An Interaction form Generation Tool: EduDesign

AbstractThis paper investigates contributions of customized and simplified generative design tools on the development of novice architects‟ abilities of accelerating their interactions with digital tools and adapting new digital design processes with them. For this purpose, a plugin, called as EduDesign and including various form generations and instructional practices based basic design education, have been developed by scripts of 3D software. Its potentials tested and enriched by different student groups experiences in KBU and ITU. According to the obtained results, positive and negative influences of the plugin are evaluated

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Ultrasonography Causes Agitation and Pain Leading to Hemodynamic Disturbance in Neonates: A Prospective Observational Study

Background: Ultrasonography is widely used in neonatological practice and studies investigating the hemodynamic effects of various treatment protocols or clinical situations. On the other hand, pain causes changes in the cardiovascular system; so, in the case of ultrasonography leading to pain in neonates, it may cause hemodynamic alterations. In this prospective study, we evaluate whether ultrasonographic application causes pain and changes in the hemodynamic system. Methods: Newborns undergoing ultrasonographic examination were enrolled in the study. Vital signs, cerebral and mesenteric tissue oxygenation (StO2) levels, and middle cerebral artery (MCA) Doppler measurements were recorded, and NPASS scores were calculated before and after ultrasonography. Results: We enrolled 39 patients in the study. After ultrasonography, Neonatal Pain, Agitation, and Sedation Scale (NPASS) scores were significantly higher (p 2, diastolic and systolic blood pressure; p = 0.03; p p p p = 0.02, p = 0.03, respectively) were altered. Cerebral (p = 0.008) and mesenteric (p = 0.039) StO2 levels were significantly lower in the whole study group, MCA end-diastolic velocity decreased (p = 0.02), and the resistive index (p = 0.03) increased in patients whose NPASS score was >7 after ultrasonography. Conclusions: This study is the first to show that ultrasonography may cause pain in newborn patients, and alters vital signs and hemodynamic parameters. Therefore, precautions should be taken to protect newborn babies from pain during ultrasound applications, as they are already exposed to many noxious stimuli. Furthermore, pain scores should be considered in studies using ultrasonography and evaluating hemodynamic parameters to increase the reliability of the studies

EVALUATION OF CHILDHOOD POISONINGS IN CUKUROVA REGION

WOS: 000269311600008Objective: The aim of this study was to clarify to determine the causes of childhood poisonings by time on account of socioeconomic and cultural alterations in Cukurova region and to steadily attain the data for treatment and prevention. Matetial and Method: This study was composed of poisoning cases attending to pediatric emergency medicine room from 1997 to 2001 with ages between 0-14 years old. The data about poisoning cases were extracted from patients' medical records in emergency room. In the study demographics of cases, the route and reason of poisonings and materials causing poisonings were evaluated. Results: In 5 years period totally 486 patients, 250 boys and 236 girls, were admitted to pediatric emergency room. Most of the poisoning cases were due to air accident (89.3%), and they were between 1-3 years old. Suicide attempts had the highest ratio in cases over 10 years age, and were more common in girls. The causes of poisoning were found to be drugs (42.6%), animal-insect bites insectisides-farming disinfectants (10.3%) and costic substances (8.6%). Most cases with drug poisonings were caused by CNS drugs, especially amitriptiline (32.8%). In all poisoning cases, 99.6% of cases have recovered completely but two cases (snake and scorpion envenomation) died (0.4%). Conclusion: The majority of poisonings in the childhood period happen due toaccidental ingestion of drugs. This condition shows us that simple precautions like family education, keeping drugs unreachable for children, unavailability of drugs without prescription and child-resistant package may prevent most of the poisonings

Early-Onset Neonatal Sepsis in Turkey: A Single-Center 7-Year Experience in Etiology and Antibiotic Susceptibility

Background: The pathogen distribution and antibiotic susceptibility of the pathogens in early-onset sepsis (EOS) differ between countries. The epidemiological data from a limited number of studies about EOS in Turkey are insufficient. In this study, we aimed to evaluate the culture-proven EOS cases, causative microorganisms, antibiotic susceptibility patterns, and risk factors for mortality in EOS. Methods: This is a retrospective, single-center study over a 7-year period, from 2013 to 2020, at Zeynep Kamil Maternity and Children’s Hospital, İstanbul, Turkey. Results: During the study period, 8229 newborns were admitted to our neonatal intensive care unit. Culture-proven EOS was detected in 101 patients (0.12%). Out of these, 56 (55.4%) were Gram-positive, and 45 (44.5%) were Gram-negative sepsis. The most common isolated organism was E. coli (28.7%, n = 29), followed by GBS (16.8%, n = 17) and S. aureus (15.8%, n = 16). An ampicillin and gentamicin combination had antimicrobial coverage in 92.6% of cases. Seventeen patients (16.8%) died because of EOS. Severe neutropenia was found to be an independent risk factor for mortality in EOS (p = 0.001, OR = 14.4, CI 95%: 2.8–74). Conclusions: Although the majority of causative agents were Gram-positive (55.4%), the most common isolated organism was E. coli. An empirical antibiotic regimen of ampicillin and gentamicin continues to have an adequate coverage for EOS in our population

The pathophysiology of Peyronie's disease

Objective: To review the contemporary knowledge of the pathophysiology of Peyronie's disease (PD)

Genetic structuring of Pseudopus apodus (Pallas, 1775) (Sauria: Anguidae) in north Anatolia, Turkey

WOS: 000325597600060In this study, mitochondrial 16S rRNA and cytochrome b sequences were used to infer the genetic structure of Pseudopus apodus (Pallas, 1775) populations sampled from 40 North latitude of Turkey. Mean percent G-C contents of 47.13 and 46.66 were determined for 16S rRNA and cytochrome b datasets, respectively. Two haplotypes were found using 16S rRNA dataset, with 6 variable loci and a haplotype diversity of 0.1053, while Cytochrome b dataset consist of 10 haplotypes, with 18 variable loci and a haplotype diversity of 0.1943. Also mean genetic distance was found to be eight times higher in the cytochrome b dataset. Kimura 2-parameter genetic distance matrix was evaluated together with neighbor joining tree and median joining network in order to reveal possible divergence points in both datasets. Results indicated signs of 3 regional populations, including potential cryptic species from Digor or subspecies from Samsun and Sinop. (C) 2013 Elsevier Ltd. All rights reserved.Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [108T559]; Biotechnology Institute of Ankara UniversityAnkara University; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)This study constitutes part of a project [Project No: 108T559] supported by the Scientific and Technological Research Council of Turkey (TUBITAK). We are indebted to TUBITAK for the financial support it has provided. The authors wish to thank Professor Hilal Ozdag for advice and comments and Y.E. Dincaslan for his help in obtaining some of the specimens. The author(s) wish to acknowledge use of the Maptool program for analysis and graphics in this paper. Maptool is a product of SEATURTLE.ORG. (Information is available at http://www.seaturtle.org). The present work was partially supported by the Biotechnology Institute of Ankara University