Proper Orthogonal Decomposition Analysis and Modelling of the wake deviation behind a squareback Ahmed body

We investigate numerically the 3-D flow around a squareback Ahmed body at Reynolds number Re = 104. Proper Orthogonal Decomposition (POD) is applied to a symmetry-augmented database in order to describe and model the flow dynamics. Comparison with experiments at a higher Reynolds number in a plane section of the near-wake at mid-height shows that the simulation captures several features of the experimental flow, in particular the antisymmetric quasi-steady deviation mode. 3-D POD analysis allows us to classify the different physical processes in terms of mode contribution to the kinetic energy over the entire domain. It is found that the dominant fluctuating mode on the entire domain corresponds to the 3-D quasi-steady wake deviation, and that its amplitude is well estimated from 2-D near-wake data. The next most energetic flow fluctuations consist of vortex shedding and bubble pumping mechanisms. It is found that the amplitude of the deviation is negatively correlated with the intensity of the vortex shedding in the spanwise direction and the suction drag coefficient. Finally, we find that despite the slow convergence of the decomposition, a POD-based low-dimensional model reproduces the dynamics of the wake deviation observed experimentally, as well as the main characteristics of the global modes identified in the simulation

Proper Orthogonal Decomposition Analysis and Modelling of the wake deviation behind a squareback Ahmed body

We investigate numerically the 3-D flow around a squareback Ahmed body at Reynolds number Re = 104. Proper Orthogonal Decomposition (POD) is applied to a symmetry-augmented database in order to describe and model the flow dynamics. Comparison with experiments at a higher Reynolds number in a plane section of the near-wake at mid-height shows that the simulation captures several features of the experimental flow, in particular the antisymmetric quasi-steady deviation mode. 3-D POD analysis allows us to classify the different physical processes in terms of mode contribution to the kinetic energy over the entire domain. It is found that the dominant fluctuating mode on the entire domain corresponds to the 3-D quasi-steady wake deviation, and that its amplitude is well estimated from 2-D near-wake data. The next most energetic flow fluctuations consist of vortex shedding and bubble pumping mechanisms. It is found that the amplitude of the deviation is negatively correlated with the intensity of the vortex shedding in the spanwise direction and the suction drag coefficient. Finally, we find that despite the slow convergence of the decomposition, a POD-based low-dimensional model reproduces the dynamics of the wake deviation observed experimentally, as well as the main characteristics of the global modes identified in the simulation

New insights into the origin of the B genome of hexaploid wheat: Evolutionary relationships at the SPA genomic region with the S genome of the diploid relative Aegilops speltoides

<p>Abstract</p> <p>Background</p> <p>Several studies suggested that the diploid ancestor of the B genome of tetraploid and hexaploid wheat species belongs to the <it>Sitopsis </it>section, having <it>Aegilops speltoides </it>(SS, 2n = 14) as the closest identified relative. However molecular relationships based on genomic sequence comparison, including both coding and non-coding DNA, have never been investigated. In an attempt to clarify these relationships, we compared, in this study, sequences of the Storage Protein Activator (SPA) locus region of the S genome of <it>Ae. speltoides </it>(2n = 14) to that of the A, B and D genomes co-resident in the hexaploid wheat species (<it>Triticum aestivum, AABBDD</it>, 2n = 42).</p> <p>Results</p> <p>Four BAC clones, spanning the SPA locus of respectively the A, B, D and S genomes, were isolated and sequenced. Orthologous genomic regions were identified as delimited by shared non-transposable elements and non-coding sequences surrounding the SPA gene and correspond to 35 268, 22 739, 43 397 and 53 919 bp for the A, B, D and S genomes, respectively. Sequence length discrepancies within and outside the SPA orthologous regions are the result of non-shared transposable elements (TE) insertions, all of which inserted after the progenitors of the four genomes divergence.</p> <p>Conclusion</p> <p>On the basis of conserved sequence length as well as identity of the shared non-TE regions and the SPA coding sequence, <it>Ae speltoides </it>appears to be more evolutionary related to the B genome of <it>T. aestivum </it>than the A and D genomes. However, the differential insertions of TEs, none of which are conserved between the two genomes led to the conclusion that the S genome of <it>Ae. speltoides </it>has diverged very early from the progenitor of the B genome which remains to be identified.</p

The Dark Energy Survey : more than dark energy – an overview

This overview paper describes the legacy prospect and discovery potential of the Dark Energy Survey (DES) beyond cosmological studies, illustrating it with examples from the DES early data. DES is using a wide-field camera (DECam) on the 4 m Blanco Telescope in Chile to image 5000 sq deg of the sky in five filters (grizY). By its completion, the survey is expected to have generated a catalogue of 300 million galaxies with photometric redshifts and 100 million stars. In addition, a time-domain survey search over 27 sq deg is expected to yield a sample of thousands of Type Ia supernovae and other transients. The main goals of DES are to characterize dark energy and dark matter, and to test alternative models of gravity; these goals will be pursued by studying large-scale structure, cluster counts, weak gravitational lensing and Type Ia supernovae. However, DES also provides a rich data set which allows us to study many other aspects of astrophysics. In this paper, we focus on additional science with DES, emphasizing areas where the survey makes a difference with respect to other current surveys. The paper illustrates, using early data (from ‘Science Verification’, and from the first, second and third seasons of observations), what DES can tell us about the Solar system, the Milky Way, galaxy evolution, quasars and other topics. In addition, we show that if the cosmological model is assumed to be +cold dark matter, then important astrophysics can be deduced from the primary DES probes. Highlights from DES early data include the discovery of 34 trans-Neptunian objects, 17 dwarf satellites of the Milky Way, one published z > 6 quasar (and more confirmed) and two published superluminous supernovae (and more confirmed)

