Intracellular Localization of Staphylococcus aureus in Osteoclasts

From the Washington University Office of Undergraduate Research Digest (WUURD), Vol. 12, 05-01-2017. Published by the Office of Undergraduate Research. Joy Zalis Kiefer, Director of Undergraduate Research and Associate Dean in the College of Arts & Sciences; Lindsey Paunovich, Editor; Helen Human, Programs Manager and Assistant Dean in the College of Arts and Sciences Mentor: Deborah Novac

Interactions of Staphylococcus aureus with Osteoclasts and Osteoblasts

From the Washington University Senior Honors Thesis Abstracts (WUSHTA), Spring 2018. Published by the Office of Undergraduate Research. Joy Zalis Kiefer, Director of Undergraduate Research and Associate Dean in the College of Arts & Sciences; Lindsey Paunovich, Editor; Helen Human, Programs Manager and Assistant Dean in the College of Arts and Sciences Mentor: Deborah Vei

Interactions of Staphylococcus aureus with Osteoblasts

From the Washington University Undergraduate Research Digest: WUURD, Volume 11, 2015-2016. Published by the Office of Undergraduate Research, Joy Zalis Kiefer Director of Undergraduate Research and Assistant Dean in the College of Arts & Sciences; Lindsey Paunovich, Editor; Kristin Sobotka, Editor; Jennifer Kohl. Mentor: Deborah Novac

Walking the Talk in Participatory Philanthropy

The philanthropic sector has been called on to increase community engagement and beneficiary voice in funding decisions — in other words, to democratize philanthropy — and foundations have responded with a variety of innovative grantmaking models. One of those, participatory grantmaking, comprises practices that range from soliciting feedback from constituents to encouraging their active participation in or control over grantmaking decisions, program implementation, and outcome evaluation. Little research, however, has examined the perceptions of foundation or community stakeholders involved in participatory grantmaking initiatives. This article examines the participatory grantmaking process of a Baltimore, Maryland, community foundation that invested $1.5 million in an initiative to support community-building and improvement activities in two communities it had engaged with in the past. It uses data from focus groups and interviews conducted over the five years of the initiative that sought to learn how the foundation’s involvement was perceived and experienced, and in what ways its model of participatory grantmaking influenced collaboration and trust among community-based organizations and resident engagement in and ownership of programs and activities. Learning from the community-based initiative suggests that changing the power dynamic between funders and grantees can facilitate project success. This article concludes with a discussion of what the foundation learned about shifting power away from the funder and closer to the community, how those lessons have informed its current strategy, and what implications this has for philanthropy more broadly

HVAC Best Practices in Arctic Climates

Arctic climates provide unique challenges for designers of HVAC, plumbing, and thermal energy systems. The importance of considering the operation outside air temperatures, system reliability, and building resiliency cannot be understated. The paper describes best practice examples of robust and reliable systems with the emphasis on their redundancy, durability, and functionality. The paper also discusses the most common heating and ventilation system approaches used in arctic climate with the emphasis on the importance of a maintenance program that allows building operators to successfully troubleshoot and maintain buildings in the arctic. More detailed discussion of concepts presented in this paper can be found in the Guide [1] where these concepts are illustrated by best practice examples from U.S. military bases in Alaska and Søndre Strømfjord, the international airport of Greenland that previously was used as a U.S. military base. The paper results from experts’ discussions during the Consultation Forum “Thermal Energy Systems Resilience in Cold/Arctic Climates” [2] and research conducted under the IEA EBC Annex 73, the Environmental Security Technology Certification Program (ESTCP) Project “Technologies Integration to Achieve Resilient, Low-Energy Military Installations” and U.S. Army Program project 633734T1500 under Military Engineering Technology Demonstration. The paper is complementary to the ASHRAE Cold Climate Design Guide [3] with a focus on resilience of thermal energy systems

Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely related protective and less protective HLA alleles, and their differential effect on viral contro