On variable hydrostatic transmission for road vehicles, powered by supply of fluid at constant pressure

Various hydrostatic power transmission systems for automotive applications with power supply at constant pressure and unrestricted flow and with a Volvo Flygmotor variable displacement motor as the principal unit were investigated. Two most promising concepts were analyzed in detail and their main components optimized for minimum power loss at the EPA Urban Driving Cycle. The best fuel consumption is less than 10 lit. per 100 kM for a 1542 kG vehicle with a hydrostatic motor and a two speed gear box in series (braking power not recovered). Realistic system pressure affects the fuel consumption just slightly, but the package volume/weight drastically. Back pressure increases losses significantly. Special attention was paid to description of the behavior and modeling of the losses of variable displacement hydrostatic machines

Inhibition by alloxan of mitochondrial aconitase and other enzymes associated with the citric acid cycle

AbstractConsiderable variations were found in the in vitro effect of alloxan on mouse liver enzymes associated with the citric acid cycle. The following approximative alloxan concentrations induced 50% inhibition of enzyme activity: 10−6 M for aconitase, 10−4 M for NAD-linked isocitrate dehydrogenase, glutamate dehydrogenase, α-ketoglutarate dehydrogenase, succinyl-CoA synthetase and fumarase, and 10−3 M for citrate synthase and NADP-linked isocitrate dehydrogenase. Pyruvate dehydrogenase, succinate dehydrogenase and malate dehydrogenase were not inhibited by 10−3 M alloxan. The inhibition of aconitase was competitive both when using mouse liver and purified porcine heart enzyme. The Ki values for the purified enzyme in the presence of 5 μM alloxan were 0.22 μM with citrate, 4.0 μM with cis-aconitate and 0.62 μM with isocitrate as substrate. The high sensitivity of aconitase for inhibition by alloxan probably plays a prominent role for the toxic effects of alloxan

Expertise Shapes Multimodal Imagery for Wine

Although taste and smell seem hard to imagine, some people nevertheless report vivid imagery in these sensory modalities. We investigate whether experts are better able to imagine smells and tastes because they have learned the ability, or whether they are better imaginers in the first place, and so become experts. To test this, we first compared a group of wine experts to yoked novices using a battery of questionnaires. We show for the first time that experts report greater vividness of wine imagery, with no difference in vividness across sensory modalities. In contrast, novices had more vivid color imagery than taste or odor imagery for wines. Experts and novices did not differ on other vividness of imagery measures, suggesting a domain-specific effect of expertise. Critically, in a second study, we followed a group of students commencing a wine course and a group of matched control participants. Students and controls did not differ before the course, but after the wine course students reported more vivid wine imagery. We provide evidence that expertise improves imagery, exemplifying the extent of plasticity of cognition underlying the chemical senses

Mutually unbiased bases: tomography of spin states and star-product scheme

Mutually unbiased bases (MUBs) are considered within the framework of a generic star-product scheme. We rederive that a full set of MUBs is adequate for a spin tomography, i.e. knowledge of all probabilities to find a system in each MUB-state is enough for a state reconstruction. Extending the ideas of the tomographic-probability representation and the star-product scheme to MUB-tomography, dequantizer and quantizer operators for MUB-symbols of spin states and operators are introduced, ordinary and dual star-product kernels are found. Since MUB-projectors are to obey specific rules of the star-product scheme, we reveal the Lie algebraic structure of MUB-projectors and derive new relations on triple- and four-products of MUB-projectors. Example of qubits is considered in detail. MUB-tomography by means of Stern-Gerlach apparatus is discussed.Comment: 11 pages, 1 table, partially presented at the 17th Central European Workshop on Quantum Optics (CEWQO'2010), June 6-11, 2010, St. Andrews, Scotland, U

Modification and cross-linking parameters in hyaluronic acid hydrogels—Definitions and analytical methods

