2,699 research outputs found
Nonthermal X-Rays from Supernova Remnant G330.2+1.0 and the Characteristics of its Central Compact Object
We present results from our X-ray data analysis of the SNR G330.2+1.0 and its
CCO, CXOU J160103.1--513353 (J1601). Using our XMM-Newton and Chandra
observations, we find that the X-ray spectrum of J1601 can be described by
neutron star atmosphere models (T ~ 2.5--3.7 MK). Assuming the distance of d ~
5 kpc for J1601 as estimated for SNR G330.2+1.0, a small emission region of R ~
1--2 km is implied. X-ray pulsations previously suggested by Chandra are not
confirmed by the XMM-Newton data, and are likely not real. However, our timing
analysis of the XMM-Newton data is limited by poor photon statistics, and thus
pulsations with a relatively low amplitude (i.e., an intrinsic pulsed-fraction
< 40%) cannot be ruled out. Our results indicate that J1601 is a CCO similar to
that in the Cassiopeia A SNR.X-ray emission from SNR G330.2+1.0 is dominated by
power law continuum (Gamma ~ 2.1--2.5) which primarily originates from thin
filaments along the boundary shell. This X-ray spectrum implies synchrotron
radiation from shock-accelerated electrons with an exponential roll-off
frequency ~ 2--3 x 10^17 Hz. For the measured widths of the X-ray filaments (D
~ 0.3 pc) and the estimated shock velocity (v_s ~ a few x 10^3 km s^-1), a
downstream magnetic field B ~ 10--50 G is derived. The estimated maximum
electron energy E_max ~ 27--38 TeV suggests that G330.2+1.0 is a candidate TeV
gamma-ray source. We detect faint thermal X-ray emission in G330.2+1.0. We
estimate a low preshock density n_0 ~ 0.1 cm^-3, which suggests a dominant
contribution from an inverse Compton mechanism (than the proton-proton
collision) to the prospective gamma-ray emission. Follow-up deep radio, X-ray,
and gamma-ray observations will be essential to reveal the details of the shock
parameters and the nature of particle accelerations in this SNR.Comment: 26 pages, 3 tables, 7 figures (4 color figures), Accepted by Ap
Turbulence and particle acceleration in collisionless supernovae remnant shocks: II- Cosmic-ray transport
Supernovae remnant shock waves could be at the origin of cosmic rays up to
energies in excess of the knee (eV) if the magnetic
field is efficiently amplified by the streaming of accelerated particles in the
shock precursor. This paper follows up on a previous paper \citep{pell05} which
derived the properties of the MHD turbulence so generated, in particular its
anisotropic character, its amplitude and its spectrum. In the present paper, we
calculate the diffusion coefficients, also accounting for compression through
the shock, and show that the predicted three-dimensional turbulence spectrum
(with and the
wavenumber components along and perpendicular to the shock normal) generally
leads to Bohm diffusion in the parallel direction. However, if the anisotropy
is constrained by a relation of the form ,
which arises when the turbulent energy cascade occurs at a constant rate
independent of scale, then the diffusion coefficient loses its Bohm scaling and
scales as in isotropic Kolmogorov turbulence. We show that these diffusion
coefficients allow to account for X-ray observations of supernova remnants.
