Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

PURPOSE:The aim of this study was to retrospectively assess the correlation between minimum apparent diffusion coefficient (ADCmin) values obtained from diffusion-weighted magnetic resonance imaging (MRI) and maximum standardized uptake values (SUVmax) obtained from positron emission tomography-computed tomography (PET-CT) in rectal cancer. MATERIALS AND METHODS: Forty-one patients with pathologically confirmed rectal adenocarcinoma were included in this study. For preoperative staging, PET-CT and pelvic MRI with diffusion-weighted imaging were performed within one week (mean time interval, 3±1 day). For ADC measurements, the region of interest (ROI) was manually drawn along the border of each hyperintense tumor on b=1000 s/mm2 images. After repeating this procedure on each consecutive tumor-containing slice to cover the entire tumoral area, ROIs were copied to ADC maps. ADCmin was determined as the lowest ADC value among all ROIs in each tumor. For SUVmax measurements, whole-body images were assessed visually on transaxial, sagittal, and coronal images. ROIs were determined from the lesions observed on each slice, and SUVmax values were calculated automatically. The mean values of ADCmin and SUVmax were compared using Spearman’s test. RESULTS:The mean ADCmin was 0.62±0.19×10-3 mm2/s (range, 0.368–1.227×10-3 mm2/s), the mean SUVmax was 20.07±9.3 (range, 4.3–49.5). A significant negative correlation was found between ADCmin and SUVmax (r=-0.347; P = 0.026). CONCLUSION:There was a significant negative correlation between the ADCmin and SUVmax values in rectal adenocarcinomas

Yüksek pozitif ekspiryum sonu basıncı nedeniyle oluşan pnömomediyastinum olgusu

A 26-year-old female patient, who presented to the emergency department with chronic renal failure, general condition disturbance and dyspnea, was intubated due to low oxygen saturation. The results of the blood biochemical test were normal except for low saturation. Our case did not have any coronary artery disease or obstructive pulmonary disease. While she was undergoing the positive end-expiratory pressure (PEEP) treatment in the intensive care unit, the patient was detected to have right heart failure on her echocardiogram examination and pneumomediastinum was found on her direct radiography examination and on chest x-ray and computed tomography (CT) on the 2nd day of her hospitalization. The development of pneumomediastinum associated with PEEP for low saturation appears to be a rare phenomenon. In accompany with the findings of the case, the examination data and the literature information were prepared as a case report.Kronik böbrek yetmezliği, genel durum bozukluğu ve solunum sıkıntısı ile acil servise başvuran 26 yaşındaki kadın hasta satürasyon problemi nedeniyle entübe edildi. Satürasyon düşüklüğü dışında genel kan biyokimyasında belirgin patoloji ayırt edilmedi. Olguda koroner arter hastalığı ya da kronik obstruktif akciğer hastalığı yoktu. Yoğun bakımda, pozitif ekspiryum sonu basınç (PEEP) tedavisi altındayken, ekokardiyografi (EKO) tetkikinde olgunun sağ kalp yetmezliği olduğu ve direkt grafi tetkikinde, yatışının 2. gününde akciğer grafisinde ve bilgisayarlı tomografi (BT) tetkikinde pnömomediyastinum tespit edildi. Düşük saturasyon için yapılan pozitif expirium sonu basınç (PEEP) tedavisi altında iken pnömomediastinum gelişmesi nadir bir durumdur. Olgunun bulguları eşliğinde tetkik verileri ve literatür bilgisi olgu sunumu olarak hazırlandı

COVID-19 vaccinations: summary guidance for Cancer patients in 28Languages: breaking barriers to Cancer patient Information

Background: Covid-19 vaccination has started in the majority of the countries at the global level. Cancer patients are at high risk for infection, serious illness, and death from COVID-19 and need vaccination guidance and support. Guidance availability in the English language only is a major limit for recommendations' delivery and their application in the world's population and generates information inequalities across the different populations. Methods: Most of the available COVID-19 vaccination guidance for cancer patients was screened and scrutinized by the European Cancer Patients Coalition (ECPC) and an international oncology panel of 52 physicians from 33 countries. Results: A summary guidance was developed and provided in 28 languages in order to reach more than 70 percent of the global population. Conclusion: Language barrier and e-guidance availability in the native language are the most important barriers when communicating with patients. E-guidance availability in various native languages should be considered a major priority by international medical and health organizations that are communicating with patients at the global level.info:eu-repo/semantics/publishedVersio

The Sariçiçek Howardite Fall in Turkey: Source Crater of HED Meteorites on Vesta and İmpact Risk of Vestoids

The Sariçiçek howardite meteorite shower consisting of 343 documented stones occurred on 2 September 2015 in Turkey and is the first documented howardite fall. Cosmogenic isotopes show that Sariçiçek experienced a complex cosmic ray exposure history, exposed during ~12–14 Ma in a regolith near the surface of a parent asteroid, and that an ~1 m sized meteoroid was launched by an impact 22 ± 2 Ma ago to Earth (as did one third of all HED meteorites). SIMS dating of zircon and baddeleyite yielded 4550.4 ± 2.5 Ma and 4553 ± 8.8 Ma crystallization ages for the basaltic magma clasts. The apatite U-Pb age of 4525 ± 17 Ma, K-Ar age of ~3.9 Ga, and the U,Th-He ages of 1.8 ± 0.7 and 2.6 ± 0.3 Ga are interpreted to represent thermal metamorphic and impact-related resetting ages, respectively. Petrographic, geochemical and O-, Cr- and Tiisotopic studies confirm that Sariçiçek belongs to the normal clan of HED meteorites. Petrographic observations and analysis of organic material indicate a small portion of carbonaceous chondrite material in the Sariçiçek regolith and organic contamination of the meteorite after a few days on soil. Video observations of the fall show an atmospheric entry at 17.3 ± 0.8 kms-1 from NW, fragmentations at 37, 33, 31 and 27 km altitude, and provide a pre-atmospheric orbit that is the first dynamical link between the normal HED meteorite clan and the inner Main Belt. Spectral data indicate the similarity of Sariçiçek with the Vesta asteroid family (V-class) spectra, a group of asteroids stretching to delivery resonances, which includes (4) Vesta. Dynamical modeling of meteoroid delivery to Earth shows that the complete disruption of a ~1 km sized Vesta family asteroid or a ~10 km sized impact crater on Vesta is required to provide sufficient meteoroids ≤4 m in size to account for the influx of meteorites from this HED clan. The 16.7 km diameter Antonia impact crater on Vesta was formed on terrain of the same age as given by the 4He retention age of Sariçiçek. Lunar scaling for crater production to crater counts of its ejecta blanket show it was formed ~22 Ma ago