AbstractDefinitions and methods for the quantification of degree of modification and cross-linking in cross-linked hyaluronic acid (HA) hydrogels are outlined. A novel method is presented in which the HA hydrogel is degraded by the enzyme chondroitinase AC and the digest product analyzed by size exclusion chromatography combined with electrospray ionization mass spectrometry (SEC–ESI-MS). This method allows for the determination of effective cross-linker ratio (CrR) which together with the degree of modification (MoD), determined by, e.g. 1H NMR spectroscopy, enables the calculation of the degree of substitution (DS) and degree of cross-linking (CrD).The method, could be applicable to the major cross-linked HA hydrogels currently on the market, and is exemplified here by application to two HA hydrogels. The definitions and methods presented are important contributions in attempts to find relationships between MoD, DS and CrD to mechanical properties as well as to biocompatibility of HA hydrogels

Zebularine induces long-term survival of pancreatic islet allotransplants in streptozotocin treated diabetic rats.

Coping with the immune rejection of allotransplants or autologous cells in patients with an active sensitization towards their autoantigens and autoimmunity presently necessitates life-long immune suppressive therapy acting on the immune system as a whole, which makes the patients vulnerable to infections and increases their risk of developing cancer. New technologies to induce antigen selective long-lasting immunosuppression or immune tolerance are therefore much needed

Vibrotactile pedals : provision of haptic feedback to support economical driving

The use of haptic feedback is currently an underused modality in the driving environment, especially with respect to vehicle manufacturers. This exploratory study evaluates the effects of a vibrotactile (or haptic) accelerator pedal on car driving performance and perceived workload using a driving simulator. A stimulus was triggered when the driver exceeded a 50% throttle threshold, past which is deemed excessive for economical driving. Results showed significant decreases in mean acceleration values, and maximum and excess throttle use when the haptic pedal was active as compared to a baseline condition. As well as the positive changes to driver behaviour, subjective workload decreased when driving with the haptic pedal as compared to when drivers were simply asked to drive economically. The literature suggests that the haptic processing channel offers a largely untapped resource in the driving environment, and could provide information without overloading the other attentional resource pools used in driving

Imaginary Phases in Two-Level Model with Spontaneous Decay

We study a two-level model coupled to the electromagnetic vacuum and to an external classic electric field with fixed frequency. The amplitude of the external electric field is supposed to vary very slow in time. Garrison and Wright [{\it Phys. Lett.} {\bf A128} (1988) 177] used the non-hermitian Hamiltonian approach to study the adiabatic limit of this model and obtained that the probability of this two-level system to be in its upper level has an imaginary geometric phase. Using the master equation for describing the time evolution of the two-level system we obtain that the imaginary phase due to dissipative effects is time dependent, in opposition to Garrison and Wright result. The present results show that the non-hermitian hamiltonian method should not be used to discuss the nature of the imaginary phases in open systems.Comment: 11 pages, new version, to appear in J. Phys.

First observations of confined fast ions in MAST Upgrade with an upgraded neutron camera

Spherical tokamaks are key to the successful design of operating scenarios of future fusion reactors in the areas of divertor physics, neutral beam current drive and fast ion physics. MAST Upgrade, which has successfully concluded its first experimental campaign, was specifically designed to address the role of the radial gradient of the fast ion distribution in driving the excitation of magneto-hydrodynamic (MHD) instabilities, such as toroidal Alfvén eigenmodes, fish-bones and long-lived mode, thanks to its two tangential neutral beam injection systems, one on the equatorial plane and one that is vertically shifted 65 cm above the equatorial plane. To study the fast ion dynamics in the presence of such instabilities, as well as of sawteeth and neo-classical tearing modes, several fast ion diagnostics were upgraded and new ones added. Among them, the MAST prototype neutron camera (NC) has been upgraded to six, equatorial sight-lines. The first observations of the confined fast ion behavior with the upgraded NC in a wide range of plasma scenarios characterized by on-axis and/or off-axis heating and different MHD instabilities are presented here. The observations presented in this study confirm previous results on MAST but with a higher level of detail and highlight new physics observations unique to the MAST Upgrade. The results presented here confirm the improved performance of the NC Upgrade, which thus becomes one of the key elements, in combination with the rich set of fast ion diagnostics available on the MAST Upgrade, for a more constrained modeling of the fast ion dynamics in fusion reactor relevant scenarios