Bazı Onobrychis Miller (Fabaceae) Taksonları'nın yağda çözünen vitamin içeriği

The goal of this study is to determine the lipid-soluble vitamin contents in seeds of the some Onobrychis Miller (Fabaceae) taxa by using HPLC. Samples were collected from the natural habitats. Studied materials were dissolved in acetonitrile/methanol (75/25 v/v) and were injected 50 μL to HPLC instrument (Shimadzu, Kyota Japan). According to data obtained from present study showed that O. hypargyrea, O. viciifolia, O. caput-galli, O. fallax and O. oxyodonta var. armena have high lipide-soluble vitamin contents. Present study found that O. oxyodonta var. armena (1777.27±6.24 µg/g), O. fallax (916.0±4.51 µg/g) O. hypargyrea (809.7±5.03 µg/g) and O. viciifolia (399.7±3.54 µg/g) have highest beta-caroten content. Also, O. caput-galli has high beta caroten content (73.3±.94 µg/g). on the other hand, it was found that O. fallax has highest gamma-tocopherol content (1401.2±8.76 µg/g). O. viciifolia (574.9±2.35 µg/g), O. caput-galli (410.1±4.56 µg/g), O. oxyodonta var. armena (267.7±3.68 µg/g), O. podporea (162.5±2.14 µg/g) were the other high gamma tocopherol content. Whereas, retinol, retinol acetate and r-tocopherol contents were found absent or trace amounts in the present study.Bu çalışmanın amacı, bazı Onobrychis Miller (Fabaceae) taksonlarının tohumlarındaki yağda çözünen vitamin içeriğini HPLC kullanarak belirlemektir. Doğal yaşam alanlarından örnekler alındı. Çalışılan malzemeler asetonitril / metanol (75/25 h / h) içinde çözüldü ve HPLC cihazına (Shimadzu, Kyota Japonya) 50 μL enjekte edildi. Bu çalışmadan elde edilen verilere göre O. hypargyrea, O. viciifolia, O. caput-galli, O. fallax ve O. oxyodonta var. armena'nın lipitte çözünen vitamin içeriğinin yüksek olduğunu göstermiştir. Bu çalışma O. oxyodonta var. armena (1777.27 ± 6.24 µg / g), O. fallax (916.0 ± 4.51 µg / g) O. hypargyrea (809.7 ± 5.03 µg / g) ve O. viciifolia (399.7 ± 3.54 µg / g) en yüksek beta karoten içeriğine sahiptir. Ayrıca, O. caput-galli de yüksek beta karoten içeriğine sahiptir (73.3 ±. 94 µg / g). Öte yandan, O. fallax'ın en yüksek gamma-tokoferol içeriğine sahip olduğu belirlendi (1401.2 ± 8.76 µg / g). O. viciifolia (574.9 ± 2.35 µg / g), O. caput-galli (410.1 ± 4.56 µg / g), O. oxyodonta var. armena (267.7 ± 3.68 µg / g), O. podporea (162.5 ± 2.14 µg / g) diğer yüksek gama tokoferol içeriğine sahip taksonlardır. Diğer taraftan bu çalışmada retinol, retinol asetat ve r-tokoferol içerikleri bulunmamakta veya eser miktarda bulunmaktadır

