354 research outputs found
Quantum Nonlocality without Entanglement
We exhibit an orthogonal set of product states of two three-state particles
that nevertheless cannot be reliably distinguished by a pair of separated
observers ignorant of which of the states has been presented to them, even if
the observers are allowed any sequence of local operations and classical
communication between the separate observers. It is proved that there is a
finite gap between the mutual information obtainable by a joint measurement on
these states and a measurement in which only local actions are permitted. This
result implies the existence of separable superoperators that cannot be
implemented locally. A set of states are found involving three two-state
particles which also appear to be nonmeasurable locally. These and other
multipartite states are classified according to the entropy and entanglement
costs of preparing and measuring them by local operations.Comment: 27 pages, Latex, 6 ps figures. To be submitted to Phys. Rev. A.
Version 2: 30 pages, many small revisions and extensions, author added.
Version 3: Proof in Appendix D corrected, many small changes; final version
for Phys. Rev. A Version 4: Report of Popescu conjecture modifie
The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial
Coherent Control of Isotope Separation in HD+ Photodissociation by Strong Fields
The photodissociation of the HD+ molecular ion in intense short- pulsed
linearly polarized laser fields is studied using a time- dependent wave-packet
approach where molecular rotation is fully included. We show that applying a
coherent superposition of the fundamental radiation with its second harmonic
can lead to asymmetries in the fragment angular distributions, with significant
differences between the hydrogen and deuterium distributions in the long
wavelength domain where the permanent dipole is most efficient. This effect is
used to induce an appreciable isotope separation.Comment: Physical Review Letters, 1995 (in press). 4 pages in revtex format, 3
uuencoded figures. Full postcript version available at:
http://chemphys.weizmann.ac.il/~charron/prl.ps or
ftp://scipion.ppm.u-psud.fr/coherent.control/prl.p
Audience preferences are predicted by temporal reliability of neural processing
Naturalistic stimuli evoke highly reliable brain activity across viewers. Here we record neural activity from a group of naive individuals while viewing popular, previously-broadcast television content for which the broad audience response is characterized by social media activity and audience ratings. We find that the level of inter-subject correlation in the evoked encephalographic responses predicts the expressions of interest and preference among thousands. Surprisingly, ratings of the larger audience are predicted with greater accuracy than those of the individuals from whom the neural data is obtained. An additional functional magnetic resonance imaging study employing a separate sample of subjects shows that the level of neural reliability evoked by these stimuli covaries with the amount of blood-oxygenation-level-dependent (BOLD) activation in higher-order visual and auditory regions. Our findings suggest that stimuli which we judge favourably may be those to which our brains respond in a stereotypical manner shared by our peers
Dual-Task Processing With Identical Stimulus and Response Sets: Assessing the Importance of Task Representation in Dual-Task Interference
Limitations in our ability to produce two responses at the same time – that is, dual-task interference – are typically measured by comparing performance when two stimuli are presented and two responses are made in close temporal proximity to when a single stimulus is presented and a single response is made. While straightforward, this approach leaves open multiple possible sources for observed differences. For example, on dual-task trials, it is typically necessary to identify two stimuli nearly simultaneously, whereas on typical single-task trials, only one stimulus is presented at a time. These processes are different from selecting and producing two distinct responses and complicate the interpretation of dual- and single-task performance differences. Ideally, performance when two tasks are executed should be compared to conditions in which only a single task is executed, while holding constant all other stimuli, response, and control processing. We introduce an alternative dual-task procedure designed to approach this ideal. It holds stimulus processing constant while manipulating the number of “tasks.” Participants produced unimanual or bimanual responses to pairs of stimuli. For one set of stimuli (two-task set), the mappings were organized so an image of a face and a building were mapped to particular responses (including no response) on the left or right hands. For the other set of stimuli (one-task set), the stimuli indicated the same set of responses, but there was not a one-to-one mapping between the individual stimuli and responses. Instead, each stimulus pair had to be considered together to determine the appropriate unimanual or bimanual response. While the stimulus pairs were highly similar and the responses identical across the two conditions, performance was strikingly different. For the two-task set condition, bimanual responses were made more slowly than unimanual responses, reflecting typical dual-task interference, whereas for the one-task set, unimanual responses were made more slowly than bimanual. These findings indicate that dual-task costs occur, at least in part, because of the interfering effects of task representation rather than simply the additional stimulus, response, or other processing typically required on dual-task trials
LSST Science Book, Version 2.0
A survey that can cover the sky in optical bands over wide fields to faint
magnitudes with a fast cadence will enable many of the exciting science
opportunities of the next decade. The Large Synoptic Survey Telescope (LSST)
will have an effective aperture of 6.7 meters and an imaging camera with field
of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over
20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with
fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a
total point-source depth of r~27.5. The LSST Science Book describes the basic
parameters of the LSST hardware, software, and observing plans. The book
discusses educational and outreach opportunities, then goes on to describe a
broad range of science that LSST will revolutionize: mapping the inner and
outer Solar System, stellar populations in the Milky Way and nearby galaxies,
the structure of the Milky Way disk and halo and other objects in the Local
Volume, transient and variable objects both at low and high redshift, and the
properties of normal and active galaxies at low and high redshift. It then
turns to far-field cosmological topics, exploring properties of supernovae to
z~1, strong and weak lensing, the large-scale distribution of galaxies and
baryon oscillations, and how these different probes may be combined to
constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at
http://www.lsst.org/lsst/sciboo
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts
LSST: from Science Drivers to Reference Design and Anticipated Data Products
(Abridged) We describe here the most ambitious survey currently planned in
the optical, the Large Synoptic Survey Telescope (LSST). A vast array of
science will be enabled by a single wide-deep-fast sky survey, and LSST will
have unique survey capability in the faint time domain. The LSST design is
driven by four main science themes: probing dark energy and dark matter, taking
an inventory of the Solar System, exploring the transient optical sky, and
mapping the Milky Way. LSST will be a wide-field ground-based system sited at
Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m
effective) primary mirror, a 9.6 deg field of view, and a 3.2 Gigapixel
camera. The standard observing sequence will consist of pairs of 15-second
exposures in a given field, with two such visits in each pointing in a given
night. With these repeats, the LSST system is capable of imaging about 10,000
square degrees of sky in a single filter in three nights. The typical 5
point-source depth in a single visit in will be (AB). The
project is in the construction phase and will begin regular survey operations
by 2022. The survey area will be contained within 30,000 deg with
, and will be imaged multiple times in six bands, ,
covering the wavelength range 320--1050 nm. About 90\% of the observing time
will be devoted to a deep-wide-fast survey mode which will uniformly observe a
18,000 deg region about 800 times (summed over all six bands) during the
anticipated 10 years of operations, and yield a coadded map to . The
remaining 10\% of the observing time will be allocated to projects such as a
Very Deep and Fast time domain survey. The goal is to make LSST data products,
including a relational database of about 32 trillion observations of 40 billion
objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures
available from https://www.lsst.org/overvie
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing
molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN
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