ON INTERACTION BETWEEN FALLING BODIES AND THE SURROUNDING FLUID

Interactions between a finite number of bodies and the surrounding fluid, in a channel for instance, are investigated theoretically. In the planar model here the bodies or modelled grains are thin solid bodies free to move in a nearly parallel formation within a quasi-inviscid fluid. The investigation involves numerical and analytical studies and comparisons. The three main features that appear are a linear instability about a state of uniform motion, a clashing of the bodies (or of a body with a side wall) within a finite scaled time when nonlinear interaction takes effect, and a continuum-limit description of the body–fluid interaction holding for the case of many bodies

PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE TGT DENGAN MENGGUNAKAN MEDIA BONEKA BERBICARA UNTUK MENINGKATKAN HASIL BELAJAR IPS TERPADU SISWA KELAS VII SMP NEGERI 17 BANDA ACEH

ABSTRAK Ellis Afnita Sari, Nyimas. 2017. Penerapan Model Pembelajaran Tipe TGTMenggunakan Media Boneka Berbicara Untuk Meningkatkan Hasil Belajar IPSTerpadu Siswa Kelas VII SMP Negeri 17 Banda Aceh. Skripsi, JurusanPendidikan Geografi, Fakultas Keguruan dan Ilmu Pendidikan, UniversitasSyiah Kuala. Pembimbing: (1) Drs. Hasmunir, M.Si (2) Drs. Abdul Wahab Abdi, M.SiKata Kunci : penerapan, kooperatif, team games tourtnament, boneka, hasil belajar. Model pembelajaran kooperatif merupakan salah satu model yang menekankan pada adanya aktivitas dan interaksi di antara siswa untuk saling memotivasi dansaling membantu dalam menguasai materi pelajaran. Penelitian ini bertujuan untukmengetahui: (1) Peningkatan hasil belajar siswa; (2) Aktivitas guru dan siswa; (3)Keterampilan guru dalam mengelola pembelajaran; dan (4) Respon siswa terhadapmodel pembelajaran kooperatif tipe TGT menggunakan media boneka berbicara.Subjek dalam penelitian ini adalah siswa kelas VII SMP Negeri 17 Banda Aceh yangberjumlah 25 orang. Pengumpulan data dilakukan dengan menggunakan (1) Soal pre-test dan posttest;(2) pengamatan aktivitas guru dan siswa; (3) pengamatan keterampilan guru;dan (4) respon siswa. Analisis data menggunakan statistik deskriptif persentase.Hasil penelitian menunjukkan bahwa (1) Persentase ketuntasan secara individualmeningkat dari 10 siswa yang tuntas pada siklus I, 22 siswa tuntas pada siklus II, dan25 tuntas pada siklus III, persentase ketuntasan klasikal pun meningkat dari 40%pada siklus I, 60% pada siklus II, dan 90% pada siklus III; (2) Aktivitas guru dansiswa meningkat menjadi sesuai dengan persentase waktu ideal; (3) Keterampilanguru meningkat dari perolehan skor 2,78 pada siklus I dengan kategori baik, skor3,08 pada siklus II dengan kategori baik, dan 3,34 pada siklus III dengan kategoribaik; (4) Respon siswa, terhadap model pembelajaran kooperatif tipe TGTmenggunakan media boneka berbicara dapat dikatakan baik

Trapping of air in impact between a body and shallow water

Near-impact behaviour is investigated for a solid body approaching another solid body with two immiscible incompressible viscous fluids occupying the gap in between. The fluids have viscosity and density ratios which are extreme, the most notable combination being water and air, such that either or both of the bodies are covered by a thin film of water. Air-water interaction and the commonly observed phenomenon of air trapping are of concern in the presence of the two or three thin layers and one or two interfaces. The subcritical regime is of most practical significance here and it leads physically to the effect of inviscid water dynamics Coupling With a viscous-dominated air response locally. This physical mechanism induces touchdown (or an approach to touchdown), which IS found to occur in the sense that the scaled air-gap thickness shrinks towards zero within a finite scaled time according to analysis performed hand in hand with computation. A global influence oil the local touchdown properties is also identified. Comparisons With computations prove favourable. Air trapping is produced between two touchdown positions, at each of which there is a pressure peak; an oblique approach Would not affect the finding unless the approach itself Is extremely shallow. The mechanism of air-water interaction leading to air trapping is suggested as a quite wide-ranging result

