265 research outputs found
Perception Change in Rice Pest Management: A Case Study of Farmers\u27 Evaluation of Conflict Information
A simple rule-of-thumb, or heuristic, in pest management which was in conflict with farmers\u27 prevailing perceptions was communicated to farmers to examine whether their cognitive dissonance would challenge them to evaluate it and change their misperceptions
Communication and Behavior Change in Rice Farmers’ Pest Management: The Case of Using Mass Media In Vietnam
Rice farmers’ unnecessary insecticide use for leaf folder control is due to misperceptions. A mass media campaign was organized to motivate farmers to test a conflict information expressed as a heuristic. After the campaign, insecticide use dropped from 3.35 sprays per farmer to 1.56. Proportions of farmers spraying at the early and late tillering and booting stages decreased from 59%, 84% and 85% to 0.2%, 19% and 30%, respectively. Leaf folder control perceptions, expressed as the belief index, changed from 11.25 to 7.62. Proportions of farmers believing that leaf folders could cause damages, yield loss and needed sprays, dropped from 66%, 70% and 77% to 24%, 25% and 23%, respectively. The study showed that mass media could effectively transfer some elements of knowledge-intensive pest management, especially simple non-site specific information designed to motivate
Effectiveness and Efficiency of Persuasive Space Graphics (PSG) in Motivating UK Primary School Children’s Hand Hygiene
Good hand hygiene is necessary to control and prevent infections, but many children do not adequately wash their hands. While there are classroom communications targeted at children, the toilet space, the location of many hand hygiene activities, is neglected. This paper describes an initial evaluation of “123” persuasive space graphics (images and messages integrated within an architectural environment that encourage specific actions). The effectiveness (whether hand hygiene improves) and efficiency (the ease with which a setting can adopt and implement an intervention) is evaluated in three UK schools and one museum. Five evaluations (participant demographic, handwashing frequency, handwashing quality, design persuasiveness, stakeholder views) were conducted. In the school settings, persuasive space graphics increased the quality and frequency of handwashing. In the museum setting, frequency of handwashing slightly increased. In all settings children found the graphics persuasive, and stakeholders also believed them to be effective. Stakeholders considered persuasive space graphics a low-cost and time-efficient way to communicate. It can be concluded that persuasive space graphics are effective in increasing hand hygiene, particularly in school settings where children have a longer exposure to the graphics. Persuasive space graphics are also an efficient low-cost means of communicating hand hygiene
Assessment of weed control via foliar application of quinate
En estudios previos se detectó una importante acumulación de quinato en la parte aérea de las plantas tratadas con herbicidas inhibidores de la biosíntesis de aminoácidos, lo que podría explicar su capacidad de inducir la respuesta tóxica. También se evaluó el potencial efecto fitotóxico en función del modo de aplicación exógena, que fue superior tras aplicaciones radicales que foliares. En este trabajo se planteó valorar la utilización del quinato, pulverizado exógenamente, para el control del crecimiento de ciertas malas hierbas. Se realizaron aplicaciones foliares de quinato mediante pulverización en post-emergencia sobre plantas en diferentes estados fenológicos de “Sinapis alba”, “Papaver rhoeas”, “Lolium rigidum”, “Bromus diandrus” y “Cynodon dactylon”. Los resultados muestran que dicho compuesto presentó un mayor control y un efecto fitotóxico más evidente en las especies dicotiledóneas que en las monocotiledóneas, siendo “P. rhoeas” la única especie susceptible de ser controlada en sus estadios iniciales con este compuesto. En “S. alba” únicamente se produjo una reducción temporal del crecimiento sin llegar a ser letal.In previous studies quinate was accumulated in leaves of plants treated with amino acid biosynthesis inhibiting herbicides, which begged the question of whether quinate have the capacity of inducing the toxic effects of the herbicides. The phytotoxic effects of exogenous application were more evident when quinate was applied to the nutrient solution than when it was sprayed onto the foliage. The objective of this study was to evaluate whether sprayed quinate could control the growth of some weed species. This was evaluated by spraying quinate to the leaves of plants of “Sinapis alba”, “Papaver rhoeas”, “Lolium rigidum”, “Bromus diandrus” and “Cynodon dactylon” at different phenological states in postemergence. Exogenous application of quinate was more phytotoxic on dicotyledonous species than monocotyledonous species. “Papaver rhoeas” was the only species tested that would be potentially affected and controlled with the application of quinate, specifically in the initial states of plant development. Growth of “S. alba” was only temporally arrested after quinate application, but the treatment was not lethal
Nuevas estrategias terapéuticas en diabetes mellitus tipo 1
El principal determinante del riesgo de complicaciones
derivadas de la diabetes mellitus tipo 1 se debe a los
altos niveles de glucosa en sangre mantenidos durante
largo tiempo. Para conseguir un beneficio terapéutico en
pacientes con diabetes mellitus es necesario desarrollar
tratamientos que permitan de manera segura, efectiva y
estable mantener la normoglucemia. Lamentablemente,
el tratamiento de la diabetes mellitus tipo 1 mediante el
aporte exógeno de insulina no es capaz de conseguir
niveles estables de glucosa en sangre, de manera que con
frecuencia se producen casos de severa hipoglucemia o
hiperglucemia. Hasta la fecha la única solución para reestablecer
de manera permanente la normoglucemia se
consigue mediante el trasplante de páncreas o de islotes
pancreáticos. Sin embargo, a medida que se incrementa
el número de centros especializados en el trasplante de
islotes, mayor es la necesidad de islotes para su trasplante.
