Predicting the deleterious effects of mutation load in fragmented populations.

Human-induced habitat fragmentation constitutes a major threat to biodiversity. Both genetic and demographic factors combine to drive small and isolated populations into extinction vortices. Nevertheless, the deleterious effects of inbreeding and drift load may depend on population structure, migration patterns, and mating systems and are difficult to predict in the absence of crossing experiments. We performed stochastic individual-based simulations aimed at predicting the effects of deleterious mutations on population fitness (offspring viability and median time to extinction) under a variety of settings (landscape configurations, migration models, and mating systems) on the basis of easy-to-collect demographic and genetic information. Pooling all simulations, a large part (70%) of variance in offspring viability was explained by a combination of genetic structure (F(ST)) and within-deme heterozygosity (H(S)). A similar part of variance in median time to extinction was explained by a combination of local population size (N) and heterozygosity (H(S)). In both cases the predictive power increased above 80% when information on mating systems was available. These results provide robust predictive models to evaluate the viability prospects of fragmented populations

Perspectives on player performance during FIFA World Cup Qatar 2022: a brief report

Changing the date of the FIFA World Cup Qatar 2022 may represent a factor to consider for the expected performance of participating players. This was due to fixture congestion at the start of the season and expected weather conditions during the competition. Thus, the main purpose of this brief report was to critically analyze the potential impact of changing the competition date and weather conditions on players’ performance. In addition, a brief description about the performance during the World Cup is also provided. For the research, the Web of Science, PubMed and SPORTDiscus databases were accessed using the primary keywords FIFA World Cup and World Soccer Cup associated with the secondary keywords match running performance, fixture congestion, fatigue and weather conditions. After applying inclusion and exclusion criteria, 52 articles were considered for analysis. The results seem to indicate that although changes were expected due to the modifications made (i.e., the competition date and scheduling congestion), the performance of the players seems not to have been affected in terms of the analyzed indicators. Furthermore, it seems possible to identify some patterns in the behavior of the teams that reached the most advanced stages of the competition.This research was founded by the Higher Institute of Educational Sciences of the Douro, by national funds (FCT—Portuguese Foundation for Science and Technology) under the project UIBD/DTP/04045/2020 and by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP— Grant number: 2021/03601-1).info:eu-repo/semantics/publishedVersio

SNhunt151: An explosive event inside a dense cocoon

Indexación: Scopus.We thank S. Spiro, R. Rekola, A. Harutyunyan, and M. L. Graham for their help with the observations. We are grateful to the collaboration of Massimo Conti, Giacomo Guerrini, Paolo Rosi, and Luz Marina Tinjaca Ramirez from the Osservatorio Astronomico Provinciale di Montarrenti. The staffs at the different observatories provided excellent assistance with the observations.The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement No. 267251, ‘Astronomy Fellowships in Italy’ (AstroFIt)’. NE-R acknowledges financial support from MIUR PRIN 2010-2011, ‘The Dark Universe and the Cosmic Evolution of Baryons: From Current Surveys to Euclid’. NE-R, AP, SB, LT, MT, and GP are partially supported by the PRIN-INAF 2014 (project ‘Transient Universe: Unveiling New Types of Stellar Explosions with PESSTO’). GP acknowledges support provided by the Millennium Institute of Astrophysics (MAS) through grant IC120009 of the Programa Iniciativa Cientíifica Milenio del Ministerio de Economía, Fomento y Turismo de Chile. TK acknowledges financial support from the Emil Aaltonen Foundation. CRTS was supported by the NSF grants AST-0909182, AST-1313422, and AST-1413600. AVF is grateful for generous financial assistance from the Christopher R. Redlich Fund, the TABASGO Foundation, the Miller Institute for Basic Research in Science (UC Berkeley), and NASA/HST grant GO-14668 from the Space Telescope Science Institute, which is operated by AURA, Inc. under NASA contract NAS5-26555. The work of AVF was conducted in part at the Aspen Center for Physics, which is supported by NSF grantPHY-1607611; he thanks the Center for its hospitality during the neutron stars workshop in June and July 2017. NE-R acknowledges the hospitality of the ‘Institut de Ciències de l'Espai (CSIC), where this work was completed.This research is based on observations made with the Nordic Optical Telescope, operated by the Nordic Optical Telescope Scientific Association at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofísica de Canarias; the Gran Telescopio Canarias (GTC), installed in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias, on the island of La Palma; the Italian Telescopio Nazionale Galileo (TNG), operated on the island of La Palma by the Fundaci Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias; the Liverpool Telescope, operated on the island of La Palma by Liverpool John Moores University in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias with financial support from the UK Science and Technology Facilities Council; the 1.82-m Copernico Telescope and the Schmidt 67/92 cm of INAF-Asiago Observatory; the Catalina Real Time Survey (CRTS) Catalina Sky Survey (CSS) 0.7-m Schmidt Telescope; and the Las Cumbres Observatory (LCO) network. This work is also based in part on archival data obtained with the NASA/ESA Hubble Space Telescope, obtained from the Data Archive at the Space Telescope Science Institute (STScI), which is operated by the Association of Universities for Research in Astronomy (AURA), Inc., under NASA contract NAS5-26555; the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA (support was provided by NASA through an award issued by JPL/Caltech); and the Swift telescope.This work has made use of the NASA/IPAC Extragalactic Database (NED), which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under contract with NASA.SNhunt151 was initially classified as a supernova (SN) impostor (nonterminal outburst of a massive star). It exhibited a slow increase in luminosity, lasting about 450 d, followed by a major brightening that reaches M V ≈ -18 mag. No source is detected to M V ≳ -13 mag in archival images at the position of SNhunt151 before the slow rise. Low-to-mid-resolution optical spectra obtained during the pronounced brightening show very little evolution, being dominated at all times by multicomponent Balmer emission lines, a signature of interaction between the material ejected in the new outburst and the pre-existing circumstellar medium. We also analysed mid-infrared images from the Spitzer Space Telescope, detecting a source at the transient position in 2014 and 2015. Overall, SNhunt151 is spectroscopically a Type IIn SN, somewhat similar to SN 2009ip. However, there are also some differences, such as a slow pre-discovery rise, a relatively broad light-curve peak showing a longer rise time (~50 d), and a slower decline, along with a negligible change in the temperature around the peak (T ≤ 10 4 K). We suggest that SNhunt151 is the result of an outburst, or an SN explosion, within a dense circumstellar nebula, similar to those embedding some luminous blue variables like η Carinae and originating from past mass-loss events. © 2017 The Author(s).https://academic.oup.com/mnras/article/475/2/2614/479530

Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis.

Harlequin Ichthyosis is a severe skin disease caused by mutations in the human gene encoding ABCA12. Here, we characterize a novel mutation in intron 29 of the mouse Abca12 gene that leads to the loss of a 5' splice donor site and truncation of the Abca12 RNA transcript. Homozygous mutants of this smooth skin or smsk allele die perinatally with shiny translucent skin, typical of animal models of Harlequin Ichthyosis. Characterization of smsk mutant skin showed that the delivery of glucosylceramides and CORNEODESMOSIN was defective, while ultrastructural analysis revealed abnormal lamellar bodies and the absence of lipid lamellae in smsk epidermis. Unexpectedly, mutant stratum corneum remained intact when subjected to harsh chemical dissociation procedures. Moreover, both KALLIKREIN 5 and -7 were drastically decreased, with retention of desmoplakin in mutant SC. In cultured wild type keratinocytes, both KALLIKREIN 5 and -7 colocalized with ceramide metabolites following calcium-induced differentiation. Reducing the intracellular levels of glucosylceramide with a glucosylceramide synthase inhibitor resulted in decreased secretion of KALLIKREIN proteases by wild type keratinocytes, but not by smsk mutant keratinocytes. Together, these findings suggest an essential role for ABCA12 in transferring not only lipids, which are required for the formation of multilamellar structures in the stratum corneum, but also proteolytic enzymes that are required for normal desquamation. Smsk mutant mice recapitulate many of the pathological features of HI and can be used to explore novel topical therapies against a potentially lethal and debilitating neonatal disease

Shea (Vitellaria paradoxa C.F. Gaertn.) – a peripheral empire commodity in French West Africa, 1894–1960

Burkinabé women have traded shea kernels and shea butter in periodic local markets, and on a regional scale with the densely-populated West African littoral, for centuries. This paper traces the origins of French colonial efforts to develop shea as a commodity of empire from the 1890s to independence in 1960. Colonial effo rts to incorporate Upper Volta, a French colonial backwater, into the world economy was drawn out, heterogenous, and messy. The colonial state assumed erroneously that little shea trade existed, and that producers would respond positively to market incentives. Yet, we suggest that French colonial policies failed due to a composite of factors including the limited investment in either the colony or shea as an oilseed crop, adaptation by women shea producers to the extraction of male labour and the trade opportunities created by new international borders, and the ‘blindness’ of colonial officials to the economic, social and cultural functions of periodic local markets used by women shea traders. The historical trajectory of the shea trade continues to have implications for current-day shea markets and their actors

The long-lived Type IIn SN 2015da: Infrared echoes and strong interaction within an extended massive shell star star star

