Antimicrobial activity of ceftolozane-tazobactam against Enterobacterales and Pseudomonas aeruginosa recovered during the Study for Monitoring Antimicrobial Resistance Trends (SMART) program in Spain (2016-2018)

Objective: To analyse the susceptibility to ceftolozane-tazobactam and comparators in Enterobacterales and Pseudomonas aeruginosa isolates recovered from intraabdominal (IAI), urinary (UTI), respiratory (RTI) and bloodstream infection (BSI) in the SMART (Study for Monitoring Antimicrobial Resistance Trends) study. Methods: The susceptibility of 5,351 isolates collected in 11 Spanish hospitals (2016-2018) were analysed (EUCAST-2020 criteria) by broth microdilution and were phenotypically studied for the presence of extended-spectrum beta-lactamases (ESBL). Ceftolozane-tazobactam and/or carbapenem resistant isolates were genetically characterized for ESBL and carbapenemases. Results: Escherichia coli was the most frequent pathogen (49.3% IAI, 54.9% UTI, 16.7% RTI and 50% BSI), followed by Klebsiella pneumoniae (11.9%, 19.1%, 13.1% and 15.4%, respectively). P. aeruginosa was isolated in 9.3%, 5.6%, 32% and 9%, respectively. The frequency of isolates with ESBLs (2016-2017) was: 30.5% K. pneumoniae, 8.6% E. coli, 2.3% Klebsiella oxytoca and 0.7% Proteus mirabilis. Ceftolozane-tazobactam was very active against non-ESBL-(99.3% susceptible) and ESBL-(95.2%) producing E. coli being less active against K. pneumoniae (98% and 43.1%, respectively) isolates. CTX-M-15 was the most prevalent ESBL in E. coli (27.5%) and K. pneumoniae (51.9%) frequently associated with OXA-48-like carbapenemase. Overall, 93% of P. aeruginosa isolates were susceptible to ceftolozane-tazobactam, preserving this activity (>75%) in isolates resistant to other beta-lactams except in those resistant to meropenen or ceftazidime-avibactam. GES-5, PER-1, VIM-1/2 were the most prevalent enzymes in isolates resistant to ceftolozane-tazobactam. Conclusions: Ceftolozane-tazobactam showed high activity rates against isolates recovered in the SMART study although it was affected in K. pneumoniae and P. aeruginosa isolates with ESBL and/or carbapenemases

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Evolución de Studium. Despliegue de la plataforma moodle 2.x

Memoria ID-2012.001. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2012-2013

100 años investigando el mar. El IEO en su centenario (1914-2014).

Se trata de un libro que pretende divulgar a la sociedad las principales investigaciones multidisciplinares llevadas a cabo por el Instituto Español de Oceanografía durante su primer siglo de vida, y dar a conocer la historia del organismo, de su Sede Central y de los nueve centros oceanográficos repartidos por los litorales mediterráneo y atlántico, en la península y archipiélagos.Kongsberg 20

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Adelante / Endavant

Séptimo desafío por la erradicación de la violencia contra las mujeres del Institut Universitari d’Estudis Feministes i de Gènere "Purificación Escribano" de la Universitat Jaume

Experiencia profesional en Europa III

Proyecto realizado por cuatro profesores del Instituto de Educación Secundaria de Astorga (León) en el contexto de la nueva formación profesional, módulo de Formación en Centros de Trabajo, perteneciente al ciclo formativo de grado superior Administración y Finanzas, al Ciclo formativo de grado medio Sistemas de Regulación y control automáticos y al Ciclo Formativo de Grado Medio Equipos e Instalaciones Electrotécnicas, el objetivo es ampliar los conocimientos y experiencia profesional y humana, realizando la formación en Centros de trabajo, no solamente en empresas del entorno, sino también en empresas de la Comunidad Europea. Integrado en un proyecto más amplio -Leonardo- tiene como centro promotor al propio Instituto de Educación Secundaria de Astorga y centro asociado -La Escuela Comunal Superior de Secretariado, Administración y Comercio de Lieja (Bélgica)-. Han sido en total once alumnos que han realizado 110 horas de prácticas en empresas de la ciudad de Lieja, así como: 1) Conocimiento del funcionamiento de empresas extranjeras. 2) Familiarización con hábitos de trabajo y horarios diferentes a los españoles. 3) Mejora de la cualificación profesional. 4) Toma de contacto con una cultura socio-económica con rasgos propios. 5) Conocimiento de un país diferente económica y culturalmente. Experiencia altamente enriquecedora tanto para los alumnos como profesores, estos últimos destacan el aspecto metodológico. El trabajo no ha sido publicado.Comunidad Autónoma de Castilla y León, Consejería de Educación y Cultura, Dirección General de EducaciónCastilla y LeónES

Effect of Crushed Glass Cullet Sizes on Physical and Mechanical Properties of Red Clay Bricks

This study reports the effect of clear waste glass from bottles added on 20 to 30 wt.% and variable particle size (<500, <300, and <212 μm), into clay mixtures for the handmade brick manufacturing process. The bricks were manufactured with mixtures of clay, crushed glass, and water in different proportions, homogenized, casted in wooden molds, air-dried at room temperature for 72 h, and sintered at 1000°C for 12 h. Total shrinkage, water absorption, compressive strength, microstructure, and phase composition are discussed with respect to glass content and its particle size. The results indicate that increasing the content of glass and decreasing its particle size enhanced significantly the brick properties of water absorption and compressive strength by up to 18.5% and 6.8 MPa, for bricks with 30 wt% and particle size lower than 212 μm. It is proposed that decreasing the glass particle size its surface area increases allowing easier melting of glass by lower energy consumption, reducing porosity and enhancing brick properties

Validation of the Childhood Family Mealtime Questionnaire in Mexican Adolescents with Obesity and Their Caregivers

Background: Childhood obesity is a significant public health concern in Mexico, with far-reaching implications for the nation’s healthcare system and economy. In light of this challenge, our study sought to validate the Childhood Family Mealtime Questionnaire (CFMQ) in Mexican adolescents living with obesity and their primary caregivers. Methods: A sample of 56 adolescents ages 13 to 17 years and their primary caregivers from one pediatric obesity clinic participated in the study. We conducted a comprehensive assessment of the CFMQ’s consistency, reliability, and construct validity among all participants. Internal consistency was determined using Cronbach’s α, and the questionnaire’s reliability was assessed through test–retest and intraclass correlation coefficients. Construct validity was assessed through an exploratory factor analysis. Results: Our findings confirmed strong internal consistency and reliability for both adolescents and caregivers. Construct validity was established through exploratory factor analysis, refining the questionnaire while preserving its original seven dimensions. This validation of the CFMQ highlights its applicability in evaluating family mealtime experiences in this context, providing valuable insights into the dynamics that influence adolescent nutrition and health. Conclusion: The CFMQ proves to be a reliable tool for assessing family mealtime experiences in Mexican adolescents living with obesity and their caregivers who seek care at third-level public hospitals

La Garrucha : memoria 1993-1994

No publicadoEl Grupo de Trabajo La Garrucha, formado por once profesores docentes en el Colegio Público Anejas de León y en el Colegio Público Emilia Menéndez (La Robla, León), presenta la memoria de las actividades realizadas con los alumnos y alumnas de Educación Infantil, Primaria y EGB ciclo medio y superior. Alrededor de un tema central, en este caso una canción popular infantil leonesa, se han elaborado distintas aplicaciones o guías didácticas para las asignaturas de Conocimiento del Medio, Lenguaje, Educación Musical y Matemáticas. Para los alumnos y alumnas los objetivos fundamentales fueron: desarrollar la autonomía para resolver pequeñas dificultades, progresar en las actitudes de respeto hacia los demás, descubrir las posibilidades motrices y expresivas de su cuerpo, conocer costumbres de su entorno social y disfrutar con ellas, sentir curiosidad por conocer su medio físico y social, observar los cambios y modificaciones del entorno por efecto de los agentes climatológicos, comprender los mensajes orales que le comunican los adultos valorando el lenguaje como vínculo de relación, utilizar las posibilidades de representación matemática para describir objetos y sus características.Castilla y LeónES