Fyn Kinase regulates GluN2B subunit-dominant NMDA receptors in human induced pluripotent stem cell-derived neurons

NMDA receptor (NMDAR)-mediated fast excitatory neurotransmission is implicated in a broad range of physiological and pathological processes in the mammalian central nervous system. The function and regulation of NMDARs have been extensively studied in neurons from rodents and other non-human species, and in recombinant expression systems. Here, we investigated human NMDARs in situ by using neurons produced by directed differentiation of human induced pluripotent stem cells (iPSCs). The resultant cells showed electrophysiological characteristics demonstrating that they are bona fide neurons. In particular, human iPSC-derived neurons expressed functional ligand-gated ion channels, including NMDARs, AMPA receptors, GABAA receptors, as well as glycine receptors. Pharmacological and electrophysiological properties of NMDAR-mediated currents indicated that these were dominated by receptors containing GluN2B subunits. The NMDAR currents were suppressed by genistein, a broad-spectrum tyrosine kinase inhibitor. The NMDAR currents were also inhibited by a Fyn-interfering peptide, Fyn(39-57), but not a Src-interfering peptide, Src(40-58). Together, these findings are the first evidence that tyrosine phosphorylation regulates the function of NMDARs in human iPSC-derived neurons. Our findings provide a basis for utilizing human iPSC-derived neurons in screening for drugs targeting NMDARs in neurological disorders

Testing non-autonomous antimalarial gene drive effectors using self-eliminating drivers in the African mosquito vector Anopheles gambiae

Gene drives for mosquito population modification are novel tools for malaria control. Strategies to safely test antimalarial effectors in the field are required. Here, we modified the Anopheles gambiae zpg locus to host a CRISPR/Cas9 integral gene drive allele (zpgD) and characterized its behaviour and resistance profile. We found that zpgD dominantly sterilizes females but can induce efficient drive at other loci when it itself encounters resistance. We combined zpgD with multiple previously characterized non-autonomous payload drives and found that, as zpgD self-eliminates, it leads to conversion of mosquito cage populations at these loci. Our results demonstrate how self-eliminating drivers could allow safe testing of non-autonomous effector-traits by local population modification. They also suggest that after engendering resistance, gene drives intended for population suppression could nevertheless serve to propagate subsequently released non-autonomous payload genes, allowing modification of vector populations initially targeted for suppression

Which game narratives do adolescents of different gameplay and sociodemographic backgrounds prefer? a mixed-methods analysis

OBJECTIVE: The aim of this study was to investigate which narrative elements of digital game narratives are preferred by the general adolescent population, and to examine associations with gender, socioeconomic status (SES), and gameplay frequency. Further, the study aims to discuss how results can be translated to serious digital games. MATERIALS AND METHODS: Adolescents were recruited through school to complete a survey on narrative preferences in digital games. The survey included questions on sociodemographic information, frequency of gameplay, and an open-ended question on what could be an appealing narrative for them. Data were analyzed in a mixed-methods approach, using thematic analysis and chi-square analyses to determine narrative preferences and the associations between game narrative elements and player characteristics (gender, SES, and frequency of gameplay). RESULTS: The sample consisted of 446 adolescents (12-15 years old) who described 30 narrative subthemes. Preferences included human characters as protagonists; nonhuman characters only as antagonists; realistic settings, such as public places or cities; and a strong conflict surrounding crime, catastrophe, or war. Girls more often than boys defined characters by their age, included avatars, located the narrative in private places, developed profession-related skills, and included a positive atmosphere. Adolescents of nonacademic education more often than adolescents of academic education defined characters by criminal actions. Infrequent players more often included human characters defined by their age than frequent players. After performing a Bonferroni correction, narrative preferences for several gender differences remained. CONCLUSION: Different narrative elements related to subgroups of adolescents by gender, SES, and frequency of gameplay. Customization of narratives in serious digital health games should be warranted for boys and girls; yet, further research is needed to specify how to address girls in particular