This paper also calculates the modification of the Fermi cycle due to the
energy lost by cosmic rays in generating upstream turbulence and the
concomittant steepening of the energy spectrum. Finally we confirm that cosmic
rays can produced an amplified turbulence in young SNr during their free
expansion phase such that the maximal energy is close to the knee and the
spectral index is close to 2.3 in the warm phase of the interstellar mediumComment: 13 pages, 4 figures, accepted for publication in Astronomy &
Astrophysics main journa
Receptor tyrosine kinase inhibitors negatively impact on pro-reparative characteristics of human cardiac progenitor cells
Receptor tyrosine kinase inhibitors improve cancer survival but their cardiotoxicity requires investigation. We investigated these inhibitors' effects on human cardiac progenitor cells in vitro and rat heart in vivo. We applied imatinib, sunitinib or sorafenib to human cardiac progenitor cells, assessing cell viability, proliferation, stemness, differentiation, growth factor production and second messengers. Alongside, sunitinib effects were assessed in vivo. Inhibitors decreased (\u1d631 < 0.05) cell viability, at levels equivalent to 'peak' (24 h; imatinib: 91.5 ± 0.9%; sunitinib: 83.9 ± 1.8%; sorafenib: 75.0 ± 1.6%) and 'trough' (7 days; imatinib: 62.3 ± 6.2%; sunitinib: 86.2 ± 3.5%) clinical plasma levels, compared to control (100% viability). Reduced (\u1d631 < 0.05) cell cycle activity was seen with imatinib (29.3 ± 4.3% cells in S/G2/M-phases; 50.3 ± 5.1% in control). Expression of PECAM-1, Nkx2.5, Wnt2, linked with cell differentiation, were decreased (\u1d631 < 0.05) 2, 2 and 6-fold, respectively. Expression of HGF, p38 and Akt1 in cells was reduced (\u1d631 < 0.05) by sunitinib. Second messenger (p38 and Akt1) blockade affected progenitor cell phenotype, reducing c-kit and growth factor (HGF, EGF) expression. Sunitinib for 9 days (40 mg/kg, i.p.) in adult rats reduced (\u1d631 < 0.05) cardiac ejection fraction (68 ± 2% \u1d637\u1d634. baseline (83 ± 1%) and control (84 ± 4%)) and reduced progenitor cell numbers. Receptor tyrosine kinase inhibitors reduce cardiac progenitor cell survival, proliferation, differentiation and reparative growth factor expression
Transplantation of Skeletal Muscle-Derived Sca-1⁺/PW1⁺/Pax7⁻ Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction
We have previously shown that skeletal muscle-derived Sca-1⁺/PW1⁺/Pax7⁻ interstitial cells (PICs) are multi-potent and enhance endogenous repair and regeneration. Here, we investigated the regenerative potential of PICs following intramyocardial transplantation in mice subjected to an acute myocardial infarction (MI). MI was induced through the ligation of the left anterior descending coronary artery in 8-week old male C57BL/6 mice. 5 × 10⁵ eGFP-labelled PICs (MI + PICs; n = 7) or PBS (MI-PBS; n = 7) were injected intramyocardially into the border zone. Sham mice (n = 8) were not subjected to MI, or the transplantation of PICs or PBS. BrdU was administered via osmotic mini-pump for 14 days. Echocardiography was performed prior to surgery (baseline), and 1-, 3- and 6-weeks post-MI and PICs transplantation. Mice were sacrificed at 6 weeks post-MI + PICs transplantation, and heart sections were analysed for fibrosis, hypertrophy, engraftment, proliferation, and differentiation of PICs. A significant (\u1d631 < 0.05) improvement in ejection fraction (EF) and fractional shortening was observed in the MI-PICs group, compared to MI + PBS group at 6-weeks post MI + PICs transplantation. Infarct size/fibrosis of the left ventricle significantly (\u1d631 < 0.05) decreased in the MI-PICs group (14.0 ± 2.5%), compared to the MI-PBS group (32.8 ± 2.2%). Cardiomyocyte hypertrophy in the border zone significantly (\u1d631 < 0.05) decreased in the MI-PICs group compared to the MI-PBS group (330.0 ± 28.5 µM2 vs. 543.5 ± 26.6 µm2), as did cardiomyocyte apoptosis (0.6 ± 0.9% MI-PICs vs. 2.8 ± 0.8% MI-PBS). The number of BrdU+ cardiomyocytes was significantly (\u1d631 < 0.05) increased in the infarct/border zone of the MI-PICs group (7.0 ± 3.3%), compared to the MI-PBS