Tomates orgánicos - HAYU

En el presente documento se explica el desarrollo del proyecto HAYU basado en la producción de tomates cherry orgánicos mediante una capacitación realizada a diversos agricultores del Perú. Asimismo, se busca poder contar con una certificación que abale la calidad de nuestros productos, la cual no se presenta en el mercado local. Primero, se plantea el estudio de mercado donde se realizó el análisis del público objetivo, posibles competidores, clientes potenciales y planificación de estrategias por ejecutar con el fin de posicionar el producto. Además, se efectuó un estudio técnico donde se desarrollaron los balances para los distintos elementos a utilizar. Posteriormente, se realizó el estudio organizativo, tributario, legal y el estudio financiero que ayudo a evaluar la viabilidad del proyecto con una proyección a cinco años. Este último permitió realizar ajustes respecto a los montos de inversión que se necesitaran, y a identificar los posibles costos, gastos y ganancias. Por último, se desarrolló un análisis del proyecto con ayuda del programa Risk para una mejor proyección de los posibles escenarios y se estableció la planificación de riesgos y seguimiento

Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry

AIMS: Calmodulinopathy due to mutations in any of the three CALM genes (CALM1-3) causes life-threatening arrhythmia syndromes, especially in young individuals. The International Calmodulinopathy Registry (ICalmR) aims to define and link the increasing complexity of the clinical presentation to the underlying molecular mechanisms. METHODS AND RESULTS: The ICalmR is an international, collaborative, observational study, assembling and analysing clinical and genetic data on CALM-positive patients. The ICalmR has enrolled 140 subjects (median age 10.8 years [interquartile range 5-19]), 97 index cases and 43 family members. CALM-LQTS and CALM-CPVT are the prevalent phenotypes. Primary neurological manifestations, unrelated to post-anoxic sequelae, manifested in 20 patients. Calmodulinopathy remains associated with a high arrhythmic event rate (symptomatic patients, n = 103, 74%). However, compared with the original 2019 cohort, there was a reduced frequency and severity of all cardiac events (61% vs. 85%; P = .001) and sudden death (9% vs. 27%; P = .008). Data on therapy do not allow definitive recommendations. Cardiac structural abnormalities, either cardiomyopathy or congenital heart defects, are present in 30% of patients, mainly CALM-LQTS, and lethal cases of heart failure have occurred. The number of familial cases and of families with strikingly different phenotypes is increasing. CONCLUSION: Calmodulinopathy has pleiotropic presentations, from channelopathy to syndromic forms. Clinical severity ranges from the early onset of life-threatening arrhythmias to the absence of symptoms, and the percentage of milder and familial forms is increasing. There are no hard data to guide therapy, and current management includes pharmacological and surgical antiadrenergic interventions with sodium channel blockers often accompanied by an implantable cardioverter-defibrillator

Prediction of Opioid-Induced Respiratory Depression on Inpatient Wards Using Continuous Capnography and Oximetry: An International Prospective, Observational Trial.

BACKGROUND: Opioid-related adverse events are a serious problem in hospitalized patients. Little is known about patients who are likely to experience opioid-induced respiratory depression events on the general care floor and may benefit from improved monitoring and early intervention. The trial objective was to derive and validate a risk prediction tool for respiratory depression in patients receiving opioids, as detected by continuous pulse oximetry and capnography monitoring. METHODS: PRediction of Opioid-induced respiratory Depression In patients monitored by capnoGraphY (PRODIGY) was a prospective, observational trial of blinded continuous capnography and oximetry conducted at 16 sites in the United States, Europe, and Asia. Vital signs were intermittently monitored per standard of care. A total of 1335 patients receiving parenteral opioids and continuously monitored on the general care floor were included in the analysis. A respiratory depression episode was defined as respiratory rate ≤5 breaths/min (bpm), oxygen saturation ≤85%, or end-tidal carbon dioxide ≤15 or ≥60 mm Hg for ≥3 minutes; apnea episode lasting \u3e30 seconds; or any respiratory opioid-related adverse event. A risk prediction tool was derived using a multivariable logistic regression model of 46 a priori defined risk factors with stepwise selection and was internally validated by bootstrapping. RESULTS: One or more respiratory depression episodes were detected in 614 (46%) of 1335 general care floor patients (43% male; mean age, 58 ± 14 years) continuously monitored for a median of 24 hours (interquartile range [IQR], 17-26). A multivariable respiratory depression prediction model with area under the curve of 0.740 was developed using 5 independent variables: age ≥60 (in decades), sex, opioid naivety, sleep disorders, and chronic heart failure. The PRODIGY risk prediction tool showed significant separation between patients with and without respiratory depression (P \u3c .001) and an odds ratio of 6.07 (95% confidence interval [CI], 4.44-8.30; P \u3c .001) between the high- and low-risk groups. Compared to patients without respiratory depression episodes, mean hospital length of stay was 3 days longer in patients with ≥1 respiratory depression episode (10.5 ± 10.8 vs 7.7 ± 7.8 days; P \u3c .0001) identified using continuous oximetry and capnography monitoring. CONCLUSIONS: A PRODIGY risk prediction model, derived from continuous oximetry and capnography, accurately predicts respiratory depression episodes in patients receiving opioids on the general care floor. Implementation of the PRODIGY score to determine the need for continuous monitoring may be a first step to reduce the incidence and consequences of respiratory compromise in patients receiving opioids on the general care floor

