A Versatile Active Block: DXCCCII and Tunable Applications

The study describes dual-X controlled current conveyor (DXCCCII) as a versatile active block and its application to inductance simulators for testing. Moreover, the high pass filter application using with DXCCCII based inductance simulator and oscillator with flexible tunable oscillation frequency have been presented and simulated to confirm the theoretical validity. The proposed circuit which has a simple circuit design requires the low-voltage and the DXCCCII can also be tuned in the wide range by the biasing current. The proposed DXCCCII provides a good linearity, high output impedance at Z terminals, and a reasonable current and voltage transfer gain accuracy. The proposed DXCCCII and its applications have been simulated using the CMOS 0.18 µm technology

Yarı Kristal Polimer Malzemelerin Çok Ölçekli Modellenmesi

Konferans Bildirisi -- Teorik ve Uygulamalı Mekanik Türk Milli Komitesi, 2013Conference Paper -- Theoretical and Applied Mechanical Turkish National Committee, 2013Bu çalışmada iki fazlı yarı kristal polimerik malzemeler için geometrik olarak doğrusal olmayan, mikromekaniksel motivasyonlu ve çok ölçekli bir malzeme modeli geliştirilmiştir. Bu amaç doğrultusunda, amorf ve kristal fazlar için en önemli şekil değiştirme mekanizmaları belirlenmiş ve bu bilgi ışığında her iki faz için ayrı ayrı mikromekaniksel motivasyonu bulunan malzeme modelleri kullanılmıştır. Ardından, iki fazlı yapıyı homojenleştirerek yarı kristal polimer malzemenin makroskopik davranışını betimleyecek bir model geliştirilmiştir.In this paper a geometrically non-linear micromechanically-motivated multi-scale model is developed for two phase semi-crystalline polymeric materials. To this end, most important deformation mechanisms of amorphous and crystalline phases are determined; and in the light of this information, micromechanically-motivated material models are employed separately for both phases. Afterwards, by homogenization of the two-phase structure, , a model that would render the macroscopic response of the semi crystalline polymeric material is developed

Anti-cancer efficiency of natural killer cells differentiated from human adipose tissue-derived mesenchymal stem cells and transfected with miRNA150

Aim: The aim of this study is to investigate the effects of miR150 transfection on NK-like cells differentiated from adipose tissue derived mesenchymal stem cells (AD-MSCs). Methods: NK-like cells were differentiated from AD-MSCs and activated by miR150 transfection. Transfected/non-transfected NK-like cells were characterized by immunohistochemical and RTPCR analyzes. Apoptotic efficiency of the transfected/non-transfected NK-like cells on pancreatic cancer cells PANC1 were determined by TUNEL and RT-PCR. Results: In miR150-transfected cells, the increased expression of NK cell-specific genes such as GZMB, KIR2DL2, CD16, CD56, NKG2D, NKp46 and increased immunoreactivity of NK cell-specific surface marker CD314 (NKG2D) were evident. TUNEL assays showed that NK-like cells with/without transfection induced apoptosis in PANC1 cells in the same manner. The decrease in oncogene expression and the increase in the tumor suppressor gene expression in PANC1 cells upon co-culture with NK-like cells differentiated from AD-MSCs were more prominent following miRNA150 transfection. Conclusion: It was shown in vitro that NK-like cells could be obtained by differentiation from AD-MSCs and their efficiency could be increased via miR150 transfection. The results are encouraging for further clinical studies in improvement of immunotherapeutic approaches for cancer therapy

Higher P-Wave Dispersion in Migraine Patients with Higher Number of Attacks

Objective and Aim. An imbalance of the sympathetic system may explain many of the clinical manifestations of the migraine. We aimed to evaluate P-waves as a reveal of sympathetic system function in migraine patients and healthy controls. Materials and Methods. Thirty-five episodic type of migraine patients (complained of migraine during 5 years or more, BMI < 30 kg/m2) and 30 controls were included in our study. We measured P-wave durations (minimum, maximum, and dispersion) from 12-lead ECG recording during pain-free periods. ECGs were transferred to a personal computer via a scanner and then used for magnification of x400 by Adobe Photoshop software. Results. P-wave durations were found to be similar between migraine patients and controls. Although P WD (P-wave dispersion) was similar, the mean value was higher in migraine subjects. P WD was positively correlated with P max (P < 0.01). Attacks number per month and male gender were the factors related to the P WD (P < 0.01). Conclusions. Many previous studies suggested that increased sympathetic activity may cause an increase in P WD. We found that P WD of migraine patients was higher than controls, and P WD was related to attacks number per month and male gender. Further studies are needed to explain the chronic effects of migraine

Possible evolution of dim radio quiet neutron star 1E 1207.4-5209 based on a B-decay model

