Engineering geology and geotechnical summary of central Glasgow in the vicinity of the UK Geoenergy Observatories field sites

This report presents the engineering and geotechnical properties of the geological units that will be encountered in the Glasgow UK Geoenergy Observatories (UKGEOS) site and environs, Glasgow. The data is from third party ground investigations provided by client, consultants and contractors. The data is extracted from analogue reports (paper or pdf files) or is ‘downloaded’ from Association of Geotechnical and Geoenvironmental Specialist (AGS) data transfer file and stored in the BGS National Geotechnical Properties Database from where it was accessed. As there is limited data nearby the proposed UKGEOS sites the data is from a wider area most notably for the deeper bedrock. The first part of the report briefly introduces the UKGEOS project and the context of this report. Section 2 shows where the UKGEOS site locations and the target formation for the low enthalpy energy. Section 3 gives the borehole locations of the different parameters. Section 4 is about the engineering geology of the different geological units and includes engineering descriptions, various graphs of the different geotechnical parameters and gives a brief interpretation of the data

3D geological models and their hydrogeological applications : supporting urban development : a case study in Glasgow-Clyde, UK

Urban planners and developers in some parts of the United Kingdom can now access geodata in an easy-to-retrieve and understandable format. 3D attributed geological framework models and associated GIS outputs, developed by the British Geological Survey (BGS), provide a predictive tool for planning site investigations for some of the UK's largest regeneration projects in the Thames and Clyde River catchments. Using the 3D models, planners can get a 3D preview of properties of the subsurface using virtual cross-section and borehole tools in visualisation software, allowing critical decisions to be made before any expensive site investigation takes place, and potentially saving time and money. 3D models can integrate artificial and superficial deposits and bedrock geology, and can be used for recognition of major resources (such as water, thermal and sand and gravel), for example in buried valleys, groundwater modelling and assessing impacts of underground mining. A preliminary groundwater recharge and flow model for a pilot area in Glasgow has been developed using the 3D geological models as a framework. This paper focuses on the River Clyde and the Glasgow conurbation, and the BGS's Clyde Urban Super-Project (CUSP) in particular, which supports major regeneration projects in and around the City of Glasgow in the West of Scotland

Environmental factors influencing pipe failures

This report details work carried out under NERC grants NE/M008339/1 and NE/NO13026/1 which were collaborations between the British Geological Survey and Yorkshire Water, with an additional knowledge transfer component involving Scottish Water and Dŵr Cymru Welsh Water. The work examines whether models developed using environmental, topographical and geohazard information could complement existing management tools, and increase the understanding as to how pipe networks of different materials interact with their broader environment. This can be seen as a first step in identifying ways in which greater resilience could be built into pipe networks

Emergence of good conduct, scaling and Zipf laws in human behavioral sequences in an online world

We study behavioral action sequences of players in a massive multiplayer online game. In their virtual life players use eight basic actions which allow them to interact with each other. These actions are communication, trade, establishing or breaking friendships and enmities, attack, and punishment. We measure the probabilities for these actions conditional on previous taken and received actions and find a dramatic increase of negative behavior immediately after receiving negative actions. Similarly, positive behavior is intensified by receiving positive actions. We observe a tendency towards anti-persistence in communication sequences. Classifying actions as positive (good) and negative (bad) allows us to define binary 'world lines' of lives of individuals. Positive and negative actions are persistent and occur in clusters, indicated by large scaling exponents alpha~0.87 of the mean square displacement of the world lines. For all eight action types we find strong signs for high levels of repetitiveness, especially for negative actions. We partition behavioral sequences into segments of length n (behavioral `words' and 'motifs') and study their statistical properties. We find two approximate power laws in the word ranking distribution, one with an exponent of kappa-1 for the ranks up to 100, and another with a lower exponent for higher ranks. The Shannon n-tuple redundancy yields large values and increases in terms of word length, further underscoring the non-trivial statistical properties of behavioral sequences. On the collective, societal level the timeseries of particular actions per day can be understood by a simple mean-reverting log-normal model.Comment: 6 pages, 5 figure

A 3D geological model for B90745 North Trans Pennine Electrification East between Leeds and York

This report and accompanying 3D geological model were produced for Tata Steel Projects. The report describes the bedrock and Quaternary geology of the study area, comprising 28 km (17.5 miles) of railway line between Leeds and York. The description and spatial distribution of each geological unit is based on the 3D geological model, which was constructed using 1:10,000 scale digital geological map data and 102 borehole logs from the British Geological Survey’s national archive. All boreholes located within the modelled area were considered in the construction of the geological model, together with key boreholes that fall outside the area of study. The top and base of weathered rock as defined is depicted as layers within the model