group (1.7 ± 0.5%). The proliferation index (total BrdU+ cells) was significantly increased in the MI-PICs group compared to the MI-PBS group (27.0 ± 3.4% vs. 7.6 ± 1.0%). PICs expressed and secreted pro-survival and reparative growth factors, supporting a paracrine effect of PICs during recovery/remodeling. Skeletal muscle-derived PICs show significant reparative potential, attenuating cardiac remodelling following transplantation into the infarcted myocardium. PICs can be easily sourced from skeletal muscle and therefore show promise as a potential cell candidate for supporting the reparative and regenerative effects of cell therapie
Transplantation of Skeletal Muscle-Derived Sca-1(+)/PW1(+)/Pax7(-) Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction
We have previously shown that skeletal muscle-derived Sca-1+/PW1+/Pax7− interstitial cells (PICs) are multi-potent and enhance endogenous repair and regeneration. Here, we investigated the regenerative potential of PICs following intramyocardial transplantation in mice subjected to an acute myocardial infarction (MI). MI was induced through the ligation of the left anterior descending coronary artery in 8-week old male C57BL/6 mice. 5 × 105 eGFP-labelled PICs (MI + PICs; n = 7) or PBS (MI-PBS; n = 7) were injected intramyocardially into the border zone. Sham mice (n = 8) were not subjected to MI, or the transplantation of PICs or PBS. BrdU was administered via osmotic mini-pump for 14 days. Echocardiography was performed prior to surgery (baseline), and 1-, 3- and 6-weeks post-MI and PICs transplantation. Mice were sacrificed at 6 weeks post-MI + PICs transplantation, and heart sections were analysed for fibrosis, hypertrophy, engraftment, proliferation, and differentiation of PICs. A significant (p < 0.05) improvement in ejection fraction (EF) and fractional shortening was observed in the MI-PICs group, compared to MI + PBS group at 6-weeks post MI + PICs transplantation. Infarct size/fibrosis of the left ventricle significantly (p < 0.05) decreased in the MI-PICs group (14.0 ± 2.5%), compared to the MI-PBS group (32.8 ± 2.2%). Cardiomyocyte hypertrophy in the border zone significantly (p < 0.05) decreased in the MI-PICs group compared to the MI-PBS group (330.0 ± 28.5 µM2 vs. 543.5 ± 26.6 µm2), as did cardiomyocyte apoptosis (0.6 ± 0.9% MI-PICs vs. 2.8 ± 0.8% MI-PBS). The number of BrdU+ cardiomyocytes was significantly (p < 0.05) increased in the infarct/border zone of the MI-PICs group (7.0 ± 3.3%), compared to the MI-PBS group (1.7 ± 0.5%). The proliferation index (total BrdU+ cells) was significantly increased in the MI-PICs group compared to the MI-PBS group (27.0 ± 3.4% vs. 7.6 ± 1.0%). PICs expressed and secreted pro-survival and reparative growth factors, supporting a paracrine effect of PICs during recovery/remodeling. Skeletal muscle-derived PICs show significant reparative potential, attenuating cardiac remodelling following transplantation into the infarcted myocardium. PICs can be easily sourced from skeletal muscle and therefore show promise as a potential cell candidate for supporting the reparative and regenerative effects of cell therapies
Strong evidences of hadron acceleration in Tycho's Supernova Remnant
Very recent gamma-ray observations of G120.1+1.4 (Tycho's) supernova remnant
(SNR) by Fermi-LAT and VERITAS provided new fundamental pieces of information
for understanding particle acceleration and non-thermal emission in SNRs. We
want to outline a coherent description of Tycho's properties in terms of SNR
evolution, shock hydrodynamics and multi-wavelength emission by accounting for
particle acceleration at the forward shock via first order Fermi mechanism. We
adopt here a quick and reliable semi-analytical approach to non-linear
diffusive shock acceleration which includes magnetic field amplification due to
resonant streaming instability and the dynamical backreaction on the shock of
both cosmic rays (CRs) and self-generated magnetic turbulence. We find that
Tycho's forward shock is accelerating protons up to at least 500 TeV,
channelling into CRs about the 10 per cent of its kinetic energy. Moreover, the
