Quality management system as part of integrated management system in nuclear industry organization

Представлено описание процесса «Управление качеством», являющегося частью интегрированной системы менеджмента предприятия.This article describes the «Quality Management» process that is part of the integrated management system

People of the British Isles: preliminary analysis of genotypes and surnames in a UK control population

There is a great deal of interest in fine scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to play a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. Here we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK control population that can be used as a resource by the research community as well as providing fine scale genetic information on the British population. So far, some 4,000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3,865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1,057 samples demonstrates the value of these samples for investigating fine scale population structure within the UK, and shows how this can be enhanced by the use of surnames

Studies of Genetic Diversity of Yersinia pestis Strains Isolated in Central-Caucasian High-Mountain Natural Plague Focus

Studied have been Yersinia pestis strains isolated in Central-Caucasian high-mountain natural plague focus within the period of 1971–2012 using MLVA typing on 25 VNTR-loci. Analysis of dendrogram cluster association with certain areas, objects, and periods of the strain isolation has been carried out by means of Arc GIS 10.1 software. Established has been the connection between 25 MLVA Y. pestis types and spatial and temporal characteristics of strains isolation in the Central-Caucasian high-mountain natural plague focus, and proline requirement too. Clusters, groups and subgroups of the strains are confined to particular territories as it follows: groups are attributed to landscape-epizootiological regions, subgroups – to mountain souslik settlements. Occasionally groups of the strains disseminate onto the other landscape-epizootiological regions of the focus. Genetic variations of plague agent strains within the limits of mountain souslik settlements evolve over time which can be viewed as indirect evidence of microevolution mechanism effect

A case of acute disseminated encephalomyelitis with reversible cognitive deficits

Acute disseminated encephalomyelitis is a monophasic autoimmune demyelinating disease of the central nervous system. The diagnosis of acute disseminated encephalomyelitis is based on clinical and radiological features. The presence of encephalopathy is obligatory for diagnosis. The differential diagnosis may be difficult in a case of dementia as a main clinical manifestation of disease. We report a case of subacute severe cognitive deficits and movement disorders. Acute disseminated encephalomyelitis was diagnosed. MRI showed a combination of abnormalities in the white matter of the cerebral hemispheres, brainstem and the deep gray nuclei, with a contrast of enhancement. We reviewed clinical features and diagnostic criteria of acute disseminated encephalomyelitis, differential diagnosis.Острый рассеянный энцефаломиелит— аутоиммунное демиелинизирующее заболевание центральной нервной системы. Диагностика его базируется на клинических и нейровизуализационных данных, необходимым элементом для постановки диагноза является наличие синдрома энцефалопатии. Диагностический интерес представляют случаи заболевания, основным клиническим проявлением которого является выраженный когнитивный дефицит, когда крайне сложной задачей становится дифференциальный диагноз с другими причинами деменции. В статье приводится клиническое наблюдение подостро развившегося синдрома выраженного когнитивного дефицита в сочетании с экстрапирамидными нарушениями. На основании клинических данных был диагностирован острый рассеянный энцефаломиелит. При магнитно-резонансном томографическом исследовании были верифицированы очаги в белом веществе и подкорковых структурах головного мозга с признаками накопления контрастного вещества. В статье приводятся клинические особенности и критерии диагностики острого рассеянного энцефаломиелита, дифференциальный диагноз с заболеваниями, проявляющимися деменцией

The genetic history of admixture across inner Eurasia

This is the author accepted manuscript. The final version is available from Nature Research via the DOI in this record.Data Availability. Genome-wide sequence data of two Botai individuals (BAM format) are available at the European Nucleotide Archive under the accession number PRJEB31152 (ERP113669). Eigenstrat format array genotype data of 763 present-day individuals and 1240K pulldown genotype data of two ancient Botai individuals are available at the Edmond data repository of the Max Planck Society (https://edmond.mpdl.mpg.de/imeji/collection/Aoh9c69DscnxSNjm?q=).The indigenous populations of inner Eurasia, a huge geographic region covering the central Eurasian steppe and the northern Eurasian taiga and tundra, harbor tremendous diversity in their genes, cultures and languages. In this study, we report novel genome-wide data for 763 individuals from Armenia, Georgia, Kazakhstan, Moldova, Mongolia, Russia, Tajikistan, Ukraine, and Uzbekistan. We furthermore report additional damage-reduced genome-wide data of two previously published individuals from the Eneolithic Botai culture in Kazakhstan (~5,400 BP). We find that present-day inner Eurasian populations are structured into three distinct admixture clines stretching between various western and eastern Eurasian ancestries, mirroring geography. The Botai and more recent ancient genomes from Siberia show a decrease in contribution from so-called “ancient North Eurasian” ancestry over time, detectable only in the northern-most “forest-tundra” cline. The intermediate “steppe-forest” cline descends from the Late Bronze Age steppe ancestries, while the “southern steppe” cline further to the South shows a strong West/South Asian influence. Ancient genomes suggest a northward spread of the southern steppe cline in Central Asia during the first millennium BC. Finally, the genetic structure of Caucasus populations highlights a role of the Caucasus Mountains as a barrier to gene flow and suggests a post-Neolithic gene flow into North Caucasus populations from the steppe.Max Planck SocietyEuropean Research Council (ERC)Russian Foundation for Basic Research (RFBR)Russian Scientific FundNational Science FoundationU.S. National Institutes of HealthAllen Discovery CenterUniversity of OstravaCzech Ministry of EducationXiamen UniversityFundamental Research Funds for the Central UniversitiesMES R

Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

Background and purpose: Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods: In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results: The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions: Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013