Few-body hydrodynamic interactions probed by optical trap pulling experiment

We study the hydrodynamic coupling of neighboring micro-beads placed in a dual optical trap setup allowing us to precisely control the degree of coupling and directly measure time-dependent trajectories of the entrained beads. Average experimental trajectories of a probe bead entrained by the motion of a neighboring scan bead are compared with theoretical computation, illustrating the role of viscous coupling and setting timescales for probe bead relaxation. The findings provide direct experimental corroborations of hydrodynamic coupling at larger, micron spatial scales and millisecond timescales, of relevance to hydrodynamic-assisted colloidal assembly as well as improving the resolution of optical tweezers. We repeat the experiments for three bead setups

Flash Flood Risk Estimation of Wadi Qena Watershed, Egypt Using GIS Based Morphometric Analysis

Flash flooding is one of the periodic geohazards in the eastern desert of Egypt where many parts of Upper Egypt, Sinai, and Red Sea areas were hit by severe flash floods, for example in 1976, 1982, 1996 and January 2010. The hazard degree for each sub-basin was determined using the approach developed by El-Shamy for assessing susceptibility of sub-basins to flash flooding risk. To identify at-risk sub-basins, two different methods were applied. The first method is based on the relationship between the drainage density and bifurcation ratio, and the second one uses the relationship between drainage frequency and bifurcation ratio. The three morphometric parameters (the bifurcation ratio, drainage density, and stream frequency) were extracted and calculated for each sub-basin of the watershed. Based on the final hazard degree resulting from the two methods, a detailed hazard degree map was extracted for all sub-basins. The results illustrate that there are no sub-basins with low risk of flooding. The sub-basins with the highest hazard degree are concentrated in the middle of the watershed although they have smaller areas compared with the surrounding sub-basins. The sub-basins located at the boundary of the watershed have an intermediate risk of flooding and moderate potential for groundwater recharge. This constructed map can be used as a basic data for assessment of flood mitigation and planning

Flood Hazard Mapping and Assessment of Precipitation Monitoring System Using GIS-Based Morphometric Analysis and TRMM Data: A Case Study of the Wadi Qena Watershed, Egypt

Wadi Qena is one of the Nile Valley areas particularly at risk of severe flash flooding, located in Egypt. The study aims to verify TRMM rainfall data (TRMM 3B42), using eight stations across Egypt as well as relies on morphometric analysis to generate a flood risk map based on the ranking method. Three process could be recognized through the study, calibration, correction and verification processes. The results discuss the match daily rainfall trends of TRMM and observed data, producing a correction equation for TRMM data with root mean square error (RMSE) value of 0.837 mm d-1 and R2= 0.238 (calibration process). On the other hand, a verification process, using the developed correction equation, obtain RMSE value of 1.701 mm d-1 and R2= 0.601. The morphometric analysis shows 32 sub-basins with a hazard degree from moderate to high, amounting to 50.3% of the watershed area. Conclusively, this study confirms that the current monitoring system is not enough to cover the whole area, especially the high-risk sub-basins, and TRMM data could provide key information for water-related applications in Egypt

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Investigating the Avocado (Persea americana) fruit's anti-anxiety potentials in rat models

Background and aim: Anxiety has an effect on the common regular living of a human as it causes fatigue and restlessness. In the current study, an effort was undertaken to investigate the anti-anxiety behavior of male albino by the treatment of Avocado Powder and Juice in vivo. Methods: Avocado Powder 10 % (AP1) and 15 % (AP2) substituted from the diet and Avocado Juice 100 mL/kg (AJ1) and150ml/kg body weight (AJ2) rat over control rats. Results: The oral intake of Avocado powder and Juice caused a significant decrease in the body weight gain, daily feed intake, and feed efficiency ratio (FER) in all experimental groups tested as compared to control. Also, the activity of the antioxidant enzymes like SOD, GST, GPX, and Catalase is not much influenced by the intake of avocado fruit. This significant result has confirmed the effectiveness of this fruit for the treatment of anxiety. The anti-anxiety effect of the avocado fruit was tested by exploring the behavioral changes tests in experimental rats. All the experiments conducted showed that the intake of dose AP2 and AJ2 has significantly decreased the number of head dips and cage crossing and increased the time spent in light side in light–dark transition box test, and increased time spent in open arm in elevated plus maze test. Conclusions: This result proved that the avocado fruit as powder then as juice have an anxiolytic effects and will be a better alternative for people with an anxiety disorder

Efficacy of Carnosine administration along with or without Coenzyme Q10 on sodium valproate induced testicular toxicity in vivo models

Background and aim: In the present study, the effect of carnosine along with or without Coenzyme Q10 was tested on the sodium valporate induced testicular toxicity in male rats. Methods: The five different treatments were designed and its biological, relative weight of reproductive organs, serum lipid profiles, reproductive hormones levels and sperm motility factors were evaluated to provide a possible alternative to meet the problem of infertility in males. Results: the experimental rats showed a significant decrease in body weight gain and no difference was recorded feed intake and feed efficiency ratio in different treatments. The treatment of Carnosine along with CoQ10 does not produce any significant change in the relative weight of prostate in SVA induced rats. Further, the SVA induced male rats treated with the combination of Carnosine and CoQ10 showed significant decrease in total cholesterol, triglycerides and a significant increase in HDL-c, LDL-C, VLDL-C levels as compared to control. The same treatment resulted in the significant improvement in the reproductive hormones like testosterone, FSH and LH levels in the serum. Also, the biochemical parameters such as SOD, GST, GPX and catalase levels increased and decreased MDA serum antioxidant level when treated with both Carnosine and CoQ10. Conclusions: The combination of Carnosine and CoQ10 showed a succeeding increase in sperm motility even after 6 h of sperm storage. Thus, the obtained results from current study proved that the carnosine along with CoQ10 may be best alternative solution to treat male infertility

Dynamic Jellyfish Search Algorithm Based on Simulated Annealing and Disruption Operators for Global Optimization with Applications to Cloud Task Scheduling

This paper presents a novel dynamic Jellyfish Search Algorithm using a Simulated Annealing and disruption operator, called DJSD. The developed DJSD method incorporates the Simulated Annealing operators into the conventional Jellyfish Search Algorithm in the exploration stage, in a competitive manner, to enhance its ability to discover more feasible regions. This combination is performed dynamically using a fluctuating parameter that represents the characteristics of a hammer. The disruption operator is employed in the exploitation stage to boost the diversity of the candidate solutions throughout the optimization operation and avert the local optima problem. A comprehensive set of experiments is conducted using thirty classical benchmark functions to validate the effectiveness of the proposed DJSD method. The results are compared with advanced well-known metaheuristic approaches. The findings illustrated that the developed DJSD method achieved promising results, discovered new search regions, and found new best solutions. In addition, to further validate the performance of DJSD in solving real-world applications, experiments were conducted to tackle the task scheduling problem in cloud computing applications. The real-world application results demonstrated that DJSD is highly competent in dealing with challenging real applications. Moreover, it achieved gained high performances compared to other competitors according to several standard evaluation measures, including fitness function, makespan, and energy consumption