Lyman continuum leaker candidates among highly ionised, low-redshift dwarf galaxies selected from HeII

Contemporary research suggests that the reionisation of the intergalactic medium (IGM) in the early Universe was predominantly realised by star-forming (proto-)galaxies (SFGs). Due to observational constraints, our knowledge on the origins of sufficient amounts of ionising Lyman continuum (LyC) photons and the mechanisms facilitating their transport into the IGM remains sparse. Recent efforts have thus focussed on the study of local analogues to these high-redshift objects. We used archival spectroscopic SDSS DR12 data to select a sample of low-z He II 4686 emitters and restricted it to a set of SFGs with an emission line diagnostic sensitive to the presence of an AGN, which serves as our only selection criterion. Our final sample consists of eighteen low-mass, low-metallicity dwarf galaxies which appear to be predominantly ionised by stellar sources. We find large O32 ratios and [S II] deficiencies, which provide strong indications for these galaxies to be LyC Emitters (LCEs). At least 40% of these objects are candidates for featuring cosmologically significant LyC escape fractions >10%. Their SFHs exhibit strong similarities and almost all galaxies appear to contain an old (>1 Gyr) stellar component, while also harbouring a young, two-stage (~10 Myr and <1 Myr) starburst, which we speculate might be related to LyC escape. The properties of the compact emission line galaxies presented here align well with those observed in many local LCEs. In fact, our sample may prove as an extension to the rather small catalogue of local LCEs, as the extreme interstellar medium (ISM) conditions we find are assumed to facilitate LyC leakage. Notably, all of our eighteen candidates are significantly closer (z<0.1) than most established LCEs. If the inferred LyC photon loss is genuine, this demonstrates that selecting SFGs from He II 4686 is a powerful selection criterion in the search for LCEs.Comment: 28 pages, 22 figures. Accepted for publication in Astronomy & Astrophysic

Chronic psychosocial and financial burden accelerates 5-year telomere shortening: findings from the Coronary Artery Risk Development in Young Adults Study.

Leukocyte telomere length, a marker of immune system function, is sensitive to exposures such as psychosocial stressors and health-maintaining behaviors. Past research has determined that stress experienced in adulthood is associated with shorter telomere length, but is limited to mostly cross-sectional reports. We test whether repeated reports of chronic psychosocial and financial burden is associated with telomere length change over a 5-year period (years 15 and 20) from 969 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study, a longitudinal, population-based cohort, ages 18-30 at time of recruitment in 1985. We further examine whether multisystem resiliency, comprised of social connections, health-maintaining behaviors, and psychological resources, mitigates the effects of repeated&nbsp;burden on telomere attrition over 5 years. Our results indicate that adults with high chronic burden do not show decreased telomere length over the 5-year period. However, these effects do vary by level of resiliency, as regression results revealed a significant interaction between chronic burden and multisystem resiliency. For individuals with high repeated&nbsp;chronic burden and low multisystem resiliency (1 SD below the mean), there was a significant 5-year shortening in telomere length, whereas no significant relationships between chronic burden and attrition were evident for those at moderate and higher levels of resiliency. These effects apply similarly across the three components of resiliency. Results imply that interventions should focus on establishing strong social connections, psychological resources, and health-maintaining behaviors when attempting to ameliorate stress-related decline in telomere length among at-risk individuals

Effect of E-coli Nissle 1917 on post-inflammatory visceral sensory function in a rat model

Article first published online: 3 FEB 2005Objective:  Visceral hyperalgesia (VH) plays a key role for the manifestation of functional gastrointestinal (GI) disorders. In a subgroup of patients, the initial manifestation is preceded by GI inflammation. Recent studies have demonstrated an improvement of inflammation and symptoms during treatment with Escherichia coli Nissle 1917 (EcN). Aim:  We aimed to characterize the effects of EcN on visceral sensitivity in a rat model of post-inflammatory VH. Methods:  Male Lewis rats underwent colorectal instillation of trinitrobenzenesulphonic acid (TNBS) plus an equal amount of ethanol (test group) or physiological saline solution (control group). After 28, 35 and 42 days, standardized colorectal distensions were performed and the visceromotor reflex (VMR) of abdominal wall muscles was quantified by electromyographic recording. From day 28 onwards, EcN was administered in drinking water. Results:  After TNBS, a significant increase of VMR was observed compared with saline controls over all study days. Administration of EcN reduced the TNBS-induced hyperalgesia [EcN: 863 ± 125 μV vs placebo: 1258 ± 157 μV (P < 0.05)] at day 35, while there were no significant alterations at any other study day. Conclusion:  The EcN administration caused a significant reduction of VH. Whether EcN might play a role in the treatment of post-infectious functional bowel disorders remains to be investigated in further studies.Liebregts, B. Adam, A. Bertel, S. Jones, J. Schulze, C. Enders, U. Sonnenborn, K. Lackner and G. Holtman