Pengaruh Terapi Aktifitas Kelompok (Tak) Stimulasi Persepsi Sessi 1-3 terhadap Kemampuan Mengendalikan Halusinasi pada Pasien Skizofrenia Hebefrenik

Schizoprenia was not a single disorder, but a group of related disorder characterized by disordered thinking and perception. One positive symptoms of schizophrenia was hallucination. Hallucination generally flange at behavior that can injury themselves, other people and environment. Destructive agresive action or hardness behavior that be done by schizophrenia patient to injury themselves or other people, most of it caused by hallucination. Design used in this study was Quasy-eksperiment two group pre test- post test design, sampel consist of 14 respondent, 7 people treatment group and 7 people control group. The independent variable was group activity therapy (TAK) perspective stimulation, while the dependent variable was the ability to cut of hallucination. Data were collected using observation. Data that obtained at the time of pre test and post test would be collected and analized using Wilcoxon Signed Rank Test with level of significance <0,05, while to knew the difference of pain level post test between treatment group and control group would be analized using Mann-Whitney Test with level of significance <0,05. The result showed that giving aromatherapy had strong influence to decrease pain level of migraine patient, with the result of statistical test had same significant level p=0,014. The result showed that there was differences of pain level post test between treatment group and control group, with the result of statistical test had same significance level p= 0,002. It can be concluded that group activity therapy (TAK) perspective stimulation could increased ability to cut of hallucination. Recommendation for the nurse and other health profession to use group activity therapy (TAK) perspective stimulation to increased ability to cut of hallucination. Futher study of group activity therapy (TAK) perspective stimulation to increased ability to cut of hallucination so hopefully assisted curing prosess

Hidrolisis Eceng Gondok dan Sekam Padi untuk Menghasilkan Gula Reduksi sebagai Tahap Awal Produksi Bioetanol

Eceng gondok (Eichhornia crassipes) merupakan gulma air dengan pertumbuhan cepat yang disebabkan oleh eutrofikasi di badan air. Eceng gondok yang mengandung struktur lignoselulosa ini memiliki ketersediaan yang sangat melimpah. Lignoselulosa yang terdiri dari lignin, selulosa, dan hemiselulosa ini juga terkandung dalam sekam padi. Sekam padi merupakan limbah pertanian yang pemanfaatannya masih belum maksimum. Penelitian ini bertujuan untuk mengetahui campuran terbaik eceng gondok dan sekam padi yang dapat menghasilkan gula reduksi terbanyak. Perbandingan campuran eceng gondok dan sekam padi yang digunakan adalah 100:0, 75:25, 50:50, 25:72, 0:100 dengan berat total 100 gram. Tahap awal penelitian ini yaitu pretreatment dengan H2SO4 1% sebanyak 1000 mL dan pemanasan suhu 100oC selama 60 menit. Tahap selanjutnya adalah hidrolisis enzimatik dengan memanfaatkan Aspergillus Niger dan Trichoderma viride dengan perbandingn 2:1. Reaktor yang digunakan merupakan reaktor kaca dengan volume 2 L. Parameter yang diukur meliputi lignoselulosa dan gula reduksi. Hasil penelitian ini menunjukkan bahwa sampel yang mengandung 100:0 eceng gondok dan sekam padi mampu menghasilkan kadar gula reduksi tertinggi, yaitu sebesar 23,33 mg/g

Potensi Daur Ulang dan Partisipasi Masyarakat dalam Pengelolaan Sampah di Kecamatan Jabon, Kabupaten Sidoarjo

Tujuan penelitian ini adalah menentukan potensi timbulan sampah organik, potensi daur ulang dan menentukan rekomendasi untuk meningkatkan partisipasi masyarakat dalam pengelolaan sampah di Kecamatan Jabon. Penelitian ini dilakukan pada 2 aspek yaitu aspek teknis dan aspek masyarakat. Untuk aspek teknis melakukan sampling timbulan, komposisi dan densitas sampah rumah tangga, sentra industri tempe dan kerupuk, peternakan ayam dan bebek. Sedangkan untuk aspek masyarakat menyebarkan kuisioner yang berisikan kategori pengetahuan, sikap dan perilaku yang kemudian akan diolah dengan metode likert scale dan chi kuadrat. Jumlah responden rumah tangga berjumlah 100 KK yang tersebar di 3 desa. Rata-rata timbulan sampah yang dihasilkan untuk sampah rumah tangga adalah 0,27 kg/org/hari, sentra industri tempe 28.639,16 kg/hari, sentra industri kerupuk 9.766,83 kg/hari, peternakan ayam 166,70 kg/hari dan peternakan bebek 630,15 kg/hari

Adhesion of thiolated silica nanoparticles to urinary bladder mucosa: effects of PEGylation, thiol content and particle size

Intravesical drug administration is used to deliver cytotoxic agents through a catheter to treat bladder cancer. One major limitation of this approach is poor retention of the drug in the bladder due to periodic urine voiding. Mucoadhesive dosage forms thus offer significant potential to improve drug retention in the bladder. Here, we investigate thiolated silica nanoparticles retention on porcine bladder mucosa in vitro, quantified through Wash Out50 (WO50) values, defined as the volume of liquid necessary to remove 50% of the adhered particles from a mucosal tissue. Following irrigation with artificial urine solution, the thiolated nanoparticles demonstrate significantly greater retention (WO50 up to 36 mL) compared to non-mucoadhesive dextran (WO50 7 mL), but have weaker mucoadhesive properties than chitosan (WO50 89 mL). PEGylation of thiolated silica reduces their mucoadhesion with WO50 values of 29 and 8 mL for particles decorated with 750 and 5000 Da PEG, respectively. The retention of thiolated silica nanoparticles is dependent on their thiol group contents and physical dimensions