CR-induced streaming instability is consistent with all the observational
evidences indicating a very efficient magnetic field amplification (up to ~300
micro Gauss). In such a strong magnetic field the velocity of the Alfv\'en
waves scattering CRs in the upstream is expected to be enhanced and to make
accelerated particles feel an effective compression factor lower than 4, in
turn leading to an energy spectrum steeper than the standard prediction
{\propto} E^-2. This latter effect is crucial to explain the GeV-to-TeV
gamma-ray spectrum as due to the decay of neutral pions produced in nuclear
collisions between accelerated nuclei and the background gas. The
self-consistency of such an hadronic scenario, along with the fact that the
concurrent leptonic mechanism cannot reproduce both the shape and the
normalization of the detected the gamma-ray emission, represents the first
clear and direct radiative evidence that hadron acceleration occurs efficiently
in young Galactic SNRs.Comment: Minor changes. Accepted for publication in Astronomy & Astrophysic
A Broadband Study of the Emission from the Composite Supernova Remnant MSH 11-62
MSH 11-62 (G291.1-0.9) is a composite supernova remnant for which radio and
X-ray observations have identified the remnant shell as well as its central
pulsar wind nebula. The observations suggest a relatively young system
expanding into a low density region. Here we present a study of MSH 11-62 using
observations with the Chandra, XMM-Newton, and Fermi observatories, along with
radio observations from the Australia Telescope Compact Array (ATCA). We
identify a compact X-ray source that appears to be the putative pulsar that
powers the nebula, and show that the X-ray spectrum of the nebula bears the
signature of synchrotron losses as particles diffuse into the outer nebula.
Using data from the Fermi LAT, we identify gamma-ray emission originating from
MSH 11-62. With density constraints from the new X-ray measurements of the
remnant, we model the evolution of the composite system in order to constrain
the properties of the underlying pulsar and the origin of the gamma-ray
emission.Comment: 12 Pages, 12 figures. Accepted for publication in the Astrophysical
Journa
Active GSK3β and an intact β-catenin TCF complex are essential for the differentiation of human myogenic progenitor cells
CA was in receipt of a KCL studentship. The work was part funded by the BBSRC ref
BB/L009943/1
Electrostatic Potentials in Supernova Remnant Shocks
Recent advances in the understanding of the properties of supernova remnant
shocks have been precipitated by the Chandra and XMM X-ray Observatories, and
the HESS Atmospheric Cerenkov Telescope in the TeV band. A critical problem for
this field is the understanding of the relative degree of dissipative
heating/energization of electrons and ions in the shock layer. This impacts the
interpretation of X-ray observations, and moreover influences the efficiency of
injection into the acceleration process, which in turn feeds back into the
thermal shock layer energetics and dynamics. This paper outlines the first
stages of our exploration of the role of charge separation potentials in
non-relativistic electron-ion shocks where the inertial gyro-scales are widely
disparate, using results from a Monte Carlo simulation. Charge density spatial
profiles were obtained in the linear regime, sampling the inertial scales for
both ions and electrons, for different magnetic field obliquities. These were
readily integrated to acquire electric field profiles in the absence of
self-consistent, spatial readjustments between the electrons and the ions. It
was found that while diffusion plays little role in modulating the linear field
structure in highly oblique and perpendicular shocks, in quasi-parallel shocks,
where charge separations induced by gyrations are small, and shock-layer
electric fields are predominantly generated on diffusive scales.Comment: 7 pages, 2 embedded figures, Accepted for publication in Astrophysics
and Space Science, as part of the HEDLA 2006 conference proceeding
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