122 research outputs found
Clustering of galaxies around radio quasars at 0.5 < z < 0.8
We have observed the galaxy environments around a sample of 21 radio-loud,
steep-spectrum quasars at 0.5<z<0.82, spanning several orders of magnitude in
radio luminosity. The observations also include background control fields used
to obtain the excess number of galaxies in each quasar field. The galaxy excess
was quantified using the spatial galaxy-quasar correlation amplitude, B_gq, and
an Abell-type measurement, N_0.5 (Hill & Lilly 1991). A few quasars are found
in relatively rich clusters, but on average, they seem to prefer galaxy groups
or clusters of approximately Abell class 0. We have combined our sample with
literature samples extending down to z=0.2 and covering the same range in radio
luminosity. By using Spearman statistic to disentangle redshift and luminosity
dependences, we detect a weak, but significant, positive correlation between
the richness of the quasar environment and the quasar's radio luminosity.
However, we do not find any epoch dependence in B_gq, as has previously been
reported for radio quasars and galaxies. We discuss the radio
luminosity-cluster richness link and possible explanations for the weak
correlation that is seen.Comment: 18 pages, 9 figures, submitted to MNRA
Hot Carrier Transport and Photocurrent Response in Graphene
Strong electron-electron interactions in graphene are expected to result in
multiple-excitation generation by the absorption of a single photon. We show
that the impact of carrier multiplication on photocurrent response is enhanced
by very inefficient electron cooling, resulting in an abundance of hot
carriers. The hot-carrier-mediated energy transport dominates the photoresponse
and manifests itself in quantum efficiencies that can exceed unity, as well as
in a characteristic dependence of the photocurrent on gate voltages. The
pattern of multiple photocurrent sign changes as a function of gate voltage
provides a fingerprint of hot-carrier-dominated transport and carrier
multiplication.Comment: 4 pgs, 2 fg
Obscured Starburst Activity in High Redshift Clusters and Groups
Using Spitzer-MIPS 24um imaging and Keck spectroscopy we examine the nature
of the obscured star forming population in three clusters and three groups at
z~0.9. These six systems are components of the Cl1604 supercluster, the largest
structure imaged by Spitzer at redshifts near unity. We find that the average
density of 24um-detected galaxies within the Cl1604 clusters is nearly twice
that of the surrounding field and that this overdensity scales with the
cluster's dynamical state. The 24um-bright members often appear optically
unremarkable and exhibit only moderate [OII] line emission due to severe
obscuration. Their spatial distribution suggests they are an infalling
population, but an examination of their spectral properties, morphologies and
optical colors indicate they are not simply analogs of the field population
that have yet to be quenched. Using stacked composite spectra, we find the
24um-detected cluster and group galaxies exhibit elevated levels of Balmer
absorption compared to galaxies undergoing normal, continuous star formation. A
similar excess is not observed in field galaxies with equivalent infrared
luminosities, indicating a greater fraction of the detected cluster and group
members have experienced a burst of star formation in the recent past compared
to their counterparts in the field. Our results suggest that gas-rich galaxies
at high redshift experience a temporary increase in their star formation
activity as they assemble into denser environments. Using HST-ACS imaging we
find that disturbed morphologies are common among the 24um-detected cluster and
group members and become more prevalent in regions of higher galaxy density. We
conclude that mergers are the dominant triggering mechanism responsible for the
enhanced star formation found in the Cl1604 groups, while a mix of harassment
and mergers are likely driving the activity of the cluster galaxies.Comment: 18 pages, 19 figures, submitted to Ap
NIMG-56IMMUNOTHERAPY RESPONSE ASSESSMENT IN NEURO-ONCOLOGY (iRANO): A REPORT OF THE RANO WORKING GROUP
The XMM Cluster Survey: Active Galactic Nuclei and Starburst Galaxies in XMMXCS J2215.9-1738 at z=1.46
We use Chandra X-ray and Spitzer infrared observations to explore the AGN and
starburst populations of XMMXCS J2215.9-1738 at z=1.46, one of the most distant
spectroscopically confirmed galaxy clusters known. The high resolution X-ray
imaging reveals that the cluster emission is contaminated by point sources that
were not resolved in XMM observations of the system, and have the effect of
hardening the spectrum, leading to the previously reported temperature for this
system being overestimated. From a joint spectroscopic analysis of the Chandra
and XMM data, the cluster is found to have temperature T=4.1_-0.9^+0.6 keV and
luminosity L_X=(2.92_-0.35^+0.24)x10^44 erg/s extrapolated to a radius of 2
Mpc. As a result of this revised analysis, the cluster is found to lie on the
sigma_v-T relation, but the cluster remains less luminous than would be
expected from self-similar evolution of the local L_X-T relation. Two of the
newly discovered X-ray AGN are cluster members, while a third object, which is
also a prominent 24 micron source, is found to have properties consistent with
it being a high redshift, highly obscured object in the background. We find a
total of eight >5 sigma 24 micron sources associated with cluster members (four
spectroscopically confirmed, and four selected using photometric redshifts),
and one additional 24 micron source with two possible optical/near-IR