Seed fatty acid amounts of some Salvia L. taxa in Elazig

Fatty acid amounts in mature seeds of thirteen Salvia L. taxa were determined by using gas chromatography in this study. Palmitic acid (C 16:0; 4.2-11.7 %) was major saturated fatty acid among in the studied Salvia species. Results of present study indicated that the seed oils of studied Salvia L. taxa have oleic acid (C 18:1 n-9), linoleic acid (C18:2 n-6) and linolenic acid (C 18:3 n-3) as unsaturated major fatty acids. The highest oleic acid (C 18:1 n-9) amount is found in S. tricholoda Bentham (30.7 %) but it is found at the lowest level in S. verticillata L. subsp. verticillata (11.3 %). Also, linoleic acid (C 18:2 n-6) amount was highest in S. euphratica var. leicaliyeina (60.4 %) but it was found at the lowest levels in S. aethiopis (12.1 %). However, linolenic acid (C18:3 n-3) amount of the Salvia L. seeds studied showed the greatest variation (0.5-57.8 %). As a result, present study determined that Salvia L. species had the highest unsaturated fatty acid amounts (81.5-94.4 %) and low saturated fatty acid amounts (5.8-18.3 %).Bu çalışmada, on üç Salvia L. taksonu tohumlarındaki yağ asidi miktarları gaz kromatografisi kullanılarak tespit edildi. Çalışılan Salvia türleri arasında palmitik asit (C:16 0; % 4.2-11.7) başlıca doymuş yağ asididir. Bu çalışmanın sonuçları çalışılan Salvia L. taksonlarının tohumlarında major doymamış yağ asitleri olarak oleik asit (C 18: 1 n-9), linoleik asit (C 18: 2 n-6) ve linolenik asitin (C 18: 3 n-3) olduğunu göstermiştir. En yüksek oleik asit (C 18: 1 n-9) miktarı S. tricholoda Bentham’da (% 30.7) iken en düşük oleik asit miktarı S. verticillata L. subsp. verticillata’da (% 11.3) bulunmuştur. Ayrıca, linoleik asit (C 18:2 n-6) miktarı en yüksek oranda S. euphratica var. leicaliyeina (% 60.4)’da bulunurken en düşük oranda ise S. aethiopis (12.1 %)’te bulunmuştur. Bununla birlikte çalışılan Salvia tohumlarının linolenik asit (C18:3 n-3) miktarları büyük varyasyon göstermiştir (% 0.5-57.8). Sonuç olarak bu çalışma Salvia L. türlerinin yüksek oranda doymamış yağ asidi miktarına (% 81.5-94.4) ve düşük oranda doymuş yağ asidi miktarına (% 5.8-18.3) sahip olduklarını belirlemiştir

Gilteritinib (XOSPATA (R)) in Turkey: Early access program results

Background And Objectives: Gilteritinib (XOSPATA (R), Astellas) is a type I oral FLT3 inhibitor, a tyrosine kinase AXL inhibitor, involved in both c-Kit and FMS-like tyrosine kinase 3 (FLT3) resistance. In the phase 3 ADMIRAL trial, gilteritinib was compared with the standard of care in (R/R) acute myeloid leukemia (AML) patients who harbored any FLT3 mutation and showed superior efficacy with regard to response and survival. Objectives: This research aimed to investigate the real-life efficacy and safety of gilteritinib in FLT3-positive R/R AML patients who were treated as a part of an early access program held in Turkey in April 2020 (NCT03409081). Results: The research included 17 R/R AML patients who had received gilteritinib from seven centers. The overall response rate was 100%. The most common adverse events were anemia and hypokalemia (7 patients, 41.2%). Grade 4 thrombocytopenia was observed in one patient only (5.9%), leading to permanent treatment discontinuation. Patients with peripheral edema had a 10.47 (95% CI: 1.64-66.82) times higher risk of death than those without peripheral edema (p<0.05). Conclusion: This research showed that patients with febrile neutropenia and peripheral edema were at a high risk of death when compared to patients without febrile neutropenia and peripheral edema

Cytotoxic and Genotoxic Effects of Sulfonamide-Aldehyde Derivative in Allium cepa Root Tip Cells

The continuous production and release into the environment of chemicals has revealed the need to determine their cytotoxicity and genotoxicity. Sulfonamide-aldehyde (SA) derivatives, whose biological activity properties vary in a wide spectrum, are frequently used in agriculture, medicine, pharmacy and many other fields. These compounds have an important cycle in the ecological system due to their use and diversity. In the present study, the potential cytotoxic and genotoxic effects of sulfonamide-aldehyde derivative were investigated using Allium test system with the concentrations of 6.25, 12.5, 25, 50, and 100 μM. In A. cepa cells, the increasing concentrations of SA caused cytotoxic effects by inducing nuclear lesions and inhibition of mitotic index. In addition, the increasing concentrations of SA caused genotoxic effects by inducing micronucleus and chromosome aberrations, which the most common ones are C-mitosis, sticky metaphase, and anaphase bridge. The results indicate that the concentration of 25 μM is EC50 in micronucleus, nuclear lesions, and chromosome aberrations; and 50 μM is EC50 in mitotic index (p lt; 0.05)

Kullanıcı teknoloji benimseme faktörleri: yapısal eşitlik modeli yaklaşımı ile farklı bağlamlarda amprik incelemeler

