Synthesis and Biological Evaluation of (Hydroxethyl) Urea Peptidomimetic Transition-State Analogs for Use in a Click Chemistry Approach to Studying the Gamma-Secretase Complex

(Statement of Responsibility) by Eric Gars(Thesis) Thesis (B.A.) -- New College of Florida, 2009Online version not currently available.(Electronic Access) RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE(Bibliography) Includes bibliographical references.(Source of Description) This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.(Local) Faculty Sponsor: Scudder, Pau

High-pressure glass-ceramics for iodine nuclear waste immobilization: Preliminary experimental results

International audienceSeveral matrix types have been considered for the immobilization of iodine radioisotopes from which glass-ceramics represent a serious candidate; however, I-bearing glass-ceramics are challenging owing to the iodine volatility. We have synthesised glass-ceramics from the partial crystallization of a parental glass enriched with different iodine sources (I2 and I2O5) under high-pressure conditions (up to 1.5 GPa). The samples were characterized using Scanning and Transmission Electron Microscopy and X-ray Diffraction. Using standard synthesis protocol: melting, nucleation and crystal growth, we have obtained glass-ceramics showing the coexistence between I-bearing glass (<0.8 mol.% I), nepheline (NaAlSiO4) and iodosodalite (Na8Al6Si6O24I2 with up to 14 mol.% I). For several samples, we observed also the presence NaPt3O4 witnessing a chemical reaction between the container walls and the inside experimental charge. The structure of iodosodalite is entirely resolved by Rietveld refinement of the XRD pattern for I2 experiments whereas it cannot be solved for I2O5 experiments suggesting a change in the iodosodalite structure probably due to the β cage filling by IO3− clusters instead of I−. Our present work could represent a potential solution to tackle the problem of iodine radioisotopes immobilizatio