Summer crops: relative water use efficiencies and legacy impacts in farming systems

Take home message • While summer crops offer rotational options in the farming system, choose the correct crop to match your available soil water and crop history • Sorghum is a reliable performer often exceeding other options in terms of $returned per mm used • Cotton and maize require higher water availability and produce less reliable WUE ($/mm). However, cotton has legacy impacts on water availability for subsequent crops that should be considered • Mungbean can produce higher $/mm in low water availability situations ( 150 mm of plant available water will maximise crop WUE and profitability. Every extra mm at sowing could be worth as much as$35-70 extra return/ha • Higher density sorghum crops may provide greater crop competition against weeds and potential upside yield benefits in good season. We have seen limited legacy benefits (e.g. improved ground cover) or costs (e.g. greater soil water/nutrient extraction) for soil water or nutrient availability

Cover crops improve ground cover in a very dry season

Take home messages • Previous trials have shown cover crops can increase stored fallow water and improve crop performance and returns in northern farming systems • A cover crop in a long fallow (14 months) in a dry season allowed improved ground cover with no net deficit in soil water. The extra ground cover improved the opportunity to deep plant wheat. • A cover crop in a short fallow had a water cost that translated to a yield penalty. • When the sorghum stopped growing in dry conditions it continued to use water, for no biomass (or cover) increase when it wasn’t sprayed out

Nitrogen and water dynamics in farming systems – multi-year impact of crop sequences

Take home messages • Grain legumes have utilised soil mineral nitrogen (N) to the same extent as cereal crops and have higher N export which often offsets N fixation inputs • Additional applied N reduced the depletion of background soil mineral N status at most sites; we are recovering a high percentage (>50%) in soil mineral pool. • Application of ~50 t/ha of compost or manure (10 t/ha OC) coupled with N fertiliser rates for 90th percentile yield potential has dramatically increased the soil mineral N in four years • Decreasing cropping frequency has reduced N export and so stored more N over the longer fallows, which has reduced N fertiliser requirements for following crops • Long fallows are mineralising N and moving N down the soil profile even under some very dry conditions • Most excess N is not lost in the system rather it is moved down the soil profile for future crops • The marginal WUE of crops (i.e. the grain yield increase per extra mm of available water) is lower when crops have less than 100 mm prior to planting. Hence, waiting until soil moisture reaches these levels is critical to maximise conversion of accumulated soil moisture into grain • The previous crop influences the efficiency of fallow water accumulation with winter cereals > sorghum > pulses. Long fallows are also less efficient than shorter fallows (<8 months). This has implications for assuming how much soil moisture may have accumulated during fallows

Target prices for mass production of tyrosine kinase inhibitors for global cancer treatment

OBJECTIVE: To calculate sustainable generic prices for 4 tyrosine kinase inhibitors (TKIs). BACKGROUND: TKIs have proven survival benefits in the treatment of several cancers, including chronic myeloid leukaemia, breast, liver, renal and lung cancer. However, current high prices are a barrier to treatment. Mass production of low-cost generic antiretrovirals has led to over 13 million people being on HIV/AIDS treatment worldwide. This analysis estimates target prices for generic TKIs, assuming similar methods of mass production. METHODS: Four TKIs with patent expiry dates in the next 5 years were selected for analysis: imatinib, erlotinib, lapatinib and sorafenib. Chemistry, dosing, published data on per-kilogram pricing for commercial transactions of active pharmaceutical ingredient (API), and quotes from manufacturers were used to estimate costs of production. Analysis included costs of excipients, formulation, packaging, shipping and a 50% profit margin. Target prices were compared with current prices. Global numbers of patients eligible for treatment with each TKI were estimated. RESULTS: API costs per kg were $347–$746 for imatinib, $2470 for erlotinib,$4671 for lapatinib, and $3000 for sorafenib. Basing on annual dose requirements, costs of formulation/packaging and a 50$128–$216 for imatinib,$240 for erlotinib, $1450 for sorafenib, and$4020 for lapatinib. Over 1 million people would be newly eligible to start treatment with these TKIs annually. CONCLUSIONS: Mass generic production of several TKIs could achieve treatment prices in the range of $128–$4020 per person-year, versus current US prices of $75161–$139 138. Generic TKIs could allow significant savings and scaling-up of treatment globally, for over 1 million eligible patients

Managing crop differences in soil water extraction and legacy impacts within a farming system

Take home message Shorter season, faster maturing crops can leave residual surface water from unutilised late season rain and/or residual deep water due to shallower roots and quicker maturity Legumes such as lentils, fababeans, field pea, and chickpea often leave 20-40 mm extra residual soil water compared to canola and winter cereals Higher residual water may not remain at sowing of next crop – fallow efficiency differences between crops and seasons can influence this – e.g. low cover after legumes For summer crops, mungbean typically leaves 20mm more residual water than sorghum/maize while cotton leaves 20mm less (i.e. mungbean > sorghum/maize > cotton) Early-sown, slower maturing crops (e.g. early sown winter crops) can dry the profile deeper (>2m) and utilise deep stored soil to support higher yield in dry springs. The legacy of drier soil may warrant changes to crop sequence and management to avoid yield penalties Extra residual water at sowing can increase grain yield of subsequent crops when water is limited during the critical period for yield determination so the marginal WUE (i.e. extra yield per mm of extra soil water available) can be very high (>60kg/ha/mm) As the value of the residual water is seasonally dependent, understanding how management (crop choice, sowing dates, N management) can be adjusted to capture value from such legacies across a sequence of crops is the goal of current farming systems research

Midlatitude shelf seas in the Cenomanian-Turonian greenhouse world: Temperature evolution and North Atlantic circulation

An 8 million year record of subtropical and midlatitude shelf-sea temperatures, derived from oxygen isotopes of well-preserved brachiopods from a variety of European sections, demonstrates a long-term Cenomanian temperature rise (16–20°C, midlatitudes) that reached its maximum early in the late Turonian (23°C, midlatitudes). Superimposed on the long-term trend, shelf-sea temperatures vary at shorter timescales in relation to global carbon cycle perturbations. In the mid-Cenomanian and the late Turonian, two minor shelf-sea cooling events (2–3°C) coincide with carbon cycle perturbations and times of high-amplitude sea level falls. Although this evidence supports the hypothesis of potential glacioeustatic effects on Cretaceous sea level, the occurrence of minimum shelf-sea temperatures within transgressive beds argues for regional changes in shelf-sea circulation as the most plausible mechanism. The major carbon cycle event in the latest Cenomanian (oceanic anoxic event 2) is accompanied by a substantial increase in shelf-sea temperatures (4–5°C) that occurred ∼150 kyr after the commencement of the δ13C excursion and is related to the spread of oceanic conditions in western European shelf-sea basins. Our oxygen isotope record and published δ18O data of pristinely preserved foraminifera allow the consideration of North Atlantic surface water properties in the Cenomanian along a transect from the tropics to the midlatitudes. On the basis of fossil-derived δ18O, estimated δw ranges, and modeled salinities, temperature-salinity-density ranges were estimated for tropical, subtropical, and midlatitude surface waters. Accordingly, the Cenomanian temperate shelf-seas waters have potentially the highest surface water density and could have contributed to North Atlantic intermediate to deep waters in the preopening stage of the equatorial Atlantic gateway

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis