Condiciones que Inciden en el aprendizaje del idioma inglés en el nivel básico de adultos del programa de Extensión Universitaria en Idiomas Extrangeros de la Facultad Multidisciplinaria de Occidente, de la Universidad de El Salvador, en el periodo comprendido entre octubre-diciembre de 2010.

La administración de un programa de extensión de idioma inglés -- El perfil del.pdfente universitario -- Analisis del proceso de enseñanza y aprendizaje del idioma ingles, que es usado por los.pdfentes que inparten el n ivel básico de adultos y su relación con el rendimiento academico

Influence of a football match on landing biomechanics and jump performance in female football players

This study aimed to assess the acute effect of a competitive football match on jump performance and kinematic parameters during jump landing in semiprofessional female football players. Twenty-two semiprofessional players (20 ± 3 years) underwent a drop jump task for a posterior video analysis of the landing phase. These measurements were obtained at (1) baseline, (2) after, and (3) 48 h after a competitive football match. A one-way ANOVA with repeated measures was employed to detect differences over the time. There was a main effect of time for maximal knee flexion angle during drop landing (p = 0.001). In comparison with baseline, maximal knee flexion angle was reduced immediately post-match and was still reduced 48 h after the match (63.4 ± 8.6 vs 57.0 ± 11.7 vs 48.9 ± 19.1, p ≤ 0.038). There was also a main effect of time for drop jump height (p < 0.001). Drop jump height was reduced immediately post-match and remained low 48 h after the match in comparison with baseline (27.3 ± 3.6 vs 24.5 ± 2.8 ~ 25.5 ± 3.0 cm, p ≤ 0.002). There was a main effect of time on hip flexion angle during landing (p = 0.001), but the pairwise comparison revealed that this variable was not affected immediately post-match but was lower 48 h after the match than at baseline (50.1 ± 10.1 ~ 50.8 ± 13.2 vs 38.1 ± 17.8 °, p ≤ 0.005). A competitive football match worsened jump performance and several landing biomechanical parameters in female football players, which were still decreased in comparison with baseline even 48 h after the match

Assessment of discretely measured indicators and maximum daily trunk shrinkage for detecting water stress in pomegranate trees

Measurements obtained by the continuous monitoring of trunk diameter fluctuations were comparedwith discrete measurements of midday stem water potential and midday leaf conductance (gl)in adult pomegranate trees (Punica granatum L. cv. Mollar de Elche). Control plants (T0) were irrigateddaily above their crop water requirements in order to attain non-limiting soil water conditions in 2009 and 2010, while T1 plants were subjected to water stress by depriving them of irrigation water for34 days in 2010, after which time irrigation was restored and plant recovery was studied for 7 days.T1 plants showed a substantial degree of water stress, which developed slowly. Maximum daily trunkshrinkage (MDS) was identified to be the most suitable plant-based indicator for irrigation scheduling inadult pomegranate trees, because its signal:noise ((T1/T0):coefficient of variation) ratio was higher thanthat for midday stem water potential((T1/T0):coefficient of variation) and gl((T0/T1):coefficient of variation). MDS increasedin response to water stress, but when the stemfell below ¿1.67 MPa, the MDS values decreased. Fornon-limiting water conditions, MDS could be predicted from mean daily air temperature (Tm) throughexponential equations fitted to pooled data across several seasons. First-order equations were alsoobtained by pooling data across several seasons to predict MDS from crop reference evapotranspira-tion (ETo), mean daily air vapour pressure deficit (VPDm), Tmand solar radiation (Rs), but these should beused only within a certain range of values (ETo, 2.1¿7.4 mm; VPDm, 0.64¿2.96 kPa; Tm, 12.1¿28.3¿C; Rs,119.4¿331.3 Wm¿2). Hence, automated MDS measurements have the potential to be used in irrigationscheduling of pomegranate, and these values can be normalized to non-limiting water conditions bylocally derived empirical relationships with meteorological variables.Ministerio de Ciencia e Innovación (CICYT/FEDER) AGL2010-19201-C04-01AGRAgencia Española de Cooperación Internacional para el Desarrollo (AECID

Exposure and Knowledge of Sharps Injuries among Medical Students in Seven States of Mexico

Background: Medical students are vulnerable to accidental exposure to blood-borne pathogens when performing clinical activities. Knowledge of both the prevalence of exposure and necessary reporting procedures is important to minimize the risk of harm to medical students. Methods: A cross-sectional online survey of medical students from 19 universities from seven states in Mexico was utilized to determinethe prevalence of needle stick injuries amongst medical students and the associated reporting procedures. Results: We included 312 respondents; of these, 52.24% were men and 47.76% were women, and the mean age was 23.19 years (SD ± 2.11 years). Nearly all of them (94.23%) were medical students doing clerkships in public hospitals. Mean knowledge score of blood-borne pathogens was 3.6 (SD ± 1.16) on a scale of 0-10 designed specifically for this study. Thirty-five per cent of the respondents had sustained a needle stick injury at some point during their medical school training, and 33.97% reported some type of mucocutaneous exposure. Overall, the non-reporting rate of needle stick injury was 48.34%. Approximately 25% of the respondents were not familiar with reporting procedures in the event of a needle stick injury or mucocutaneous exposure; 61.50% had received information from their hospital about the standard protocol to follow after a blood or body fluid exposure. Conclusion: In this Mexican population of medical students, there is a high risk of suffering needle stick injuries&nbsp; during medical training. Furthermore, knowledge regarding prevention, evaluation, and reporting of needle stick injuries is suboptimal

Dimensions of Exercise Self-efficacy Scale by Type of Activity in Independent Older Adult Women

For cultural reasons, for many women in Mexico the adoption of active behavior was restricted to the execution of tasks at home. It was proposed to analyze the psychometric properties of the Self-efficacy to Regulate Exercise Scale. As a secondary objective, the association of scale dimensions by type of physical activity in older adults independent of the community was analyzed. Instrumental and empirical research with two samples totaling 614 older women (M = 70.27 years, SD = 6.3). The participants present functional independence and cognitive integrity and were assistants of seniors clubs in the urban area. The Self-efficacy to Regulate Exercise Scale and the Physical Activity Scale of the Elderly were applied. Psychometric properties of the scale, descriptive and inferential analyzes with Pearson's correlation matrix are presented. SPSS version 21.0 and LISREL 8.80 were used. The adaptation to Spanish in this population has four dimensions with acceptable psychometric properties: stress, competing demands, external influences and climate. It was estimated an expenditure of 1,25 METs (SD= ,54) of physical activity in the home, 5,83 METs (SD= 4,40) for exercise and 2,09 METs (SD= 1,90) during free time. After the elimination of three items an adjustment model with four dimensions are presented. Directing strategies to increase self-efficacy secondary to external influences could increase the physical activity of this growing population group.Por cuestiones culturales, para muchas mujeres en México la adopción de una conducta activa fue restringida a la ejecución de tareas en el hogar. Se propuso analizar las propiedades psicométricas de la Escala de Autoeficacia para el Ejercicio. Como objetivo secundario, se analiza la asociación de las dimensiones de la escala por tipo de actividad física en adultas mayores independientes de la comunidad. Investigación instrumental y empírica con dos muestras que suman 614 mujeres mayores (M= 70.27 años, DE= 6.3). Las participantes presentan independencia funcional e integridad cognitiva y son asistentes de clubes de adultos mayores del área urbana. Se aplicaron la Escala de Autoeficacia para el Ejercicio y el Cuestionario de Actividad Física de Adultos Mayores. Se presentan propiedades psicométricas de la escala, análisis descriptivos e inferenciales con matriz de correlación de Spearman. Se utilizaron SPSS versión 21,0 y LISREL 8,80. La adaptación al castellano en esta población presenta cuatro dimensiones con propiedades psicométricas aceptables: estrés, demandas en competencia, influencias externas y el clima. Se estimó un gasto de 1,25 METs (DE= ,54) de actividad física en el hogar, 5,83 METs (DE= 4,40) de ejercicio y 2,09 METs (DE= 1,90) del tiempo libre. Se presenta modelo de ajuste y propiedades psicométricas de la Escala de Autoeficacia para el Ejercicio. Dirigir estrategias para incrementar la autoeficacia secundaria a influencias externas pudiera incrementar la actividad física de este creciente grupo poblacional.Por razões culturais, para muitas mulheres no México, a adoção de comportamento ativo restringia-se à execução de tarefas em casa. Foi proposto analisar as propriedades psicométricas da Escala de Autoeficácia para o Exercício. Como objetivo secundário, analisa-se a associação das dimensões da escala por tipo de atividade física em idosos independentes da comunidade. Pesquisa instrumental e empírica com duas amostras, totalizando 614 mulheres mais velhas (M = 70,27 anos, DP = 6,3). Os participantes apresentam independência funcional e integridade cognitiva e são assistentes de clubes idosos na área urbana. Foram aplicadas a Escala de Autoeficácia para Exercício e o Questionário de Atividade Física para Idosos. São apresentadas propriedades psicométricas da escala, análises descritivas e inferenciais com a matriz de correlação de Spearman. Foram utilizadas as versões 21.0 e LISREL 8.80 do SPSS. A adaptação ao espanhol nessa população possui quatro dimensões com propriedades psicométricas aceitáveis: estresse, demandas concorrentes, influências externas e clima. Estima-se uma despesa de 1,25 METs (DP =, 54) de atividade física em casa, 5,83 METs (DP = 4,40) de exercício e 2,09 METs (DP = 1,90) de tempo livre. O modelo de ajuste e as propriedades psicométricas da Escala de Autoeficácia para o Exercício são apresentados. Direcionar estratégias para aumentar a autoeficácia secundária a influências externas pode aumentar a atividade física desse crescente grupo populacional

