2,469 research outputs found
Calculation of the number of partitions with constraints on the fragment size
This article introduces recursive relations allowing the calculation of the
number of partitions with constraints on the minimum and/or on the maximum
fragment size
Investigation of the D and E regions of the ionosphere
Details of an experimental program that investigates the ionosphere using sounding rockets are presented. The investigation is part of a continuing program to gather data on the D and E regions of the ionosphere during periods of recurring natural phenomena that influence these regions. To achieve these ends, four vehicles were launched during the eclipse of the sun on March 7, 1970. Other vehicles totalling 10 in all were launched to investigate transient phenomena such as the sporadic E layer
LiBeB: High and low energy cosmic ray production and comparison with neutrino induced nucleosynthesis in SNII
We present new calculations of LiBeB production by accelerated particles with
various compositions and energy spectra ranging from low energies to
relativistic energies, and various ambient medium metallicities ().
The observed, essentially constant, Be/Fe ratio as a function of
can be best understood if the metallicity of the accelerated particles (high
energy or low energy) does not vary much with . This could be
achieved if the particles are accelerated directly from the ejecta of Type II
supernovae (SNII) and not from the interstellar medium. Using the observed
Be/Fe and the fact that most of the Fe at low is from SNII, we
derive the energy content in accelerated particles per SNII (a few times
10 erg). We show that additional B production by neutrinos is
consistent with the available data, allowing a neutrino yield from SNII less
than or equal to the nominal published yields. We further show that the
observed Li at low suggests that the accelerated particles
responsible for the LiBeB at such are confined to low energies and
have a relatively high He/O abundance.Comment: 9 pages with 4 emdedded figures, uuencoded, compressed, tared, style
files included. In press Nuclei In the Cosmos, Nuclear Physics, Conference
Proceeding
A phase Ib/II study of cabozantinib (XL184) with or without erlotinib in patients with non-small cell lung cancer.
PurposeCabozantinib is a multi-kinase inhibitor that targets MET, AXL, and VEGFR2, and may synergize with EGFR inhibition in NSCLC. Cabozantinib was assessed alone or in combination with erlotinib in patients with progressive NSCLC and EGFR mutations who had previously received erlotinib.MethodsThis was a phase Ib/II study (NCT00596648). The primary objectives of phase I were to assess the safety, pharmacokinetics, and pharmacodynamics and to determine maximum tolerated dose (MTD) of cabozantinib plus erlotinib in patients who failed prior erlotinib treatment. In phase II, patients with prior response or stable disease with erlotinib who progressed were randomized to single-agent cabozantinib 100 mg qd vs cabozantinib 100 mg qd and erlotinib 50 mg qd (phase I MTD), with a primary objective of estimating objective response rate (ORR).ResultsSixty-four patients were treated in phase I. Doses of 100 mg cabozantinib plus 50 mg erlotinib, or 40 mg cabozantinib plus 150 mg erlotinib were determined to be MTDs. Diarrhea was the most frequent dose-limiting toxicity and the most frequent AE (87.5% of patients). The ORR for phase I was 8.2% (90% CI 3.3-16.5). In phase II, one patient in the cabozantinib arm (N = 15) experienced a partial response, for an ORR of 6.7% (90% CI 0.3-27.9), with no responses for cabozantinib plus erlotinib (N = 13). There was no evidence that co-administration of cabozantinib markedly altered erlotinib pharmacokinetics or vice versa.ConclusionsDespite responses with cabozantinib/erlotinib in phase I, there were no responses in the combination arm of phase II in patients with acquired resistance to erlotinib. Cabozantinib did not appear to re-sensitize these patients to erlotinib
The Role of Demography in the Transition to Sustainable Societies
Currently, although the global population has surpassed 7.5 billion and continues to increase in about 80 million each year, attention to demography is almost absent in most of the studies and publications related to the current situation of planetary emergency and the necessary transition to sustainable societies. For this reason, our first aim in this paper has been to discuss if this current lack of attention to demography is justified or not. With this purpose, we begin considering the scientific meaning of Sustainability, in order to overlay distorted and impoverish views of this concept that may hinder our study. Then, we analyse the reasons given by experts for and against the incidence of demographic growth in the current unsustainable situation of planetary emergency. Finally, we present proposals to face the ensemble of interconnected socio-environmental problems (including demographic evolution), to make possible an appropriate transition to sustainable societies. Aunque la población mundial ha sobrepasado los 7500 millones y continúa aumentando anualmente