Educational Games in Elementary Education: Unlocking the Potentials

The advent of technology has made big strides in the development of humans’ life in different spheres. The integration of technology in education has introduced other teaching methods that could improve and emulate the traditional way of teaching. The use of educational games is a by-product of integrating technology into teaching to enhance teaching methods and students’ performance. This study, hence, aims to evaluate the effect of using educational games in teaching mathematics to second-graders in a Palestinian school using a quasi-experimental approach. Thirty male and female second-graders from Al Aqsa Integrated School, Kuala Lumpur, were the targeted sample. The sample was divided into an experimental group and a control group. A selected educational game was used to explain mathematics lessons, namely addition within 99 or 999, to the experimental group. The same content was taught to the students in the control group using the traditional method. Findings showed that teaching mathematics via educational games was significantly effective in improving students’ achievement in the experimental group compared to the achievement of their counterparts taught via the traditional method. These findings provide evidence that educational games could substantially improve primary second-grade students’ skills in mathematics compared to the traditional teaching method

MOOCs in Omani Higher Education Institutions: Use and Popularity

Due to the rapid influence of technology on the teaching-learning process, both instructors and students alike are expected to keep abreast of the perpetual developments in the field of education. The introduction of Massive Open Online Courses (Henceforth MOOCs), as one form of e-learning, has made skyrocketing changes in the manner and availability of education provided to mass numbers of learners all the world, including Arab countries. The use of MOOCs in Oman is relatively new, and thus it appears to be unbeknown to a large segment of undergraduate students. The study beforehand, therefore, is meant to explore Omani undergraduate students’ awareness of MOOCs both locally and globally via the use a self-administered questionnaire targeting three main academic institutions in Oman with a total number of 306 participants. In-depth scrutiny of the obtained data evidently shows that unfamiliarity of MOOCs among Omani undergraduate students is significantly high, a fact reflected in the high percentage of those oblivious of its existence (88.89%) as opposed to those (11.11 %) who are familiar with MOOCs. Lack of publicity of these platforms in the Omani academic institutions and the academic community in general, among several other reasons, stand behind such unawareness of these platforms

Effect of Depth of Total Intravenous General Anesthesia on Intraoperative Electrically Evoked Compound Action Potentials in Cochlear Implantation Surgery.

PURPOSE: This study aims to compare the effect of the depth of total intravenous anesthesia (TIVA) on intraoperative electrically evoked compound action potential (e-ECAP) thresholds in cochlear implant operations. METHODS: Prospectively, a total of 39 patients aged between 1 and 48 years who were scheduled to undergo cochlear implantation surgeries were enrolled in this study. Every patient received both light and deep TIVA during the cochlear implant surgery. The e-ECAP thresholds were obtained during the light and deep TIVA. RESULTS: After comparing the e-ECAP means for each electrode (lead) between the light and deep anesthesia, no significant differences were detected between the light and deep anesthesia. CONCLUSION: The depth of TIVA may have no significant influence on the e-ECAP thresholds as there was no statistical difference between the light and deep anesthesia

Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite

Background: Tuberculosis (TB), is caused by the bacteria, Mycobacterium tuberculosis and its a threat to humans since centuries. Depending on the type of TB, its treatment can last for 6-24 months which is a major cause for patients non-compliance and treatment failure. Many adverse effects are associated with the currently available TB medicines, and there has been no new anti-tuberculosis drug on the market for more than 50 year, as the drug development is very lengthy and budget consuming process.Development of the biocompatible nano drug delivery systems with the ability to minimize the side effects of the drugs, protection of the drug from enzymatic degradation. And most importantly the drug delivery systems which can deliver the drug at target site would increase the therapeutic efficacy. Nanovehicles with their tendency to release the drug in a sustained manner would result in the bioavalibilty of the drugs in the body for a longer period of time and this would reduce the dosing frequency in drug administration. The biocompatible nanovehicles with the properties like sustained release of drug of the target site, protection of the drug from physio-chemical degradation, reduction in dosing frequency, and prolong bioavailability of drug in the body would result in the shortening of the treatment duration. All of these factors would improve the patient compliance with chemotherapy of TB.Result: An anti-tuberculosis drug, 4-amino salicylic acid (4-ASA) was successfully intercalated into the interlamellae of zinc layered hydroxide (ZLH) via direct reaction with zinc oxide suspension. The X-ray diffraction patterns and FTIR analyses indicate that the molecule was successfully intercalated into the ZLH interlayer space with an average basal spacing of 24 Å. Furthermore, TGA and DTG results show that the drug 4-ASA is stabilized in the interlayers by electrostatic interaction. The release of 4-ASA from the nanocomposite was found to be in a sustained manner. The nanocomposite treated with normal 3T3 cells shows it reduces cell viability in a dose- and time-dependent manner.Conclusions: Sustained release formulation of the nanocomposite, 4-ASA intercalated into zinc layered hydroxides, with its ease of preparation, sustained release of the active and less-toxic to the cell is a step forward for a more patient-friendly chemotherapy of Tuberculosis