Discussing a new direction for design management through a new design management audit framework

12th International Conference of the European-Academy-of-Design (EAD) -- APR 12-14, 2017 -- Sapienza Univ Rome, Fac Architecture, Rome, ITALYWOS: 000419738000046Design management has evolved from the simple view as the management of design projects and processes, to include more upstream responsibilities and skills, at the intersection of design and strategic management. Recent literature highlights the role of design in leading and shaping company strategy, conceiving new business models, and in driving organizational change and renewal. Yet existing tools and frameworks for assessing design management capabilities fall short in catching up with the transition that has been undergoing in the ways design is utilized and managed inside organizations. This paper presents a new Design Management Audit Framework that aims to fill the gaps in existing tools by incorporating new capabilities that are increasingly emphasized by the emerging design, design management and strategic management literature. The tool also seeks to provide an answer to the question: "What are the new capabilities to be integrated into design management practices of our future economies?"European Academy of Desig

Technical Difficulties and Proposed Solutions of Özkan Manav’s “Aman Avcı” Arrangement for Op.41 for Double Bass and Piano

When looking at Contemporary Turkish Music, it is noticeable that the works of the second and third generation Turkish composers who came after the Turkish Five have achieved an advanced level of mastery. This research examines “Aman Avcı” for Op.41 Double Bass and Piano, an arrangement of Özkan Manav, one of the third-generation composers. By blending the touches of Western and Turkish music, a unique musical perceptions seen in the composer’s works, where pieces from Stravinsky, Saygun and Sciarrio can also be felt. Especially his emphasis on locality in his music is a notable musical perception that stands out in his other works, as in the example of the Azeri folk song "Aman Avcı", which is the subject of this research. In the content of the research, firstly Contemporary Turkish Music composers were mentioned, the life of the composer was explained and by introducing the Op.41 Double Bass and Piano arrangement of “Aman Avcı”, technical difficulties of the work were identified. At this point, it is aimed to shed light on the works of the double bass artists who will perform the piece

Eduard Tubin Kontrabas Konçertosu ve İcrasındaki Zorluk Dereceleri’nin Ölçümü

The double bass concerto, written by Estonian composer Eduard Tubin in 1948, greatly contributed to double bass repertoire. It can be said that this work, which is in the repertoires of musicians playing double bass today and is appreciated, is worth performing in terms of technical difficulty, melodic structure, and rhythmic difficulty among other double bass works. The purpose of this research is to identify the difficulties and reveal some solutions by solving them. In this study, a questionnaire form was created in consultation with experts in the field to determine the melodic, rhythmic, and technical difficulties that may be encountered during the performance of the concerto. The prepared questionnaire was distributed to the double bass students and lecturers at the State Conservatories of universities in Turkey and to the double bass artists from symphony orchestras in Turkey. The research is a qualitative research method. The data were analysed by purposive sampling method. The research includes the voluntarily participated 9 double bass academicians and musicians. The answers were obtained by e-mail. The solutions and interpretations of the data were made in accordance with qualitative research methods. In the light of the findings obtained from the survey results, it is believed that the approach and the interpretation of the work will carry the performance of the work to a different and beautiful level.Estonyalı besteci Eduard Tubin’in 1948 yılında yazdığı kontrabas konçertosu, kontrabas repertuvarına büyük ölçüde katkı sağlamıştır. Günümüzde kontrabas çalan müzisyenlerin repertuvarlarında yer alan ve beğenilen bu eserin, diğer kontrabas eserleri arasında; melodik yapı, teknik ve ritmik zorluk bakımından seslendirilmeye değer olduğu söylenebilir. Bu araştırmanın amacı; meydana gelen zorlukların tespitini yapmak ve bulguların yorumuyla, bazı çözüm önerilerini ortaya koymaktır. Çalışmada konçertonun icrası esnasında karşılaşılabilecek melodik, teknik ve ritmik zorlukların tespit edilmesi için alanında uzman kişilere danışılarak anket formu oluşturulmuştur. Hazırlanan anket formu, Türkiye’deki Üniversitelerin Devlet Konservatuvarlarındaki akademisyenlere ve senfoni orkestralarında yer alan kontrabas sanatçılarına dağıtılmıştır. Araştırma nitel araştırma yöntemidir. Veriler amaçlı örnekleme yöntemi ile incelenmiştir. Araştırma; akademisyen ve kontrabas sanatçılarının oluşturduğu, gönüllü katılan dokuz kişiyi kapsamaktadır. Cevaplar elektronik posta yolu ile elde edilmiştir. Verilerin çözümleri ve yorumları nitel araştırma yöntemlerine uygun olarak yapılmıştır. Anket sonuçlarından edinilen bulgular ışığında; esere yaklaşım ve yorumlamayla birlikte, icranın daha farklı ve güzel bir boyuta taşınması amaçlanmıştır