Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer

The distribution of lip, oral cavity, and pharynx (LOCP) cancer mortality rates in small domains (defined as the combination of province, age group, and gender) remains unknown in Spain. As many of the LOCP risk factors are preventable, specific prevention programmes could be implemented but this requires a clear specification of the target population. This paper provides an in-depth description of LOCP mortality rates by province, age group and gender, giving a complete overview of the disease. This study also presents a methodological challenge. As the number of LOCP cancer cases in small domains (province, age groups and gender) is scarce, univariate spatial models do not provide reliable results or are even impossible to fit. In view of the close link between LOCP and lung cancer, we consider analyzing them jointly by using shared component models. These models allow information-borrowing among diseases, ultimately providing the analysis of cancer sites with few cases at a very disaggregated level. Results show that males have higher mortality rates than females and these rates increase with age. Regions located in the north of Spain show the highest LOCP cancer mortality rates.The work was supported by Project MTM2017-82553-R (AEI, UE), Project PID2020-113125RB-I00/MCIN/ AEI/10.13039/501100011033 and Proyecto Jóvenes Investigadores PJUPNA2018-11

Fungsi Promosi Dalam Meningkatkan Daya Beli Gadget Samsung Di Kota Manado

Promosi adalah upaya untuk memberitahukan penawaran produk atau jasa dengan tujuan menarik calon konsumen untuk membeli atau mengkonsumsinya. Dengan adanya promosi produsen atau distributor mengharapkan kenaikan angka penjualannya.Penelitian ini menggunakan teori konsep promosi dengan metode pendekatan secara kualitatif. Hasil penelitian di lapangan menemukan bahwa fungsi promosi dalam meningkatkan daya beli gadget sangat mempengaruhi peningkatan penjualan gadget, dalam persaingan antar gadget yang semakin banyak.Dengan hasil tersebut maka sebagai saran ialah: perlu meningkatkan intensitas promosi produk kepada masyarakat dengan mengoptimalkan semua pendekatan komunikasi, baik personal, kelompok dan media massa modern

Modular micropumps fabricated by 3D printed technologies for polymeric microfluidic device applications

In order to facilitate the implementation of microfluidic technology for rapid point-of-care analysis, there is a demand for self-powered microfluidics. The modular architecture of degas driven plug-and-play polymeric micropumps and microfluidic cartridges arose during last decade as a powerful strategy for autonomous flow control. So far, reported polymeric micropumps were made of poly-dimethyl siloxane and were fabricated by moulding. In this work, we showed that the advantages of three-dimensional printing can greatly benefit the development of modular micropumps. In addition, micropumps were created with a geometry that cannot be manufactured with conventional techniques, making it easily assemblable to microfluidic devices. Four types of polymeric resins and three printing methods were used to create a set of functional micropumps. It was shown that the material and the design of the printed micropumps were related to their power, making them tuneable and programmable. Finally, as proof of concept, a self-powered colorimetric test for the detection of starch was demonstrated. Three-dimensional printed micropumps emerge as an innovative element in the field of self-powered microfluidics, which may be the key to develop integrated microsystems for several applications such as in rapid point-of-care analysis.Authors would like to acknowledge the funding support from Gobierno de España, Ministerio de Economia y Competitividad, with Grant No. BIO2016-80417-P ((AEI/FEDER, UE); the University of the Basque Country (ESPPOC 16/65) and Gobierno Vasco Dpto. Educación for the consolidation of the research groups (IT1271-19). FBL acknowledges the Ramón y Cajal programme (Ministerio de Economía y Competitividad). FBL and LBD acknowledge the “Red de Microfluídica Española” MIFLUNET (RED2018-102829-T). Authors acknowledge to Prof. Javier del Campo and to Dr. Cristian Mendes from BC Materials, Spain, for their help during the fabrication of the micropumps with the DLP technique

Age- and sex-specific spatio-temporal patterns of colorectal cancer mortality in Spain (1975-2008)

Incluye 2 ficheros de datosIn this paper, space-time patterns of colorectal cancer (CRC) mortality risks are studied by sex and age group (50-69, ≥70) in Spanish provinces during the period 1975-2008. Space-time conditional autoregressive models are used to perform the statistical analyses. A pronounced increase in mortality risk has been observed in males for both age-groups. For males between 50 and 69 years of age, trends seem to stabilize from 2001 onward. In females, trends reflect a more stable pattern during the period in both age groups. However, for the 50-69 years group, risks take an upward trend in the period 2006-2008 after the slight decline observed in the second half of the period. This study offers interesting information regarding CRC mortality distribution among different Spanish provinces that could be used to improve prevention policies and resource allocation in different regions.This research has been supported by the Spanish Ministry of Science and Innovation (project MTM 2011-22664, which is co-funded by FEDER)