Immunophenotype and Transcriptome Profile of Patients With Multiple Sclerosis Treated With Fingolimod: Setting Up a Model for Prediction of Response in a 2-Year Translational Study

BackgroundFingolimod is a functional sphingosine-1-phosphate antagonist approved for the treatment of multiple sclerosis (MS). Fingolimod affects lymphocyte subpopulations and regulates gene expression in the lymphocyte transcriptome. Translational studies are necessary to identify cellular and molecular biomarkers that might be used to predict the clinical response to the drug. In MS patients, we aimed to clarify the differential effects of fingolimod on T, B, and natural killer (NK) cell subsets and to identify differentially expressed genes in responders and non-responders (NRs) to treatment.Materials and methodsSamples were obtained from relapsing–remitting multiple sclerosis patients before and 6 months after starting fingolimod. Forty-eight lymphocyte subpopulations were measured by flow cytometry based on surface and intracellular marker analysis. Transcriptome sequencing by next-generation technologies was used to define the gene expression profiling in lymphocytes at the same time points. NEDA-3 (no evidence of disease activity) and NEDA-4 scores were measured for all patients at 1 and 2 years after beginning fingolimod treatment to investigate an association with cellular and molecular characteristics.ResultsFingolimod affects practically all lymphocyte subpopulations and exerts a strong effect on genetic transcription switching toward an anti-inflammatory and antioxidant response. Fingolimod induces a differential effect in lymphocyte subpopulations after 6 months of treatment in responder and NR patients. Patients who achieved a good response to the drug compared to NR patients exhibited higher percentages of NK bright cells and plasmablasts, higher levels of FOXP3, glucose phosphate isomerase, lower levels of FCRL1, and lower Expanded Disability Status Scale at baseline. The combination of these possible markers enabled us to build a probabilistic linear model to predict the clinical response to fingolimod.ConclusionMS patients responsive to fingolimod exhibit a recognizable distribution of lymphocyte subpopulations and a different pretreatment gene expression signature that might be useful as a biomarker

Social Representation of Dementia: An Analysis of 5,792 Consecutive Cases Evaluated in a Memory Clinic

Abstract. Background: Different interpretations of cognitive impairment and dementia due to differences in health structures, such as cultural differences could affect the diagnosis and treatment of the condition. it is reasonable to expect that the social and family impact of the disease and coping strategies will differ among societies. Objective: The general aim of this study is to understand the social representations of dementia, its associated practices, and the effects they imply. Methods: People diagnosed with clinical dementia and their families were assessed from 2005 to 2015 in the memory clinic of the Fundacio ́ ACE, Institut Catala` de Neurocie`ncies Aplicades in Barcelona, Spain. Results: 9,898 people were examined and 5,792 were diagnosed with dementia. For those with a caregiver (71%), the decision-making fell on the person with dementia in 16.2% of the cases; and for those without a caregiver, in 26.4% of the cases the family did not perceive the deficits as a disease, which led to multiple risk situations (74.6%). Conclusions: The recognition of dementia as part of aging is common among families. Consequently, risk situations may arise and diagnosis and access to treatment may be delayed. The incorporation of a social appraisal to the diagnostic process is a necessity to evaluate these situations