Controlling the size of thiolated organosilica nanoparticles

Nanoparticle characteristics, including their size, are governed by the reagents employed and the reaction parameters. Here, we systemically vary the catalyst, oxygen content, temperature and solvent to modify the size and zeta potential of thiolated organosilica nanoparticles. Particles were synthesized by self-condensation of 3-mercaptopropyltrimethoxysilane (MPTS) in a range of organic solvents in contact with oxygen, with NaOH and other catalysts. Particle size increased with increasing reaction temperature (70 ± 1 nm at 50 °C; 50 ± 1 nm at room temperature) but decreased when air was bubbled through the reaction mixture compared to no bubbling. Significant decrease in particle size was seen with increasing the dielectric constant of the solvent and with increasing catalyst concentration; from these we provide empirical equations that can be used to design particle sizes by manipulating the dielectric constant of the solvent (or co-solvents) or by varying NaOH catalyst concentration when DMSO is the selected solvent

Including Limited Partners in the Diversity Jurisdiction Analysis

This paper presents the results of the Dynamic Pricing Challenge, held on the occasion of the 17th INFORMS Revenue Management and Pricing Section Conference on June 29–30, 2017 in Amsterdam, The Netherlands. For this challenge, participants submitted algorithms for pricing and demand learning of which the numerical performance was analyzed in simulated market environments. This allows consideration of market dynamics that are not analytically tractable or can not be empirically analyzed due to practical complications. Our findings implicate that the relative performance of algorithms varies substantially across different market dynamics, which confirms the intrinsic complexity of pricing and learning in the presence of competition

Trends in the Development of University Education in the Postmodern Period

The purpose of the research was to study the changes in the ranking of professional skills of students, which determine trends in university education in the postmodern era. The presented results of the experiment allowed to determine the level of perception of new professional skills by university students under the influence of the ideology of postmodernism. The general hypothesis of the study was that postmodern ideology influences the model of university education, contributes to the creation of the foundations for the formation of new professional skills of students. This study is part of a broader study that explores ways to improve the quality of university education based on the substantive professional priorities of students in the context of postmodernism. The results of the experiment allowed us to draw conclusions about the relationship between the quality of education and professional priorities of students, a properly organized system of university education in the postmodern period

Provider risks connected with uncertainty in the legal nature of online games’ terms of use

In the practice of the Russian courts, when creating an account in an online multiplayer game, any agreement concluded between the provider and the user seems to be covered by article 1062 of the Civil Code of the Russian Federation, which is why this topic is not subject to judicial examination. However, this approach is unlikely to be applied for much longer, as it does not stand up to criticism. It can only be interpreted as a court attempt to insulate itself from the issue of virtual property. This article is devoted to the consideration the key risks to a provider related to the uncertain legal status of an online games’ terms of use, particularly the prohibition to share a user’s account or login credentials with anyone and a user’s actual rights to virtual content associated with his account. To achieve the research goal, the authors review the legal literature and perform a case study in this area, use a comparative method to identify legislative approaches in different legal systems regarding a user’s rights to their account and the virtual content connected with it, and determine the aspects of the user agreement that obviously contain risks for the provider. As a result of the research, the authors conclude that online multiplayer games are a sphere that tends to self-regulate. Therefore, to the extent possible, the risk of imbalance between self-regulation capabilities and the need to avoid abuse of the current situation, both by providers and users, should be minimized. The main source of regulation for relations between providers and players remains an agreement between them, which can be qualified as a mixed contract. However, such a qualification carries a risk for the provider, due to the complexity of determining the consequences of using the agreement as a single document, which combines various goals, ranging from determining the amount of processing of a player’s data and to fixing the legal regime of a user’s account. Regarding prohibition to share a user’s account, the authors assume that, according to Russian legislation, the most appropriate path is to determine it as a prohibition of assignment to secure providers from the liability for protection of users’ data. The lack of special regulation in this area allows the provider, through the terms of use, to sidestep the potential risk of protecting the player’s copyright on virtual content associated with his account. The authors, however, suggest that using an analogue of the American “sweat of the brow” doctrine in user agreements can to a certain extent remove the provider’s risks associated with the players’ real rights to their in-game property

Radiation-induced alternative transcription and splicing events and their applicability to practical biodosimetry

Accurate assessment of the individual exposure dose based on easily accessible samples (e.g. blood) immediately following a radiological accident is crucial. We aimed at developing a robust transcription-based signature for biodosimetry from human peripheral blood mononuclear cells irradiated with different doses of X-rays (0.1 and 1.0 Gy) at a dose rate of 0.26 Gy/min. Genome-wide radiation-induced changes in mRNA expression were evaluated at both gene and exon level. Using exon-specific qRT-PCR, we confirmed that several biomarker genes are alternatively spliced or transcribed after irradiation and that different exons of these genes exhibit significantly different levels of induction. Moreover, a significant number of radiation-responsive genes were found to be genomic neighbors. Using three different classification models we found that gene and exon signatures performed equally well on dose prediction, as long as more than 10 features are included. Together, our results highlight the necessity of evaluating gene expression at the level of single exons for radiation biodosimetry in particular and transcriptional biomarker research in general. This approach is especially advisable for practical gene expression-based biodosimetry, for which primer-or probe-based techniques would be the method of choice