5 research outputs found
CMV-specific T cell isolation from G-CSF mobilized peripheral blood: depletion of myeloid progenitors eliminates non-specific binding of MHC-multimers
Impact of intestinal dysbiosis-related drugs on the efficacy of immune checkpoint inhibitors in clinical practice
[Purpose]: Intestinal dysbiosis has emerged as a biomarker of response to immune checkpoint inhibitors (ICIs). It can be caused by antibiotics, although it may also result from the use of other drugs that have been studied to a lesser extent. The objective of our study was to analyze the association between the use of potentially dysbiosis-related drugs and survival in patients treated with ICIs in the clinical practice.[Materials and methods]: A retrospective, multicenter, cohort study was conducted. Clinicopathological variables were collected and the concomitant use of drugs was analyzed. A descriptive analysis of variables and overall survival, estimated by the Kaplan–Meier method, was performed, and association with various independent variables was assessed using Cox regression.[Results]: We included 253 patients, mainly with non-small cell lung cancer and melanoma. The most commonly used drugs were acid reducers, prescribed to 55.3% of patients, followed by corticosteroids (37.9%), anxiolytic drugs (35.6%), and antibiotics (20.5%). The use of acid reducers (9 vs. 18 months, P < .0001), antibiotics (7 vs. 15 months, P < .017), anxiolytic drugs (8 vs. 16 months, P < .015), and corticosteroids (6 vs. 19 months, P < .00001) was associated with poorer overall survival. Furthermore, the greater the number of drugs used concomitantly with ICIs, the higher the risk of death (1 drug: hazard ratio, 1.88; CI 95%, 1.07–3.30; 4 drugs: hazard ratio, 4.19; CI9 5%, 1.77–9.92; P < .001).[Conclusion]: Response to ICIs may be influenced by the use of drugs that lead to intestinal dysbiosis. Although a confirmatory prospective controlled study is required, our findings should be taken into account when analyzing ICI efficacy
Taller de Aptitud Vocacional para Arquitectura - AR206 - 202102
Descripción:
El Taller de Aptitud Vocacional para Arquitectura es un curso del ciclo 0 de la carrera de Arquitectura, de
carácter teórico-práctico dirigido a los estudiantes que no aprobaron o no rindieron la "Prueba de aptitud
Vocacional para Arquitectura".
En este sentido, el curso brinda el primer acercamiento a los conceptos arquitectónicos básicos y a la historia
del arte y arquitectura, a través de ejercicios de diseño (maquetas, exposiciones individuales y grupales, afiches
gráficos, entre otros) con los cuales el alumno se entrena (o prepara) para los talleres de diseño y los cursos de
historia de la carrera.
Propósito:
1El curso permite verificar si el perfil de los estudiantes coincide con lo necesario para el seguimiento de la
Carrera de Arquitectura además de corroborar y/o reforzar las aptitudes vocacionales para la misma y de esta
manera el estudiante, aumente sus probabilidades de un buen desempeño académico y la exitosa culminación de
la carrera.
El curso contribuye directamente al desarrollo de la competencia general de Pensamiento Innovador y la
competencia especÃfica de Diseño Fundamentado y Cultura Arquitectónica a un nivel novato (nivel 1). No tiene
requisitos previos. Aprobar este curso es requisito para llevar los curso de carrera: Expresión ArtÃstica y
Espacial y TI - Introducción al Diseño Arquitectónico, ambos del Ciclo 1