Effective transfer entropy approach to information flow between exchange rates and stock markets

We investigate the strength and direction of information flow between exchange rates and stock prices in several emerging countries by the novel concept of effective transfer entropy (an alternative non-linear causality measure) with symbolic encoding methodology. Analysis shows that before the 2008 crisis, only low level interaction exists between these two variables and exchange rates dominate stock prices in general. During crisis, strong bidirectional interaction arises. In the post-crisis period, the strong interaction continues to exist and in general stock prices dominate exchange rates. © 2014 Elsevier Ltd. All rights reserved

Anti-microbial Activity Of Graphene Oxide Against Bacteria And Fungi

Graphene Oxide (GO) is a promising material for various applications. The team prepared GO from graphite and studied the interaction with different microorganisms. Anti-microbial properties were detected for the prepared GO. Anti-microbial activities of GO was tested against one eukaryotic fungi (Candida albicans) two prokaryotic bacteria Gram-negative bacilli (Escherichia coli ATCC 41570 and Pseudomonas aeruginosa ATCC 25619) and two prokaryotic bacteria Gram-positive cocci (Streptococcus feacalis 19433 and Staphylococcus aureus ATCC 11632). Spectrophotometer was used to measure the growth as an indirect method, viable cell counting was used as direct method. Readings were taken at successive incubated times. Results revealed that GO exhibited stronger antibacterial and anti-fungal activity against the used bacteria and fungi species. Acknowledgements: This research was made possible by NPRP grant (NPRP5-039-2-014) from the Qatar National Research Fund (a member of Qatar Foundation). The statement made herein are solely the responsibility of the author.qscienc

Thermotolerant isolates of Beauveria bassiana as potential control agent of insect pest in subtropical climates

The use of Beauveria bassiana in biological control of agricultural pests is mainly hampered by environmental factors, such as elevated temperatures and low humidity. These limitations, further amplified in a global warming scenario, could nullify biological control strategies based on this fungus. The identification of thermotolerant B. bassiana isolates represents a possible strategy to overcome this problem. In this study, in order to maximize the probability in the isolation of thermotolerant B. bassiana, soil samples and infected insects were collected in warm areas of Syria. The obtained fungal isolates were tested for different biological parameters (i.e., growth rate, sporulation and spore germination) at growing temperatures ranging from 20\u2daC to 35\u2daC. Among these isolates (eight from insects and 11 from soil samples), the five with the highest growth rate, spore production and germination at 30\u2daC were tested for their entomopathogenicity through in vivo assays on Ephestia kuehniella larvae. Insect mortality induced by the five isolates ranged from 31% to 100%. Two isolates, one from Phyllognathus excavatus and one from soil, caused 50% of the larval mortality in less than four days, reaching values exceeding 92% in ten days. These two isolates were molecularly identified as B. bassiana sensu stricto by using three markers (i.e., ITS, Bloc and EF1-\u3b1). Considering these promising results, further studies are ongoing, testing their efficiency in field conditions as control agents for agricultural insect pests in Mediterranean and Subtropical regions

7-O-methylpunctatin, a novel homoisoflavonoid, inhibits phenotypic switch of human arteriolar smooth muscle cells

