1,747 research outputs found
Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations
Numerical model for the non-linear dynamic analysis of multi-storey structures with semi-rigid joints with specific reference to the Algerian code
Plasmoid ejection and secondary current sheet generation from magnetic reconnection in laser-plasma interaction
Reconnection of the self-generated magnetic fields in laser-plasma
interaction was first investigated experimentally by Nilson {\it et al.} [Phys.
Rev. Lett. 97, 255001 (2006)] by shining two laser pulses a distance apart on a
solid target layer. An elongated current sheet (CS) was observed in the plasma
between the two laser spots. In order to more closely model magnetotail
reconnection, here two side-by-side thin target layers, instead of a single
one, are used. It is found that at one end of the elongated CS a fan-like
electron outflow region including three well-collimated electron jets appears.
The ( MeV) tail of the jet energy distribution exhibits a power-law
scaling. The enhanced electron acceleration is attributed to the intense
inductive electric field in the narrow electron dominated reconnection region,
as well as additional acceleration as they are trapped inside the rapidly
moving plasmoid formed in and ejected from the CS. The ejection also induces a
secondary CS
miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions
MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system
MVA2023 Small Object Detection Challenge for Spotting Birds: Dataset, Methods, and Results
Small Object Detection (SOD) is an important machine vision topic because (i)
a variety of real-world applications require object detection for distant
objects and (ii) SOD is a challenging task due to the noisy, blurred, and
less-informative image appearances of small objects. This paper proposes a new
SOD dataset consisting of 39,070 images including 137,121 bird instances, which
is called the Small Object Detection for Spotting Birds (SOD4SB) dataset. The
detail of the challenge with the SOD4SB dataset is introduced in this paper. In
total, 223 participants joined this challenge. This paper briefly introduces
the award-winning methods. The dataset, the baseline code, and the website for
evaluation on the public testset are publicly available.Comment: This paper is included in the proceedings of the 18th International
Conference on Machine Vision Applications (MVA2023). It will be officially
published at a later date. Project page :
https://www.mva-org.jp/mva2023/challeng
A huge-amplitude white-light superflare on a L0 brown dwarf discovered by GWAC survey
White-light superflares from ultra cool stars are thought to be resulted from
magnetic reconnection, but the magnetic dynamics in a fully convective star is
not clear yet. In this paper, we report a stellar superflare detected with the
Ground Wide Angle Camera (GWAC), along with rapid follow-ups with the F60A,
Xinglong 2.16m and LCOGT telescopes. The effective temperature of the
counterpart is estimated to be K by the BT-Settl model,
corresponding to a spectral type of L0. The band light curve can be modeled
as a sum of three exponential decay components, where the impulsive component
contributes a fraction of 23\% of the total energy, while the gradual and the
shallower decay phases emit 42\% and 35\% of the total energy, respectively.
The strong and variable Balmer narrow emission lines indicate the large
amplitude flare is resulted from magnetic activity. The bolometric energy
released is about ergs, equivalent to an energy release in a
duration of 143.7 hours at its quiescent level. The amplitude of mag ( or mag), placing it one of the highest amplitudes of
any ultra cool star recorded with excellent temporal resolution. We argue that
a stellar flare with such rapidly decaying and huge amplitude at distances
greater than 1 kpc may be false positive in searching for counterparts of
catastrophic events such as gravitational wave events or gamma-ray bursts,
which are valuable in time-domain astronomy and should be given more attention.Comment: 9 pages, 5 figures, 1 table, MNRAS accepte
Towards the clinical implementation of pharmacogenetics in bipolar disorder.
BackgroundBipolar disorder (BD) is a psychiatric illness defined by pathological alterations between the mood states of mania and depression, causing disability, imposing healthcare costs and elevating the risk of suicide. Although effective treatments for BD exist, variability in outcomes leads to a large number of treatment failures, typically followed by a trial and error process of medication switches that can take years. Pharmacogenetic testing (PGT), by tailoring drug choice to an individual, may personalize and expedite treatment so as to identify more rapidly medications well suited to individual BD patients.DiscussionA number of associations have been made in BD between medication response phenotypes and specific genetic markers. However, to date clinical adoption of PGT has been limited, often citing questions that must be answered before it can be widely utilized. These include: What are the requirements of supporting evidence? How large is a clinically relevant effect? What degree of specificity and sensitivity are required? Does a given marker influence decision making and have clinical utility? In many cases, the answers to these questions remain unknown, and ultimately, the question of whether PGT is valid and useful must be determined empirically. Towards this aim, we have reviewed the literature and selected drug-genotype associations with the strongest evidence for utility in BD.SummaryBased upon these findings, we propose a preliminary panel for use in PGT, and a method by which the results of a PGT panel can be integrated for clinical interpretation. Finally, we argue that based on the sufficiency of accumulated evidence, PGT implementation studies are now warranted. We propose and discuss the design for a randomized clinical trial to test the use of PGT in the treatment of BD
Evidence for the h_b(1P) meson in the decay Upsilon(3S) --> pi0 h_b(1P)
Using a sample of 122 million Upsilon(3S) events recorded with the BaBar
detector at the PEP-II asymmetric-energy e+e- collider at SLAC, we search for
the spin-singlet partner of the P-wave chi_{bJ}(1P) states in the
sequential decay Upsilon(3S) --> pi0 h_b(1P), h_b(1P) --> gamma eta_b(1S). We
observe an excess of events above background in the distribution of the recoil
mass against the pi0 at mass 9902 +/- 4(stat.) +/- 2(syst.) MeV/c^2. The width
of the observed signal is consistent with experimental resolution, and its
significance is 3.1sigma, including systematic uncertainties. We obtain the
value (4.3 +/- 1.1(stat.) +/- 0.9(syst.)) x 10^{-4} for the product branching
fraction BF(Upsilon(3S)-->pi0 h_b) x BF(h_b-->gamma eta_b).Comment: 8 pages, 4 postscript figures, submitted to Phys. Rev. D (Rapid
Communications
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