en alrededor de 80 millones, la atención a la demografía está hoy prácticamente ausente en la mayoría de los estudios y publicaciones acerca de la actual situación de emergencia planetaria y la necesidad de una transición a sociedades sostenibles. Con el propósito de analizar si esta falta de atención a la demografía está o no justificada, en esta contribución comenzamos discutiendo el significado científico de Sostenibilidad socioambiental, para evitar concepciones distorsionadas y empobrecidas de este concepto que pueden dificultar dicho análisis. A continuación estudiaremos las razones dadas por distintos expertos a favor y en contra de la incidencia del crecimiento demográfico en la insostenible situación actual de emergencia planetaria. Finalmente presentamos propuestas para hacer frente al conjunto de problemas estrechamente interconectados - incluido el problema demográfico - que caracterizan dicha situación, para hacer así posible una adecuada transición a sociedades sostenibles
Molecular motion in cell membranes: analytic study of fence-hindered random walks
A theoretical calculation is presented to describe the confined motion of
transmembrane molecules in cell membranes. The study is analytic, based on
Master equations for the probability of the molecules moving as random walkers,
and leads to explicit usable solutions including expressions for the molecular
mean square displacement and effective diffusion constants. One outcome is a
detailed understanding of the dependence of the time variation of the mean
square displacement on the initial placement of the molecule within the
confined region. How to use the calculations is illustrated by extracting
(confinement) compartment sizes from experimentally reported published
observations from single particle tracking experiments on the diffusion of
gold-tagged G-protein coupled mu-opioid receptors in the normal rat kidney cell
membrane, and by further comparing the analytical results to observations on
the diffusion of phospholipids, also in normal rat kidney cells.Comment: 10 pages, 5 figure
Deciphering the folding kinetics of transmembrane helical proteins
Nearly a quarter of genomic sequences and almost half of all receptors that
are likely to be targets for drug design are integral membrane proteins.
Understanding the detailed mechanisms of the folding of membrane proteins is a
largely unsolved, key problem in structural biology. Here, we introduce a
general model and use computer simulations to study the equilibrium properties
and the folding kinetics of a -based two helix bundle fragment
(comprised of 66 amino-acids) of Bacteriorhodopsin. Various intermediates are
identified and their free energy are calculated toghether with the free energy
barrier between them. In 40% of folding trajectories, the folding rate is
considerably increased by the presence of non-obligatory intermediates acting
as traps. In all cases, a substantial portion of the helices is rapidly formed.
This initial stage is followed by a long period of consolidation of the helices
accompanied by their correct packing within the membrane. Our results provide
the framework for understanding the variety of folding pathways of helical
transmembrane proteins
Pion-Lambda-Sigma Coupling Extracted from Hyperonic Atoms
The latest measurements of the atomic level width in Sigma-hyperonic Pb atom
offer the most accurate datum in the region of low-energy Sigma-hyperon
physics. Atomic widths are due to the conversion of Sigma-nucleon into
Lambda-nucleon. In high angular momentum states this conversion is dominated by
the one-pion exchange. A joint analysis of the data of the scattering of
negative-Sigma on proton converting into a Lambda and a neutron and of the
atomic widths allows to extract a pseudovector pion-hyperon-Sigma coupling
constant of 0.048 with a statistical error of +-0.005 and a systematic one of
+-0.004. This corresponds to a pseudoscalar coupling constant of 13.3 with a
statistical uncertainty of 1.4 and a systematic one of 1.1.Comment: 12 pages, 1 figure, Use of Revtex.st
Meshfree finite differences for vector Poisson and pressure Poisson equations with electric boundary conditions
We demonstrate how meshfree finite difference methods can be applied to solve
vector Poisson problems with electric boundary conditions. In these, the
tangential velocity and the incompressibility of the vector field are
prescribed at the boundary. Even on irregular domains with only convex corners,
canonical nodal-based finite elements may converge to the wrong solution due to
a version of the Babuska paradox. In turn, straightforward meshfree finite
differences converge to the true solution, and even high-order accuracy can be
achieved in a simple fashion. The methodology is then extended to a specific
pressure Poisson equation reformulation of the Navier-Stokes equations that
possesses the same type of boundary conditions. The resulting numerical
approach is second order accurate and allows for a simple switching between an
explicit and implicit treatment of the viscosity terms.Comment: 19 pages, 7 figure
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