Remodeling of arterioles is a pivotal event in the manifestation of many inflammation-based cardio-vasculopathologies, such as hypertension. During these remodeling events, vascular smooth muscle cells (VSMCs) switch from a contractile to a synthetic phenotype. The latter is characterized by increased proliferation, migration, and invasion. Compounds with anti-inflammatory actions have been successful in attenuating this phenotypic switch. While the vast majority of studies investigating phenotypic modulation were undertaken in VSMCs isolated from large vessels, little is known about the effect of such compounds on phenotypic switch in VSMCs of microvessels (microVSMCs). We have recently characterized a novel homoisoflavonoid that we called 7-O-methylpunctatin (MP). In this study, we show that MP decreased FBS-induced cell proliferation, migration, invasion, and adhesion. MP also attenuated adhesion of THP-1 monocytes to microVSMCs, abolished FBS-induced expression of MMP-2, MMP-9, and NF-?B, as well as reduced activation of ERK1/2 and FAK. Furthermore, MP-treated VSMCs showed an increase in early (myocardin, SM-22?, SM-?) and mid-term (calponin and caldesmon) differentiation markers and a decrease in osteopontin, a protein highly expressed in synthetic VSMCs. MP also reduced transcription of cyclin D1, CDK4 but increased protein levels of p21 and p27. Taken together, these results corroborate an anti-inflammatory action of MP on human microVSMCs. Therefore, by inhibiting the synthetic phenotype of microVSMCs, MP may be a promising modulator for inflammation-induced arteriolar pathophysiology. - 2019 by the authors. Licensee MDPI, Basel, Switzerland.Funding: This work was supported by the American University of Beirut (Grant # MPP 320133 to A.E.), University of Petra (Grant #: 5/4/2019) to A.B., E.B., and A.E., and the National Council for Scientific Research (CNRS) to M.F.Scopu

Macrofouling remediation strategies for water intakes of desalination and other industrial plants – A review

Marine benthic organisms and their rapid growth in successional stages pose widespread challenges in macrofouling, causing operational issues for industrial plants and facilities. Current research, sea trials, and industrial studies lack insights into the practicality of macrofouling remediation technologies when applied to industrial sites experiencing dynamic seawater flow and diverse fouling community conditions. This review aims to present globally developed mitigation strategies for managing macrofouling in industrial plants, such as desalination and power plants, along with other large-scale subsea applications. It addresses challenges, proposes performance aspects, and aims for more sustainable approaches in industrial settings. The review highlights recent mature technologies used to inhibit or eliminate macrofouling in large marine infrastructures, encompassing industrial water intakes, plants, facilities, harbors, and hulls. It also outlines the technical review of mitigation efficiency, costs, and environmental impacts related to macrofouling remediation technologies. The concluding section of the review discusses potential approaches to address marine macrofouling, emphasizing future research and industry studies for the commercialization of prospective technologies in sustainable biofouling remediation, particularly for water intake in industrial plants, such as desalination plants.Desalination, 590, art. no. 117987; 2024journal articl

Central Venous Pressure and Impaired Renal Function in Children and Young Adults With Cardiovascular Disease

BACKGROUND: Traditionally, low cardiac output has been considered the primary hemodynamic driver of renal function and injury. Adult data suggest that central venous pressure (CVP) is a more important factor. OBJECTIVES: The authors hypothesized that in children with cardiovascular disease, higher CVP predicts lower estimated glomerular filtration rate (eGFR) and worsening renal function (WRF). METHODS: We performed a single-center cohort study of patients aged 3 months to 21 years with biventricular circulation undergoing cardiac catheterization. Pearson\u27s correlation and linear and Cox regression analyses were performed to determine associations with eGFR at the time of catheterization and WFR within 180 days after catheterization. RESULTS: 312 patients had median age 7.9 years (IQR: 2.3 to 14.5 years), median eGFR 97 mL/min/1.73 m CONCLUSIONS: Among children with a spectrum of cardiovascular disease, higher CVP is associated with lower eGFR and development of WRF, independent of cardiac index