Así pues, el estudio de nuevas fuentes de células
productoras de insulina así como de nuevos tratamientos
que permitan preservar o incluso aumentar la masa de
células beta en los pacientes con diabetes mellitus representa
un objetivo de primera necesidad en este campo.
En este sentido, en la última década ha habido un
avance significativo en el campo de la biología de las
células madre. Sin embargo, la identificación de células
apropiadas para la generación de nuevas células beta,
además del desarrollo de técnicas para la caracterización
de estas células, así como de ensayos y modelos
animales apropiados para probar su capacidad de diferenciación
tanto in vitro como in vivo son de vital importancia
para la puesta en marcha de nuevas estrategias
terapéuticas basadas en la aplicación de las células
madre para el tratamiento de la diabetes mellitus tipo 1
Evaluating children's handwashing in schools: an integrative review of indicative measures and measurement tools.
Children are a key target of handwashing interventions as washing hands reduces the spread of disease and reliance on antibiotics. While there is guidance for evaluating handwashing with adults in other settings, this is lacking for children in schools. An integrative review of 65 studies where handwashing was measured in schools was conducted to establish which indicative measures (what is measured to evaluate the processes and/or impacts of, handwashing) and measurement tools (data collection instruments) have been applied to evaluate handwashing in schools, and under what circumstances. Further analysis highlighted different challenges when seeking to apply such measures and tools in schools, as opposed to other settings. It was concluded that indicative measures, and measurement tools need to be appropriate to the organizational setting, the study participants, and research objectives. A summative analysis of relevant considerations is presented
Association of Patient Profile with Glycemic Control and Hypoglycemia with Insulin Glargine 300 U/mL in Type 2 Diabetes: A Post Hoc Patient-Level Meta-Analysis
ABSTRACT
Aims: To examine the association of baseline patient characteristics with study outcomes in people with type 2 diabetes receiving insulin glargine 300 U/mL (Gla-300) versus glargine 100 U/mL (Gla-100), over a 6-month period. Methods: A post hoc patient-level metaanalysis using data from three multicenter, randomized, open-label, parallel-group, phase 3a studies of similar design, in people previously receiving either basal and prandial insulin, basal
insulin ? oral antihyperglycemic drugs, or no prior insulin (EDITION 1, 2 and 3, respectively). The endpoints, glycated hemoglobin (HbA1c), hypoglycemia, body weight change, and insulin dose were investigated by subgroups: age (\65 and C 65 years), body mass index (BMI; \ 30 and C 30 kg/m2), age at onset (\40, 40–50, and [ 50 years), and diabetes duration (\ 10 and C 10 years). Results: Reduction in HbA1c was comparable between insulins, regardless of subgroup. The lower risk of C 1 nocturnal (00:00–05:59 h) confirmed (B 3.9 mmol/L [B 70 mg/dL]) or severe hypoglycemic event with Gla-300 versus Gla-100 was also unaffected by participant characteristics. While heterogeneity of treatment effect between diabetes duration subgroups was seen for the risk of C 1 confirmed (B 3.9 mmol/L [B 70 mg/dL]) or severe hypoglycemic event at any time (24 h), treatment effect consistently favored Gla-300; no evidence of heterogeneity was observed for the other subgroups. Annualized rates of confirmed (B 3.9 mmol/L [B 70 mg/dL]) or severe hypoglycemia and body weight change were not influenced by participant characteristics; a similar pattern was observed with insulin dose. Conclusions: Comparable glycemic control was observed with Gla-300 versus Gla-100, with less hypoglycemia, regardless of age, BMI, age at onset or diabetes duration. Funding: Sanofi. Plain Language Summary: Plain language summary available for this article.
Keywords: Glycated Hemoglobin A; Hypoglycemia; Insulin Glargine; Type 2 Diabetes
PLAIN LANGUAGE SUMMARY
Treatments for patients with type 2 diabetes aim to reduce the levels of blood glucose and can include injections with insulin. However, care must be taken to prevent blood glucose levels falling too low (a state called hypoglycemia). Previous studies have shown that insulin glargine 300 units/mL (Gla-300) provides similar reductions in blood glucose levels as insulin glargine 100 units/mL (Gla-100) but is less likely to cause hypoglycemia. However, different patients may respond differently to treatments depending on their individual clinical and biological characteristics. The aim of this study was to evaluate how different profiles of patients with type 2 diabetes responded to Gla-300 and Gla-100 injections. Patients were grouped by different ages, weights, age at diabetes diagnosis, and number of years since diagnosis of diabetes. We found that Gla-300 and Gla-100 reduced glycated hemoglobin (HbA1c; a marker of blood glucose control over the previous 2–3 months) similarly, regardless of how patients were grouped. However, patients treated with Gla-300 were less likely to experience hypoglycemia than those treated with Gla-100, and this association was also true regardless of different patient characteristics. We therefore concluded that Gla-300 is an effective and safe treatment in patients with type 2 diabetes,
regardless of their age, weight, age at diabetes diagnosis, and years since diagnosis
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