TÜBİTAK SOBAG30.09.2011Teknoloji ve uygulamalarının hayatımızda giderek daha fazla yer alması ile kullanıcıların kendilerine sunulan teknoloji ürün veya uygulamalarını benimsemelerini etkileyen faktörler araştırmacıların dikkatini çekmiştir. Bu alanda temel olarak kabul edilen Teknoloji Kabul Modeli (Technology Acceptance Model-TAM) ele alınarak yapılan çeşitli çalışmalarla literatürde karşılaşmaktayız. Bu çalışmada, Teknoloji Kabul Modelinin dört farklı bağlamda geliştirilerek her bir bağlam için kullanıcıların kendilerine sunulan uygulamaya ya da ürünlere olan tutumlarını etkileyen faktörler araştırılmış, analiz edilmiş ve çapraz karşılaştırma ile ortak faktörler bulunmuş, sonuç olarak genel bir teknoloji benimseme modeli geliştirilmiştir. Araştırma e-devlet, e-sağlık, e-öğrenme ve e-ticaret bağlamlarından veri toplanarak gerçekleştirilmiştir. Veri toplama ve ölçüm aracı olarak anket kullanılmış; veriler Yapısal Eşitlik Modeli yaklaşımı ile analiz edilerek sunulan modeller doğrulanmıştır. Doğrulanan modeller ile ürün ve uygulama geliştiricilere tasarım aşamasında yol göstermek, bu alanda kullanılan teknolojilerin kullanımı açısından güçlü ve zayıf yönlerini ortaya koymak ve modelin etkinliğinin değişik bağlamlarda test edilerek literatüre katkıda bulunmak amaçlarına erişilmiştir. Bu bağlamda bulgular değerlendirilmiştir ve çapraz karşılaştırmalar yapılarak sonuçların akademik literatüre katkısı 3 ulusal ve 8 uluslararası konferansta bildiri sunumu, bir uluslararası kitapta bölüm ve değerlendirilme aşamasında olan 2 uluslararası dergi yayını ile sağlanmıştır. Çalışma kapsamında Orta Doğu Teknik Üniversitesi, Bilişim Sistemleri Bölümü’nde 2 Yüksek Lisans tezi tamamlanmış, 3 Doktora tezinin zemini oluşturulmuştur.By the increasing use of technology, the factors that affect users’ behaviors towards technology and its applications had drawn attention of researchers. In the literature, there are plenty of studies covering user’s behavior and adoption towards technologies which were based on Technology Acceptance Model (TAM). It should be noted that TAM was accepted as a cornerstone in behavioral studies by many authorities. In this study, TAM was developed in four different domains, and in each domain, factors affecting users’ adoption towards specific applications and products were investigated. Then, the findings were analyzed and common factors were extracted by cross sectional comparison. In the bottom line, it was intended to create a joint technology acceptance model. The study was conducted by collecting and analyzing data from the domains of e-health, e-government, e-learning and e-commerce. Survey method was employed for collecting data and measurement. Structural Equation Modeling approach was employed for analysis of data and verification of models. The aims of the study were (1) to guide developers by verified models in the design phase, (2) to unveil strengths and weaknesses of the technologies in terms of user adoption which were categorized under these four domains and (3) to test and verify the effectiveness of the model in different domains and thus, contribute to the literature. In the path of these purposes, findings were evaluated and cross sectional comparisons were conducted. At the end of the study, valuable findings were extracted which can serve for determined purposes. Besides, social contributions have been accomplished by delivering feedbacks to related organizations. In addition, as an outcome of this project work 2 Master’s theses within the Information Systems Department of Middle East Technical University have been completed and the research has formed the basis of 3 PhD theses which are currently ongoing at the same department

Comparison of Genial Tubercule Anatomy Based on Age and Gender

Objective: In our study, it was aimed to determine whether there were differences in genial tubercle dimensions depending on age and gender.Methods: In this study, 220 cone beam computed tomography (CBCT) images of patients (110 female and 110 male) between the ages of 20-80 years were obtained from the archive of İzmir Katip Çelebi University Faculty of Dentistry. All patients were divided into decade groups according to their age, and each decade group was divided into two subgroups according to gender. The genial tubercle was defined radiologically using axial, coronal and sagittal sections as well as 3D reconstruction image with NNT software program. Sagittal, vertical and horizontal dimensions of the genial tubercle were measured and statistically analyzed.Results: There was a weak negative correlation between age groups and vertical values (r=-0.142; p=0.036) whereas the correlation coefficients between age groups and sagittal and horizontal values were not statistically significant (r=-0.043; p=0.530 and r=-0.039; p=0.563). There was a strong positive correlation between vertical and sagittal values in men (r=0.705, p<0.001) and women (r=0.714, p<0.001) in the whole group. There was a weak positive correlation between horizontal and sagittal, horizontal and vertical values in men (r=0.362, p<0.001; r=0.231, p<0.001) and women (r=0.304, p<0.001; r=0.257, p=0.007) in the whole group.Conclusion: The vertical and horizontal dimensions of genial tubercle of men were higher than that of women. As the age of the patients increased, a decrease in the vertical values of the genial tubercle was observed