Change of nuclear configurations in the neutrinoless double-β\beta decay of 130^{130}Te →\rightarrow 130^{130}Xe and 136^{136}Xe →\rightarrow 136^{136}Ba

The change in the configuration of valence protons between the initial and final states in the neutrinoless double-$\beta$ decay of $^{130}$Te $\rightarrow$ $^{130}$Xe and of $^{136}$Xe $\rightarrow$ $^{136}$Ba has been determined by measuring the cross sections of the ($d$,$^3$He) reaction with 101-MeV deuterons. Together with our recent determination of the relevant neutron configurations involved in the process, a quantitative comparison with the latest shell-model and interacting-boson-model calculations reveals significant discrepancies. These are the same calculations used to determine the nuclear matrix elements governing the rate of neutrinoless double-$\beta$ decay in these systems.Comment: 10 pages, 4 figures, 9 table

Anti-tumour therapeutic efficacy of OX40L in murine tumour model

OX40 ligand (OX40L), a member of TNF superfamily, is a co-stimulatory molecule involved in T cell activation. Systemic administration of mOX40L fusion protein significantly inhibited the growth of experimental lung metastasis and subcutaneous (s.c.) established colon (CT26) and breast (4T1) carcinomas. Vaccination with OX40L was significantly enhanced by combination treatment with intra-tumour injection of a disabled infectious single cycle-herpes simplex virus (DISC-HSV) vector encoding murine granulocyte macrophage-colony stimulating factor (mGM-CSF). Tumour rejection in response to OX40L therapy required functional CD4+ and CD8+ T cells and correlated with splenocyte cytotoxic T lymphocytes (CTLs) activity against the AH-1 gp70 peptide of the tumour associated antigen expressed by CT26 cells. These results demonstrate the potential role of the OX40L in cancer immunotherapy

Safety and immunogenicity of a novel multiple antigen pneumococcal vaccine in adults: A Phase 1 randomised clinical trial

BACKGROUND: Pneumococcal vaccines, combining multiple protein antigens, provide an alternative approach to currently marketed vaccines and may provide broader protection against pneumococcal disease. This trial evaluated the safety and immunogenicity of a novel vaccine candidate PnuBioVax in healthy young adults. METHODS: In a Phase 1 double-blind study, 36 subjects (18–40 years) were randomised to receive 3 doses of PnuBioVax, 28 days apart, at one of three dose levels (50, 200, 500 µg) or placebo. Safety assessments included rates of emergent adverse events (AEs), injection site and systemic reactions. Immunogenicity endpoints included antibody titre against PnuBioVax and selected pneumococcal antigens. RESULTS: In the placebo (n = 9) and PnuBioVax (n = 27) vaccinated subjects, there were 15 and 72, reported TEAEs, respectively. The majority of TEAEs were classified as common vaccine related AEs. There were no serious AEs. Common vaccine-related AEs occurred in 13 PnuBioVax (48%) and 2 placebo (22%) subjects and were all headaches (mild and moderate). Injection site reactions, mostly pain and tenderness (graded mild or moderate) were reported, in particular in the 200 µg and 500 µg PnuBioVax groups. There were no clinically significant changes in vital signs, ECG or blood chemistries. Subjects receiving the higher dose (200 and 500 μg) demonstrated a greater fold increase in IgG titre compared with the starting dose (50 μg) or the placebo group. The fold-increase was statistically significantly higher for 200 and 500 µg PnuBioVax vs 50 µg PnuBioVax and placebo at each timepoint post-immunisation. Most subjects receiving 200 and 500 µg PnuBioVax demonstrated a ≥2-fold increase in antibody against pneumolysin (Ply), Pneumococcal surface antigen (PsaA), PiaA (Pneumococcal iron acquisition), PspA (Pneumococcal surface protein A) and pilus proteins (RrgB and RrgA). CONCLUSIONS: All dose levels were considered safe and well tolerated. There was a statistically significant increase in anti-PnuBioVax IgG titres at the 200 and 500 µg dose levels compared to 50 µg and placebo. Trial registration number: NCT02572635https://www.clinicaltrials.gov

Quaternary Heterogeneities: geospatial products for scientists, industry and decision making