Switching to Glycerol Phenylbutyrate in 48 Patients with Urea Cycle Disorders: Clinical Experience in Spain

Background and objectives: Glycerol phenylbutyrate (GPB) has demonstrated safety and efficacy in patients with urea cycle disorders (UCDs) by means of its clinical trial program, but there are limited data in clinical practice. In order to analyze the efficacy and safety of GPB in clinical practice, here we present a national Spanish experience after direct switching from another nitrogen scavenger to GPB. Methods: This observational, retrospective, multicenter study was performed in 48 UCD patients (age 11.7 ± 8.2 years) switching to GPB in 13 centers from nine Spanish regions. Clinical, biochemical, and nutritional data were collected at three different times: prior to GPB introduction, at first follow-up assessment, and after one year of GPB treatment. Number of related adverse effects and hyperammonemic crisis 12 months before and after GPB introduction were recorded. Results: GPB was administered at a 247.8 ± 102.1 mg/kg/day dose, compared to 262.6 ± 126.1 mg/kg/day of previous scavenger (46/48 Na-phenylbutyrate). At first follow-up (79 ± 59 days), a statistically significant reduction in ammonia (from 40.2 ± 17.3 to 32.6 ± 13.9 μmol/L, p < 0.001) and glutamine levels (from 791.4 ± 289.8 to 648.6 ± 247.41 μmol/L, p < 0.001) was observed. After one year of GPB treatment (411 ± 92 days), we observed an improved metabolic control (maintenance of ammonia and glutamine reduction, with improved branched chain amino acids profile), and a reduction in hyperammonemic crisis rate (from 0.3 ± 0.7 to less than 0.1 ± 0.3 crisis/patients/year, p = 0.02) and related adverse effects (RAE, from 0.5 to less than 0.1 RAEs/patients/year p < 0.001). Conclusions: This study demonstrates the safety of direct switching from other nitrogen scavengers to GPB in clinical practice, which improves efficacy, metabolic control, and RAE compared to previous treatments.This study was funded by AECOM (Spanish Association for the Study of Inborn Errors of Metabolism). Immedica Pharma Spain funded medical writing support and article processing charges

Relationships between heavy metal concentrations in three different body fluids and male reproductive parameters: a pilot study

<p>Abstract</p> <p>Background</p> <p>Animal studies have shown the reproductive toxicity of a number of heavy metals. Very few human observational studies have analyzed the relationship between male reproductive function and heavy metal concentrations in diverse biological fluids.</p> <p>Methods</p> <p>The current study assessed the associations between seminal and hormonal parameters and the concentration of the 3 most frequent heavy metal toxicants (lead, cadmium and mercury) in three different body fluids. Sixty one men attending infertility clinics that participated in a case-control study to explore the role of environmental toxins and lifestyles on male infertility were analyzed. Concentration of lead, cadmium and mercury were measured in blood and seminal plasma and whole blood using anodic stripping voltammetry and atomic absorption spectrophotometry. Serum samples were analyzed for follicle-stimulating hormone, luteinizing hormone and testosterone. Semen analyses were performed according to World Health Organization criteria. Mann-Whitney test and Spearman's rank correlations were used for unadjusted analyses. Multiple linear regression models were performed controlling for age, body mass index and number of cigarettes per day.</p> <p>Results</p> <p>There were no significant differences between cases and controls in the concentrations of heavy metals in any of the three body fluids. In multivariate analyses using all subjects no significant associations were found between serum hormone levels and metal concentrations. However there was a significant positive association between the percentage of immotile sperms and seminal plasma levels of lead and cadmium.</p> <p>Conclusions</p> <p>Our results suggest that the presence of lead and cadmium in the reproductive tract of men may be related to a moderate alteration of their seminal parameters.</p