Florid cemento-osseous dysplasia: report of a case documented with clinical,radiographic, biochemical and histological findings

Florid cemento-osseous dysplasia (FCOD) has been described as a condition that characteristically affects the jaws of middle-aged black women. This condition has also been classified as gigantiform cementoma, chronic sclerosing osteomyelitis, sclerosing osteitis, multiple estenosis and sclerotic cemental masses. It usually exhibits as multiple radiopaque cementum-like masses distributed throughout the jaws. Radiographically, FCOD appears as dense, lobulated masses, often symmetrically located in various regions of the jaws. Computed tomography, because of its ability to give axial, sagittal, and frontal views, is useful in the evaluation of these lesions. This article reports the case of a 45-year-old white man who was diagnosed with FCOD on the basis of clinical, radiographic, biochemical and histological findings. It is of major importance to realize that all dentists have a unique opportunity as well as ethical obligation to assist in the struggle against wrong dental treatments that might save patients dental health. This case report illustrates the point that periapical radiolucencies may represent benign fibro-osseous lesions that may be overlooked or result in unnecessary endodontic treatment

Surface characteristics of scots pine treated with chemicals containing some copper compounds after weathering

In this study, it was aimed to investigate surface hardness, gloss, and color changes of Scots pine treated with chemicals containing some copper compounds after six months weathering. Adolit KD-5 (AD KD-5), celcure AC-500 (CAC-500), and wolmanit CX-8 (WCX-8) were used as impregnation chemicals containing copper compounds. Scots pine wood specimens were treated with 2 % aqueous solution of chemicals according to ASTM D1413-07e1 (2007) standard. Results showed that while surface hardness and gloss values of untreated Scots pine wood specimens were decreased after weathering, they increased treated Scots pine wood specimens after weathering. The decrease in L* of untreated and treated wood indicates that the specimens became darker after weathering. While weathering caused less green and less yellow for untreated control specimen, it caused less red and less yellow for treated wood. Treated Scots pine wood specimens showed better color stability compared to untreated Scots pine after weathering. In terms of surface hardness, gloss, and color stability values CAC-500 treated Scots pine gave the best results after weathering

Nestin(+) Tissue-Resident Multipotent Stem Cells Contribute to Tumor Progression by Differentiating into Pericytes and Smooth Muscle Cells Resulting in Blood Vessel Remodeling

Tumor vessels with resistance to anti-angiogenic therapy are characterized by the normalization of the vascular structures through integration of mature pericytes and smooth muscle cells (SMC) into the vessel wall, a process termed vessel stabilization. Unfortunately, stabilization-associated vascular remodeling can result in reduced sensitivity to subsequent anti-angiogenic therapy. We show here that blockade of VEGF by bevacizumab induces stabilization of angiogenic tumor blood vessels in human tumor specimen by recruiting Nestin-positive cells, whereas mature vessels down-regulated Nestin-expression. Using xenograft tumors growing on bone-marrow (BM) chimera of C57Bl/6 wildtype and Nestin-GFP transgenic mice, we show for first time that Nestin(+) cells inducing the maturation of tumor vessels do not originate from the BM but presumably reside within the adventitia of adult blood vessels. Complementary ex vivo experiments using explants of murine aortas revealed that Nestin(+) multipotent stem cells (MPSCs) are mobilized from their niche and differentiated into pericytes and SMC through the influence of tumor-cell-secreted factors. We conclude that tissue-resident Nestin(+) cells are more relevant than BM-derived cells for vessel stabilization and therefore have to be considered in future strategies for anti-angiogenic therapy. The identification of proteins mediating recruitment or differentiation of local Nestin(+) cells with potential stem cell character to angiogenic blood vessels may allow the definition of new therapeutic targets to reduce tumor resistance against anti-angiogenic drugs

Old name, new face: a systematic analysis of flexor digitorum superficialis muscle with "chiasma antebrachii"

he gross anatomy of the forearm flexors, particularly that of the flexor digitorum superficialis (FDS) muscle, has been described and graphically illustrated in several anatomical books and atlases starting in the middle of the century before last. However, in anatomical dissection studies as well as in clinical-anatomical courses training muscle-specific targeted injections due to movement disorders such as dystonia or spasticity, it has become apparent that there is a need for a closer investigation of the complex construction of the FDS muscle. To this end, we studied the structure of the muscle bellies and tendons of FDS on 46 human body donates that have been used either in our dissection or clinical-anatomical training courses. With this, we demonstrate here the topographical configuration of the individual muscle belly for each of digits 2 through 5 and the exact paths of their tendons until their passing through the carpal tunnel. Furthermore, we demonstrate the presence of a chiasm of the FDS tendons for the digits 2 and 3, approximately 3-4 cm proximal of the carpal tunnel. Thus, we introduce herewith the terminology “chiasma antebrachii”. These findings were confirmed in situ by imaging of fixed human body donates via MRI and corroborated by MRI and ultrasound imaging in two volunteers. Taken together, the present findings enable an updated understanding of the complex organization of the heads, bellies, and tendons of FDS that is relevant not only for anatomical teaching but also clinical interventions