Glaciation and permafrost has had a profound impact upon the UK landscape during the Quaternary. Their impact is most relevant within the ‘zone of human interaction’, the surface and near-surface parts of the geological record that humans utilise and exploit for societal and economic gain (e.g. infrastructure development, groundwater, energy, storage and minerals). However, whilst the broad range of glacial and periglacial processes that have affected the UK are known, their spatial influence on the applied properties of the substrate are poorly-understood but have major implications for ground conditions and civil engineering. This lack of understanding is partly due to the complexity of the geological evidence, point or linear approaches to geological investigation and ‘lithostratigraphic’ approaches that have largely-overlooked the significance of heterogeneous products of glaciation and permafrost. Within this project, we are developing a range of national-scale GIS datasets that will highlight the ‘known’ distribution of specific ‘Quaternary Heterogeneities’ in the shallow sub-surface and identify zones of extrapolated susceptibility in areas where data coverage is limited using a series of genetic and geostatistical rules. Spatial data-sets are currently in development for glaciotectonic structure, buried valleys, drift-filled hollows, blockfields and frost weathering. These datasets are aimed at both scientific and applied users (e.g. civil engineers, insurers, hydrogeologists, planners and decision makers), enhancing scientific understanding of glacial and periglacial processes and their spatial influence on the properties of the landscape and sub-surface

The mineralogy and fabric of 'Brickearths' in Kent, UK and their relationship to engineering behaviour

Mineralogical and petrographical investigation of two loessic brickearth profiles from Ospringe and Pegwell Bay in north Kent, UK have differentiated two types of brickearth fabric that can be correlated with different engineering behaviour. Both sequences comprise metastable (collapsing) calcareous brickearth, overlain by non collapsing ‘non-calcareous’ brickearth. This study has demonstrated that the two types of brickearth are discretely different sedimentary units, with different primary sedimentary characteristics and an erosional junction between the two units. A palaeosol is developed on the calcareous brickearth, and is associated with the formation of rhizolithic calcrete indicating an arid or semi-arid environment. No evidence has been found for decalcification being responsible for the fabric of the upper ‘non-calcareous’ brickearth. Optically-stimulated dates lend further support for the calcareous and ‘non-calcareous’ brickearth horizons being of different age or origins. The calcareous brickearth is metastable in that it undergoes rapid collapse settlement when wetted under applied stresses. It is characterised by an open-packed arrangement of clay-coated, silt-sized quartz particles and pelletised aggregate grains (peds) of compacted silt and clay, supported by an interped matrix of loosely packed, silt/fine-grained sand, in which the grains are held in place by a skeletal framework of illuviated clay. The illuviated clay forms bridges and pillars separating and binding the dispersed component silt/sand grains. There is little direct grain-to-grain contact and the resultant fabric has a very high voids ratio. Any applied load is largely supported by these delicate clay bridge and pillar microfabrics. Collapse of this brickearth fabric can be explained by a sequence of processes involving: (1) dispersion and disruption of the grain-bridging clay on saturation, leading to initial rapid collapse of the loose packed inter-ped silt/sand; (2) rearrangement and closer stacking of the compact aggregate silt/clay peds; (3) with increasing stress further consolidation may result from deformation and break up of the peds as they collapse into the inter-ped regions. Smectite is a significant component of the clay assemblage and will swell on wetting, further encouraging disruption and breaking of the clay bonds. In contrast, the ‘non-calcareous’ brickearth already possesses a close-packed and interlocking arrangement of silt/sand grains with only limited scope for further consolidation under load. Minor authigenic calcite and dolomite may also form meniscus cements between silt grains. These have either acted as ‘‘scaffolds’’ on which illuviated clay has subsequently been deposited or have encrusted earlier formed grain-bridging clay. In either case, the carbonate cements may help to reinforce the clay bridge fabrics. However, these carbonate features are a relatively minor feature and not an essential component of the collapsible brickearth fabric. Cryoturbation and micromorphological features indicate that the calcareous brickearth fabric has probably been developed through periglacial freeze–thaw processes. Freezing could have produced the compact silt/clay aggregates and an open porous soil framework containing significant inter-ped void space. Silt and clay were remobilised and translocated deeper into the soil profile by water percolating through the active layer of the sediment profile during thawing cycles, to form the loosed packed inter-ped silt matrix and grain-bridging meniscus clay fabrics. In contrast, the upper ‘non-calcareous’ brickearth may represent a head or solifluction deposit. Mass movement during solifluction will have destroyed any delicate grain-bridging clay microfabrics that may have been present in this material