counterparts that may be associated with the cluster. Examining the IRAC colors
of these sources, we find one object is likely to be an AGN. Assuming that the
other 24 micron sources are powered by star formation, their infrared
luminosities imply star formation rates ~100 M_sun/yr. We find that three of
these sources are located at projected distances of <250 kpc from the cluster
center, suggesting that a large amount of star formation may be taking place in
the cluster core, in contrast to clusters at low redshift.Comment: Accepted for publication in ApJ, 16 pages, 10 figure
Objective response rate targets for recurrent glioblastoma clinical trials based on the historic association between objective response rate and median overall survival
Durable objective response rate (ORR) remains a meaningful endpoint in recurrent cancer; however, the target ORR for single-arm recurrent glioblastoma trials has not been based on historic information or tied to patient outcomes. The current study reviewed 68 treatment arms comprising 4793 patients in past trials in recurrent glioblastoma in order to judiciously define target ORRs for use in recurrent glioblastoma trials. ORR was estimated at 6.1% [95% CI 4.23; 8.76%] for cytotoxic chemothera + pies (ORR = 7.59% for lomustine, 7.57% for temozolomide, 0.64% for irinotecan, and 5.32% for other agents), 3.37% for biologic agents, 7.97% for (select) immunotherapies, and 26.8% for anti-angiogenic agents. ORRs were significantly correlated with median overall survival (mOS) across chemotherapy (R= 0.4078, P 25% is needed to demonstrate statistical significance compared to control with a high level of confidence (P 80%). Given this historic data and potential biases in patient selection, we recommend that well-controlled, single-arm phase II studies in recurrent glioblastoma should have a target ORR > 25% (which translates to a median OS of approximately 15 months) and a sample size of â„ 40 patients, in order to convincingly demonstrate antitumor activity. Crucially, this response needs to have sufficient durability, which was not addressed in the current study
Objective response rate targets for recurrent glioblastoma clinical trials based on the historic association between objective response rate and median overall survival
Durable objective response rate (ORR) remains a meaningful endpoint in recurrent cancer; however, the target ORR for single-arm recurrent glioblastoma trials has not been based on historic information or tied to patient outcomes. The current study reviewed 68 treatment arms comprising 4793 patients in past trials in recurrent glioblastoma in order to judiciously define target ORRs for use in recurrent glioblastoma trials. ORR was estimated at 6.1% [95% CI 4.23; 8.76%] for cytotoxic chemothera + pies (ORR = 7.59% for lomustine, 7.57% for temozolomide, 0.64% for irinotecan, and 5.32% for other agents), 3.37% for biologic agents, 7.97% for (select) immunotherapies, and 26.8% for anti-angiogenic agents. ORRs were significantly correlated with median overall survival (mOS) across chemotherapy (R2= 0.4078, P < .0001), biologics (R2= 0.4003, P = .0003), and immunotherapy trials (R2= 0.8994, P < .0001), but not anti-angiogenic agents (R2= 0, P = .8937). Pooling data from chemotherapy, biologics, and immunotherapy trials, a meta-analysis indicated a strong correlation between ORR and mOS (R2= 0.3900, P < .0001; mOS [weeks] = 1.4xORR + 24.8). Assuming an ineffective cytotoxic (control) therapy has ORR = 7.6%, the average ORR for lomustine and temozolomide trials, a sample size of â„40 patients with target ORR>25% is needed to demonstrate statistical significance compared to control with a high level of confidence (P < .01) and adequate power (>80%). Given this historic data and potential biases in patient selection, we recommend that well-controlled, single-arm phase II studies in recurrent glioblastoma should have a target ORR >25% (which translates to a median OS of approximately 15 months) and a sample size of â„40 patients, in order to convincingly demonstrate antitumor activity. Crucially, this response needs to have sufficient durability, which was not addressed in the current study.</p
Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimerâs disease
Introduction: Cardiorespiratory fitness (CRF) has been shown to be related to brain health in older adults. In individuals at risk for developing Alzheimer\u27s disease (AD), CRF may be a modifiable risk factor that could attenuate anticipated declines in brain volume and episodic memory. The objective of this study was to determine the association between CRF and both hippocampal volume and episodic memory in a cohort of cognitively healthy older adults with familial and/or genetic risk for Alzheimer\u27s disease (AD).
Methods: Eightyâsix enrollees from the Wisconsin Registry for Alzheimer\u27s Prevention participated in this study. Participants performed a graded maximal exercise test, underwent a Tâ1 anatomical magnetic resonance imaging scan, and completed the Rey Auditory Verbal Learning Test (RAVLT).
Results: There were no significant relationships between CRF and HV or RAVLT memory scores for the entire sample. When the sample was explored on the basis of gender, CRF was significantly associated with hippocampal volume for women. For men, significant positive associations were observed between CRF and RAVLT memory scores.
Summary: These results suggest that CRF may be protective against both hippocampal volume and episodic memory decline in older adults at risk for AD, but that the relationships may be gender specific
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