Adjustable high emittance gap filler

A flexible, adjustable refractory filler is disclosed for filling gaps between ceramic tiles forming the heat shield of a space shuttle vehicle, to protect its aluminum skin during atmospheric reentry. The easily installed and replaced filler consists essentially of a strip of ceramic cloth coated, at least along both its longitudinal edges with a room temperature vulcanizable silicone rubber compound with a high emittance colored pigment. The filler may have one or more layers as the gap width requires. Preferred materials are basket weave aluminoborosilicate cloth, and a rubber compounded with silicon tetraboride as the emittance agent and finely divided borosilicate glass containing about 7.5% B2O3 as high temperature binder. The filler cloth strip or tape is cut to proper width and length, inserted into the gap, and fastened with previously applied drops of silicone rubber adhesive

Rhabdomyolysis in an HIV cohort: epidemiology, causes and outcomes.

BackgroundThe Literature on rhabdomyolysis in the HIV-positive population is sparse and limited. We aimed to explore the incidence, patient characteristics, etiologies and outcomes of rhabdomyolysis in a cohort of HIV-positive patients identified through the Johns Hopkins HIV clinical registry between June 1992 and April 2014.MethodsA retrospective analysis of 362 HIV-positive patients with non-cardiac CK elevation ≥1000 IU/L was performed. Both inpatients and outpatients were included. Incidence rate and potential etiologies for rhabdomyolysis were ascertained. The development of acute kidney injury (AKI, defined as doubling of serum creatinine), need for dialysis, and death in the setting of rhabdomyolysis were determined. Logistic regression was used to evaluate the association of peak CK level with the development of AKI.ResultsThree hundred sixty two cases of rhabdomyolysis were identified in a cohort of 7079 patients with a 38,382 person years follow-up time. The incidence rate was nine cases per 1000 person-years (95% CI: 8.5-10.5). Infection was the most common etiology followed by compression injury and drug/alcohol use. One-third of cases had multiple potential etiologies. AKI developed in 46% of cases; 20% of which required dialysis. Thirteen percent died during follow-up. After adjustment, AKI was associated with higher CK (OR 2.05 for each 1-log increase in CK [95% CI: 1.40-2.99]), infection (OR 5.48 [95% CI 2.65-11.31]) and higher HIV viral load (OR 1.22 per 1-log increase [95% CI: 1.03-1.45]).ConclusionRhabdomyolysis in the HIV-positive population has many possible causes and is frequently multifactorial. HIV-positive individuals with rhabdomyolysis have a high risk of AKI and mortality

Introduction to the special issue devoted to the 2018 ESHET conference at Madrid

The 22nd Annual ESHET Conference was held at the Faculty of Economic Sciences and Business of the Complutense University of Madrid from 7 to 9 June 2018.Depto. de Economía Aplicada, Estructura e HistoriaFac. de Ciencias Económicas y EmpresarialesTRUEpu

3D modelling of angiogenesis and vascular tumour growth

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute

Sorting Nexin 1 Down-Regulation Promotes Colon Tumorigenesis

PURPOSE: Colon cancer is one of the most common human malignancies, yet studies have only begun to identify the multiple mechanisms that underlie the development of this tumor. In this study, we have identified a novel mechanism, dysregulation of endocytic sorting, which promotes colon cancer development. EXPERIMENTAL DESIGN: Immunohistochemical and microarray analyses were done on human colon cancer tissue specimens to determine the levels of one endocytic protein, sorting nexin 1 (SNX1). SW480 cells, a human colon cancer cell line that retains a relatively high level of SNX1 expression, were used to assess the effects of down-regulating this protein by small hairpin RNA. Activation of signal transduction cascades was evaluated in these cells using Western blotting, and multiple functional assays were done. RESULTS: We determined by immunohistochemistry that the level of SNX1 was significantly down-regulated in 75% of human colon cancers. In corroborative studies using microarray analysis, SNX1 message was significantly decreased (log(2) ratio less than -1) for 8 of 19 colon carcinomas. Cell lines with reduced SNX1 levels showed increased proliferation, decreased apoptosis, and decreased susceptibility to anoikis. They also showed increased activation of epidermal growth factor receptor and extracellular signal-regulated kinase 1/2 in response to epidermal growth factor. This increased activation was abolished by inhibition of endocytosis. CONCLUSIONS: These data suggest that loss of SNX1 may play a significant role in the development and aggressiveness of human colon cancer, at least partially through the mechanism of increased signaling from endosomes. Further, these findings suggest that dysregulation of endocytic proteins may represent a new paradigm in the process of carcinogenesis.Fil: Nguyen, Lananh N.. University of Washington; Estados UnidosFil: Holdren, Matthew S.. University of Washington; Estados UnidosFil: Nguyen, Anthony P.. Baylor College of Medicine; Estados UnidosFil: Furuya, Momoko H.. University of Washington; Estados UnidosFil: Bianchini, Michele. Fundación Cáncer. Centro de Investigaciones Oncológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Levy, Estrella Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Cáncer. Centro de Investigaciones Oncológicas; ArgentinaFil: Mordoh, Jose. Fundación Cáncer. Centro de Investigaciones Oncológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Liu, Annie. University of Washington; Estados UnidosFil: Guncay, Gabriela D.. University of Washington; Estados UnidosFil: Campbell, Jean S.. University of Washington; Estados UnidosFil: Parks, W. Tony. University of Washington; Estados Unido