In this paper we report the results of the first similar to four years of spectroscopic and photometric monitoring of the Type IIn supernova SN 2015da (also known as PSN J13522411+3941286, or iPTF16tu). The supernova exploded in the nearby spiral galaxy NGC 5337 in a relatively highly extinguished environment. The transient showed prominent narrow Balmer lines in emission at all times and a slow rise to maximum in all bands. In addition, early observations performed by amateur astronomers give a very well-constrained explosion epoch. The observables are consistent with continuous interaction between the supernova ejecta and a dense and extended H-rich circumstellar medium. The presence of such an extended and dense medium is difficult to reconcile with standard stellar evolution models, since the metallicity at the position of SN 2015da seems to be slightly subsolar. Interaction is likely the mechanism powering the light curve, as confirmed by the analysis of the pseudo bolometric light curve, which gives a total radiated energy greater than or similar to 10(51) erg. Modeling the light curve in the context of a supernova shock breakout through a dense circumstellar medium allowed us to infer the mass of the prexisting gas to be similar or equal to 8 M-circle dot, with an extreme mass-loss rate for the progenitor star similar or equal to 0.6 M-circle dot yr(-1), suggesting that most of the circumstellar gas was produced during multiple eruptive events. Near- and mid-infrared observations reveal a fluxexcess in these domains, similar to those observed in SN 2010jl and other interacting transients, likely due to preexisting radiatively heated dust surrounding the supernova. By modeling the infrared excess, we infer a mass greater than or similar to 0.4 x 10(-3) M-circle dot for the dustSpanish MICINN gran

Octet magnetic moments and the Coleman-Glashow sum rule violation in the chiral quark model

Baryon octet magnetic moments when calculated within the chiral quark model, incorporating the orbital angular momentum as well as the quark sea contribution through the Cheng-Li mechanism, not only show improvement over the non relativistic quark model results but also gives a non zero value for the right hand side of Coleman-Glashow sum rule. When effects due to spin-spin forces between constituent quarks as well as `mass adjustments' due to confinement are added, it leads to an excellent fit for the case of p, \Sigma^+, \Xi^o and violation of Coleman-Glashow sum rule, whereas in almost all the other cases the results are within 5% of the data.Comment: 5 RevTeX pages, accepted for publication in PRD(Rapid Communication

Search for venous endothelial biomarkers heralding venous thromboembolism in space: a qualitative systematic review of terrestrial studies

Background: The recent discovery of a venous thrombosis in the internal jugular vein of an astronaut has highlighted the need to predict the risk of venous thromboembolism in otherwise healthy individuals (VTE) in space. Virchow's triad defines the three classic risk factors for VTE: blood stasis, hypercoagulability, and endothelial disruption/dysfunction. Among these risk factors, venous endothelial disruption/dysfunction remains incompletely understood, making it difficult to accurately predict risk, set up relevant prophylactic measures and initiate timely treatment of VTE, especially in an extreme environment. Methods: A qualitative systematic review focused on endothelial disruption/dysfunction was conducted following the guidelines produced by the Space Biomedicine Systematic Review Group, which are based on Cochrane review guidelines. We aimed to assess the venous endothelial biochemical and imaging markers that may predict increased risk of VTE during spaceflight by surveying the existing knowledge base surrounding these markers in analogous populations to astronauts on the ground. Results: Limited imaging markers related to endothelial dysfunction that were outside the bounds of routine clinical practice were identified. While multiple potential biomarkers were identified that may provide insight into the etiology of endothelial dysfunction and its link to future VTE, insufficient prospective evidence is available to formally recommend screening potential astronauts or healthy patients with any currently available novel biomarker. Conclusion: Our review highlights a critical knowledge gap regarding the role biomarkers of venous endothelial disruption have in predicting and identifying VTE. Future population-based prospective studies are required to link potential risk factors and biomarkers for venous endothelial dysfunction to occurrence of VTE

Cardy-Verlinde Formula and Achucarro-Ortiz Black Hole

In this paper it is shown that the entropy of the black hole horizon in the Achucarro-Ortiz spacetime, which is the most general two-dimensional black hole derived from the three-dimensional rotating BTZ black hole, can be described by the Cardy-Verlinde formula. The latter is supposed to be an entropy formula of conformal field theory in any dimension.Comment: 10 pages, LaTeX, v2: minor changes, references added, to appear in Phys. Rev.

Understanding Business Travel Time and Its Place in the Working Day

This article argues that there is a need to understand business travel time in the context of the wider organization of work time. It considers why travel time use is potentially changing with the use of mobile technologies by the increasing number of individuals engaged in ‘knowledge work’, and examines existing evidence that indicates that travel time use is part of a wider work-related ‘taskscape’. However, it not only considers material productive output, but suggests that travel time as ‘time out’ from work-related activities also plays a vital role for employees. It also suggests that business travel time use that is not of benefit to the employer may not be at the employer's expense. This is contrasted with the assumptions used in UK transport appraisal. Data gathered from the autumn 2004 wave of the National Rail Passenger Survey (GB) is used to illustrate some key issues concerning productivity and ‘anti-activity’. A case study of an individual business traveller then points towards the need for a new approach to exploring the role played by travel time in the organization of work practices to be considered. © 2008, Sage Publications. All rights reserved