The role of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer

The Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), also known as CD66a, is a member of the immunoglobulin superfamily. CEACAM1 was shown to be a prognostic marker in patients suffering from cancer. In this review, we summarize pre-clinical and clinical evidence linking CEACAM1 to tumorigenicity and cancer progression. Furthermore, we discuss potential CEACAM1-based mechanisms that may affect cancer biology

Duloxetine alleviates high light-induced anxiety-related behaviors in Wistar rats

Purpose: To investigate the effect of subchronic duloxetine treatment on high light-induced anxietyrelated behaviors in Wistar rats. Methods: Adult male Wistar rats (n = 30) were randomly assigned to three groups of rats (10 rats/group): control group, 30 mg/kg duloxetine group, and 60 mg/kg duloxetine group. Intraperitoneal injection of duloxetine was given once a day for ten days. The anxiolytic effect of duloxetine in the rats was assessed using light/dark box (LDB) anxiety test. Results: Anxiety-related behaviors were significantly reduced in duloxetine-treated rats, when compared with control group. The reductions were not dose-dependent (light zone time and latency time were significantly increased, while dark zone time decreased significantly, p < 0.05). The number of rearings significantly increased in 30 mg/kg duloxetine group, relative to control and 60 mg/kg duloxetine groups (p < 0.05). However, there were no significant differences in the number of light-todark entrances among the groups (p > 0.05). Conclusion: These results show that subchronic treatment with duloxetine alleviates anxiety-related behaviors in Wistar rats

İstabul Üniversitesi gözlemevi odak düzlemi aygıtı test ve karakterizasyon laboratuvarı

Doğu Anadolu Gözlemevi Odak Düzlemi Aygıtları ve Adaptif Optik Sistemi başlıklı, 2016K121370 numaralı T.C. Kalkınma Bakanlığı projesi ve İstanbul Üniversitesi Rektörlüğü desteğinde yürüyen çalışmalar kapsamında İstanbul Üniversitesi Astronomi ve Uzay Bilimleri Bölümü’nde teleskop odak düzlemi aygıtı test ve karakterizasyon laboratuvarı kurulum çalışmaları başlatılmıştır. Başta DAG Teleskobu olmak üzere ülkemizdeki tüm gözlemevlerine hizmet verebilecek şekilde tasarlanan laboratuvar, CCD kamera, filtre ve odak düzlemi aygıtları için bir test masasına sahip olacaktır. Bu sunumda, laboratuvarın kurulumu ve alımlarında gelinen son noktanın yanı sıra, İstanbul Üniversitesi Fizik Bölümü Nano-Optoelektronik Araştırma Laboratuvarları ile birlikte yapılması planlanan çalışmalar sunulacaktır.Publisher's Versio

Vascular Wall-Resident CD44+ Multipotent Stem Cells Give Rise to Pericytes and Smooth Muscle Cells and Contribute to New Vessel Maturation

Here, we identify CD44(+)CD90(+)CD73(+)CD34(−)CD45(−) cells within the adult human arterial adventitia with properties of multipotency which were named vascular wall-resident multipotent stem cells (VW-MPSCs). VW-MPSCs exhibit typical mesenchymal stem cell characteristics including cell surface markers in immunostaining and flow cytometric analyses, and differentiation into adipocytes, chondrocytes and osteocytes under culture conditions. Particularly, TGFß1 stimulation up-regulates smooth muscle cell markers in VW-MPSCs. Using fluorescent cell labelling and co-localisation studies we show that VW-MPSCs differentiate to pericytes/smooth muscle cells which cover the wall of newly formed endothelial capillary-like structures in vitro. Co-implantation of EGFP-labelled VW-MPSCs and human umbilical vein endothelial cells into SCID mice subcutaneously via Matrigel results in new vessels formation which were covered by pericyte- or smooth muscle-like cells generated from implanted VW-MPSCs. Our results suggest that VW-MPSCs are of relevance for vascular morphogenesis, repair and self-renewal of vascular wall cells and for local capacity of neovascularization in disease processes

Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma

Angiogenesis is not only dependent on endothelial cell invasion and proliferation, it also requires pericyte coverage of vascular sprouts for stabilization of vascular walls. Clinical efficacy of angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signaling pathway is still limited to date. We hypothesized that the level of vessel maturation is critically involved in the response to antiangiogenic therapies. To test this hypothesis, we evaluated the vascular network in spontaneously developing melanomas of MT/ret transgenic mice after using PTK787/ZK222584 for anti-VEGF therapy but also analyzed human melanoma metastases taken at clinical relapse in patients undergoing adjuvant treatment using bevacizumab. Both experimental settings showed that tumor vessels, which are resistant to anti-VEGF therapy, are characterized by enhanced vessel diameter and normalization of the vascular bed by coverage of mature pericytes and immunoreactivity for desmin, NG-2, platelet-derived growth factor receptor β, and the late-stage maturity marker α smooth muscle actin. Our findings emphasize that the level of mural cell differentiation and stabilization of the vascular wall significantly contribute to the response toward antiangiogenic therapy in melanoma. This study may be useful in paving the way toward a more rational development of second generation antiangiogenic combination therapies and in providing, for the first time, a murine model to study this