“The Lolelaplap (Marshall Islands) in Us: Sailing West to East (Ralik→Ratak) to These Our Atolls (Aelon Kein Ad) Ad Jolet Jen Anij (Our Blessed Inheritance from God)”

This paper discusses the expansion of Oceania through a Marshallese indigenous lens as a focal point. It explains that decolonizing methodologies allows reclaiming of space for mental liberation and reassurement of constitutional rights. It highlights similar occurrences of decolonization practices meeting resistance in the 21st century all while strengthening the human right argument that no human deserves any less than their fellow human brothers and sisters. It argues that an indigenous imagery can only be viewed through an indigenous lens where the researches’ level of purity is retained and unfiltered. It nevertheless argues that Marshallese ethnolinguistics reveal the same cultural practices in America, Judeo-Christianity, and Oceania thus dictating the reality that “we are the same not withstanding one stays here and one there (Bedbedjin Bedbedjen, Bedbedjinma wot Kwe)”. It further explains the importance in these similarities and how Marshallese spirituality predates introduced American Judeo-Christianity despite the latter attempting to marginalize the former. It concludes by stating that Marshallese contributions on the global stage are rooted in that culture of love (IaKwe) which is echoed by the custom(s) revealing the significance of Marshallese validation academically, spiritually, economically, & socially to prevent institutionalized discrimination. This paper ends stating that the agency to know one’s self and how one should fit in the world, is a human right in itself and Marshallese are entitled to this sense of self worth through knowing thy self by thy self where real thinking takes place in one’s own mind as we all live our own lives

Prognostic factors for regorafenib treatment in patients with refractory metastatic colorectal cancer: A real-life retrospective multi-center study

Regorafenib, an oral multikinase inhibitor, has improved survival in metastatic colorectal cancer (mCRC) patients who have progressed on standard therapies. Our study aimed to evaluate prognostic factors influencing regorafenib treatment and assess the optimal dosing regimen in a real-life setting. We retrospectively analysed 263 patients with mCRC from multiple medical oncology clinics in Turkey. Treatment responses and prognostic factors for survival were evaluated using univariate and multivariate analysis. Of the patients, 120 were male, and 143 were female; 28.9% of tumors were located in the rectum. RAS mutations were present in 3.0% of tumors, while BRAF, K-RAS, and N-RAS mutations were found in 3.0%, 29.7%, and 25.9% of tumor tissues, respectively. Dose escalation was preferred in 105 (39.9%) patients. The median treatment duration was 3.0 months, with an objective response rate (ORR) of 4.9%. Grade ≥ 3 treatment-related toxicity occurred in 133 patients, leading to discontinuation, interruption, and modification rates of 50.6%, 43.7%, and 79.0%, respectively. Median progression-free survival (PFS) and overall survival (OS) were 3.0 and 8.1 months, respectively. RAS/RAF mutation (hazard ratio [HR] 1.5, 95% confidence interval [CI] 1.1-2.3; P = 0.01), pretreatment carcinoembryonic antigen (CEA) levels (HR 1.6, 95% CI 1.1-2.3; P = 0.008), and toxicity-related treatment interruption or dose adjustment (HR 1.6, 95% CI 1.1-2.4; P = 0.01) were identified as independent prognostic factors for PFS. Dose escalation had no significant effect on PFS but was associated with improved OS (P < 0.001). Independent prognostic factors for OS were the initial TNM stage (HR 1.3, 95% CI 1.0-1.9; P = 0.04) and dose interruption/adjustment (HR 0.4, 95% CI 0.2-0.9; P = 0.03). Our findings demonstrate the efficacy and safety of regorafenib. Treatment line influences the response, with dose escalation being more favorable than adjustment or interruption, thus impacting survival