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis

Community factors influencing the prevalence of homeless youth services

Studies of homeless youth services conclude that services contribute to improving the life chances of homeless youth, but little research has addressed the structural conditions that promote the creation of these services. This study investigates the prevalence of programs serving unaccompanied homeless youth in 26 metropolitan areas from 1989 to 2006. Specifically, it examines the extent to which the supply of funds, the need for services, and politics affect the prevalence of services. The findings suggest that political culture and supply measures (e.g., federal grants and homeless youth funding) have a greater effect on the prevalence of programs than the need for services.Runaway and homeless youth Poverty Social service provision

Estado nutricional y actividad laboral en el personal operativo de una empresa procesadora de alimentos

El presente trabajo analizó la relación entre estado nutricional, calidad de dieta y actividad física del personal operativo de una empresa procesadora de alimentos del Ecuador, a través de un estudio cuantitativo, observacional con diseño transeccional correlacional-causal. Se evaluó medidas antropométricas por bioimpedancia determinando Índice de Masa Corporal (IMC), porcentaje de grasa, músculo esquelético y grasa visceral, así como calidad de dieta y actividad física con encuesta de Índice de Alimentación Saludable (IASE) y Cuestionario Internacional de Actividad Física (IPAQ). Los resultados mostraron la dominancia de sobrepeso y obesidad en más de la mitad de los trabajadores operativos, con una masa muscular óptima en el 86,17%, porcentaje de grasa alta en el 74,47% y grasa visceral alta en el 53,19%. Concluyendo que la mayor actividad física al provenir de una actividad laboral diaria y una dieta no adecuada no favorecía al gasto calórico para reducción de grasa corporal y que la calidad de la dieta y actividad física influyen en el estado nutricional, y tiene un mayor impacto la práctica de ambas

I’d Like to Thank the Academy, Team Spillovers, and Network Centrality

In this article we use Academy Award nominations for acting to explore how artistic achievement is situated within collaborative context. The context of individual effort is particularly important in film since quality is not transparent and the project-based nature of the field allows us to observe individuals in multiple contexts. Controlling for the actor’s personal history and basic traits of the film we explore two basic predictions. First, we find that status, as measured by asymmetric centrality in the network of screen credits, is an efficient measure of star power and mediates the relationship between experience and formal artistic consecration. Second, we find that actors are most likely to be consecrated when working with elite collaborators. We conclude by arguing that selection into privileged work teams is a locus of cumulative advantage

I’d Like to Thank the Academy, Team Spillovers, and Network Centrality

In this article we use Academy Award nominations for acting to explore how artistic achievement is situated within collaborative context. The context of individual effort is particularly important in film since quality is not transparent and the project-based nature of the field allows us to observe individuals in multiple contexts. Controlling for the actor’s personal history and basic traits of the film we explore two basic predictions. First, we find that status, as measured by asymmetric centrality in the network of screen credits, is an efficient measure of star power and mediates the relationship between experience and formal artistic consecration. Second, we find that actors are most likely to be consecrated when working with elite collaborators. We conclude by arguing that selection into privileged work teams is a locus of cumulative advantage