Effect of visitor activities on topsoil hydrophysical properties in two protected areas in northern blacksea region

In this study, the effects of visitor acitivities on topsoil hydrophysical properties in two protected areas in northern Bleacksea region were investigated. For this purpose, soil samples taken from study area that was characterized as heavily trafficked site (HTS), moderately trafficked sites (MTS) and control (non-trafficked site). The soil bulk density and soil penetration resistance increased from 1.02 to 1.39 g cm–3 and 0.66 to 1.55 MPa, respectively, saturated hydraulic conductivity decreased from 60.60 to 10.35 mm h–1 in moderately and heavily trafficked sites, respectively, at 0–10 cm soil depth in Ayder protected area. The soil bulk density and soil penetration resistance increased from 0.85 to 1.40 g cm–3 and 0.68 to 1.50 MPa, respectively, saturated hydraulic conductivity decreased from 58.75 to 10.35 mm h–1 in moderately and heavily trafficked sites, respectively, at 0–10 cm soil depth in Kafkasor protected area. The intensity of visitor activities had a negative impact on topsoil hydrophysical properties in the study area in Ayder and Kafkasor. The principles of management in Ayder and Kafkasor protected areas should be revised, and use of this area without a plan should be stopped as soon as possible

Coşku yarışında 10. yılda çakılıp kaldık:Haydi marş marş

Taha Toros Arşivi, Dosya No: 127-İstiklal Marşı ve MarşlarUnutma İstanbul projesi İstanbul Kalkınma Ajansı'nın 2016 yılı "Yenilikçi ve Yaratıcı İstanbul Mali Destek Programı" kapsamında desteklenmiştir. Proje No: TR10/16/YNY/010

Nanostructured modifications of titanium surfaces improve vascular regenerative properties of exosomes derived from mesenchymal stem cells: Preliminary in vitro results

© 2021 by the authors. Licensee MDPI, Basel, Switzerland.(1) Background: Implantation of metal-based scaffolds is a common procedure for treating several diseases. However, the success of the long-term application is limited by an insufficient endothelialization of the material surface. Nanostructured modifications of metal scaffolds represent a promising approach to faster biomaterial osteointegration through increasing of endothelial commitment of the mesenchymal stem cells (MSC). (2) Methods: Three different nanotubular Ti surfaces (TNs manufactured by electrochemical anodization with diameters of 25, 80, or 140 nm) were seeded with human MSCs (hMSCs) and their exosomes were isolated and tested with human umbilical vein endothelial cells (HUVECs) to assess whether TNs can influence the secretory functions of hMSCs and whether these in turn affect endothelial and osteogenic cell activities in vitro. (3) Results: The hMSCs adhered on all TNs and significantly expressed angiogenic-related factors after 7 days of culture when compared to untreated Ti substrates. Nanomodifications of Ti surfaces significantly improved the release of hMSCs exosomes, having dimensions below 100 nm and expressing CD63 and CD81 surface markers. These hMSC-derived exosomes were efficiently internalized by HUVECs, promoting their migration and differentiation. In addition, they selectively released a panel of miRNAs directly or indirectly related to angiogenesis. (4) Conclusions: Preconditioning of hMSCs on TNs induced elevated exosomes secretion that stimulated in vitro endothelial and cell activity, which might improve in vivo angiogenesis, supporting faster scaffold integration

High-K volcanism in the Afyon region, western Turkey: from Si-oversaturated to Si-undersaturated volcanism

Volcanic rocks of the Afyon province (eastern part of western Anatolia) make up a multistage potassic and ultrapotassic alkaline series dated from 14 to 12 Ma. The early-stage Si-oversaturated volcanic rocks around the Afyon city and further southward are trachyandesitic volcanic activity (14.23 ± 0.09 Ma). Late-stage Si-undersaturated volcanism in the southernmost part of the Afyon volcanic province took place in three episodes inferred from their stratigraphic relationships and ages. Melilite– leucitites (11.50 ± 0.03 Ma), spotted rachyandesites, tephryphonolites and lamproites (11.91 ± 0.13 Ma) formed in the first episode; trachyandesites in the second episode and finally phonotephrites, phonolite, basaltic trachyandesites and nosean-bearing trachyandesites during the last episode. The parameter Q [normative q-(ne + lc + kls + ol)] of western Anatolia volcanism clearly decreased southward with time becoming zero in the time interval 10–15 Ma. The magmatism experienced a sudden change in the extent of Si saturation after 14 Ma, during late-stage volcanic activity of Afyon volcanic province at around 12 Ma, though there was some coexistence of Si-oversaturated and Si-undersaturated magmas during the whole life of Afyon volcanic province

Anodization of 316L stainless steel for implant applications

316L stainless steel (SS) surfaces were modified via anodization to form nanopit structures with aim of improving its corrosion resistance, bone cell adhesion, proliferation and enhance its bioactivity. Surface characterization studies revealed that nanopit structures were composed of Fe2O3 and Cr2O3. The in vitro results showed that nanopit surfaces enhanced bone cell proliferation. Thus, we concluded that fabrication of nanostructures on 316L SS surfaces is a promising way to enhance bone cell functions for implant applications