Content assessment of the primary biodiversity data published through GBIF network: Status, challenges and potentials

With the establishment of the Global Biodiversity Information Facility (GBIF) in 2001 as an inter-governmental co-ordinating body, concerted efforts were made during the past decade to establish a global research infrastructure to facilitate the sharing, discovery and access to primary biodiversity data. As on date the participants in GBIF have enabled the discovery and access to over 267+ million such data records. While this remarkable achievement in terms of volume of data must be acknowledged, concerns about the quality and ‘fitness-for-use’ of the data should also be carefully considered in future developments. This contribution is therefore a direct response to the calls for comprehensive content assessment of the GBIF mobilised data. It is the first comprehensive assessment of the coverage of the content mobilised so far through GBIF, as well as a mean to identify the existing gaps and reflect on fitness-for-use requirements. This paper describes the complementary methodologies adopted by the GBIF Secretariat and University of Navarra for the development of a comprehensive content assessment. Outcomes of these research initiatives are summarised in four categories, namely, (a) data quality assessment, (b) trends/patterns assessment, (c) fitness-for-use assessment, and (d) ecosystem specific data diversity assessment. In conclusion we make specific suggestions to the GBIF community on the adoption of common indicators to assess progress towards future targets as well as recommendations to populate such exercise at various levels within the GBIF Network from national level to thematic levels

Sociology and hierarchy of voids: A study of seven nearby CAVITY galaxy voids and their dynamical CosmicFlows-3 environment

The present study addresses a key question related to our understanding of the relation between void galaxies and their environment: the relationship between luminous and dark matter in and around voids. Aims. To explore the extent to which local Universe voids are empty of matter, we study the full (dark+luminous) matter content of seven nearby cosmic voids that are fully contained within the CosmicFlows-3 volume. Methods. We obtained the matter-density profiles of seven cosmic voids using two independent methods. These were built from the galaxy redshift space two-point correlation function in conjunction with peculiar velocity gradients from the CosmicFlows-3 dataset. Results. The results are striking, because when the redshift survey is used, all voids show a radial positive gradient of galaxies, while based on the dynamical analysis, only three of these voids display a clear underdensity of matter in their center. Conclusions. This work constitutes the most detailed observational analysis of voids conducted so far, and shows that void emptiness should be derived from dynamical information. From this limited study, the Hercules void appears to be the best candidate for a local Universe pure “pristine volume”, expanding in three directions with no dark matter located in that void.Institut Universitaire de FranceCentre National D'etudes SpatialesInstituto de Salud Carlos III Spanish GovernmentEuropean Commission PID2020-224414GB-I00 PID2020-113689GB-I00Spanish Ministerio de Ciencia e Innovacion (MCIN)Agencia Estatal de Investigacion (AEI)European Social Fund (ESF) 20215AT016 CEX2020-001058-MCentro Superior de Investigaciones Cientificas (CSIC) under the PIE project KR4598/2-1German Research Foundation (DFG) PID2019-105602GBI00Junta de AndaluciaSpanish Government FQM108MCIN/AEIEuropean Union NextGenerationEUAgencia Estatal de Investigacion Espanola (AEI)Center for Forestry Research & Experimentation (CIEF) CEX2021-001131-SEuropean Union-Next Generation EU FundsState Research Agency (AEI-MCINN) of the Spanish Ministry of Science and Innovation under the grant "The structure and evolution of galaxies and their central regions" - Ministry of Universitie

ENLACE: A Combination of Layer-Based Architecture and Wireless Communication for Emotion Monitoring in Healthcare

Owing to the increase in the number of people with disabilities, as a result of either accidents or old age, there has been an increase in research studies in the area of ubiquitous computing and the Internet of Things. They are aimed at monitoring health, in an efficient and easily accessible way, as a means of managing and improving the quality of life of this section of the public. It also involves adopting a Health Homes policy based on the Internet of Things and applied in smart home environments. This is aimed at providing connectivity between the patients and their surroundings and includes mechanisms for helping the diagnosis and prevention of accidents and/or diseases. Monitoring gives rise to an opportunity to exploit the way computational systems can help to determine the real-time emotional state of patients. This is necessary because there are some limitations to traditional methods of health monitoring, for example, establishing the behavior of the user’s routine and issuing alerts and warnings to family members and/or medical staff about any abnormal event or signs of the onset of depression. This article discusses how a layer-based architecture can be used to detect emotional factors to assist in healthcare and the prevention of accidents within the context of Smart Home Health. The results show that this process-based architecture allows a load distribution with a better service that takes into account the complexity of each algorithm and the processing power of each layer of the architecture to provide a prompt response when there is a need for some intervention in the emotional state of the user

Random mobility and spatial structure often enhance cooperation

The effects of an unconditional move rule in the spatial Prisoner's Dilemma, Snowdrift and Stag Hunt games are studied. Spatial structure by itself is known to modify the outcome of many games when compared with a randomly mixed population, sometimes promoting, sometimes inhibiting cooperation. Here we show that random dilution and mobility may suppress the inhibiting factors of the spatial structure in the Snowdrift game, while enhancing the already larger cooperation found in the Prisoner's dilemma and Stag Hunt games.Comment: Submitted to J. Theor. Bio