tested on data affected by severe motion artifacts and data with no prominent motion artifacts as determined by visual assessment or fast optical motion tracking. ESTATICS improved the quality of the R2* maps and reduced the coefficient of variation for both types of data—with average reductions of 30% when severe motion artifacts were present. ESTATICS can be applied to any protocol comprised of multiple 2D/3D multi-echo FLASH acquisitions as used in the general research and clinical setting
Causal structures and causal boundaries
We give an up-to-date perspective with a general overview of the theory of
causal properties, the derived causal structures, their classification and
applications, and the definition and construction of causal boundaries and of
causal symmetries, mostly for Lorentzian manifolds but also in more abstract
settings.Comment: Final version. To appear in Classical and Quantum Gravit
Characterisation of Gut Microbiota in Ossabaw and Göttingen Minipigs as Models of Obesity and Metabolic Syndrome
Recent evidence suggests that the gut microbiota is an important contributing factor to obesity and obesity related metabolic disorders, known as the metabolic syndrome. The aim of this study was to characterise the intestinal microbiota in two pig models of obesity namely Göttingen minipigs and the Ossabaw minipigs.The cecal, ileal and colonic microbiota from lean and obese Osabaw and Göttingen minipigs were investigated by Illumina-based sequencing and by high throughput qPCR, targeting the 16S rRNA gene in different phylogenetic groups of bacteria. The weight gain through the study was significant in obese Göttingen and Ossabaw minipigs. The lean Göttingen minipigs' cecal microbiota contained significantly higher abundance of Firmicutes (P<0.006), Akkermensia (P<0.01) and Methanovibribacter (P<0.01) than obese Göttingen minipigs. The obese Göttingen cecum had higher abundances of the phyla Spirochaetes (P<0.03), Tenericutes (P<0.004), Verrucomicrobia (P<0.005) and the genus Bacteroides (P<0.001) compared to lean minipigs. The relative proportion of Clostridium cluster XIV was 7.6-fold higher in cecal microbiota of obese Göttingen minipigs as compared to lean. Obese Ossabaw minipigs had a higher abundance of Firmicutes in terminal ileum and lower abundance of Bacteroidetes in colon than lean Ossabaw minipigs (P<0.01). Obese Ossabaws had significantly lower abundances of the genera Prevotella and Lactobacillus and higher abundance of Clostridium in their colon than the lean Ossabaws. Overall, the Göttingen and Ossabaw minipigs displayed different microbial communities in response to diet-induced obesity in the different sections of their intestine.Obesity-related changes in the composition of the gut microbiota were found in lean versus obese Göttingen and Ossabaw minipigs. In both pig models diet seems to be the defining factor that shapes the gut microbiota as observed by changes in different bacteria divisions between lean and obese minipigs
Charge Asymmetries for D, D_s and Lambda_c Production in Sigma- - Nucleus Interactions at 340 GeV/c
CERN experiment WA89 has studied charmed particles produced by a Sigma^- beam
at 340 GeV/c on nuclear targets. Production of particles which have light
quarks in common with the beam is compared to production of those which do not.
Considerable production asymmetries between D^- and D^p, D_s^ and D_s^+ and
Lambda_c and Antilambda_c are observed. The results are compared with pion beam
data and with theoretical calculations.Comment: LaTeX ; 16 pages including 4 ps figure
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