High-resolution investigations of Transverse Aeolian Ridges on Mars

Transverse Aeolian Ridges (TARs) are the most pervasive aeolian feature on Mars. Their small size requires high-resolution data for thorough analyses. We have utilized Mars Reconnaissance Orbiter (MRO) Context Camera (CTX) and High Resolution Image Stereo Experiment (HiRISE) images, along with MRO Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) spectroscopic data to study TARs in detail. TAR deposits, along with related dark dune material and layered terrains, have been mapped in six study areas in order to identify sediment pathways and determine whether TARs are sourced locally or from global wind-borne materials. TAR morphology and orientation were mapped in grids within each study area; the results show that TARs are probably locally sourced. We constructed four HiRISE Digital Terrain Models (DTMs) to measure TAR heights, widths, spacing, areas, symmetry, and to calculate sediment volumes. Results show that TARs have average heights of ∼1.5 m, are very symmetrical, and are similar in form to terrestrial megaripples. Orthorectified HiRISE images taken 3 years apart were analyzed for TAR movement and none was found. Superposed craters on equatorial TARs give ages of ∼2 Ma, suggesting that these are relatively ancient and generally inactive aeolian deposits. CRISM data were analyzed over TAR deposits, dark dune material, and light-toned terrains. Although the surfaces were somewhat obscured by dust cover, the results did not show any remarkable difference between TARs and other deposits. We conclude that TARs may be sourced from local materials and form in a similar way to terrestrial megaripples

Transformation of Trojans into Quasi-Satellites During Planetary Migration and Their Subsequent Close-Encounters with the Host Planet

We use numerical integrations to investigate the dynamical evolution of resonant Trojan and quasi-satellite companions during the late stages of migration of the giant planets Jupiter, Saturn, Uranus, and Neptune. Our migration simulations begin with Jupiter and Saturn on orbits already well separated from their mutual 2:1 mean-motion resonance. Neptune and Uranus are decoupled from each other and have orbital eccentricities damped to near their current values. From this point we adopt a planet migration model in which the migration speed decreases exponentially with a characteristic timescale tau (the e-folding time). We perform a series of numerical simulations, each involving the migrating giant planets plus test particle Trojans and quasi-satellites. We find that the libration frequencies of Trojans are similar to those of quasi-satellites. This similarity enables a dynamical exchange of objects back and forth between the Trojan and quasi-satellite resonances during planetary migration. Furthermore, under the influence of these secondary resonances quasi-satellites can have their libration amplitudes enlarged until they undergo a close-encounter with their host planet and escape from the resonance. High-resolution simulations of this escape process reveal that ~80% of Jovian quasi-satellites experience one or more close-encounters within Jupiter's Hill radius (R_H) as they are forced out of the quasi-satellite resonance. As many as ~20% come within R_H/4 and ~2.5% come within R_H/10. Close-encounters of escaping quasi-satellites occur near or even below the 2-body escape velocity from the host planet

Detectable clonal mosaicism and its relationship to aging and cancer

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events42Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Detectable clonal mosaicism and its relationship to aging and cancer

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases

Risk of COVID-19 after natural infection or vaccinationResearch in context

Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health