Aromatase inhibitor-associated bone and musculoskeletal effects: new evidence defining etiology and strategies for management

Aromatase inhibitors are widely used as adjuvant therapy in postmenopausal women with hormone receptor-positive breast cancer. While the agents are associated with slightly improved survival outcomes when compared to tamoxifen alone, bone and musculoskeletal side effects are substantial and often lead to discontinuation of therapy. Ideally, the symptoms should be prevented or adequately treated. This review will focus on bone and musculoskeletal side effects of aromatase inhibitors, including osteoporosis, fractures, and arthralgias. Recent advances have been made in identifying potential mechanisms underlying these effects. Adequate management of symptoms may enhance patient adherence to therapy, thereby improving breast cancer-related outcomes

La Gestion du Temps

Professorat des lycées et collègesOrganiser le temps de l’enseignement / apprentissage de l’anglais : comment ? pourquoi ? Les différents niveaux de la gestion du temps en classe de langue sont : la progression sur l’année, le projet que constitue la séquence, et le rythme de la séance. La séance peut être divisée en un certain nombre de petites unités temporelles, que l’on a appelées " micro-temps " ou " micro-durées " : ce sont les lieux du tâtonnement comme de la délimitation des priorités de l’apprentissage, ceux de l’expression comme de la compréhension. Ce sont les temps de la parole du professeur (consignes) comme de la parole de l’apprenant. Les rythmes en sont variés, de l’approfondissement à l’accélération. Dans le cadre d’une concertation avec le temps du professeur qui le guide, l’apprenant doit arriver à la maîtrise de son temps – impératif social s’il en est

Towards an Information System on Health Care Costs, Public and Complementary Health Insurance Reimbursements, and Out-of-pocket Payments

Le projet Monaco (Méthodes, outils et normes pour la mise en commun des données des assurances complémentaire et obligatoire) représente une première étape visant à mettre en place un système d’information qui permette d’améliorer la connaissance des restes à charge des assurés après remboursements par l’Assurance maladie obligatoire (AMO) et l’Assurance maladie complémentaire (AMC). Il s’agit d’un test sur la possibilité technique d’associer des données individuelles issues de l’Assurance maladie et des organismes de couverture complémentaire s’appuyant sur le dispositif de l’Enquête santé et protection sociale (ESPS). Monaco rassemble les principales caisses d’assurance maladie et dix organismes de couverture complémentaire sous l’égide de l’Institut des données de santé (IDS). Après avoir décrit la méthodologie de cet appariement, nous présentons un premier bilan technique et les perspectives de recherche qui pourraient s’ouvrir grâce à ce nouvel outil

Evaluation of the RESIST-4 K-SeT assay, a multiplex immunochromatographic assay for the rapid detection of OXA-48-like, KPC, VIM and NDM carbapenemases.

OBJECTIVES: Accurate and fast identification of carbapenemase producers is essential for optimal patient management. Here, a new lateral flow immunochromatographic RESIST-4 K-SeT assay was assessed for the detection of carbapenemases in Enterobacteriaceae and non-fermenters. METHODS: The RESIST-4 K-SeT assay targets OXA-48-like, KPC, VIM and NDM, but not IMP carbapenemases. The assay was first evaluated using a collection of isolates with well-characterized resistance mechanisms to β-lactams (n = 134) and against an international external quality assessment carbapenemase panel (n = 8). The assay was then challenged prospectively using 345 consecutive, non-duplicate isolates including 279 Enterobacteriaceae and 66 non-fermenters (mostly Pseudomonas spp.) that were sent to the Belgian National Reference Centre for identification of the mechanisms related to carbapenem resistance. RESULTS: Globally, for the collection of retrospective and prospective clinical isolates (n = 479), the assay showed a sensitivity ranging from 99% for the detection of VIM to 100% for the detection of OXA-48-like, KPC and NDM carbapenemase-producing strains. The specificity was 100% for each carbapenemase and a perfect match in results was observed for the external quality assessment for the carbapenemases targeted by the assay. CONCLUSIONS: The RESIST-4 K-SeT assay is a valuable alternative for detection and identification of carbapenemases from culture isolates compared with the more costly molecular assays, which may also further require skilled staff and dedicated facilities

Evaluation of the ePlex Blood Culture Identification Panels for Detection of Pathogens in Bloodstream Infections.

Rapid identification and susceptibility testing results are of importance for the early appropriate therapy of bloodstream infections. The ePlex (GenMark Diagnostics) Blood Culture Identification (BCID) Panels are fully automated PCR-based assays designed to identify Gram-positive, Gram-negative bacteria, fungi and bacterial resistance genes within 1.5 hours from positive blood culture. Consecutive non-duplicate positive blood culture episodes were tested by the ePlex system prospectively. The choice of panel(s) (Gram-positive/Gram-negative/fungal pathogens) was defined by Gram-stained microscopy of BC+ bottles (BactAlert, bioMérieux). Results with the ePlex panels were compared to the identification results obtained by standard culture-based workflow. In total, 216 positive blood culture episodes were evaluable yielding 263 identification results. The sensitivity/positive predictive value for detection by the ePlex panels of targeted cultured isolates were of 97%/99% for the Gram-positive panel and of 99%/96% for the Gram-negative panel, resulting in overall agreement rates of 96% and 94% for the Gram-positive and Gram-negative panel, respectively. All 26 samples with targeted resistance results were correctly detected by the ePlex panels. The ePlex panels provided highly accurate results and proved to be an excellent diagnostic tool for the rapid identification of pathogens causing bloodstream infections. The short time to results may be of added value for optimizing the clinical management of patients with sepsis