Medium-term seed storage of 50 genera of forage legumes and evidence-based genebank monitoring intervals

Genebanks maintaining seeds for long-term genetic resources conservation monitor seed lots to detect early loss in viability. Monitoring is costly and depletes valuable seed. Three decades of genebank seed germination test results of diverse forage species from 50 legume genera in the International Livestock Research Institute’s medium-term store (circa 8° C with 5 % moisture content) were analysed to determine whether advice on seed monitoring intervals could be derived. Cumulative normal distributions were fitted by probit analysis for each seed lot and compared within each genus. Six patterns of within-genus variation were identified: no detectable trend in germination test results during storage (4 genera); detectable trends, but variable (positive to negative) amongst lots (5); consistent slope of loss in viability amongst lots (17); consistent slope of increase in ability to germinate amongst lots (21); common loss in viability amongst lots (2); common increase in ability to germinate amongst lots (1). Seed lot monitoring intervals for the medium-term store were derived for each of 19 genera with consistent loss in viability across seed lots: three genera provided comparatively rapid deterioration, five met the general expectations for a medium-term store (2-10 years’ maintenance of high viability), whilst 11 provided much better survival. Moreover, 26 further genera provided no evidence as yet of seed deterioration; of these, 22 improved in ability to germinate during storage indicating confounding of hardseededness with viability in germination tests

Evo-devo of human adolescence: beyond disease models of early puberty

Despite substantial heritability in pubertal development, much variation remains to be explained, leaving room for the influence of environmental factors to adjust its phenotypic trajectory in the service of fitness goals. Utilizing evolutionary development biology (evo-devo), we examine adolescence as an evolutionary life-history stage in its developmental context. We show that the transition from the preceding stage of juvenility entails adaptive plasticity in response to energy resources, other environmental cues, social needs of adolescence and maturation toward youth and adulthood. Using the evolutionary theory of socialization, we show that familial psychosocial stress fosters a fast life history and reproductive strategy rather than early maturation being just a risk factor for aggression and delinquency. Here we explore implications of an evolutionary-developmental-endocrinological-anthropological framework for theory building, while illuminating new directions for research

Live to cheat another day: bacterial dormancy facilitates the social exploitation of beta-lactamases

The breakdown of antibiotics by β-lactamases may be cooperative, since resistant cells can detoxify their environment and facilitate the growth of susceptible neighbours. However, previous studies of this phenomenon have used artificial bacterial vectors or engineered bacteria to increase the secretion of β-lactamases from cells. Here, we investigated whether a broad-spectrum β-lactamase gene carried by a naturally occurring plasmid (pCT) is cooperative under a range of conditions. In ordinary batch culture on solid media, there was little or no evidence that resistant bacteria could protect susceptible cells from ampicillin, although resistant colonies could locally detoxify this growth medium. However, when susceptible cells were inoculated at high densities, late-appearing phenotypically susceptible bacteria grew in the vicinity of resistant colonies. We infer that persisters, cells that have survived antibiotics by undergoing a period of dormancy, founded these satellite colonies. The number of persister colonies was positively correlated with the density of resistant colonies and increased as antibiotic concentrations decreased. We argue that detoxification can be cooperative under a limited range of conditions: if the toxins are bacteriostatic rather than bacteridical; or if susceptible cells invade communities after resistant bacteria; or if dormancy allows susceptible cells to avoid bactericides. Resistance and tolerance were previously thought to be independent solutions for surviving antibiotics. Here, we show that these are interacting strategies: the presence of bacteria adopting one solution can have substantial effects on the fitness of their neighbours

Gateway vectors for efficient artificial gene assembly in vitro and expression in yeast Saccharomyces cerevisiae

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