Dim radio-quiet neutron star (DRQNS) 1E 1207.4-5209 is one of the most heavily examined isolated neutron stars. Wide absorption lines were observed in its spectrum obtained by both XMM-Newton and Chandra X-ray satellites. These absorption lines can be interpreted as a principal frequency centered at 0.7 keV and its harmonics at 1.4, 2.1 and possibly 2.8 keV. The principal line can be formed by resonant proton cyclotron scattering leading to a magnetic field which is two orders of magnitude larger than the perpendicular component of the surface dipole magnetic field (B) found from the rotation period (P) and the time rate of change in the rotation period (\.{P}) of 1E 1207.4-5209. Besides, age of the supernova remnant (SNR) G296.5+10.0 which is physically connected to 1E 1207.4-5209 is two orders of magnitude smaller than the characteristic age ($\tau$=P/2\.{P}) of the neutron star. These huge differences between the magnetic field values and the ages can be explained based on a B-decay model. If the decay is assumed to be exponential, the characteristic decay time turns out to be several thousand years which is three orders of magnitude smaller than the characteristic decay time of radio pulsars represented in an earlier work. The lack of detection of radio emission from DRQNSs and the lack of point sources and pulsar wind nebulae in most of the observed SNRs can also be partly explained by such a very rapid exponential decay. The large difference between the characteristic decay times of DRQNSs and radio pulsars must be related to the differences in the magnetic fields, equation of states and masses of these isolated neutron stars.Comment: 13 pages, 1 figur

TOPLU KONUT ÜRETİMİNDE TÜNEL KALIP SİSTEMİ UYGULAMALARI VE KARŞILAŞILAN SORUNLAR

This study is about the problems faced in the application and the utilization of tunnel formwork system that is commonly used to meet the residence need increasing every passing day. Having some problems that could not be solved because of the details not applied by the manufacturers thought of production costs, constitutes disadvantages beside its benefits to our country and manufacture in terms of system. In the formation of the study, various books, thesis, articles, web sites about the industrialized construction techniques and tunnel formwork production system and the catalogues of construction firms are scanned and these materials contributed to obtain the findings by the use of scan-describe method. During the stage of determining the problems, the housing estate applications built with tunnel formwork system in Konya are chosen as the work area and the visual data – obtained by research-observation – belonging to these applications are utilized. As a result it can be said that if solution ways directed at the encountered problems depending on the wrong applications of production firms because of their economical worries are not searched, this system will no longer be advantageous.Bu çalışma, her geçen gün daha da çok artan konut ihtiyacının karşılanmasında yaygın olarak kullanılan tünel kalıp sisteminin uygulama ve kullanımında karşılaşılan sorunlarla ilgilidir. Ülkemiz ve üretim adına kazandırdıklarının yanında üretici firmaların maliyeti düşünerek uygulayamadıkları detaylar sonucunda halen çözülemeyen sorunlarının bulunması sistem açısından dezavantaj oluşturmaktadır. Çalışmanın oluşmasında, endüstrileşmiş yapım teknikleri ve tünel kalıp üretim sistemiyle ilgili olan çeşitli kitaplar, tezler, makaleler, web siteleri, inşaat firmalarının katalogları taranmış ve bu materyaller tarama-betimleme yöntemi kullanılarak bulguların elde edilmesine katkı sağlamıştır. Sorunların tespitinin yapılması aşamasında çalışma alanı olarak Konya’da tünel kalıp sistemiyle üretilen toplu konut uygulamaları seçilerek, bu uygulamalara ait araştırma-gözlemleme sonucu elde edilen görsel verilerden yararlanılmıştır. Üretici firmaların ekonomik kaygıları sebebiyle yanlış uygulamalarından dolayı karşılaşılan sorunlara yönelik bir an önce çözüm yolları aranmaz ise sistemin avantajlı durumunun zaman içerisinde tersine döneceği sonucuna varılmıştır

The Limbic Degradation of Aging Brain: A Quantitative Analysis with Diffusion Tensor Imaging

WOS: 000335020000001PubMed ID: 24977184Introduction. The limbic system primarily responsible for our emotional life and memories is known to undergo degradation with aging and diffusion tensor imaging (DTI) is capable of revealing thewhite matter integrity. Theaimof this study is to investigate agerelated changes of quantitative diffusivity parameters and fiber characteristics on limbic system in healthy volunteers. Methods. 31 healthy subjects aged 25-70 years were examined at 1,5 TMR. Quantitative fiber tracking was performed of fornix, cingulum, and the parahippocampal gyrus. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) measurements of bilateral hippocampus, amygdala, fornix, cingulum, and parahippocampal gyrus were obtained as related components. Results. The FA values of left hippocampus, bilateral parahippocampal gyrus, and fornix showed negative correlations with aging. The ADC values of right amygdala and left cingulum interestingly showed negative relation and the left hippocampus represented positive relation with age. The cingulum showed no correlation. The significant relative changes per decade of age were found in the cingulum and parahippocampal gyrus FA measurements. Conclusion. Our approach shows that aging affects hippocampus, parahippocampus, and fornix significantly but not cingulum. These findings reveal age-related changes of limbic system in normal population that may contribute to future DTI studies